CN119552163A - 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 - Google Patents

钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 Download PDF

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Publication number
CN119552163A
CN119552163A CN202411689939.3A CN202411689939A CN119552163A CN 119552163 A CN119552163 A CN 119552163A CN 202411689939 A CN202411689939 A CN 202411689939A CN 119552163 A CN119552163 A CN 119552163A
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CN
China
Prior art keywords
formula
complex
gadolinium
rrr
sss
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Pending
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CN202411689939.3A
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English (en)
Chinese (zh)
Inventor
斯瓦兹克·格雷纽
艾伦·切内德
马丁尼·瑟夫
米里亚姆·佩塔
艾曼纽尔·马拉斯
布鲁诺·弗朗索瓦
卡罗琳·罗比克
斯蒂芬妮·卢盖
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Fa Guojiabai
Original Assignee
Fa Guojiabai
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Application filed by Fa Guojiabai filed Critical Fa Guojiabai
Publication of CN119552163A publication Critical patent/CN119552163A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202411689939.3A 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 Pending CN119552163A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR1900432 2019-01-17
FR1900432A FR3091873B1 (fr) 2019-01-17 2019-01-17 Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
PCT/EP2020/051153 WO2020148436A1 (fr) 2019-01-17 2020-01-17 Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
CN202080009625.8A CN113646308B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法

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CN202080009625.8A Division CN113646308B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法

Publications (1)

Publication Number Publication Date
CN119552163A true CN119552163A (zh) 2025-03-04

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CN202411689939.3A Pending CN119552163A (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法
CN202111049738.3A Active CN113735854B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法
CN202080009625.8A Active CN113646308B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202111049738.3A Active CN113735854B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法
CN202080009625.8A Active CN113646308B (zh) 2019-01-17 2020-01-17 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法

Country Status (28)

Country Link
US (3) US11590246B2 (enAn)
EP (2) EP3902800B1 (enAn)
JP (2) JP7071596B2 (enAn)
KR (2) KR102502862B1 (enAn)
CN (3) CN119552163A (enAn)
AR (1) AR117835A1 (enAn)
AU (1) AU2020208794B2 (enAn)
BR (1) BR112021014006B1 (enAn)
CA (1) CA3126268C (enAn)
CL (1) CL2021001868A1 (enAn)
CO (1) CO2021009261A2 (enAn)
DK (2) DK3943493T3 (enAn)
ES (2) ES2930136T3 (enAn)
FI (1) FI3943493T3 (enAn)
FR (1) FR3091873B1 (enAn)
HR (2) HRP20230678T1 (enAn)
HU (2) HUE062554T2 (enAn)
IL (1) IL284884B1 (enAn)
MA (2) MA55389A (enAn)
MX (1) MX2021008651A (enAn)
PH (1) PH12021551725A1 (enAn)
PL (2) PL3943493T3 (enAn)
PT (2) PT3902800T (enAn)
RS (1) RS64334B1 (enAn)
SG (1) SG11202107779SA (enAn)
TW (1) TWI811518B (enAn)
WO (1) WO2020148436A1 (enAn)
ZA (1) ZA202104994B (enAn)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
US20230339945A1 (en) * 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
EP4222861A4 (en) * 2020-10-02 2024-10-02 Eagle Harbor Technologies, Inc. IONIC CURRENT DROP COMPENSATION
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
IT1292128B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US8119817B2 (en) * 2009-09-29 2012-02-21 Degussa-Huels Ag Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
EP2786768A1 (en) 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
WO2014174120A1 (fr) 2013-04-26 2014-10-30 Guerbet Formulation de produit de contraste et son procede de preparation associe
CN104188957B (zh) * 2014-05-28 2017-04-26 中国中医科学院西苑医院 一种防治再狭窄的药物及其制备和使用方法
US11155519B2 (en) * 2017-04-28 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for manufacturing diastereomer of citric acid derivative
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

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Publication number Publication date
MA54626A (fr) 2022-04-20
CA3126268A1 (fr) 2020-07-23
CL2021001868A1 (es) 2022-01-21
US12064487B2 (en) 2024-08-20
IL284884A (en) 2021-08-31
JP2022508496A (ja) 2022-01-19
PL3943493T3 (pl) 2023-08-07
PT3943493T (pt) 2023-07-12
PT3902800T (pt) 2022-11-16
EP3902800B1 (fr) 2022-09-07
CN113735854A (zh) 2021-12-03
BR112021014006B1 (pt) 2023-05-02
CA3126268C (fr) 2024-01-09
EP3902800A1 (fr) 2021-11-03
RS64334B1 (sr) 2023-08-31
CN113735854B (zh) 2024-05-14
AU2020208794A1 (en) 2021-08-05
ES2930136T3 (es) 2022-12-07
ES2950118T3 (es) 2023-10-05
US20220062443A1 (en) 2022-03-03
HUE060343T2 (hu) 2023-02-28
FR3091873A1 (fr) 2020-07-24
KR102502862B1 (ko) 2023-02-23
JP2022009463A (ja) 2022-01-14
WO2020148436A1 (fr) 2020-07-23
AU2020208794B2 (en) 2023-01-12
CO2021009261A2 (es) 2021-12-10
KR20210109039A (ko) 2021-09-03
CN113646308B (zh) 2024-12-13
MA55389A (fr) 2022-01-26
EP3943493B1 (fr) 2023-04-19
CN113646308A (zh) 2021-11-12
AR117835A1 (es) 2021-08-25
DK3902800T3 (da) 2022-11-28
TW202043227A (zh) 2020-12-01
HRP20230678T1 (hr) 2023-09-29
EP3943493A1 (fr) 2022-01-26
DK3943493T3 (da) 2023-07-24
PL3902800T3 (pl) 2022-12-27
JP7321230B2 (ja) 2023-08-04
US20240358863A1 (en) 2024-10-31
TWI811518B (zh) 2023-08-11
US11590246B2 (en) 2023-02-28
FI3943493T3 (fi) 2023-07-19
KR102438394B1 (ko) 2022-09-01
ZA202104994B (en) 2023-04-26
US20230149568A1 (en) 2023-05-18
HUE062554T2 (hu) 2023-11-28
HRP20221402T1 (hr) 2023-01-06
IL284884B1 (en) 2025-05-01
BR112021014006A2 (pt) 2021-09-21
FR3091873B1 (fr) 2020-12-25
MX2021008651A (es) 2021-10-26
JP7071596B2 (ja) 2022-05-19
KR20210138134A (ko) 2021-11-18
PH12021551725A1 (en) 2022-04-11
SG11202107779SA (en) 2021-08-30

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