TWI811518B - 釓和基於ｐｃｔａ的螯合配位基的非鏡像異構物富集的錯合物及其製備和純化方法 - Google Patents

釓和基於ｐｃｔａ的螯合配位基的非鏡像異構物富集的錯合物及其製備和純化方法 Download PDF

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Publication number
TWI811518B
TWI811518B TW109101779A TW109101779A TWI811518B TW I811518 B TWI811518 B TW I811518B TW 109101779 A TW109101779 A TW 109101779A TW 109101779 A TW109101779 A TW 109101779A TW I811518 B TWI811518 B TW I811518B
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Taiwan
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formula
complex
rrr
sss
composition
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TW109101779A
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Chinese (zh)
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TW202043227A (zh
Inventor
索立克 里加尼爾
艾萊恩 齊尼迪
馬汀尼 洽爾夫
麥瑞安 皮塔
艾曼紐 馬瑞亞斯
布努諾 法蘭索瓦
卡羅尼 羅比克
史蒂芬妮 羅古特
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法商加柏公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW109101779A 2019-01-17 2020-01-17 釓和基於ｐｃｔａ的螯合配位基的非鏡像異構物富集的錯合物及其製備和純化方法 TWI811518B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1900432 2019-01-17
FR1900432A FR3091873B1 (fr) 2019-01-17 2019-01-17 Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Publications (2)

Publication Number Publication Date
TW202043227A TW202043227A (zh) 2020-12-01
TWI811518B true TWI811518B (zh) 2023-08-11

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TW109101779A TWI811518B (zh) 2019-01-17 2020-01-17 釓和基於ｐｃｔａ的螯合配位基的非鏡像異構物富集的錯合物及其製備和純化方法

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US (3) US11590246B2 (enAn)
EP (2) EP3902800B1 (enAn)
JP (2) JP7071596B2 (enAn)
KR (2) KR102502862B1 (enAn)
CN (3) CN119552163A (enAn)
AR (1) AR117835A1 (enAn)
AU (1) AU2020208794B2 (enAn)
BR (1) BR112021014006B1 (enAn)
CA (1) CA3126268C (enAn)
CL (1) CL2021001868A1 (enAn)
CO (1) CO2021009261A2 (enAn)
DK (2) DK3943493T3 (enAn)
ES (2) ES2930136T3 (enAn)
FI (1) FI3943493T3 (enAn)
FR (1) FR3091873B1 (enAn)
HR (2) HRP20230678T1 (enAn)
HU (2) HUE062554T2 (enAn)
IL (1) IL284884B1 (enAn)
MA (2) MA55389A (enAn)
MX (1) MX2021008651A (enAn)
PH (1) PH12021551725A1 (enAn)
PL (2) PL3943493T3 (enAn)
PT (2) PT3902800T (enAn)
RS (1) RS64334B1 (enAn)
SG (1) SG11202107779SA (enAn)
TW (1) TWI811518B (enAn)
WO (1) WO2020148436A1 (enAn)
ZA (1) ZA202104994B (enAn)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
US20230339945A1 (en) * 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
EP4222861A4 (en) * 2020-10-02 2024-10-02 Eagle Harbor Technologies, Inc. IONIC CURRENT DROP COMPENSATION
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제

Citations (4)

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CN101305006A (zh) * 2005-10-07 2008-11-12 加柏公司 含有短氨基醇链的化合物和用于医学成像的金属络合物
CN105073144A (zh) * 2013-04-04 2015-11-18 爱克发医疗保健公司 制造具有大环配体的镧系元素配合物的方法
CN105142649A (zh) * 2013-04-26 2015-12-09 法国加柏公司 造影剂配制品与有关制备方法
TW202039506A (zh) * 2019-01-17 2020-11-01 法商加柏公司 釓和基於pcta的螯合配位基的非鏡像異構物富集的錯合物和合成方法

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US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
IT1292128B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US8119817B2 (en) * 2009-09-29 2012-02-21 Degussa-Huels Ag Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
CN104188957B (zh) * 2014-05-28 2017-04-26 中国中医科学院西苑医院 一种防治再狭窄的药物及其制备和使用方法
US11155519B2 (en) * 2017-04-28 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for manufacturing diastereomer of citric acid derivative
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101305006A (zh) * 2005-10-07 2008-11-12 加柏公司 含有短氨基醇链的化合物和用于医学成像的金属络合物
CN105073144A (zh) * 2013-04-04 2015-11-18 爱克发医疗保健公司 制造具有大环配体的镧系元素配合物的方法
CN105142649A (zh) * 2013-04-26 2015-12-09 法国加柏公司 造影剂配制品与有关制备方法
TW202039506A (zh) * 2019-01-17 2020-11-01 法商加柏公司 釓和基於pcta的螯合配位基的非鏡像異構物富集的錯合物和合成方法

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MA54626A (fr) 2022-04-20
CA3126268A1 (fr) 2020-07-23
CL2021001868A1 (es) 2022-01-21
US12064487B2 (en) 2024-08-20
IL284884A (en) 2021-08-31
JP2022508496A (ja) 2022-01-19
PL3943493T3 (pl) 2023-08-07
PT3943493T (pt) 2023-07-12
PT3902800T (pt) 2022-11-16
EP3902800B1 (fr) 2022-09-07
CN113735854A (zh) 2021-12-03
BR112021014006B1 (pt) 2023-05-02
CA3126268C (fr) 2024-01-09
EP3902800A1 (fr) 2021-11-03
RS64334B1 (sr) 2023-08-31
CN113735854B (zh) 2024-05-14
AU2020208794A1 (en) 2021-08-05
ES2930136T3 (es) 2022-12-07
ES2950118T3 (es) 2023-10-05
US20220062443A1 (en) 2022-03-03
HUE060343T2 (hu) 2023-02-28
FR3091873A1 (fr) 2020-07-24
KR102502862B1 (ko) 2023-02-23
JP2022009463A (ja) 2022-01-14
WO2020148436A1 (fr) 2020-07-23
CN119552163A (zh) 2025-03-04
AU2020208794B2 (en) 2023-01-12
CO2021009261A2 (es) 2021-12-10
KR20210109039A (ko) 2021-09-03
CN113646308B (zh) 2024-12-13
MA55389A (fr) 2022-01-26
EP3943493B1 (fr) 2023-04-19
CN113646308A (zh) 2021-11-12
AR117835A1 (es) 2021-08-25
DK3902800T3 (da) 2022-11-28
TW202043227A (zh) 2020-12-01
HRP20230678T1 (hr) 2023-09-29
EP3943493A1 (fr) 2022-01-26
DK3943493T3 (da) 2023-07-24
PL3902800T3 (pl) 2022-12-27
JP7321230B2 (ja) 2023-08-04
US20240358863A1 (en) 2024-10-31
US11590246B2 (en) 2023-02-28
FI3943493T3 (fi) 2023-07-19
KR102438394B1 (ko) 2022-09-01
ZA202104994B (en) 2023-04-26
US20230149568A1 (en) 2023-05-18
HUE062554T2 (hu) 2023-11-28
HRP20221402T1 (hr) 2023-01-06
IL284884B1 (en) 2025-05-01
BR112021014006A2 (pt) 2021-09-21
FR3091873B1 (fr) 2020-12-25
MX2021008651A (es) 2021-10-26
JP7071596B2 (ja) 2022-05-19
KR20210138134A (ko) 2021-11-18
PH12021551725A1 (en) 2022-04-11
SG11202107779SA (en) 2021-08-30

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