JP7071596B2 - ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス - Google Patents

ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス Download PDF

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JP7071596B2
JP7071596B2 JP2021541202A JP2021541202A JP7071596B2 JP 7071596 B2 JP7071596 B2 JP 7071596B2 JP 2021541202 A JP2021541202 A JP 2021541202A JP 2021541202 A JP2021541202 A JP 2021541202A JP 7071596 B2 JP7071596 B2 JP 7071596B2
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complex
formula
isomers
gadolinium
rrr
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JP2022508496A (ja
Inventor
グルニエ ソワジック ル
アラン シェンデ
マルティーヌ セール
ミリアン ペッタ
エマニュエル マレ
ブリュノ フランソワ
カロリーヌ ロビック
ステファニー ルーゲ
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Guerbet SA
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Guerbet SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021541202A 2019-01-17 2020-01-17 ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス Active JP7071596B2 (ja)

Priority Applications (1)

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JP2021173867A JP7321230B2 (ja) 2019-01-17 2021-10-25 ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1900432 2019-01-17
FR1900432A FR3091873B1 (fr) 2019-01-17 2019-01-17 Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
PCT/EP2020/051153 WO2020148436A1 (fr) 2019-01-17 2020-01-17 Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

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JP2021173867A Division JP7321230B2 (ja) 2019-01-17 2021-10-25 ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス

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JP7071596B2 true JP7071596B2 (ja) 2022-05-19

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JP2021541202A Active JP7071596B2 (ja) 2019-01-17 2020-01-17 ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス
JP2021173867A Active JP7321230B2 (ja) 2019-01-17 2021-10-25 ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス

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US (3) US11590246B2 (enAn)
EP (2) EP3902800B1 (enAn)
JP (2) JP7071596B2 (enAn)
KR (2) KR102502862B1 (enAn)
CN (3) CN119552163A (enAn)
AR (1) AR117835A1 (enAn)
AU (1) AU2020208794B2 (enAn)
BR (1) BR112021014006B1 (enAn)
CA (1) CA3126268C (enAn)
CL (1) CL2021001868A1 (enAn)
CO (1) CO2021009261A2 (enAn)
DK (2) DK3943493T3 (enAn)
ES (2) ES2930136T3 (enAn)
FI (1) FI3943493T3 (enAn)
FR (1) FR3091873B1 (enAn)
HR (2) HRP20230678T1 (enAn)
HU (2) HUE062554T2 (enAn)
IL (1) IL284884B1 (enAn)
MA (2) MA55389A (enAn)
MX (1) MX2021008651A (enAn)
PH (1) PH12021551725A1 (enAn)
PL (2) PL3943493T3 (enAn)
PT (2) PT3902800T (enAn)
RS (1) RS64334B1 (enAn)
SG (1) SG11202107779SA (enAn)
TW (1) TWI811518B (enAn)
WO (1) WO2020148436A1 (enAn)
ZA (1) ZA202104994B (enAn)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022009463A (ja) * 2019-01-17 2022-01-14 ゲルベ ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
US20230339945A1 (en) * 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
EP4222861A4 (en) * 2020-10-02 2024-10-02 Eagle Harbor Technologies, Inc. IONIC CURRENT DROP COMPENSATION
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501430A (ja) 1999-06-09 2003-01-14 ゲルベ ２環式ポリアミノ酸金属複合体、その製法および医療用画像化での使用
JP2009513574A (ja) 2005-10-07 2009-04-02 ゲルベ 医用画像のための短いアミノアルコール鎖および金属錯体を含む化合物
JP2016521275A (ja) 2013-04-26 2016-07-21 ゲルベＧｕｅｒｂｅｔ 造影製剤および関連する調製方法

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US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
IT1292128B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US8119817B2 (en) * 2009-09-29 2012-02-21 Degussa-Huels Ag Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
EP2786768A1 (en) 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
CN104188957B (zh) * 2014-05-28 2017-04-26 中国中医科学院西苑医院 一种防治再狭窄的药物及其制备和使用方法
US11155519B2 (en) * 2017-04-28 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for manufacturing diastereomer of citric acid derivative
CA3105610C (en) 2018-08-06 2024-05-28 Bracco Imaging Spa Gadolinium bearing pcta-based contrast agents
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501430A (ja) 1999-06-09 2003-01-14 ゲルベ ２環式ポリアミノ酸金属複合体、その製法および医療用画像化での使用
JP2009513574A (ja) 2005-10-07 2009-04-02 ゲルベ 医用画像のための短いアミノアルコール鎖および金属錯体を含む化合物
JP2016521275A (ja) 2013-04-26 2016-07-21 ゲルベＧｕｅｒｂｅｔ 造影製剤および関連する調製方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022009463A (ja) * 2019-01-17 2022-01-14 ゲルベ ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス
JP7321230B2 (ja) 2019-01-17 2023-08-04 ゲルベ ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス

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MA54626A (fr) 2022-04-20
CA3126268A1 (fr) 2020-07-23
CL2021001868A1 (es) 2022-01-21
US12064487B2 (en) 2024-08-20
IL284884A (en) 2021-08-31
JP2022508496A (ja) 2022-01-19
PL3943493T3 (pl) 2023-08-07
PT3943493T (pt) 2023-07-12
PT3902800T (pt) 2022-11-16
EP3902800B1 (fr) 2022-09-07
CN113735854A (zh) 2021-12-03
BR112021014006B1 (pt) 2023-05-02
CA3126268C (fr) 2024-01-09
EP3902800A1 (fr) 2021-11-03
RS64334B1 (sr) 2023-08-31
CN113735854B (zh) 2024-05-14
AU2020208794A1 (en) 2021-08-05
ES2930136T3 (es) 2022-12-07
ES2950118T3 (es) 2023-10-05
US20220062443A1 (en) 2022-03-03
HUE060343T2 (hu) 2023-02-28
FR3091873A1 (fr) 2020-07-24
KR102502862B1 (ko) 2023-02-23
JP2022009463A (ja) 2022-01-14
WO2020148436A1 (fr) 2020-07-23
CN119552163A (zh) 2025-03-04
AU2020208794B2 (en) 2023-01-12
CO2021009261A2 (es) 2021-12-10
KR20210109039A (ko) 2021-09-03
CN113646308B (zh) 2024-12-13
MA55389A (fr) 2022-01-26
EP3943493B1 (fr) 2023-04-19
CN113646308A (zh) 2021-11-12
AR117835A1 (es) 2021-08-25
DK3902800T3 (da) 2022-11-28
TW202043227A (zh) 2020-12-01
HRP20230678T1 (hr) 2023-09-29
EP3943493A1 (fr) 2022-01-26
DK3943493T3 (da) 2023-07-24
PL3902800T3 (pl) 2022-12-27
JP7321230B2 (ja) 2023-08-04
US20240358863A1 (en) 2024-10-31
TWI811518B (zh) 2023-08-11
US11590246B2 (en) 2023-02-28
FI3943493T3 (fi) 2023-07-19
KR102438394B1 (ko) 2022-09-01
ZA202104994B (en) 2023-04-26
US20230149568A1 (en) 2023-05-18
HUE062554T2 (hu) 2023-11-28
HRP20221402T1 (hr) 2023-01-06
IL284884B1 (en) 2025-05-01
BR112021014006A2 (pt) 2021-09-21
FR3091873B1 (fr) 2020-12-25
MX2021008651A (es) 2021-10-26
KR20210138134A (ko) 2021-11-18
PH12021551725A1 (en) 2022-04-11
SG11202107779SA (en) 2021-08-30

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