CN1193664C - Effervescent table as agricultural chemical and its preparing process - Google Patents
Effervescent table as agricultural chemical and its preparing process Download PDFInfo
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- CN1193664C CN1193664C CN 00107465 CN00107465A CN1193664C CN 1193664 C CN1193664 C CN 1193664C CN 00107465 CN00107465 CN 00107465 CN 00107465 A CN00107465 A CN 00107465A CN 1193664 C CN1193664 C CN 1193664C
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- agricultural chemical
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- effervescent table
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Abstract
The present invention relates to an effervescent table as an agricultural chemical and a preparing process thereof. The effervescent tablet as an agricultural chemical is prepared from raw agricultural chemical, sour source, carbon dioxide source, water-blocking agent and agricultural chemical adjuvant. In preparation, soft materials are firstly prepared and are then pressed to tablets to prepare the effervescent tablet as an agricultural chemical and various Insecticidal and acaricidal agents, germicides, herbicides and plant growth regulating agents are prepared into the effervescent tablet. The effervescent tablet has the advantages of small volume and convenient transportation and storage, can automatically disintegrate in water to become an agricultural chemical suspending liquid which can be sprayed and spread in water fields, and can be widely used for agricultural production.
Description
The present invention relates to the pesticide processing field, specifically the present invention relates to a kind of pesticides new formulation---effervescent table as agricultural chemical.
The formulations of pesticide commonly used have missible oil, pulvis, wetting powder, colloidal suspending agent etc., and pesticide species is many mostly becomes the commercially available agricultural chemical list marketing with these several dosage form.In these formulations of pesticide commonly used, missible oil is owing to contain organic solvent, thus inflammable, easy leakage, produce and transportation in must be strict with prevent fires, leakage-preventing; Pulvis, wetting powder easily lump in storage because granularity is very little, and the volume that accounts for is big, bring inconvenience to use; There is leakage problem too in colloidal suspending agent.The present invention intends working out a kind of pesticides new formulation, to overcome the deficiency of above preparation form.So effervescent table as agricultural chemical has just arisen at the historic moment.
The objective of the invention is to propose a kind of effervescent table as agricultural chemical and manufacture method thereof.
Below narrate main contents of the present invention:
Effervescent tablet of the present invention is made up of pesticide original medicine, acid source, carbon dioxide source, waterproofing agent, insecticides adjuvant, through certain process obtain can be in water disintegration and form the tablet of the suspension that can be used for spraying automatically.
Agricultural chemicals in the effervescent tablet of the present invention can be a desinsection, kill one or both compositions in mite, sterilization, weeding, the plant growth regulating.Wherein insecticide can be: the young urea that goes out, deinsectization azoles, diflubenzuron, UC 62644, Cyhalothrin, cyfloxylate, tefluthrin, bifenthrin, Avermectin, ivermectin; Miticide comprises: Cyhalothrin, Avermectin, bifenthrin, azacyclotin, binapacryl, fenbutatin oxide, fenothiocarb, plictran; Weed killer herbicide can be: metsulfuron-methyl, chlorsulfuron, tribenuron-methyl, triasulfuron, thiophene methyl, ethyl methyl, benzyl ethyl methyl, surely kill, clean, the quinclorac of fluazifop-p-butyl, Dicamba, the wealthy pleasure of gram, prowers, thiameturonmethyl, broad-leaved, fixed, the happy spirit of quinoline of fluorine grass; Bactericide can be the mould prestige of second, thiophanate, triazolone, alkene azoles alcohol, nitrile bacterium azoles, propiconazole, Flusilazole, carboxin; Plant growth regulator can be: heteroauxin, indolebutyric acid, kinetin, paclobutrazol, maleic hydrazide, alar-85, naa, chlormequat, Lodging-proof agent, inabenfide, ethrel, triacontanol, gibberellin.
The acid source material of effervescent tablet of the present invention is any one in citric acid, tartaric acid, fumaric acid, hexanedioic acid, malic acid, the water-soluble amino acids.
Carbon dioxide source material in the effervescent tablet of the present invention is a sodium carbonate, any one in the materials such as sodium bicarbonate, saleratus, potash, calcium carbonate.
Insecticides adjuvant in the effervescent tablet of the present invention, can be one or more mixtures in the following material, as draw back materials such as powder, saponin, lignin sulfonic acid salt material, alkyl sulfonates material, laruyl alcohol, alkylphenol polyoxyethylene succinic acid sodium sulfonate, dodecyl benzene sulfonate, succinic acid-monooctyl ester sodium sulfonate, nekal, sodium phosphate trimer, sodium silicate, Sodium Benzoate (potassium), stearate.
Waterproofing agent in the effervescent tablet of the present invention can be any one or a few mixture in the materials such as zeolite, silicic acid, white carbon black, talcum powder, bentonite, alundum (Al, silicon bath soil.
The processing technology of effervescent tablet of the present invention is divided three steps:
A. with the acid source material, carbon dioxide source material, waterproofing agent be dry respectively, pulverized 60 mesh sieves, mixes; With isopropyl alcohol or butanols or isobutanol with mixture furnishing pasty state; Under vacuum, remove adding alcohol, cross 20 mesh sieves, promptly get soft material.
B. soft material and pesticide original medicine, the insecticides adjuvant with the steps A gained mixes, and gets the disintegratable shot-like particle.
C. in tablet press machine, the disintegratable shot-like particle of step B gained is pressed into the tablet of suitable size, promptly get this effervescent table as agricultural chemical.
Each component optimum weight percentage in the effervescent tablet of the present invention is:
Pesticide original medicine 2～30%
Acid source 15～30%
Carbon dioxide source 15～20%
Waterproofing agent 5～20%
Insecticides adjuvant 5～50%
The present invention compares than prior art has following typical advantages:
1. have that production process safety, tablet volume are little, convenient transportation, advantage such as easy to use.The characteristics of effervescent tablet are with after forming the various raw materials compactings in flakes of this agent and since acid source and carbon dioxide source in water rapidly reaction generate carbonic acid gas, make this tablet can disintegration automatically in water, and become operable liquid or suspension.This formulation is applied to pharmaceutical preparation the earliest, the patient of particularly suitable children, the elderly and the solid pharmaceutical preparation of can not swallowing; Because of taking with the solution form, drug effect is rapid again, bioavilability height, and comparing with liquid preparation, its advantage be carry more convenient.This research has successfully also been made effervescent tablet with various agricultural chemicals on the basis of medical effervescent tablet.And before this, from domestic patent and practical application, also there is not pesticide species with this dosage form application, effervescent table as agricultural chemical of the present invention, overcome many shortcomings of agricultural chemicals common formulations such as missible oil, wetting powder, pulvis, colloidal suspending agent, and have that production process safety, tablet volume are little, convenient transportation, advantage such as easy to use.
2. employed insecticides adjuvant in the effervescent tablet of the present invention, suspending agent, wetting agent, emulsifier etc. have been comprised, so this effervescent tablet is in water after the disintegration, can form the soup that meets the pesticide standard requirement, this soup can be used for spraying, regulates with the disease of control in the agricultural production, worm, crop smothering and to growth and development of plant.
3. effervescent table as agricultural chemical of the present invention, owing to added the waterproofing agent of tool high dispersive performance, and make tablet be difficult for influencing the disintegration ability of tablet because of the moisture absorption.The pesticide original medicine that is suitable for being processed into effervescent tablet can be a solid, can be liquid also, but when pesticide original medicine is liquid, need with porous filler such as carbon black, alundum (Al etc. the former medicine of liquid to be adsorbed earlier, mix with other auxiliary material again, become effervescent tablet through compressing tablet.
4. consumption is little.When being liquid except that the pesticide original medicine when processing, the agricultural chemicals consumption under normal conditions that is processed into effervescent tablet should be not more than 500g/ha.
Below narrate embodiments of the invention:
Embodiment 1: take by weighing citric acid 25.0g, and potash 25.0g, dry respectively, and be crushed to 60 mesh sieves; Zeolite and each 6.0g of silicic acid of adding 400 mesh sieves mix the back and with an amount of isobutanol mixture are modulated into pasty state, remove isobutanol under vacuum, residue is crossed 20 mesh sieves, promptly makes soft material; Take by weighing lauryl sodium sulfate 10g, draw back powder 8g, Sodium Benzoate 15g, former medicine 5.0g of diflubenzuron (pure) and the soft material of gained fully mix, and compacting promptly gets 5% diflubenzuron effervescent tablet in flakes in tablet press machine.This diflubenzuron effervescent tablet disintegration automatically in water, and form uniform suspension is used to spray and can effectively prevents and treats Lepidoptera on the various crops, insects such as coleoptera.
Embodiment 2: take by weighing vinic acid 20.0g, sodium bicarbonate 20.0g, and dry respectively and be crushed to 60 mesh sieves; Add 10g respectively and cross the alundum (Al and the carbon black of 425 mesh sieves, fully mix, with an amount of isopropyl alcohol this mixture is modulated into pasty state again, remove isopropyl alcohol under vacuum, residue is crossed 20 mesh sieves, promptly makes soft material; Take by weighing dolomol 15g, sodium lignin sulfonate 15g, sodium silicate 15g, the former medicine 10g of benzene ethyl methyl (pure) after mixing with soft material, neutralizes in flakes through tablet press machine, promptly get 10% benzene ethyl methyl effervescent tablet, this effervescent tablet is in water after the disintegration, and the suspension of formation is suitable for spraying, to broad leaved weed and the rice field very high preventive effect of taking to the greenwood.
Embodiment 3: take by weighing malic acid 30g, saleratus 30g is dry respectively and be crushed to 60 mesh sieves; Took by weighing the swelling ± 10g of 400 mesh sieves, and mixed the back and be modulated into pasty state with isobutanol, isobutanol is removed in vacuum drying, promptly makes soft material; Soft material and 5g laruyl alcohol, 5g sodium phosphate trimer, 3g bulk myclobutanil (pure) and the former medicine of 7g thiophanate-methyl (pure) are fully mixed, get 10% formonitrile HCN effervescent tablet through the tablet press machine film-making.This tablet forms the suspension can be used for spraying after the disintegration in water, can effectively prevent and treat the disease such as scab, powdery mildew of crops such as apple, pears, cucumber and wheat powdery mildew, grape bunch and fruit black rot are also had good preventive effect.
EXPERIMENTAL EXAMPLE 1: with the preparation of the different dosage form of diflubenzuron to three age mythimna separata carried out toxicity test.Measure and adopt leaf dipping method, every kind of preparation is established 5-6 concentration, and every concentration is established 3 repetitions, and every reprocessing 20 cephalont are contrast with the clear water.Check 5 days and symptom or dead examination worm ratio occur.Ask the school preventive effect with the Abbort formula, obtain the virulence curve and the EC of each preparation with the probit value analytical method
50, the results are shown in Table 1.
Four kinds of diflubenzuron preparations of table 1 to 3 age mythimna separata virulence relatively
Formulation virulence equation (y=) EC
50(mg/L)
Effervescent tablet 6.0822+1.1799x 0.1210
Wetting powder 5.9952+1.0962x 0.1236
Colloidal suspending agent 5.3561+1.1782x 0.4986
Missible oil 5.6832+0.8379x 0.1530
The result shows: the diflubenzuron effervescent tablet is higher than other three kinds of common dosage forms to the virulence of mythimna separata.
EXPERIMENTAL EXAMPLE 2: adopt pesticide wettable to measure the method for effective ingredient suspensibility, measured the suspensibility of diflubenzuron effervescent tablet, the suspensibility of diflubenzuron effervescent tablet of the present invention is 71.34%, satisfies the pesticidal preparations suspensibility greater than 60% requirement.
Claims (7)
1. effervescent table as agricultural chemical, it is characterized in that this effervescent table as agricultural chemical is made up of pesticide original medicine, acid source, carbon dioxide source, waterproofing agent, insecticides adjuvant, wherein agricultural chemicals can be the mixture of nitrile bacterium azoles and thiophanate-methyl, and the mixed proportion of nitrile bacterium azoles and thiophanate-methyl is 30: 70～40: 60.
2. effervescent table as agricultural chemical as claimed in claim 1 is characterized in that the optimum weight percentage of each component in this effervescent table as agricultural chemical is:
Pesticide original medicine 2～30%
Acid source 15～30%
Carbon dioxide source 15～20%
Waterproofing agent 5～20%
Insecticides adjuvant 5～50%
Wherein pesticide original medicine is the mixture of nitrile bacterium azoles and thiophanate-methyl, and the mixed proportion of two kinds of farm chemical ingredients is 30: 70～40: 60.
3. effervescent table as agricultural chemical as claimed in claim 1 is characterized in that acid source used in this effervescent tablet is any one in citric acid, tartaric acid, fumaric acid, hexanedioic acid, malic acid, the water-soluble amino acids.
4. effervescent table as agricultural chemical according to claim 1, it is characterized in that carbon dioxide source can be in the materials such as sodium carbonate, sodium bicarbonate, potash, saleratus, calcium carbonate any one.
5. effervescent table as agricultural chemical according to claim 1 is characterized in that insecticides adjuvant can be one or more mixtures that draw back among powder, saponin, lignin, Sulfonates material, alkyl sulfonates material, laruyl alcohol, alkylphenol polyoxyethylene succinic acid sodium sulfonate, dodecyl benzene sulfonate, succinic acid-monooctyl ester sodium sulfonate, nekal, sodium phosphate trimer, sodium silicate, Sodium Benzoate, Potassium Benzoate, the stearate.
6. effervescent table as agricultural chemical according to claim 1 is characterized in that waterproofing agent can be any one or a few mixture among zeolite, silicic acid, white carbon black, talcum powder, bentonite, alundum (Al, the silicon bath soil.
7. the manufacture method of effervescent table as agricultural chemical according to claim 1 is characterized in that:
A. with the acid source material, carbon dioxide source material, waterproofing agent be dry respectively, pulverized 60 mesh sieves, mixes; With isopropyl alcohol or butanols or isobutanol with mixture furnishing pasty state; Under vacuum, remove adding alcohol, cross 20 mesh sieves, promptly get soft material;
B. evenly mix with the soft material of steps A gained with by the nitrile bacterium azoles of 30: 70～40: 60 mixed proportions and the former medicine of thiophanate-methyl and insecticides adjuvant, the disintegratable shot-like particle;
C. in tablet press machine, the disintegration shot-like particle of step B gained is pressed into the tablet of suitable size, promptly get this effervescent table as agricultural chemical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107465 CN1193664C (en) | 2000-05-17 | 2000-05-17 | Effervescent table as agricultural chemical and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107465 CN1193664C (en) | 2000-05-17 | 2000-05-17 | Effervescent table as agricultural chemical and its preparing process |
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| Publication Number | Publication Date |
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| CN1283388A CN1283388A (en) | 2001-02-14 |
| CN1193664C true CN1193664C (en) | 2005-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00107465 Expired - Fee Related CN1193664C (en) | 2000-05-17 | 2000-05-17 | Effervescent table as agricultural chemical and its preparing process |
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2247897B1 (en) * | 2003-12-18 | 2007-05-01 | Gat Formulation Gmbh | TABLETS WITH EMULSIONED POLYMERIC MATRIX FOR CONTROLLED GAS EMISSION AND PROCEDURE FOR MANUFACTURING. |
| CN101328087B (en) * | 2008-06-16 | 2011-05-18 | 山东农业大学 | Foliage fertilizer effervescent tablet and preparation thereof |
| CN101874491B (en) * | 2010-06-04 | 2013-02-27 | 江苏七洲绿色化工股份有限公司 | Effervescent tablet containing propiconazole and preparation method thereof |
| CN101999348B (en) * | 2010-10-26 | 2013-01-02 | 江苏七洲绿色化工股份有限公司 | Preparation method of pesticide effervescent tablet |
| CN102187861A (en) * | 2011-04-02 | 2011-09-21 | 河北三农农用化工有限公司 | Lythidathion effervescent tablets and method for preparing same |
| CN102450255A (en) * | 2011-11-08 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Forchlorfenuron effervescent granules/or effervescent tablets and preparation method thereof |
| CN102450268A (en) * | 2011-11-09 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Paclobutrazol effervescent granules/or effervescent tablets and preparation method thereof |
| CN102823622B (en) * | 2012-09-24 | 2013-12-11 | 发事达(南通)化工有限公司 | Glyphosate soluble effervescent tablet and preparation method thereof |
| CN103651585A (en) * | 2013-12-06 | 2014-03-26 | 何小刚 | Insect-resisting agent |
| CN104382863B (en) * | 2014-11-29 | 2017-07-07 | 河南后羿实业集团有限公司 | A kind of fowl ivermectin effervescence granular |
| CN106070270A (en) * | 2016-07-13 | 2016-11-09 | 陈志勤 | A kind of composition pesticide and application thereof |
| CN108124906B (en) * | 2017-12-21 | 2019-11-15 | 中国水稻研究所 | A kind of paddy rice seed soaking agent |
| CN109601541A (en) * | 2018-11-26 | 2019-04-12 | 河南三浦百草生物工程有限公司 | A kind of effervescent tablet of coordinate plant growth and its application |
| CN110100816A (en) * | 2019-05-14 | 2019-08-09 | 允发化工（上海）有限公司 | A kind of gibberellic acid soluble tablets and preparation method thereof |
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2000
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