CN110100816A - A kind of gibberellic acid soluble tablets and preparation method thereof - Google Patents
A kind of gibberellic acid soluble tablets and preparation method thereof Download PDFInfo
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- CN110100816A CN110100816A CN201910399067.XA CN201910399067A CN110100816A CN 110100816 A CN110100816 A CN 110100816A CN 201910399067 A CN201910399067 A CN 201910399067A CN 110100816 A CN110100816 A CN 110100816A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
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Abstract
The invention discloses a kind of gibberellic acid soluble tablets and preparation method thereof, are related to preparation technique of pesticide field.It is characterized in that: a kind of gibberellic acid soluble tablets, the component including following parts by weight: gibberellic acid GA3: 20~25 parts；Dispersing agent: 1~5 part；Binder: 0.5~4 part；Disintegrating agent: 0.5~4 part；Antioxidant: 0.05~0.2 part；Coating agent: part；Wherein coating agent is according to percentage composition meter, including following component: polyethylene glycol: 10~20%；Talcum powder: 5~30%；Titanium dioxide: 0~20%；Hydroxypropyl methylcellulose: 10~30%, by wrapping up one layer of coating outside tablet, so that the humidity resistance of gibberellic acid soluble tablets greatly improves, the shelf-life increases.
Description
Technical field
The present invention relates to preparation technique of pesticide field, more specifically, it relates to a kind of gibberellic acid soluble tablets and its
Preparation method.
Background technique
Gibberellin is the mixture of a variety of homologues, they differ greatly to the bioactivity of plant, wherein GA3、GA4、
GA7、GA14Stronger, the gibberellic acid GA of activity3It is then especially prominent.
The most apparent bioactivity of gibberellic acid is stimulation plant cell growth, and plant is made to grow tall, and blade increases；Kind can be broken
The suspend mode of son, stem tuber, root tuber promotes its germination；Fruit growth can be stimulated, setting percentage is improved or forms stenospermocarpy；There is part
For the effect of long-day, make some plants under the conditions of short-day also can bolting bloom.
Since gibberellic acid raw medicine is insoluble in water, it must be first dissolved in ethyl alcohol or high spirit, then add water dilute when preparing
It releases to required concentration, inconvenient to use, so soluble tablets are usually made, gibberellic acid soluble tablets both maintain gibberellic acid
The active principle and bioactivity of raw medicine, and it directly can be configured to required concentration with water, but in humid region, gibberellic acid can
The hygroscopic generation crystalline polamer of dissolubility tablet, cause tablet can not ingredient dissolution be dispersed in water, effective component cannot be fine
Application, to influence drug effect.
Summary of the invention
In view of the deficienciess of the prior art, the purpose of the present invention one is to provide a kind of gibberellic acid soluble tablets,
Can long-time stable storage, not hygroscopic generation crystalline polamer has the advantages that moisture-proof and long shelf-life.
To achieve the above object one, the present invention provides the following technical scheme that
A kind of gibberellic acid soluble tablets, the component including following parts by weight:
Gibberellic acid GA3: 20~25 parts；
Dispersing agent: 1~5 part；
Binder: 0.5~4 part；
Disintegrating agent: 0.5~4 part；
Antioxidant: 0.05~0.2 part；
Coating agent: 3~5 parts；
Wherein coating agent is according to percentage composition meter, including following component:
Polyethylene glycol: 10~20%；
Talcum powder: 5~30%；
Titanium dioxide: 0~20%；
Hydroxypropyl methylcellulose: 10~30%.
By using above-mentioned technical proposal, when gibberellic acid soluble tablets are stored in humid region, hygroscopic crystallization is led
It causes its effective component to fail, greatly reduces the shelf-life, by adding coating agent in composition of raw materials, so that it is not easy to absorb sky
Moisture in gas and go bad, can storage time increase, improve the shelf-life；Coating agent in the present invention uses a variety of macromolecule filmings
Material is prepared, and changes the physical property of film forming, after coating agent tabletting, contacts closely between ingredient, is not easy permeable, increase
The humidity resistance of tablet.
Further preferably, the dispersing agent uses dinaphthylmethanedisulfonic acid sodium, dodecyl benzene sulfonic acid and lignin
One of sodium sulfonate is a variety of.
By using above-mentioned technical proposal, dispersing agent reduces the surface-active of gibberellic acid in water, enables gibberellic acid
It sufficiently dissolves and is dispersed in water.
Further preferably, the binder includes hydroxymethyl cellulose, starch and gum arabic.
By using above-mentioned technical proposal, binder enables gibberellic acid and other auxiliary agents to bond in flakes, stores for a long time
It deposits and is not easy loosely into powder.
Further preferably, the disintegrating agent includes croscarmellose sodium.
By using above-mentioned technical proposal, croscarmellose sodium is nontoxic, nonirritant, and compressibility is good, disintegration
Power is strong, can eliminate the binding force generated by adhesive and high compression, so that tablet is disintegrated in water.
Further preferably, it is (0.8~1.5): 1 sodium bicarbonate and acid that the disintegrating agent, which includes weight fraction ratio,
Middle acid uses one of tartaric acid, formic acid and citric acid or a variety of.
By using above-mentioned technical proposal, after tablet is dissolved in water, the acid in disintegrating agent generates a large amount of with reaction of sodium bicarbonate
Carbon dioxide gas, a large amount of bubbles are disintegrated tablet rapidly, and gibberellic acid is soluble in water, and gibberellic acid part is avoided to recrystallize
Phenomenon, avoiding result in sufficiently dissolution phenomena to occur.
Further preferably, the antioxidant is using butylated hydroxy anisole, propylgallate and tertiary butyl to benzene
One of diphenol is a variety of.
By using above-mentioned technical proposal, adding antioxidant effectively can prevent gibberellic acid in formulation drying process
It decomposes, is conducive to the tablet storage stability in later period, furthermore the decomposition speed of gibberellic acid in water can also be effectively reduced in antioxidant
Degree enables plant adequately effectively to absorb progress before gibberellic acid decomposed.
Further preferably, further include in the coating agent weight percentage be 1~25% pregelatinized corn starch.
By using above-mentioned technical proposal, pregelatinized corn starch has brilliant with water binding ability, can reduce red mould
Contact of the acid with moisture in air avoids gibberellic acid from using preceding generation crystalline polamer, improves the shelf-life of tablet.
The purpose of the present invention two is to provide a kind of preparation method of gibberellic acid soluble tablets, using this method preparation
Gibberellic acid soluble tablets have the advantages that moisture-proof, long shelf-life.
To achieve the above object two, the present invention provides the following technical scheme that
A kind of preparation method of gibberellic acid soluble tablets, comprising the following steps:
Coating agent preparation: polyethylene glycol, talcum powder, titanium dioxide, hydroxypropyl methylcellulose are put into high-speed mixer by step 1
In mixed, 2500~2800r/min of revolving speed, 15~30min of incorporation time；
Step 2, by gibberellic acid GA3, dispersing agent, binder, disintegrating agent, antioxidant put into mixing 20 in mixing machine~
Then 30min puts into and carries out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted, wherein
Low-temperature vacuum drying temperature is 35~45 DEG C, and vacuum degree is not less than -0.08MPa；
Fine powder outside tablet made from step 2 is removed using asepwirator pump, is then put into die hole in advance by step 3
It is filled in the tablet press machine of coating agent and carries out second of compacting, obtain gibberellic acid soluble tablets.
By using above-mentioned technical proposal, by gibberellic acid GA3It is mixed together and is pressed in flakes with other auxiliary agents, then wrapped
The powder on its surface is siphoned away before clothing, so that gibberellic acid tablet is completely encapsulated in coating agent, avoids contacting with air, is increased
Shelf-life presses in preparation process, avoids contacting with water, and uses low-temperature vacuum drying, to remove a small amount of water that may be present
Point.
In conclusion compared with prior art, the invention has the following advantages:
(1) by adding coating agent in composition of raw materials, so that it is not easy to absorb the moisture in air and goes bad, it can storage time
Increase, improves the shelf-life；Coating agent in the present invention is prepared using a variety of macromolecule filming materials, changes the physics of film forming
Property after coating agent tabletting, is contacted closely between ingredient, is not easy permeable；
(2) stronger with water binding ability by adding pregelatinized corn starch in coating agent, thus when touch water it
Afterwards, water can be sponged first before water is contacted with gibberellic acid tablet, gibberellic acid is avoided to crystallize, improved tablet and guarantee the quality
Phase.
Detailed description of the invention
Fig. 1 is process flow chart of the invention.
Specific embodiment
With reference to the accompanying drawings and examples, the present invention will be described in detail.It is worth noting that wherein being not specified specific
Condition person, lower according to conventional conditions or manufacturer's recommended conditions to carry out, reagents or instruments used without specified manufacturer,
For the conventional products that can be obtained by commercially available purchase.
Embodiment 1: a kind of gibberellic acid soluble tablets, each component and its corresponding parts by weight are as shown in table 1, and pass through
Following steps prepare:
Coating agent preparation: Macrogol 6000, talcum powder, titanium dioxide, hydroxypropyl methylcellulose it is mixed to be put into high speed by step 1
30min, revolving speed 2500r/min are mixed in conjunction machine；
Step 2, by gibberellic acid GA3, dinaphthylmethanedisulfonic acid sodium, hydroxymethyl cellulose, croscarmellose sodium, fourth
Base hydroxyanisole is put into and mixes 30min in mixing machine, then puts into again and carries out pulverization process in pulverizer, low in vacuum
Temperature is dry and tabletted through tablet press machine, and wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Fine powder outside tablet made from step 2 is removed using asepwirator pump, is then put into die hole in advance by step 3
It is filled in the tablet press machine of coating agent and carries out second of compacting, obtain gibberellic acid soluble tablets.
Embodiment 2-6: a kind of gibberellic acid soluble tablets, difference from example 1 is that, each component and its corresponding
Parts by weight it is as shown in table 1.
Each component and its parts by weight in 1 embodiment 1-6 of table
Embodiment 7: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 1, coating agent preparation: by 0.3 part of Macrogol 6000,0.15 part of talcum powder, 0 part of titanium dioxide, 0.3 part of hydroxypropyl
Methylcellulose and 0.03 part of pregelatinized corn starch are put into and mix 30min in high-speed mixer, revolving speed 2500r/min；
Remaining is same as Example 1.
Embodiment 8: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 0.5 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of dodecyl benzene sulfonic acid, 0.5 part
Hydroxymethyl cellulose, 0.5 part of croscarmellose sodium, 0.05 part of butylated hydroxy anisole are put into mixing machine and are mixed
Then 30min puts into again and carries out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted,
Middle low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Embodiment 9: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 0.3 part of dinaphthylmethanedisulfonic acid sodium, 0.3 part of dodecyl benzene sulfonic acid, 0.3 part
Sodium lignin sulfonate, 0.5 part of hydroxymethyl cellulose, 0.5 part of croscarmellose sodium, 0.05 part of butylated hydroxy anisole are thrown
Enter and mix 30min into mixing machine, then put into again and carry out pulverization process in pulverizer, in vacuum dehydrating at lower temperature and through tabletting
Machine is tabletted, and wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Embodiment 10: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.25 part of hydroxymethyl cellulose, 0.25 part of shallow lake
Powder, 0.5 part of croscarmellose sodium, 0.05 part of butylated hydroxy anisole are put into and mix 30min in mixing machine, then again
Put into and carry out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted, wherein cryogenic vacuum is dry
Dry temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Embodiment 11: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.15 part of hydroxymethyl cellulose, 0.15 part of shallow lake
Powder, 0.15 part of gum arabic, 0.5 part of croscarmellose sodium, 0.05 part of butylated hydroxy anisole put into mixing machine
Middle mixing 30min, then puts into again and carries out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted
Agent, wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Embodiment 12: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.8 part of formic acid,
1 part of sodium bicarbonate, 0.05 part of butylated hydroxy anisole are put into and mix 30min in mixing machine, then put into pulverizer again
Carry out pulverization process, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted, wherein low-temperature vacuum drying temperature be 40 DEG C, very
Reciprocal of duty cycle is -0.08MPa；
Remaining is same as Example 1.
Embodiment 13: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.5 part of crosslinking
Sodium cellulose glycolate, 0.025 part of butylated hydroxy anisole, 0.025 propylgallate are put into mixing machine and are mixed
Then 30min puts into again and carries out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted,
Middle low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Embodiment 14: a kind of gibberellic acid soluble tablets, difference from example 1 is that:
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.5 part of crosslinking
Sodium cellulose glycolate, 0.015 part of butylated hydroxy anisole, 0.015 portion of propylgallate, 0.015 part of tertiary butyl are to benzene two
Phenol is put into and mixes 30min in mixing machine, then puts into again and carries out pulverization process in pulverizer, in vacuum dehydrating at lower temperature and passes through
Tablet press machine is tabletted, and wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Remaining is same as Example 1.
Comparative example 1: a kind of gibberellic acid soluble tablets, preparation method are as follows:
Step 1, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.5 part of crosslinking
Sodium cellulose glycolate, 0.05 butylated hydroxy anisole, which are put into, mixes 30min in mixing machine, then put into pulverizer again
Carry out pulverization process, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted, wherein low-temperature vacuum drying temperature be 40 DEG C, very
Reciprocal of duty cycle is -0.08MPa.
Comparative example 2: a kind of gibberellic acid soluble tablets, preparation method are as follows:
Step 1, coating agent preparation: by 0.3 part of Macrogol 6000,0.15 part of talcum powder, 0 part of titanium dioxide, 0.3 part of hydroxypropyl
Methylcellulose is put into and mixes 30min in high-speed mixer, revolving speed 2500r/min；
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.05 butyl hydroxyl
Base anisole is put into and mixes 30min in mixing machine, then puts into again and carries out pulverization process in pulverizer, dry in vacuum and low temperature
Dry and tabletted through tablet press machine, wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Fine powder outside tablet made from step 2 is removed using asepwirator pump, is then put into die hole in advance by step 3
It is filled in the tablet press machine of coating agent and carries out second of compacting, obtain gibberellic acid soluble tablets.
Comparative example 3: a kind of gibberellic acid soluble tablets, preparation method are as follows:
Step 1, coating agent preparation: by 0.3 part of Macrogol 6000,0.15 part of talcum powder, 0 part of titanium dioxide, 0.3 part of hydroxypropyl
Methylcellulose is put into and mixes 30min in high-speed mixer, revolving speed 2500r/min；
Step 2, by 20 parts of gibberellic acid GA3, 1 part of dinaphthylmethanedisulfonic acid sodium, 0.5 part of hydroxymethyl cellulose, 0.5 part of crosslinking
Sodium cellulose glycolate is put into and mixes 30min in mixing machine, then puts into again and carries out pulverization process in pulverizer, in vacuum
Low temperature drying is simultaneously tabletted through tablet press machine, and wherein low-temperature vacuum drying temperature is 40 DEG C, and vacuum degree is -0.08MPa；
Fine powder outside tablet made from step 2 is removed using asepwirator pump, is then put into die hole in advance by step 3
It is filled in the tablet press machine of coating agent and carries out second of compacting, obtain gibberellic acid soluble tablets.
Performance test
Humidity resistance test: precision weighing embodiment 1-14 is carried out to tablet made from embodiment 1-14 and comparative example 1-3 respectively
Tablet quality in comparative example 1-3, is placed in surface plate, and surface plate is placed in constant temperature humidity chamber, and temperature is constant
It is 44 DEG C, humidity 80%, precision weighing, record experimental data are simultaneously included in table 2 again after 7 days.
By table 2 it is found that the moisture absorption ratio of embodiment 1-17 is significantly less than comparative example 1-3, wherein in embodiment 7, due to
It joined hygroscopic Pregelatinized corn in coating agent and determine powder, moisture absorption ratio is slightly larger than embodiment 1-6；In comparative example 1, due to piece
Coating agent is not enclosed with outside agent, moisture absorption ratio is maximum, illustrates to have added tablet made of the coating agent in inventive formulation, moisture-proof
Effect is preferable, and the shelf-life is longer.
2 the performance test results of table
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment,
All technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
For those of ordinary skill, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of gibberellic acid soluble tablets, which is characterized in that the component including following parts by weight:
Gibberellic acid GA3: 20~25 parts；
Dispersing agent: 1~5 part；
Binder: 0.5~4 part；
Disintegrating agent: 0.5~4 part；
Antioxidant: 0.05~0.2 part；
Coating agent: 3~5 parts；
Wherein coating agent is according to percentage composition meter, including following component:
Polyethylene glycol: 10~20%；
Talcum powder: 5~30%；
Titanium dioxide: 0~20%；
Hydroxypropyl methylcellulose: 10~30%.
2. gibberellic acid soluble tablets according to claim 1, which is characterized in that the dispersing agent uses dinaphthylmethane
One of sodium disulfonate, dodecyl benzene sulfonic acid and sodium lignin sulfonate are a variety of.
3. gibberellic acid soluble tablets according to claim 1, which is characterized in that the binder includes hydroxylmethyl cellulose
Element, starch and gum arabic.
4. gibberellic acid soluble tablets according to claim 1, which is characterized in that the disintegrating agent includes crosslinking methylol
Sodium cellulosate.
5. gibberellic acid soluble tablets according to claim 1, which is characterized in that the disintegrating agent includes weight fraction ratio
For (0.8~1.5): 1 sodium bicarbonate and acid, wherein acid is using one of tartaric acid, formic acid and citric acid or a variety of.
6. gibberellic acid soluble tablets according to claim 1, which is characterized in that the antioxidant uses butylhydroxy
One of anisole, propylgallate and tert-butylhydroquinone are a variety of.
7. gibberellic acid soluble tablets according to claim 1, which is characterized in that further include weight hundred in the coating agent
Dividing content is 1~25% pregelatinized corn starch.
8. a kind of preparation method of gibberellic acid soluble tablets, which comprises the following steps:
Coating agent preparation: polyethylene glycol, talcum powder, titanium dioxide, hydroxypropyl methylcellulose are put into high-speed mixer by step 1
In mixed, 2500~2800r/min of revolving speed, 15~30min of incorporation time；
Step 2, by gibberellic acid GA3, dispersing agent, binder, disintegrating agent, antioxidant put into mixing 20 in mixing machine~
Then 30min puts into and carries out pulverization process in pulverizer, vacuum dehydrating at lower temperature and through tablet press machine it is tabletted, wherein
Low-temperature vacuum drying temperature is 35~45 DEG C, and vacuum degree is not less than -0.08MPa；
Fine powder outside tablet made from step 2 is removed using asepwirator pump, is then put into die hole in advance by step 3
It is filled in the tablet press machine of coating agent and carries out second of compacting, obtain gibberellic acid soluble tablets.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113729011A (en) * | 2021-07-30 | 2021-12-03 | 安徽瑞然生物药肥科技有限公司 | Glyphosate soluble granule and production method thereof |
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