CN103858866A - Effervescent composition and preparation method thereof - Google Patents
Effervescent composition and preparation method thereof Download PDFInfo
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- CN103858866A CN103858866A CN201210527414.0A CN201210527414A CN103858866A CN 103858866 A CN103858866 A CN 103858866A CN 201210527414 A CN201210527414 A CN 201210527414A CN 103858866 A CN103858866 A CN 103858866A
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- triacontanol
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Abstract
The invention discloses an effervescent composition and a preparation method thereof. The effervescent composition comprises, by mass, 0.01-10% of triacontanol, 0.5-15% of a dispersing agent, 0.5-8% of a wetting agent, 4-60% of a disintegrating agent, 1-10% of a binder and the balance a filling agent. The triacontanol effervescent granules or tablets can be metered accurately and can be used conveniently. The effervescent composition is safe for the environment, human, animals and other beneficial organisms and does not produce drug damage. The preparation method does not produce dust in production. The effervescent granules have a fast granule disintegrating speed. The effervescent composition has good storage stability and a storage period more than 2 years. The preparation method has simple processes and is suitable for industrial production and large-scale popularization application in agriculture.
Description
Technical field
The present invention relates to the effervescent of a plant growth regulators/or effervescent tablet and preparation method thereof, be specifically related to a kind of triacontanol effervescent/or effervescent tablet and preparation method thereof.
Background technology
Triacontanol is non-harmful plant growth regulator.There is multiple physiological action: can promote energy storage, improve cell permeability, regulation of physiological functions, increase chlorophyll content, improve photosynthetic efficiency, strengthen the activity of enzyme, promote the absorption of mineral matter, and can promote seed germination and taking root, water paddy and wheat class, cotton, soybean, corn, Chinese sorghum, sugarcane etc. all there are is effect of increasing production and improve the effect of quality.Structural formula:
Molecular formula: C
30h
62o, chemical name: 1-hydroxyl melissane, physicochemical property: white plates crystallization.Water-soluble hardly, be insoluble in cold ethanol, benzene, dissolve in ether, chloroform and carrene.
The triacontanol preparation occurring is in the market mainly suspending agent and microemulsion product.Suspending agent and microemulsion be because metering is inaccurate, produce and use procedure in bring many adverse effects to operator, and the problem such as ubiquity transport is inconvenient, in addition, the organic solvent of microemulsion use is unfriendly to environment.Therefore develop a kind of novel form that overcomes suspending agent and microemulsion shortcoming, especially seem important.
Effervescent/or effervescent tablet be a kind of novel form, by adding disintegrant, auxiliary agent and filler, form through granulation/compressing tablet, there is accurate measurement, the advantage such as easy to use; Effervescent/or effervescent tablet use after residual less at packaging material inwall, environmental pollution is little; Meanwhile, effervescent/or effervescent tablet product be easy to packaging, metering, transport and storage, be a kind of desirable novel form.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, provide a kind of taking triacontanol as former medicine preparation is efficient, low toxicity, environmentally friendly, and packaging, storing and triacontanol effervescent easy to use/or effervescent tablet.
Another object of the present invention is to provide above-mentioned triacontanol effervescent/or the preparation method of effervescent tablet.
Technical scheme of the present invention is: a kind of effervescence combination, each component and mass percent are: triacontanol 0.01%～10%, dispersant 0.5%～15%, wetting agent 0.5%～8%, disintegrant 4～60%, binding agent 1%-10%, surplus are filler.
Described effervescence combination, each component and mass percent are preferably: triacontanol 0.05%～5%, dispersant 1%～10%, wetting agent 1%～6%, disintegrant 8～50%, binding agent 1%-10%, surplus are filler.
Described dispersant is at least one in acrylate homopolymer salt, acrylic copolymer salt, dispersing agent MF, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, calcium lignosulfonate, naphthalenesulfonate formaldehyde condensation compound.
Described wetting agent is at least one in Nekal BX, lauryl sodium sulfate, neopelex, fatty alcohol-polyoxyethylene ether.
Described disintegrant is at least one in urea, potash, calcium carbonate, sodium carbonate, sodium bicarbonate, citric acid, malonic acid, succinic acid, adipic acid, tartaric acid, maleic acid, fumaric acid, benzoic acid, amino acid, potassium dihydrogen phosphate, sorbic acid.
Described binding agent is at least one in starch and derivative thereof, dextrin, polyvinyl alcohol, sodium carboxymethylcellulose, hydroxypropyl cellulose, polyethylene glycol, pyrrolidones, gum Arabic.
Described filler is at least one in talcum powder, bentonite, atlapulgite, White Carbon black, glucose, lactose, sucrose, starch, diatomite, attapulgite, potter's clay, kaolin.
The preparation method of described effervescence combination: each component is mixed, be ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, whole grain, selected, detection, make effervescent.
The preparation method of described effervescence combination: each component is mixed, is ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, compressing tablet, selected, detect, make effervescent tablet.
Triacontanol effervescent provided by the present invention/or the preparation method of effervescent tablet, that triacontanol of the present invention composition and auxiliary agent and filler are mixed together, be ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, whole grain/compressing tablet, selected, after detection, make triacontanol effervescent/or effervescent tablet, can be in water disintegration rapidly, dispersion, the stable suspended dispersed system of formation.
The invention has the beneficial effects as follows: triacontanol effervescent of the present invention/or effervescent tablet accurate measurement, easy to use; Preparation of the present invention is to environment, people and animals and other beneficial organism safety, and difficult generation poisoning; Fast without dust, particle disintegration rate in preparation production process of the present invention; Preparation storage-stable of the present invention is good, can preserve more than 2 years; Preparation process thereof of the present invention is simple, and suitability for industrialized is produced and agriculture large scale application.
Embodiment
Embodiment 1
The preparation of 0.05% triacontanol effervescent
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 0.053%(folding hundred 0.05% of 95% triacontanol), dispersant is dispersing agent MF 2.0%, calcium lignosulfonate 4.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is sodium bicarbonate 16.0%, sodium carbonate 4.0%, citric acid 15.0%, binding agent is dextrin 5.0%, and filler is that attapulgite supplies 100%
Calculate respectively each amounts of components by above proportioning, weigh, mix; Formulation material is through the granulation of ultra micro/air-flow crushing, oven dry, whole grain, selected.Carry out product detection according to effervescent quality control index, index includes effective component content, wetting time, disintegration rate, suspensibility, foaming characteristic, screen analysis, expulsion rate, PH scope and heat storage stability etc.Concrete grammar is as follows:
Use liquid chromatograph (Agilent company of the U.S., LC-1110) to detect active constituent content.
Take 1.0 grams of samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into, the time that record product all departs from liquid level is wetability; Repeatedly put upside down back and forth graduated cylinder, the number of times (or time) that records the whole disintegrations dispersions of sample is disintegrative; Put upside down back and forth after graduated cylinder 30 times, leave standstill and after 30 seconds, record the foaming characteristic that foam volume is product; Leave standstill after 30 minutes, remove graduated cylinder upper strata 90% volume solution to having weighed W with vavuum pump
1dried and clean culture dish, and rinse graduated cylinder with a small amount of standard hard water and move to culture dish 3 times, dry to constant weight W for 80 DEG C
2, calculate suspensibility %=[1-(W
2-W
1)] × 10/9 × 100%.
Take certain mass M
1effervescent sample, put into fill 2 steel balls (Ф 30 ± 2) or porcelain ball standard screen (aperture 420 μ m), are placed in sieve on chassis and add a cover, move in vibrating machine fixing after vibration 15min, accurately take and meet sample mass M in dish
2(being accurate to 0.1g), the expulsion rate %=M of sample
2/ M
1× 100.
Take 1.0 grams of samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, use pH instrumentation to determine pH scope;
The sample that takes certain mass packs, and places 14 days for 54 DEG C, carries out active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
Triacontanol effervescent performance indications prepared by embodiment 1 are: triacontanol content 0.0503%, wetability qualified (18 seconds), disintegration (47 seconds), foaming characteristic qualified (19 milliliters), moisture 1.2%, pH value 6.8, suspensibility 83%, expulsion rate 0.8%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.8%.
Embodiment 2
The preparation of 0.05% triacontanol effervescent tablet
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 0.053%(folding hundred 0.05% of 95% triacontanol), dispersant is naphthalenesulfonate formaldehyde condensation compound 3.0%, calcium lignosulfonate 3.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is sodium bicarbonate 21.0%, citric acid 17.0%, binding agent is polyvinyl alcohol 5.0%, filler is that talcum powder supplies 100%.
Calculate respectively each amounts of components by above proportioning, weigh, mix; Formulation material is through the granulation of ultra micro/air-flow crushing, oven dry, compressing tablet, selected.Carry out product detection according to effervescent tablet quality control index, index includes effective component content, disintegration time limited, suspensibility, foaming characteristic, screen analysis, powder and fragment rate, PH scope and heat storage stability etc.Concrete grammar is as follows:
Use liquid chromatograph (Agilent company of the U.S., LC-1110) to detect active constituent content.
Take 1.0 grams of samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into; Put upside down back and forth after graduated cylinder 30 times, leave standstill and after 30 seconds, record the foaming characteristic that foam volume is product; Leave standstill after 30 minutes, remove graduated cylinder upper strata 90% volume solution to having weighed W with vavuum pump
1dried and clean culture dish, and rinse graduated cylinder with a small amount of standard hard water and move to culture dish 3 times, dry to constant weight W for 80 DEG C
2, calculate suspensibility %=(1-(W
2-W
1)) × 10/9 × 100%.
Take 1.0 grams of samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, use pH instrumentation to determine pH scope;
Get a slice sample and put into the culture dish (Ф 100mm) that fills water, start stopwatch, measure disintegration time limited;
Take certain mass Q
1effervescent tablet sample, collect whole powder and fragment (be no more than tablet quality, be considered as fragment) and accurately claim to obtain quality Q
2(being accurate to 0.01 gram), the powder of sample and fragment rate %=Q
2/ Q
1× 100
The sample that takes certain mass packs, and places 14 days for 54 DEG C, carries out active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
The each performance indications of triacontanol effervescent tablet prepared by embodiment 2: triacontanol content 0.0502%, disintegration time limited qualified (1min28s), foaming characteristic qualified (22 milliliters), powder and fragment rate 0.3%, moisture 1.2%, pH value 7.1, suspensibility 88%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.7%.
Embodiment 3
The preparation of 0.1% triacontanol effervescent
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 0.105% of 95% triacontanol (folding hundred 0.1%), dispersant is dispersing agent MF 5.0%, wetting agent is neopelex 3.0%, disintegrant is sodium carbonate 8.0%, sodium bicarbonate 10%, citric acid 18%, binding agent is sodium carboxymethylcellulose 3.0%, filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of the each performance indications of triacontanol effervescent prepared by embodiment 3 is with embodiment 1.Concrete measurement result is: triacontanol content 0.10%, wetability qualified (24 seconds), disintegration qualified (48 seconds), foaming characteristic qualified (23 milliliters), moisture 1.0%, pH value 7.2, expulsion rate 0.6%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
Embodiment 4
The preparation of 0.1% triacontanol effervescent tablet
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 0.105% of 95% triacontanol (folding hundred 0.1%), dispersant is dispersing agent MF 5.0%, wetting agent is neopelex 3.0%, disintegrant is sodium carbonate 8.0%, sodium bicarbonate 10%, citric acid 18%, binding agent is hydroxypropyl cellulose 3.0%, filler is that attapulgite supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of the each performance indications of triacontanol effervescent tablet prepared by embodiment 4 is with embodiment 2.Concrete measurement result is: triacontanol content 0.10%, disintegration time limited qualified (1min22s), foaming characteristic qualified (23 milliliters), moisture 1.3%, pH value 7.4, powder and fragment rate 0.5%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
Embodiment 5
The preparation of 5% triacontanol effervescent
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 5.27% of 95% triacontanol (folding hundred 5.0%), dispersant is calcium lignosulfonate 6.0%, wetting agent is lauryl sodium sulfate 3.0%, disintegrant is sodium bicarbonate 19%, citric acid 18%, binding agent is carboxy-propyl cellulose sodium 3.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of the each performance indications of triacontanol effervescent prepared by embodiment 5 is with embodiment 1.Concrete measurement result is: triacontanol content 5.001%, wetability qualified (26 seconds), disintegration qualified (45 seconds), foaming characteristic qualified (22 milliliters), moisture 1.1%, pH value 7.2, expulsion rate 0.9%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.4%.
Embodiment 6
The preparation of 5% triacontanol effervescent tablet
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 5.27% of 95% triacontanol (folding hundred 5.0%), dispersant is dispersing agent MF 5.0%, wetting agent is lauryl sodium sulfate 3.0%, disintegrant is sodium bicarbonate 21%, citric acid 18%, binding agent is hydroxypropyl cellulose 3.0%, and filler is that diatomite supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of the each performance indications of triacontanol effervescent tablet prepared by embodiment 6 is with embodiment 2.Concrete measurement result is: triacontanol content 5.002%, disintegration time limited qualified (1min12s), foaming characteristic qualified (26 milliliters), moisture 1.2%, pH value 7.2, powder and fragment rate 0.4%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.4%.
Embodiment 7
Triacontanol effervescent/or effervescent tablet adjusting wheat processing test
Test method material is that wheat breed is Zheng wheat 366
The blue or green village of test site Anyang County Bai Zhuan town head test period: in October, 2009～2010 year June
Wheat seed soaking sowing after 24 hours, set and state 5 processing:
1. clear water control group;
2. contrast medicament 0.1% triacontanol missible oil is diluted to 1 mg/litre;
3. embodiment 1 product is diluted to 1 mg/litre;
4. embodiment 4 products are diluted to 1 mg/litre;
5. embodiment 5 products are diluted to 1 mg/litre;
Soak seed and sow after 24 hours, each processing repeats 4 times, 10 square metres of every community areas.Representative rice shoot 300 strains are got in every community, measure thousand kernel weight (the results are shown in Table 1) when results.
Experimental result: as shown in table 1, the triacontanol effervescent of contrast medicament 0.1% triacontanol microemulsion (Zhengzhou Tian Bang biological products Co., Ltd) and embodiment 1,4,5 preparation/or tablet all can promote thousand kernel weight increase; Between embodiment 1,4,5, difference is not remarkable, and medicament 0.1% triacontanol microemulsion difference on effect is not remarkable with contrasting.
Table 1 triacontanol effervescent/or the impact of effervescent tablet on thousand grain weight of wheat
| Process | Thousand kernel weight (gram) |
| Clear water contrast | 30.5± 1.1 |
| 0.1% triacontanol microemulsion | 33.4± 1.3 |
| Embodiment 1 | 33.7± 1.5 |
| Embodiment 4 | 33.5± 1.2 |
| Embodiment 5 | 33.9± 1.6 |
Note: after above-mentioned triacontanol dilution, liquid active ingredient is 1 mg/litre.
Embodiment 8 triacontanol effervescents/or effervescent tablet adjusting paddy rice processing test
Test method material is that rice varieties is Xinfeng No.2
Fan County, test site Puyang Dragon King village township Li Lu unit village's test period: in June, 2010～2010 year October
Rice seed soaking was sowed after 48 hours, set and stated 5 processing:
1. clear water control group;
2. contrast medicament 0.1% triacontanol microemulsion is diluted to 0.8 mg/litre;
3. embodiment 2 products are diluted to 0.8 mg/litre;
4. embodiment 3 products are diluted to 0.8 mg/litre;
5. embodiment 6 products are diluted to 0.8 mg/litre;
Soak seed and sow after 48 hours, each processing repeats 4 times, 10 square metres of every community areas.Representative rice shoot 300 strains are got in every community, measure thousand kernel weight (the results are shown in Table 2) when results.
Experimental result: as shown in table 2, the triacontanol effervescent of contrast medicament 0.1% triacontanol microemulsion (Zhengzhou Tian Bang biological products Co., Ltd) and embodiment 2,3,6 preparation/or effervescent tablet all can promote thousand kernel weight increase; Between embodiment 2,3,6, difference is not remarkable, not remarkable with 0.1% triacontanol microemulsion difference on effect.
Table 2 triacontanol effervescent/or the impact of effervescent tablet on paddy rice thousand kernel weight
| Process | Thousand kernel weight (gram) |
| Clear water contrast | 24.7± 1.2 |
| 0.1% triacontanol microemulsion | 26.6± 1.3 |
| Embodiment 2 | 26.8± 1.5 |
| Embodiment 3 | 26.7± 1.7 |
| Embodiment 6 | 26.9± 1.4 |
Note: after above-mentioned triacontanol dilution, liquid active ingredient is 0.8 mg/litre.
Embodiment 7
A kind of effervescence combination, each component and mass percent are: triacontanol 0.01%, dispersant 0.5%, wetting agent 0.5%, disintegrant 4%, binding agent 1%, surplus are filler.
Embodiment 8
A kind of effervescence combination, each component and mass percent are: triacontanol 10%, dispersant 15%, wetting agent 8%, disintegrant 60%, binding agent 10%, surplus are filler.
Embodiment 9
A kind of effervescence combination, each component and mass percent are: triacontanol 5%, dispersant 10%, wetting agent 6%, disintegrant 50%, binding agent 10%, surplus are filler.
Embodiment 10
A kind of effervescence combination, each component and mass percent are: triacontanol 0.05%, dispersant 1%, wetting agent 1%, disintegrant 8%, binding agent 1%, surplus are filler.
In above-described embodiment, dispersant is at least one in acrylate homopolymer salt, acrylic copolymer salt, dispersing agent MF, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, calcium lignosulfonate, naphthalenesulfonate formaldehyde condensation compound; Wetting agent is at least one in Nekal BX, lauryl sodium sulfate, neopelex, fatty alcohol-polyoxyethylene ether; Disintegrant is at least one in urea, potash, calcium carbonate, sodium carbonate, sodium bicarbonate, citric acid, malonic acid, succinic acid, adipic acid, tartaric acid, maleic acid, fumaric acid, benzoic acid, amino acid, potassium dihydrogen phosphate, sorbic acid; Binding agent is at least one in starch and derivative thereof, dextrin, polyvinyl alcohol, sodium carboxymethylcellulose, hydroxypropyl cellulose, polyethylene glycol, pyrrolidones, gum Arabic; Filler is at least one in talcum powder, bentonite, atlapulgite, White Carbon black, glucose, lactose, sucrose, starch, diatomite, attapulgite, potter's clay, kaolin.
The preparation method of effervescence combination: each component is mixed, be ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, whole grain, selected, detection, make effervescent.
The preparation method of effervescence combination: each component is mixed, is ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, compressing tablet, selected, detect, make effervescent tablet.
Claims (9)
1. an effervescence combination, is characterized in that, each component and mass percent are: triacontanol 0.01%～10%, dispersant 0.5%～15%, wetting agent 0.5%～8%, disintegrant 4%～60%, binding agent 1%-10%, surplus are filler.
2. effervescence combination according to claim 1, is characterized in that, each component and mass percent are: triacontanol 0.05%～5%, dispersant 1%～10%, wetting agent 1%～6%, disintegrant 8%～50%, binding agent 1%-10%, surplus are filler.
3. effervescence combination according to claim 1 and 2, is characterized in that: described dispersant is at least one in acrylate homopolymer salt, acrylic copolymer salt, dispersing agent MF, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, calcium lignosulfonate, naphthalenesulfonate formaldehyde condensation compound.
4. effervescence combination according to claim 1 and 2, is characterized in that: described wetting agent is at least one in Nekal BX, lauryl sodium sulfate, neopelex, fatty alcohol-polyoxyethylene ether.
5. effervescence combination according to claim 1 and 2, is characterized in that: described disintegrant is at least one in urea, potash, calcium carbonate, sodium carbonate, sodium bicarbonate, citric acid, malonic acid, succinic acid, adipic acid, tartaric acid, maleic acid, fumaric acid, benzoic acid, amino acid, potassium dihydrogen phosphate, sorbic acid.
6. effervescence combination according to claim 1 and 2, is characterized in that: described binding agent is at least one in starch and derivative thereof, dextrin, polyvinyl alcohol, sodium carboxymethylcellulose, hydroxypropyl cellulose, polyethylene glycol, pyrrolidones, gum Arabic.
7. effervescence combination according to claim 1 and 2, is characterized in that: described filler is at least one in talcum powder, bentonite, atlapulgite, White Carbon black, glucose, lactose, sucrose, starch, diatomite, attapulgite, potter's clay, kaolin.
8. the preparation method of effervescence combination according to claim 1 and 2, is characterized in that: each component is mixed, be ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, whole grain, selected, detection, make effervescent.
9. the preparation method of effervescence combination according to claim 1 and 2, is characterized in that: each component is mixed, is ground into powder through ultra micro/airslide disintegrating mill, then carry out granulation, dry, compressing tablet, selected, detect, make effervescent tablet.
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|---|---|---|---|
| CN201210527414.0A CN103858866A (en) | 2012-12-10 | 2012-12-10 | Effervescent composition and preparation method thereof |
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Family
ID=50898331
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104381297A (en) * | 2014-10-24 | 2015-03-04 | 深圳市格易通消毒药械科技有限公司 | O-phthaldialdehyde effervescent tablet with high-efficiency sterilization and disinfection function and preparation method of o-phthaldialdehyde effervescent tablet |
| CN104478525A (en) * | 2014-12-25 | 2015-04-01 | 京博农化科技股份有限公司 | Microelement effervescent granule for plant nutrition |
| CN105165826A (en) * | 2015-08-13 | 2015-12-23 | 广东中迅农科股份有限公司 | Pesticide effervescent granules and preparation method thereof |
| CN107434753A (en) * | 2017-07-26 | 2017-12-05 | 南京大学 | Effervescent tablet of 5 amino-laevulic acids and its derivative and preparation method thereof |
| CN109122680A (en) * | 2018-08-23 | 2019-01-04 | 南京拓际生物科技有限公司 | A kind of polycarboxylate salt dispersant and preparation method thereof |
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2012
- 2012-12-10 CN CN201210527414.0A patent/CN103858866A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104381297A (en) * | 2014-10-24 | 2015-03-04 | 深圳市格易通消毒药械科技有限公司 | O-phthaldialdehyde effervescent tablet with high-efficiency sterilization and disinfection function and preparation method of o-phthaldialdehyde effervescent tablet |
| CN104478525A (en) * | 2014-12-25 | 2015-04-01 | 京博农化科技股份有限公司 | Microelement effervescent granule for plant nutrition |
| CN105165826A (en) * | 2015-08-13 | 2015-12-23 | 广东中迅农科股份有限公司 | Pesticide effervescent granules and preparation method thereof |
| CN107434753A (en) * | 2017-07-26 | 2017-12-05 | 南京大学 | Effervescent tablet of 5 amino-laevulic acids and its derivative and preparation method thereof |
| CN109122680A (en) * | 2018-08-23 | 2019-01-04 | 南京拓际生物科技有限公司 | A kind of polycarboxylate salt dispersant and preparation method thereof |
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Application publication date: 20140618 |