CN102450258A - Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof - Google Patents
Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof Download PDFInfo
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- CN102450258A CN102450258A CN2011103504124A CN201110350412A CN102450258A CN 102450258 A CN102450258 A CN 102450258A CN 2011103504124 A CN2011103504124 A CN 2011103504124A CN 201110350412 A CN201110350412 A CN 201110350412A CN 102450258 A CN102450258 A CN 102450258A
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Abstract
The invention discloses naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and a preparation method thereof, wherein the naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets comprise the following raw materials by mass percent: 0.1-90% of naphthylacetic acid and naphthylacetic acid salt, 0.5-15% of dispersant, 0.5-8% of wetting agent, 0-12% of disintegrating agent, 0-10% of binding agent and balance of padding. The preparation method is as follows: mixing the raw materials for forming the naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets; after the naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets are smashed by ultra-micro flow, pelleting, drying, finishing granules/tabletting, precisely selecting, detecting and obtaining the naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets. The naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets provided in the invention are safe for environment, people and livestock and other beneficial organisms, not easy to generate phytotoxicity, accurately measured and convenient to use and have quick disintegrating speed; and with better storage stability and simple preparation technology, the naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets are suitable for industrial production and agricultural big area promotion.
Description
Technical field:
The present invention relates to the water dispersible granules of a plant growth regulators/or tablet and preparation method thereof, be specifically related to a kind of methyl and methyl salt water dispersible granules/or tablet and preparation method thereof.
Background technology:
Methyl is the broad spectrum type plant growth regulator, can promote cell division and expansion, induces the formation adventive root, and increase is beared fruit, and prevents shedding, changes female, male flower ratio etc.Can be through the tender epidermis of blade, branch, seed enters in the plant, arrives complete stool with the nutritional flow transporting.
Scope of application methyl is used for cereal, and increase is tillered, and improves the percentage of earbearing tiller and thousand kernel weight; Methyl is used for cotton, reduces fruit abscission rate, increases the peach weightening finish, improves the quality.Methyl is used for fruit tree, short blooming, anti-shedding, the raising the output of accelerating the ripening.Methyl is used for melon-fruit-like vegetable, prevents fallen flowers, forms stenospermocarpy; Methyl is used for cuttage branch, hestening rooting etc.
Structural formula:
Molecular formula: C
12H
10O
2
English common name: 1-Naphthalene acetic acid
CAS accession number: 86-87-3
Chemical name: NAA
Physicochemical property: white, needle-shaped crystals or crystalline powder, odorless.Be slightly soluble in cold water and ethanol, be soluble in hot water, acetone, ether, chloroform, benzene, acetic acid and aqueous slkali.
Methyl salt is methyl and alkali reaction products therefrom, and is water-soluble, stable in properties.
The methyl preparation that occurs in the market is mainly aqua and soluble powder product.There is the inaccurate problem of metering in aqua, because methyl is the highly active vegetable growth regulator, measures the inaccurate poisoning that very easily produces; Pulvis is prone to drift because particle is little, in production and use, brings many adverse effects to operator and surrounding environment.Therefore develop a kind of novel form that overcomes the soluble powder shortcoming, it is important especially to seem.
Water dispersible granules/or tablet be a kind of novel form, through adding special disintegrant, auxiliary agent and filler, form through special process granulation/compressing tablet, have accurate measurement, advantage such as easy to use; Overcome aqua be difficult for metering and soluble powder dust produce and use in the harm that brings to environment, operator such as drift; Simultaneously, water dispersible granules/or the tablet product be easy to packing, metering, transportation and storage, reduced dust pollution, to the mankind and Environmental security, be the desirable formulation that substitutes traditional soluble powder.
Summary of the invention:
The objective of the invention is the deficiency to prior art, providing a kind of is efficient, the low toxicity, environmentally friendly of former medicine preparation with methyl and methyl salt, and packing, storing and methyl easy to use and methyl salt water dispersible granules/or tablet.
Another object of the present invention provides above-mentioned methyl and methyl salt water dispersible granules/or the preparation method of tablet.
The objective of the invention is to realize through following scheme:
A kind of methyl water dispersible granules/or tablet, each constituent mass percentage in the prescription: methyl and methyl salt 1%～50%, dispersant 1%～10%, wetting agent 1%～6%, disintegrant 1～10%, binding agent 0%-10%, surplus are filler.
Said methyl salt is selected from one or more in the following substances: Nafusaku, methyl potassium, methyl ammonium.
Said dispersant is selected from one or more in the following substances: dispersing agent MF, acrylate homopolymer salt, acrylic copolymer salt, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, naphthalenesulfonate formaldehyde condensation compound, acrylic copolymer salt, calcium lignosulfonate.
Said wetting agent is selected from one or more in the following substances: Nekal BX, α-Xi Jihuangsuanyan, ethoxylated dodecyl alcohol sodium sulphate, lauryl sodium sulfate, neopelex, AEO, dioctyl sodium sulfosuccinate, ethoxylated dodecyl alcohol sodium sulphate.
Said disintegrant is selected from least two kinds in the following substances: urea, potassium sulphate, ammonium sulfate, anhydrous sodium sulfate, sodium chloride, sodium carboxymethyl starch, starch, polyvinylpyrrolidone, microcrystalline cellulose, magnesium chloride, sodium carboxymethylcellulose.
Said binding agent is selected from least a in the following substances: starch and derivative thereof, dextrin, polyvinyl alcohol, sodium carboxymethylcellulose, hydroxypropyl cellulose, polyethylene glycol, gum Arabic.
Said filler is selected from least a in the following substances: calcium carbonate, talcum powder, bentonite, atlapulgite, white carbon black, diatomite, attapulgite, potter's clay, kaolin.
Above auxiliary agent and filler all are known substances, also are the common and materials known in the pesticidal preparations processing.
Methyl provided by the present invention and methyl salt water dispersible granules/or the preparation method of tablet is that composition methyl according to the invention and methyl salt and auxiliary agent and filler are mixed together, and is ground into powder through ultra micro/airslide disintegrating mill; Carry out granulation then, drying, whole grain/compressing tablet; Selected; Make methyl and methyl salt water dispersible granules/or tablet after the detection, can disintegration rapidly, dispersion in water, form stable system.
Compared with prior art, methyl of the present invention and methyl salt water dispersible granules/or tablet following characteristics are arranged:
1, methyl of the present invention and methyl salt water dispersible granules/or tablet accurate measurement is easy to use;
2, preparation of the present invention is to environment, people and animals and other beneficial organism safety, and is difficult for producing poisoning;
3, do not have dust in the preparation production process of the present invention, the particle disintegration rate is fast;
4, preparation storage-stable of the present invention is good, can preserve more than 2 years;
5, preparation process thereof of the present invention is simple, suitability for industrialized production and agriculture large scale application.
Description of drawings
Accompanying drawing is methyl of the present invention and methyl salt water dispersible granules/or the processing process figure of tablet
Embodiment
For a better understanding of the present invention, below in conjunction with embodiment the present invention is described further.But the scope that the present invention requires to protect is the existing scope of representing in embodiment of office not.
Experimental technique described in the following embodiment like no specified otherwise, is conventional method; Said reagent and material like no specified otherwise, all can obtain from commercial sources; " % " representative " quality percentage composition " among the following embodiment.
The preparation of embodiment 15% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 6.5% of 80% methyl (rolling over hundred 5.0%); Dispersant is a dispersing agent MF 2.0%; Calcium lignosulfonate 4.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is an ammonium sulfate 8.0%; Binding agent is a starch 5.0%, and filler is that attapulgite supplies 100%
Calculate each amounts of components respectively by above proportioning, weigh, mix; Formulation material is through ultra micro/comminution by gas stream granulation, oven dry, whole grain, selected.Carry out product according to the water dispersible granules quality control index and detect, index includes effective component content, wetting time, disintegration time limited, suspensibility, foaming characteristic, screen analysis, expulsion rate, PH scope and heat storage stability etc.Concrete grammar is following:
(active constituent content LC-1110) detects in U.S. Agilent company to use liquid chromatograph.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into, the time that record product all breaks away from liquid level is wetability; Repeatedly put upside down graduated cylinder back and forth, the number of times (or time) that the whole disintegrations of record sample disperse is disintegrative; After putting upside down graduated cylinder 30 times back and forth, leave standstill that the record foam volume is the foaming characteristic of product after 30 seconds; After leaving standstill 30 minutes, remove graduated cylinder upper strata 90% volume solution to the W that weighs with vavuum pump
1The dried and clean culture dish, and move to culture dish 3 times with a small amount of standard hard water flushing graduated cylinder, dry to constant weight W for 80 ℃
2, calculate suspensibility %=[1-(W
2-W
1)] * 10/9 * 100%.
Take by weighing certain mass M
1The water dispersible granules sample, put into the standard screen (aperture 420 μ m) that fills 2 steel balls (Φ 30 ± 2) or porcelain ball, sieve is placed on the chassis adds a cover, move in the vibrating machine fixing back vibration 15min, accurately take by weighing and meet sample mass M in the dish
2(being accurate to 0.1g), the expulsion rate %=M of sample
2/ M
1* 100.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, measure the pH scope with pH meter;
The sample that takes by weighing certain mass packs, and places 14 days for 54 ℃, carries out the active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
The methyl water dispersible granules performance indications of embodiment 1 preparation are: methyl content 5.1%, wetability qualified (18 seconds), disintegration time limited (47 seconds); Foaming characteristic qualified (19 milliliters), moisture 1.2%, pH value 6.8; Suspensibility 83%, expulsion rate 0.9%, screen analysis 99%; Heat storage stability is qualified, active ingredient resolution ratio 0.8%.
The preparation of embodiment 2 5% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 6.5% of 80% methyl (rolling over hundred 5.0%); Dispersant is a naphthalenesulfonate formaldehyde condensation compound 3.0%; Calcium lignosulfonate 3.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is a microcrystalline cellulose sodium 17.0%; Binding agent is a polyvinyl alcohol 5.0%, and filler is that talcum powder supplies 100%.
Calculate each amounts of components respectively by above proportioning, weigh, mix; Formulation material is through ultra micro/comminution by gas stream granulation, oven dry, compressing tablet, selected.Carry out product according to the aqueous dispersion tablets quality control index and detect, index includes effective component content, disintegration time limited, suspensibility, foaming characteristic, screen analysis, powder and fragment rate, PH scope and heat storage stability etc.Concrete grammar is following:
(active constituent content LC-1110) detects in U.S. Agilent company to use liquid chromatograph.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into; After putting upside down graduated cylinder 30 times back and forth, leave standstill that the record foam volume is the foaming characteristic of product after 30 seconds; After leaving standstill 30 minutes, remove graduated cylinder upper strata 90% volume solution to the W that weighs with vavuum pump
1The dried and clean culture dish, and move to culture dish 3 times with a small amount of standard hard water flushing graduated cylinder, dry to constant weight W for 80 ℃
2, calculate suspensibility %=(1-(W
2-W
1)) * 10/9 * 100%.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, measure the pH scope with pH meter;
Get a slice sample and put into the culture dish of fills with water (Φ 100mm), start stopwatch, measure disintegration time limited;
Take by weighing certain mass Q
1The aqueous dispersion tablets sample, collect whole powder and fragment (be no more than tablet quality, be regarded as fragment) and accurately claim quality Q
2(being accurate to 0.01 gram), the powder of sample and fragment rate %=Q
2/ Q
1* 100
The sample that takes by weighing certain mass packs, and places 14 days for 54 ℃, carries out the active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
Each performance indications of methyl aqueous dispersion tablets of embodiment 2 preparations: methyl content 5.1%, disintegration qualified (152 seconds), foaming characteristic qualified (22 milliliters); Moisture 1.2%, pH value 7.1, suspensibility 88%; Screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.7%.
The preparation of embodiment 3 5% Nafusaku water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 6.5% of 80% Nafusaku (rolling over hundred 5.0%); Dispersant is a dispersing agent MF 2.0%; Calcium lignosulfonate 4.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is an ammonium sulfate 8.0%; Binding agent is a starch 5.0%, and filler is that attapulgite supplies 100%
Calculate each amounts of components respectively by above proportioning, weigh, mix; Formulation material is through ultra micro/comminution by gas stream granulation, oven dry, whole grain, selected.Carry out product according to the water dispersible granules quality control index and detect, index includes effective component content, wetting time, disintegration time limited, foaming characteristic, screen analysis, expulsion rate, PH scope and heat storage stability etc.Concrete grammar is following:
(active constituent content LC-1110) detects in U.S. Agilent company to use liquid chromatograph.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into, the time that record product all breaks away from liquid level is wetability; Repeatedly put upside down graduated cylinder back and forth, the time that the whole disintegrations of record sample disperse is disintegration time limited; After putting upside down graduated cylinder 30 times back and forth, leave standstill that the record foam volume is the foaming characteristic of product after 30 seconds.
Take by weighing certain mass M
1The water dispersible granules sample, put into the standard screen (aperture 420 μ m) that fills 2 steel balls (Φ 30 ± 2) or porcelain ball, sieve is placed on the chassis adds a cover, move in the vibrating machine fixing back vibration 15min, accurately take by weighing and meet sample mass M in the dish
2(being accurate to 0.1g), the expulsion rate %=M of sample
2/ M
1* 100.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, measure the pH scope with pH meter;
The sample that takes by weighing certain mass packs, and places 14 days for 54 ℃, carries out the active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
The Nafusaku water dispersible granules performance indications of embodiment 3 preparations are: methyl content 5.0%, wetability qualified (13 seconds), disintegration time limited (47 seconds); Foaming characteristic qualified (19 milliliters), moisture 1.2%, pH value 6.8; Expulsion rate 0.9%; Screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.5%.
The preparation of embodiment 4 5% Nafusaku aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 6.6% of 80% Nafusaku (rolling over hundred 5.0%); Dispersant is a naphthalenesulfonate formaldehyde condensation compound 3.0%; Calcium lignosulfonate 3.0%, wetting agent lauryl sodium sulfate 2.0%, disintegrant is a microcrystalline cellulose sodium 17.0%; Binding agent is a polyvinyl alcohol 5.0%, and filler is that talcum powder supplies 100%.
Calculate each amounts of components respectively by above proportioning, weigh, mix; Formulation material is through ultra micro/comminution by gas stream granulation, oven dry, compressing tablet, selected.Carry out product according to the aqueous dispersion tablets quality control index and detect, index includes effective component content, disintegration time limited, foaming characteristic, screen analysis, powder and fragment rate, PH scope and heat storage stability etc.Concrete grammar is following:
(active constituent content LC-1110) detects in U.S. Agilent company to use liquid chromatograph.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 250 milliliters of standard hard water are housed into; After putting upside down graduated cylinder 30 times back and forth, leave standstill that the record foam volume is the foaming characteristic of product after 30 seconds;
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, put upside down back and forth 30 times, measure the pH scope with pH meter;
Get a slice sample and put into the culture dish of fills with water (Φ 100mm), start stopwatch, measure disintegration time limited;
Take by weighing certain mass Q
1The aqueous dispersion tablets sample, collect whole powder and fragment (be no more than tablet quality, be regarded as fragment) and accurately claim quality Q
2(being accurate to 0.01 gram), the powder of sample and fragment rate %=Q
2/ Q
1* 100
The sample that takes by weighing certain mass packs, and places 14 days for 54 ℃, carries out the active ingredient index evaluation, calculates active ingredient heat storage resolution ratio.
Each performance indications of Nafusaku aqueous dispersion tablets of embodiment 4 preparations: Nafusaku content 5.1%, disintegration qualified (158 seconds), foaming characteristic qualified (18 milliliters), moisture 1.2%, pH value 7.1, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 4 preparations is with embodiment 1.The concrete result that measures is: methyl content 5.1%, and disintegration qualified (152 seconds), foaming characteristic qualified (22 milliliters), moisture 1.2%, pH value 7.1, suspensibility 88%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.7%.
The preparation of embodiment 5 10% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 13.0% of 80% methyl (rolling over hundred 10.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a neopelex 3.0%; Disintegrant is a urea 10%, and binding agent is a sodium carboxymethylcellulose 3.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of each performance indications of methyl water dispersible granules of embodiment 5 preparations is with embodiment 1.The concrete result that measures is: methyl content 10.1%, and wetability qualified (24 seconds), disintegration qualified (48 seconds), foaming characteristic qualified (23 milliliters), moisture 1.0%, pH value 7.2, suspensibility 89%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
The preparation of embodiment 6 10% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 13.0% of 80% methyl (rolling over hundred 10.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a neopelex 3.0%; Disintegrant is a microcrystalline cellulose sodium 18%, and binding agent is a hydroxypropyl cellulose 3.0%, and filler is that attapulgite supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 6 preparations is with embodiment 2.The concrete result that measures is: methyl content 10.1%, and disintegration qualified (153 seconds), foaming characteristic qualified (23 milliliters), moisture 1.3%, pH value 7.4, suspensibility 86%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
The preparation of embodiment 7 10% methyl potassium aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 13.0% of 80% methyl potassium (rolling over hundred 10.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a neopelex 3.0%; Disintegrant is a microcrystalline cellulose sodium 18%, and binding agent is a hydroxypropyl cellulose 3.0%, and filler is that attapulgite supplies 100%.Concrete preparation process is with embodiment 4.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 7 preparations is with embodiment 4.The concrete result that measures is: methyl content 10.1%, and disintegration qualified (153 seconds), foaming characteristic qualified (23 milliliters), moisture 1.3%, pH value 7.4, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.6%.
The preparation of embodiment 8 20% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 26.0% of 80% methyl (rolling over hundred 20.0%); Dispersant is a calcium lignosulfonate 6.0%, and wetting agent is a lauryl sodium sulfate 3.0%, and disintegrant is a starch 18%; Binding agent is a carboxy-propyl cellulose sodium 3.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of each performance indications of methyl water dispersible granules of embodiment 8 preparations is with embodiment 1.The concrete result that measures is: methyl content 20.1%, and wetability qualified (26 seconds), disintegration qualified (45 seconds), foaming characteristic qualified (22 milliliters), moisture 1.1%, pH value 7.2, suspensibility 86%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.4%.
The preparation of embodiment 9 20% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 26.0% of 80% methyl (rolling over hundred 20.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a lauryl sodium sulfate 3.0%; Disintegrant is a microcrystalline cellulose sodium 18%, and binding agent is a hydroxypropyl cellulose 3.0%, and filler is that diatomite supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 9 preparations is with embodiment 2.The concrete result that measures is: methyl content 20.1%, and disintegration qualified (152 seconds), foaming characteristic qualified (26 milliliters), moisture 1.2%, pH value 7.4, suspensibility 88%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.4%.
The preparation of embodiment 10 20% methyl potassium water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 26.0% of 80% methyl potassium (rolling over hundred 20.0%); Dispersant is a calcium lignosulfonate 6.0%; Wetting agent is a lauryl sodium sulfate 3.0%; Disintegrant is a starch 18%, and binding agent is a carboxy-propyl cellulose sodium 3.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 3.
The assay method of each performance indications of methyl potassium water dispersible granules of embodiment 10 preparations is with embodiment 3.The concrete result that measures is: methyl content 20.1%, and wetability qualified (26 seconds), disintegration qualified (45 seconds), foaming characteristic qualified (22 milliliters), moisture 1.1%, pH value 7.2, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.4%.
The preparation of embodiment 11 30% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 39.0% of 80% methyl (rolling over hundred 30.0%); Dispersant is naphthalenesulfonate formaldehyde condensation compound 4.0%, sodium lignin sulfonate 3.0%; Wetting agent is a lauryl sodium sulfate 3.0%; Disintegrant is a sodium carboxymethyl starch 18%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of each performance indications of methyl water dispersible granules of embodiment 11 preparations is with embodiment 1.The concrete result that measures is: methyl content 30.2%, and wetability qualified (21 seconds), disintegration qualified (46 seconds), foaming characteristic qualified (25 milliliters), moisture 1.3%, pH value 6.5, suspensibility 87%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.3%.
The preparation of embodiment 12 30% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 39.0% of 80% methyl (rolling over hundred 30.0%); Dispersant is naphthalenesulfonate formaldehyde condensation compound 4.0%, sodium lignin sulfonate 3.0%; Wetting agent is a lauryl sodium sulfate 3.0%; Disintegrant is a microcrystalline cellulose sodium 16.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 12 preparations is with embodiment 2.The concrete result that measures is: methyl content 30.2%, and disintegration qualified (140 seconds), foaming characteristic qualified (25 milliliters), moisture 1.2%, pH value 7.1, suspensibility 87%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.3%.
The preparation of embodiment 13 40% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 52.0% of 80% methyl (rolling over hundred 40.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a neopelex 3.0%; Disintegrant is a polyvinylpyrrolidone 19%, and binding agent is a carboxy-propyl cellulose sodium 3.0%, and filler is that potter's clay supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of each performance indications of methyl water dispersible granules of embodiment 13 preparations is with embodiment 1.The concrete result that measures is: methyl content 40.1%, and wetability qualified (26 seconds), disintegration qualified (48 seconds), foaming characteristic qualified (22 milliliters), moisture 1.1%, pH value 7.1, suspensibility 86%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.3%.
The preparation of embodiment 14 40% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 52.0% of 80% methyl (rolling over hundred 40.0%); Dispersant is naphthalenesulfonate formaldehyde condensation compound 4.0%, sodium lignin sulfonate 5.0%; Wetting agent is a lauryl sodium sulfate 3.0%, and disintegrant is a starch 14.0%, and filler is that kaolin supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 14 preparations is with embodiment 2.The concrete result that measures is: methyl content 40.2%, and disintegration qualified (140 seconds), foaming characteristic qualified (26 milliliters), moisture 1.2%, pH value 7.3, suspensibility 86%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.3%.
The preparation of embodiment 15 50% methyl water dispersible granules
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 65.0% of 80% methyl (rolling over hundred 50.0%); Dispersant is a dispersing agent MF 5.0%; Wetting agent is a neopelex 2.0%; Disintegrant is a magnesium chloride 14%, and binding agent is a carboxy-propyl cellulose sodium 3.0%, and filler is that diatomite supplies 100%.Concrete preparation process is with embodiment 1.
The assay method of each performance indications of methyl water dispersible granules of embodiment 15 preparations is with embodiment 1.The concrete result that measures is: methyl content 50.1%, and wetability qualified (23 seconds), disintegration qualified (50 seconds), foaming characteristic qualified (22 milliliters), moisture 1.1%, pH value 7.1, suspensibility 88%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.2%.
The preparation of embodiment 16 50% methyl aqueous dispersion tablets
Former medicine and auxiliary agent are selected and proportioning is: the former medicine 65.0% of 80% methyl (rolling over hundred 50.0%); Dispersant is a naphthalenesulfonate formaldehyde condensation compound 4.0%; Wetting agent is a lauryl sodium sulfate 2.0%, and disintegrant is a sodium carboxymethyl starch 13%, and filler is that potter's clay supplies 100%.Concrete preparation process is with embodiment 2.
The assay method of each performance indications of methyl aqueous dispersion tablets of embodiment 16 preparations is with embodiment 2.The concrete result that measures is: methyl content 50.2%, and disintegration qualified (141 seconds), foaming characteristic qualified (25 milliliters), moisture 1.2%, pH value 7.3, suspensibility 86%, screen analysis 99%, heat storage stability is qualified, active ingredient resolution ratio 0.2%.
Embodiment 17 methyls and methyl salt water dispersible granules/or tablet adjusting wheat Processing Test
The test method material is that wheat breed is the blue or green village of Zheng wheat 366 test place Anyang County Bai Zhuan town heads test periods: in October, 2009～2010 year June
Carry out foliar spray before the wheat seeding grouting, set and state 6 processing:
1. clear water control group;
2. will contrast medicament 20% methyl soluble powder and be diluted to 30 mg/litre;
3. embodiment 1 product is diluted to 30 mg/litre;
4. embodiment 4 products are diluted to 30 mg/litre;
5. embodiment 6 products are diluted to 30 mg/litre;
6. embodiment 13 products are diluted to 30 mg/litre;
Being sprayed to blade has till the droplets fall, and each handles repetition 4 times, 10 square metres of every sub-district areas.Representative rice shoot 300 strains are got in every sub-district, measure thousand kernel weight (result sees table 1) when measuring results.
Experimental result: as shown in table 1, the methyl water dispersible granules of contrast medicament 20% methyl soluble powder (Chongqing Shuan Feng agricultural chemicals Co., Ltd) and embodiment 1,4,6,13 preparations/or the thousand kernel weight increase of tablet after all promoting to gather in the crops; Embodiment 1,4,6, difference is not remarkable between 13, and is not remarkable with contrast medicament 20% methyl soluble powder difference on effect.
Table 1 methyl water dispersible granules/or tablet to the influence of thousand grain weight of wheat
Annotate: above-mentioned preparation dilution back soup active ingredient is 30 mg/litre.
Embodiment 18 methyls and Nafusaku water dispersible granules/or tablet adjusting paddy rice Processing Test
The test method material is that rice varieties is No. 2, Xinfeng
Test Fan County, Puyang, place Dragon King village township Li Lu unit village
Test period: in June, 2010～2010 year October
Plant after soaking seedling 6h, set and state 6 processing:
1. clear water control group;
2. will contrast medicament 20% methyl soluble powder and be diluted to 10 mg/litre;
3. embodiment 2 products are diluted to 10 mg/litre;
4. embodiment 3 products are diluted to 10 mg/litre;
5. embodiment 9 products are diluted to 10 mg/litre;
6. embodiment 14 products are diluted to 10 mg/litre;
Each handles repetition 4 times, 10 square metres of every sub-district areas.Representative rice shoot 300 strains are got in every sub-district, understand its situation of turning green, and measure thousand kernel weight (result sees table 2) during results.
Experimental result: as shown in table 2; The methyl water dispersible granules of contrast medicament 20% methyl soluble powder (Chongqing Shuan Feng agricultural chemicals Co., Ltd) and embodiment 2,3,9,14 preparations/or tablet all can improve the regrowth rate of rice seedling, the thousand kernel weight increase after the results; Embodiment 2,3,9, difference is not remarkable between 14, and is not remarkable with 20% methyl soluble powder difference on effect.
Table 2 methyl water dispersible granules/or tablet to the influence of paddy rice seedling growth
Annotate: above-mentioned preparation dilution back soup active ingredient is 10 mg/litre.
Claims (10)
1. methyl and methyl salt water dispersible granules/or tablet novel form, it is characterized in that each constituent and mass percent are: methyl and methyl salt 0.1%～90%, dispersant 0.5%～15%, wetting agent 0.5%～8%, disintegrant 0%～12%, binding agent 0%-10%, surplus are filler.
2. methyl according to claim 1 and methyl salt water dispersible granules/or tablet is characterized in that: described methyl and methyl salt water dispersible granules/or tablet form by the raw material of following mass percent: methyl and methyl salt 1%～50%, dispersant 1%～10%, wetting agent 1%～6%, disintegrant 1～10%, binding agent 0%-10%, surplus are filler.
3. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said methyl salt is selected from one or more in the following substances: Nafusaku, methyl potassium, methyl ammonium.
4. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said dispersant is selected from one or more in the following substances: dispersing agent MF, acrylate homopolymer salt, acrylic copolymer salt, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, naphthalenesulfonate formaldehyde condensation compound, acrylic copolymer salt, calcium lignosulfonate.
5. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said wetting agent is selected from one or more in the following substances: Nekal BX, α-Xi Jihuangsuanyan, ethoxylated dodecyl alcohol sodium sulphate, lauryl sodium sulfate, neopelex, AEO, dioctyl sodium sulfosuccinate, ethoxylated dodecyl alcohol sodium sulphate.
6. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said disintegrant is selected from least a in the following substances: urea, potassium sulphate, ammonium sulfate, anhydrous sodium sulfate, sodium chloride, sodium carboxymethyl starch, starch, polyvinylpyrrolidone, microcrystalline cellulose sodium, magnesium chloride, sodium carboxymethylcellulose.
7. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said binding agent is selected from least a in the following substances: starch and derivative thereof, dextrin, polyvinyl alcohol, sodium carboxymethylcellulose, hydroxypropyl cellulose, polyethylene glycol, gum Arabic.
8. according to claim 1 and 2 described methyls and methyl salt water dispersible granules/or tablet, it is characterized in that: said filler is selected from least a in the following substances: calcium carbonate, talcum powder, bentonite, atlapulgite, white carbon black, diatomite, attapulgite, potter's clay, kaolin.
9. according to the preparation method of claim 1～7 a described methyl and methyl salt water dispersible granules; It is characterized in that; Each constituent according to described in the claim 1 and 2 mixes according to mass percent; Be ground into powder through ultra micro/airslide disintegrating mill, carry out then granulation, drying, whole grain, selected, make methyl and methyl salt water dispersible granules after detecting.
10. according to the preparation method of claim 1～7 a described methyl and methyl salt aqueous dispersion tablets; It is characterized in that: each constituent according to described in the claim 1 and 2 mixes according to mass percent; Be ground into powder through ultra micro/airslide disintegrating mill, carry out then granulation, drying, compressing tablet, selected, make methyl and methyl salt tablets after detecting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103504124A CN102450258A (en) | 2011-11-09 | 2011-11-09 | Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011103504124A CN102450258A (en) | 2011-11-09 | 2011-11-09 | Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof |
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| CN102450258A true CN102450258A (en) | 2012-05-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011103504124A Pending CN102450258A (en) | 2011-11-09 | 2011-11-09 | Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108174849A (en) * | 2018-02-07 | 2018-06-19 | 郑州农达生化制品有限公司 | A kind of Nafusaku and butyric acid potassium compounding water dispersion granule and preparation method thereof |
| CN108391662A (en) * | 2018-02-07 | 2018-08-14 | 郑州农达生化制品有限公司 | A kind of Nafusaku effervescent tablet and preparation method thereof |
| CN115735921A (en) * | 2022-12-21 | 2023-03-07 | 郑州农达生化制品有限公司 | Preparation method of high-content naphthylacetic acid soluble powder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810169A (en) * | 2009-12-08 | 2010-08-25 | 安阳市全丰农药化工有限责任公司 | Plant growth regulator containing cycocel and naphthylacetic acid mixture |
-
2011
- 2011-11-09 CN CN2011103504124A patent/CN102450258A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810169A (en) * | 2009-12-08 | 2010-08-25 | 安阳市全丰农药化工有限责任公司 | Plant growth regulator containing cycocel and naphthylacetic acid mixture |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108174849A (en) * | 2018-02-07 | 2018-06-19 | 郑州农达生化制品有限公司 | A kind of Nafusaku and butyric acid potassium compounding water dispersion granule and preparation method thereof |
| CN108391662A (en) * | 2018-02-07 | 2018-08-14 | 郑州农达生化制品有限公司 | A kind of Nafusaku effervescent tablet and preparation method thereof |
| CN115735921A (en) * | 2022-12-21 | 2023-03-07 | 郑州农达生化制品有限公司 | Preparation method of high-content naphthylacetic acid soluble powder |
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Address after: 455000, Anyang, Henan Province North Zone Industrial Park Road, the middle of the North Road Applicant after: Anyang Quan Feng Biotechnology Co., Ltd. Address before: 455000, Anyang, Henan Province North Zone Industrial Park Road, the middle of the North Road Applicant before: Anyang Quanfeng Agriculture Chemical Co., Ltd. |
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Application publication date: 20120516 |