CN114190378B - Pesticide solid preparation for reducing decomposition rate of diethyl aminoethyl hexanoate - Google Patents
Pesticide solid preparation for reducing decomposition rate of diethyl aminoethyl hexanoate Download PDFInfo
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- CN114190378B CN114190378B CN202111661261.4A CN202111661261A CN114190378B CN 114190378 B CN114190378 B CN 114190378B CN 202111661261 A CN202111661261 A CN 202111661261A CN 114190378 B CN114190378 B CN 114190378B
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- diethyl aminoethyl
- aminoethyl hexanoate
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate, which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25). The pesticide solid preparation of the invention not only can effectively reduce the decomposition of the diethyl aminoethyl hexanoate, but also is beneficial to storage and transportation, has good heat storage and long-term stability, and has great economic benefit and wide development prospect.
Description
Technical Field
The invention relates to the field of pesticide plant growth regulator preparations, in particular to a pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate.
Background
The diethyl aminoethyl hexanoate raw material is colorless to pale yellow oily liquid, is insoluble in water and is easily soluble in organic solvents such as ethanol, acetone, chloroform and the like. Because of the existence of amino in the chemical structure, the stock solution is more alkaline, and the ester bond in the chemical structure is more damaged, so that the stock solution is directly poor in stability, can be easily decomposed under normal temperature storage, and is more decomposed under the heat storage condition. In actual production, the original drug manufacturer mainly coordinates the original drug with citric acid to form salt to prepare the diethyl aminoethyl hexanoate citrate, so that the stability of the diethyl aminoethyl hexanoate citrate can be properly improved, and in addition, the diethyl aminoethyl hexanoate citrate is in a solid state and can be completely water-soluble, so that the problems of difficult storage and transportation of the diethyl aminoethyl hexanoate and water solubility are solved.
The diethyl aminoethyl hexanoate citrate is white to off-white solid crystal or powder, has light ester flavor and greasy feel, is easy to dissolve in water, can be dissolved in polar organic solvents such as ethanol, methanol, acetone and the like, and can be prepared into water-soluble liquid preparations and solid preparations. The liquid preparation of the diethyl aminoethyl hexanoate citrate has the advantages that the diethyl aminoethyl hexanoate is easy to hydrolyze, alcoholyze and ammonolysis reaction at normal temperature due to the existence of the diethyl aminoethyl hexanoate citrate in an aqueous, alcohol or polar solvent system, and particularly when the temperature is higher, the decomposition is accelerated, so that the validity period of the diethyl aminoethyl hexanoate citrate preparation is generally short. Experimental research shows that after the diethyl aminoethyl hexanoate citrate is compounded with a plurality of fillers and solvents, the diethyl aminoethyl hexanoate citrate has higher heat storage decomposition rate, and the drug effect and the shelf life of the product are influenced. Particularly, when the conditions are poor and the stock time at the high-temperature and high-humidity places is long, the content is reduced by more than 50 percent, particularly, the water-based preparation is longer in storage time, the temperature is higher, the content degradation reaches more than 90 percent, and the storage stability of the related preparation product is seriously disqualified.
Disclosure of Invention
The invention provides a pesticide solid preparation capable of effectively reducing the decomposition rate of diethyl aminoethyl hexanoate, aiming at solving the defect that diethyl aminoethyl hexanoate citrate pesticide preparation is easy to hydrolyze in the prior art.
The invention firstly provides a pesticide solid preparation which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25).
The invention also provides the following preferable scheme:
preferably, the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (2.5-25).
Preferably, the sugar alcohol is at least one of sorbitol, mannitol, maltitol, lactitol and xylitol.
The invention also provides a pesticide solid preparation which comprises the diethyl aminoethyl hexanoate citrate, sugar alcohol and an auxiliary agent acceptable in agriculture and pharmacy.
Preferably, the formulation of the pesticide solid preparation is one of soluble powder, soluble granules and soluble tablets.
More preferably, the pesticide formulation is soluble powder and soluble granule.
Preferably, the auxiliary agent is at least one of wetting agent, dispersing agent, anti-caking agent, filler, disintegrating agent and synergist. At least one of the components in the invention means that the composition can contain one component, two components and more than two components.
More preferably, the wetting agent is one or more of alkylphenol ethoxylates, formaldehyde condensate sulfate, alkylphenol ethoxylate phosphate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, fatty alcohol polyoxyethylene ether sodium sulfate, fatty alcohol polyoxyethylene ether, sodium alkylbenzenesulfonate, sodium alkyl alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate and alkylamidyl taurate.
More preferably, the dispersant is at least one selected from lignin sulfonate, alkyl naphthalene sulfonate, and polymeric carboxylate, phosphate ester, naphthalene sulfonate.
More preferably, the anti-caking agent is white carbon black.
More preferably, the filler is a saccharide. More preferably, the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose, and cyclodextrin.
More preferably, the plant growth regulating solid preparation is in the form of soluble granule or soluble tablet, and comprises disintegrating agent. More preferably, the disintegrant is sodium carboxymethyl starch.
More preferably, the synergistic agent is at least one of organosilicon synergistic agent, tea saponin, azone, bupropion, penetrating agent JFC (fatty alcohol polyoxyethylene ether) and rapid penetrating agent T (dioctyl sodium sulfosuccinate).
The invention also provides a preparation method of the pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate, which is prepared according to a general processing technology method of the solid preparation. Premixing, crushing and re-mixing, and fully and uniformly mixing to obtain the diethyl aminoethyl hexanoate citrate soluble powder; the soluble powder can be granulated to obtain soluble granules, and the soluble powder can be tabletted to obtain soluble tablets.
The solid pesticide preparation is respectively subjected to gas chromatography to detect the content of the diethyl aminoethyl hexanoate according to the requirements of 2.2 in a pesticide thermal storage stability measuring method GB/T19136-2003 and the requirements of the pesticide normal temperature storage stability test rule NY/T1427-2016, and the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5% under the conditions of 14 days of thermal storage and 2 years of normal temperature storage.
The beneficial effects of the invention are as follows:
1. the pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate is favorable for storage and transportation, has good stability, high activity, good efficiency and safety, and has great economic benefit and wide development prospect, and not only is quick to dissolve in the use process;
2. the preparation method of the pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate has the advantages of simple steps, easy operation, no pollution to the environment and low formula cost.
3. The pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate obviously prolongs the effective period of the diethyl aminoethyl hexanoate citrate preparation by using sugar alcohol substances and soluble sugar as auxiliary materials. The action time and the action effect of the diethyl aminoethyl hexanoate are greatly improved by reducing the decomposition of the diethyl aminoethyl hexanoate.
4. The invention changes the validity period of the diethyl aminoethyl hexanoate citrate preparation by using different auxiliary materials. The invention effectively solves the problem of decomposition of the diethyl aminoethyl hexanoate.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments thereof in order to enable those skilled in the art to better understand the technical aspects of the invention.
The invention firstly provides a pesticide solid preparation which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25). Preferably, the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (2.5-25).
The decomposition of the diethyl aminoethyl hexanoate is mainly influenced by temperature, pH, moisture and filler, the storage temperature of the diethyl aminoethyl hexanoate citrate preparation cannot be controlled, and the moisture in the liquid preparation has the greatest influence on the stability of the diethyl aminoethyl hexanoate, so that the diethyl aminoethyl hexanoate preparation is preferably prepared into a solid preparation. The medicine has a lot of interactions with auxiliary materials, mainly physical and chemical effects or both. The auxiliary materials are selected, so that the results of the actions are considered, the results of the physical actions are weak, the results of the chemical actions are complex, such as hydrolysis reaction, alcoholysis reaction, ammonolysis reaction, oxidation-reduction reaction and the like, and the medicine is decomposed to generate impure substances. The diethyl aminoethyl hexanoate citrate can be prepared into a preparation by selecting a plurality of different auxiliary materials, and the different auxiliary materials have fixed acid-base property, and can have different effects on the diethyl aminoethyl hexanoate citrate preparation when being used together with the diethyl aminoethyl hexanoate citrate, so that the selection of the auxiliary materials has a vital effect on the stability and the validity period of the diethyl aminoethyl hexanoate citrate solid preparation. The research shows that after the diethyl aminoethyl hexanoate citrate is compounded with a plurality of fillers (such as potassium dihydrogen phosphate, potassium sulfate, sodium polyborate, magnesium sulfate and the like), the diethyl aminoethyl hexanoate citrate has higher heat storage and Chang Chu decomposition rate, and the drug effect of the diethyl aminoethyl hexanoate citrate is influenced. Especially, if the conditions are poor and the stock time at the high-temperature and high-humidity places is long, the content is even reduced by more than 50%, so that the thermal stability of the related preparation products is seriously disqualified. The invention prolongs the effective period of the diethyl aminoethyl hexanoate citrate preparation by using sugar alcohol substances and soluble sugar as auxiliary materials. By reducing the decomposition of the diethyl aminoethyl hexanoate, the action time and the action effect of the diethyl aminoethyl hexanoate are greatly improved.
The unique polyol structure of the sugar alcohol is beneficial to uniformly wrapping the sugar alcohol on the surface of the diethyl aminoethyl hexanoate citrate, so that the moisture is isolated as much as possible. Therefore, sugar alcohol is used as an auxiliary material of the diethyl aminoethyl hexanoate citrate soluble powder, so that the contact of the diethyl aminoethyl hexanoate citrate with water can be reduced, the hydrolysis of the diethyl aminoethyl hexanoate can be delayed, and the validity period of the diethyl aminoethyl hexanoate citrate solid preparation can be prolonged. Furthermore, sugar alcohols play an important role in the life cycle of plants. It not only provides energy and metabolic intermediate products for the growth and development of plants, but also has a signal function. It is also an important regulator of plant growth and development and gene expression. Sugar alcohol can be used as carrier of other nutrient elements such as boron, and can carry mineral nutrient for rapid transportation in phloem of plant. The plant phloem juice is a natural extract in the plant phloem juice, and has no toxicity and no damage to plants and human bodies; the molecular weight is low, the plant is easy to be absorbed by the leaves, and the plant is easy to degrade and release nutrients, so that the energy consumption is low; in particular, the sugar alcohol is a natural wetting agent, has a moisturizing function, can avoid the failure of the liquid medicine caused by rapid drying of the leaves, and prolongs the time of the leaves for absorbing nutrient elements; the natural surfactant can spread and uniformly cover nutrient elements on the whole blade, improve the absorption area of the blade, and avoid burning the blade due to overhigh local concentration of micronutrients; sugar alcohols can also improve stress resistance of plants. On the one hand, sugar alcohols are important substances involved in intracellular osmotic regulation. Under the stress of salt damage, drought, flooding and the like, the sugar alcohol can adjust the cell permeability of the plant to adapt the plant to the stress growth; on the other hand, the sugar alcohol can improve the resistance to active oxygen and avoid the damage of plant active oxygen caused by ultraviolet sunburn, drought, disease, hypoxia and other reasons.
In order to enable the sugar alcohol to be better complexed with medium and trace elements and to be rapidly transported in phloem, the sugar alcohol is at least one of sorbitol, mannitol, maltitol, lactitol and xylitol.
In order to enable the invention to be better applied to the growth of crops, the invention also provides a pesticide solid preparation, and the pesticide solid preparation also comprises an auxiliary agent acceptable in agriculture and pharmacy.
In order to adapt to different plant planting environments, the dosage form of the pesticide-planting solid preparation can be one of soluble powder, soluble granules and soluble tablets.
More preferably, the pesticide formulation is soluble powder and soluble granule.
The auxiliary agent can be at least one of wetting agent, dispersing agent, anti-caking agent, filler, disintegrating agent and synergist according to different dosage form requirements.
In the pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate, in order to make the solid material more easily soaked by water, a wetting agent can be added, wherein the wetting agent is one or more of alkylphenol ethoxylates, formaldehyde condensate sulfate, alkylphenol ethoxylate phosphate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, fatty alcohol polyoxyethylene ether sodium sulfate, fatty alcohol polyoxyethylene ether, sodium alkyl naphthalene sulfonate (Morwet EFW), alkyl alcohol polyoxyethylene ether sodium sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate and alkylamidyl taurate.
In the pesticide solid preparation for reducing the decomposition rate of the diethyl aminoethyl hexanoate, a synergistic agent can be added for improving the application performance of the preparation to crops, wherein the synergistic agent is at least one of organosilicon synergistic agent, tea saponin, azone, thioketone, penetrant JFC (fatty alcohol polyoxyethylene ether) and fast T (dioctyl sodium sulfosuccinate).
When the solid preparation is soluble powder, the pesticide solid preparation can also comprise an anti-caking agent, preferably anhydrous magnesium sulfate, white carbon black and the like, in order to prevent the soluble powder from caking and keep good fluidity of materials.
When the solid preparation is in the form of soluble powder, soluble granule or soluble tablet, the filler is saccharide. More preferably, the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose, and cyclodextrin.
When the solid preparation is in the form of soluble granule or soluble tablet, the plant growth regulating solid preparation further comprises a disintegrating agent in order to enable the preparation to be rapidly broken into fine granular active substance components in water. More preferably, the disintegrant is sodium carboxymethyl cellulose, soluble starch.
At normal temperature, the diethyl aminoethyl hexanoate citrate and the above materials are directly premixed, crushed and then mixed, and the diethyl aminoethyl hexanoate citrate soluble powder is prepared after full and even mixing, the diethyl aminoethyl hexanoate citrate soluble granule can be obtained after granulation, and the soluble tablet can be obtained after tabletting.
The solid pesticide preparation is used for detecting the content of the diethyl aminoethyl hexanoate by adopting a gas chromatography according to the requirements of 2.2 in the method for measuring the thermal storage stability of pesticides in GB/T19136-2003 and the method for testing the storage stability of pesticides at normal temperature in NY/T1427-2016, and the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5% under the conditions of 14 days of thermal storage and 2 years of storage at normal temperature.
The foregoing is a detailed description of the invention and the following examples of the invention.
The specific description is as follows: because the diethyl aminoethyl hexanoate citrate is formed by coordination reaction of diethyl aminoethyl hexanoate and citric acid, the appearance form is changed from liquid state to solid state. The raw materials of the active ingredients in the formulation table of the solid preparation containing the diethyl aminoethyl hexanoate in the embodiment are diethyl aminoethyl hexanoate citrate raw materials, and the active ingredient substances detected by adopting a gas chromatography are diethyl aminoethyl hexanoate, so that when the mass fraction of the active ingredients is calculated, the diethyl aminoethyl hexanoate citrate and the diethyl aminoethyl hexanoate are obtained by coefficient conversion, and the conversion coefficient is as follows: 407.46/215.33 =1.89 (407.46 is diethyl aminoethyl hexanoate citrate relative molecular mass, 215.33 is diethyl aminoethyl hexanoate relative molecular mass). Examples: if 100 g of 8% diethyl aminoethyl hexanoate soluble powder is prepared, the diethyl aminoethyl hexanoate citrate needs to be added according to the following mass: 100 x 8% x 1.89 = 15.12 g.
Example 1
1kg of 8% diethyl aminoethyl hexanoate soluble powder of different components is prepared, and the mass percentage compositions are shown in table 1 and table 2:
table 1 8% composition of the formulation of the diethyl aminoethyl hexanoate soluble powder (sugar alcohols)
Table 2 8% composition of the formulation of the diethyl aminoethyl hexanoate soluble powder (non-sugar alcohols)
The preparation method comprises the following steps: the components in the table 1 and the table 2 are taken to be premixed, crushed and mixed again according to the mass ratio, and the 8% diethyl aminoethyl hexanoate soluble powder is obtained.
The samples formed by the formulas in the formulas table 1 and table 2 are tested according to the technical quality index of the standard of 8% diethyl aminoethyl hexanoate soluble powder Q/91510185MA68HDG 804.25, and the specific control quality index is shown in table 3. The heat storage stability of the active ingredient is measured according to 2.2 in "method for measuring heat stability of agricultural chemical" GB/T19136-2003.
Table 3 8% quality control index of diethyl aminoethyl hexanoate soluble powder
Table 1 and table 2 the results of the quality index tests are shown in table 4.
Table 4 results of quality index detection for each technique
From the above formulation examples 1-15 and the corresponding quality index measurements, it can be concluded that: no. 1-15 all the quality indexes meet the enterprise standard requirements except that the decomposition rate of the effective component (diethyl aminoethyl hexanoate) is changed; no. 1-9 gradually decreases the decomposition rate of the diethyl aminoethyl hexanoate after heat storage along with the gradual increase of the content of the sorbitol , but the decomposition rate of the diethyl aminoethyl hexanoate after heat storage is less than 5%; no. 10-15 adopts different inorganic salts as the filler, and the decomposition rate of the diethyl aminoethyl hexanoate after heat storage is more than 5% and even more than 10% no matter which filler is.
The formula 1 and the formula 9 in the formula table 1 are subjected to a 2-year normal-temperature storage test according to the requirements of NY/T1427-2016 of general rules of pesticide normal-temperature storage stability test. The content, the decomposition rate and other control indexes of the active ingredient diethyl aminoethyl hexanoate are detected according to the quality standard (Q/91510185 MA68HDG 804.25) of 8% diethyl aminoethyl hexanoate soluble powder enterprises at the initial storage period, the 3 rd month, the 6 th month, the 12 th month and the 24 th month time points in the sample storage process. The test results of the storage test are shown in tables 5 and 6.
Table 5 formulation 1 results of quality control index test for normal temperature storage test
Table 6 formulation 9 quality control index test results of normal temperature storage test
From the detection indexes of the formula 1 and the formula 9 in the tables 5 and 6 at each time point of normal temperature storage, the decomposition rate of the active ingredient diethyl aminoethyl hexanoate in the 8% diethyl aminoethyl hexanoate soluble powder (containing sugar alcohols) for 2 years of normal temperature storage test is about 2% at most, and other quality control indexes are qualified. The formula shows that the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5% in 2 years of storage time, and all quality control indexes of the diethyl aminoethyl hexanoate completely meet the standard requirements of 8% diethyl aminoethyl hexanoate soluble powder Q/91510185MA68HDG 804.25.
Example two
1kg of 10% diethyl aminoethyl hexanoate soluble granules with different components are prepared, and the mass percentage compositions are shown in Table 7:
TABLE 7 10% diethyl aminoethyl hexanoate soluble granule (sugar alcohol containing) formulation
The preparation method comprises the following steps: the preparation method comprises the following steps: the components in the table 7 are taken to be premixed, crushed, mixed again and granulated according to the mass ratio, and 10 percent of diethyl aminoethyl hexanoate soluble granules are obtained.
The formulation samples are tested by referring to the standard of the public standard 10% diethyl aminoethyl hexanoate soluble granule (Q/PMB 594) to formulate technical quality indexes, and the specific control quality indexes are shown in Table 8. The heat storage stability of the active ingredient is measured according to 2.2 in "method for measuring heat stability of agricultural chemical" GB/T19136-2003.
TABLE 8 quality control index of 10% diethyl aminoethyl hexanoate soluble granules
Table 7 the results of the quality index measurements in the formulation are shown in table 9.
TABLE 9 quality index detection results of 10% diethyl aminoethyl hexanoate soluble granules
From the above formulation examples 1-6 and the corresponding quality index measurements, it can be concluded that: except that the decomposition rate of the effective component (diethyl aminoethyl hexanoate) of No. 1-6 is changed, the other quality indexes meet the technical standard requirements, and the heat storage decomposition rate of diethyl aminoethyl hexanoate is less than 2%.
Samples of the formula I and the formula VI in the formula table 8 are taken, and a 2-year normal-temperature storage test is carried out according to the requirements of NY/T1427-2016 of general rules of pesticide normal-temperature storage stability test. And detecting the content, the decomposition rate and other control indexes of the active ingredient diethyl aminoethyl hexanoate according to the technical indexes of 10% diethyl aminoethyl hexanoate soluble granules at the initial storage period, the 3 rd month, the 6 th month, the 12 th month and the 24 th month time points in the sample storage process. The test results of the storage test are shown in Table 10 and Table 11.
Table 10 results of quality control index detection for formula I normal temperature storage test
Table 11 results of quality control index detection for formula VI in normal temperature storage test
From the detection indexes of the formula I and the formula VI in the tables 10 and 11 at all time points of normal temperature storage, the decomposition rate of the active ingredient diethyl aminoethyl hexanoate of the 10% diethyl aminoethyl hexanoate soluble granule in a 2-year normal temperature storage test is 2.39% at most, and other quality control indexes are qualified. The formula shows that the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5% within 2 years of storage time, and all other quality control indexes completely meet the technical index requirements.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that the above-mentioned preferred embodiment should not be construed as limiting the invention, and the scope of the invention should be defined by the appended claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (4)
1. A pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate is characterized in that: comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25); the sugar alcohol is selected from sorbitol or lactitol;
the pesticide composition also comprises a pesticide auxiliary agent; the formulation of the pesticide solid preparation is one of soluble powder and soluble granules; the pesticide auxiliary agent is at least one of dispersing agent, anti-caking agent, filler, disintegrating agent and synergist and wetting agent; the wetting agent is sodium dodecyl sulfate or Morwet EFW; the synergist is fast T; the disintegrating agent is soluble starch;
the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5%.
2. The agricultural chemical solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate according to claim 1, wherein: the filler is saccharide.
3. The agricultural chemical solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate according to claim 2, wherein: the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose and cyclodextrin.
4. A pesticidal solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate according to any one of claims 1 to 3, characterized in that: the content of the diethyl aminoethyl hexanoate is detected by adopting a gas chromatography method, and the decomposition rate of the heat storage sample is less than 5% after 14 days and 2 years of normal temperature storage.
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