CN114190378A - Pesticide solid preparation for reducing decomposition rate of diethyl aminoethyl hexanoate - Google Patents
Pesticide solid preparation for reducing decomposition rate of diethyl aminoethyl hexanoate Download PDFInfo
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- CN114190378A CN114190378A CN202111661261.4A CN202111661261A CN114190378A CN 114190378 A CN114190378 A CN 114190378A CN 202111661261 A CN202111661261 A CN 202111661261A CN 114190378 A CN114190378 A CN 114190378A
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- diethyl aminoethyl
- aminoethyl hexanoate
- solid preparation
- decomposition rate
- pesticide
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a pesticide solid preparation for reducing decomposition rate of diethyl aminoethyl hexanoate, which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25). The pesticide solid preparation of the invention not only can effectively reduce the decomposition of diethyl aminoethyl hexanoate, but also is beneficial to storage and transportation, has good thermal storage and stability over time, and has great economic benefit and wide development prospect.
Description
Technical Field
The invention relates to the field of pesticide plant growth regulator preparations, in particular to a pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate.
Background
The technical grade of the diethyl aminoethyl hexanoate is colorless to light yellow oily liquid, is insoluble in water and is easily soluble in organic solvents such as ethanol, acetone, trichloromethane and the like. Because the amino exists in the chemical structure, the stock solution is stronger in alkalinity, ester bonds in the chemical structure are greatly damaged, the stability of the stock solution is directly poor, the stock solution is easy to decompose under normal-temperature storage, and the stock solution is more severely decomposed under the thermal storage condition. At present, in actual production, a raw medicine manufacturer mainly coordinates the raw medicine and citric acid into salt to prepare the diethyl aminoethyl hexanoate citrate, so that the stability of the diethyl aminoethyl hexanoate citrate can be properly improved, and in addition, the diethyl aminoethyl hexanoate citrate is in a solid state and can be completely dissolved in water, and the problems of difficult storage and transportation and water solubility of the diethyl aminoethyl hexanoate are solved.
The diethyl aminoethyl hexanoate citrate is white to off-white solid crystal or powder, has light ester fragrance and greasy feeling, is easily soluble in water, can be dissolved in polar organic solvents such as ethanol, methanol, acetone and the like, and can be prepared into water-soluble liquid preparations and solid preparations. The liquid preparation of the diethyl aminoethyl hexanoate citrate exists in a system containing water, alcohols or polar solvents, so that the diethyl aminoethyl hexanoate is easy to undergo hydrolysis, alcoholysis and ammonolysis reactions at normal temperature, and is accelerated to decompose particularly at high temperature, so that the validity period of the diethyl aminoethyl hexanoate citrate preparation is generally short. Experimental research shows that after the diethyl aminoethyl hexanoate citrate is compounded with most of fillers and solvents, the diethyl aminoethyl hexanoate shows higher heat storage decomposition rate, and the drug effect and the quality guarantee period of the product are influenced. Particularly, if the storage time is long in a poor condition and a high-temperature and high-humidity place, the content is reduced by more than 50%, especially for a water-based preparation, the longer the storage time is, the higher the temperature is, the content degradation reaches more than 90%, and the storage stability of a related preparation product is seriously unqualified.
Disclosure of Invention
The invention provides a pesticide solid preparation capable of effectively reducing the decomposition rate of diethyl aminoethyl hexanoate, aiming at solving the defect that a diethyl aminoethyl hexanoate pesticide preparation in the prior art is easy to hydrolyze.
The invention firstly provides a pesticide solid preparation which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25).
The invention also provides the following preferred schemes:
preferably, the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (2.5-25).
Preferably, the sugar alcohol is at least one of sorbitol, mannitol, maltitol, lactitol and xylitol.
The invention also provides a pesticide solid preparation which comprises the diethyl aminoethyl hexanoate citrate, sugar alcohol and an agriculturally and pharmaceutically acceptable auxiliary agent.
Preferably, the pesticide solid preparation is in the dosage form of one of soluble powder, soluble granules and soluble tablets.
More preferably, the pesticide formulation is soluble powder or soluble granules.
Preferably, the auxiliary agent is at least one of a wetting agent, a dispersing agent, an anti-caking agent, a filler, a disintegrating agent and a synergist. At least one of the components in the invention can comprise one component, two components and a compound of more than two components.
More preferably, the wetting agent is one or more of alkylphenol polyoxyethylene ether, formaldehyde condensate sulfate, alkylphenol polyoxyethylene phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, fatty alcohol polyoxyethylene ether sodium sulfate, fatty alcohol polyoxyethylene ether, sodium alkyl benzene sulfonate, alkyl alcohol polyoxyethylene ether sodium sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate and alkylamide taurate.
More preferably, the dispersant is at least one selected from the group consisting of lignosulfonates, alkylnaphthalenesulfonates, and polycarboxylates, phosphates, and naphthalenesulfonates.
More preferably, the anti-caking agent is white carbon black.
More preferably, the filler is a saccharide. More preferably, the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose and cyclodextrin.
More preferably, the plant growth regulating solid preparation comprises a disintegrating agent when the dosage form is soluble granules or soluble tablets. More preferably, the disintegrant is sodium carboxymethyl starch.
More preferably, the synergist is at least one of organosilicon synergist, tea saponin, azone, thiaketone, penetrant JFC (fatty alcohol-polyoxyethylene ether), and rapid penetrant T (dioctyl sodium sulfosuccinate).
The invention also provides a preparation method of the pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate, and the preparation method is prepared according to a general processing technique of the solid preparation. Premixing, crushing, mixing again, and fully and uniformly mixing to obtain the diethyl aminoethyl hexanoate citrate soluble powder; the soluble powder can be granulated to obtain soluble granules, and the soluble powder can be tableted to obtain soluble tablets.
The content of diethyl aminoethyl hexanoate in the pesticide solid preparation is detected by gas chromatography according to the requirements of 2.2 in a pesticide thermal storage stability determination method GB/T19136-2003 and the general test rule of pesticide normal temperature storage stability NY/T1427-2016 respectively, and the decomposition rate of diethyl aminoethyl hexanoate is lower than 5 percent under the conditions of 14 days of thermal storage and 2 years of normal temperature storage.
The invention has the beneficial effects that:
1. the pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate is beneficial to storage and transportation, has good stability, high activity, good efficiency and safety, is dissolved quickly in the using process, and has great economic benefit and wide development prospect;
2. the preparation method of the pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate has the advantages of simple steps, easy operation, no environmental pollution and low formula cost.
3. The pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate obviously prolongs the validity period of diethyl aminoethyl hexanoate citrate preparation by using sugar alcohol substances and soluble sugar as auxiliary materials. The action time and the action effect of the diethyl aminoethyl hexanoate are greatly improved by reducing the decomposition of the diethyl aminoethyl hexanoate.
4. The invention changes the effective period of the diethyl aminoethyl hexanoate citrate preparation by using different auxiliary materials. The invention effectively solves the decomposition problem of diethyl aminoethyl hexanoate.
Detailed Description
In order that those skilled in the art will better understand the technical solutions of the present invention, the present invention will be further described in detail with reference to the following embodiments.
The invention firstly provides a pesticide solid preparation which comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25). Preferably, the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (2.5-25).
The decomposition of the diethyl aminoethyl hexanoate is mainly influenced by temperature, pH, moisture and filler, the storage temperature of the diethyl aminoethyl hexanoate-containing citrate preparation can not be controlled, and the moisture in a liquid preparation has the greatest influence on the stability of the diethyl aminoethyl hexanoate, so that the diethyl aminoethyl hexanoate-containing preparation is preferably made into a solid preparation. The interaction between the drug and the adjuvant is many, and the drug mainly has physical action and chemical action, or both. The result of these actions is considered when selecting the auxiliary materials, but the result of physical action is generally weak, and the result of chemical action is complex, such as hydrolysis, alcoholysis, ammonolysis, redox, etc., which may cause drug decomposition and generation of impurities. The diethyl aminoethyl hexanoate citrate can be prepared into a preparation by selecting various different auxiliary materials, and the different auxiliary materials have fixed acidity and alkalinity, and can generate different influences on the diethyl aminoethyl hexanoate citrate preparation when being used together with the diethyl aminoethyl hexanoate citrate, so that the selection of the auxiliary materials has a vital effect on the stability and the validity period of the diethyl aminoethyl hexanoate citrate solid preparation. Researches find that after the diethyl aminoethyl hexanoate citrate is compounded with a plurality of fillers (such as monopotassium phosphate, potassium sulfate, sodium polyborate, magnesium sulfate and the like), the diethyl aminoethyl hexanoate citrate shows higher thermal storage and normal storage decomposition rates, and the drug effect of the product is influenced. Particularly, if the preparation is stored for a long time under poor conditions and at high temperature and high humidity, the content is reduced by more than 50 percent, so that the heat storage stability of the related preparation product is seriously unqualified. The invention prolongs the validity period of the diethyl aminoethyl hexanoate citrate preparation by using sugar alcohol substances and soluble sugar as auxiliary materials. By reducing the decomposition of the diethyl aminoethyl hexanoate, the action time and the action effect of the diethyl aminoethyl hexanoate are greatly improved.
The specific polyol structure of the sugar alcohol is beneficial to uniformly wrapping the sugar alcohol on the surface of the diethyl aminoethyl citrate, and the moisture is isolated as much as possible. Therefore, the sugar alcohol is used as an auxiliary material of the diethyl aminoethyl hexanoate citrate soluble powder, so that the contact between the diethyl aminoethyl hexanoate citrate and water can be reduced, the hydrolysis of the diethyl aminoethyl hexanoate can be delayed, and the effective period of the diethyl aminoethyl hexanoate citrate solid preparation can be prolonged. In addition, sugar alcohols play an important role in the life cycle of plants. It not only provides energy and metabolic intermediate products for the growth and development of plants, but also has a signal function. It is also an important regulator of plant growth and development and gene expression. The sugar alcohol can be used as carriers of other nutrient elements such as boron and the like, and carries mineral nutrients to be rapidly transported in the phloem of the plant. It is a natural extract in plant phloem juice, has no toxicity and no damage to plants and human bodies; the molecular weight is low, the fertilizer is easily absorbed by leaves, and the fertilizer is easily degraded to release nutrients when entering into plants, so that the energy consumption is low; particularly, the sugar alcohol is a natural wetting agent, has the moisturizing function, can prevent the liquid medicine from losing efficacy due to rapid drying of the liquid medicine on the leaves, and prolongs the time for the leaves to absorb nutrient elements; is a natural surfactant, can ensure that nutrient elements are spread and uniformly covered on the whole leaves, improve the absorption area of the leaves, and simultaneously avoid burning the leaves due to overhigh local concentration of micronutrients; sugar alcohols can also improve the stress resistance of plants. On the one hand, sugar alcohols are important substances involved in intracellular osmotic regulation. Under the adversity stresses of salt damage, drought, flooding and the like, the sugar alcohol can adjust the cell permeability to lead the plant to adapt to the adversity growth; on the other hand, the sugar alcohol can improve the resistance to active oxygen, and avoid the active oxygen damage of plants caused by ultraviolet sun burn, drought, diseases, oxygen deficiency and the like.
In order to enable the sugar alcohol to be better complexed with medium and trace elements and to be rapidly transported in the phloem, the sugar alcohol is at least one of sorbitol, mannitol, maltitol, lactitol and xylitol.
In order to enable the pesticide composition to be better applied to the growth of crops, the invention also provides a pesticide solid preparation, and the pesticide solid preparation further comprises an agriculturally and pharmaceutically acceptable auxiliary agent.
In order to adapt to different plant planting environments, the plant pesticide solid preparation can be prepared into one of soluble powder, soluble granules and soluble tablets.
More preferably, the pesticide formulation is soluble powder or soluble granules.
The auxiliary agent can be at least one of wetting agent, dispersing agent, anti-caking agent, filler, disintegrating agent and synergist according to different dosage form requirements.
In order to enable the solid materials to be more easily wetted by water, a wetting agent can be added into the pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate, wherein the wetting agent is one or more of alkylphenol ethoxylates, formaldehyde condensate sulfate, alkylphenol ethoxylate phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, fatty alcohol polyoxyethylene ether sodium sulfate, fatty alcohol polyoxyethylene ether, sodium alkyl naphthalene sulfonate (Morwet EFW), alkyl alcohol polyoxyethylene ether sodium sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate and alkylamide taurate.
In the pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate, in order to improve the application performance of the preparation to crops, a synergist can be added, wherein the synergist is at least one of an organosilicon synergist, tea saponin, azone, thiaketone, a penetrant JFC (fatty alcohol polyoxyethylene ether) and fast T (dioctyl sodium sulfosuccinate).
When the solid preparation is in the form of soluble powder, in order to prevent the soluble powder from caking and keep good fluidity of the material, the pesticide solid preparation can further comprise an anti-caking agent, and preferably, the anti-caking agent is anhydrous magnesium sulfate, white carbon black and the like.
When the solid preparation is in the form of soluble powder, soluble granules or soluble tablets, the filler is a saccharide. More preferably, the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose and cyclodextrin.
When the solid preparation is in the form of soluble granules or soluble tablets, the plant growth regulating solid preparation further comprises a disintegrant in order to enable the preparation to be rapidly disintegrated into fine particles of the active substance ingredient in water. More preferably, the disintegrant is sodium carboxymethyl cellulose, soluble starch.
At normal temperature, the diethyl aminoethyl hexanoate citrate is directly used for premixing with the substances, crushing and mixing, and the mixture is fully and uniformly mixed to prepare diethyl aminoethyl hexanoate citrate soluble powder, and soluble granules can be obtained by granulation, and soluble tablets can be obtained by tabletting.
The content of diethyl aminoethyl hexanoate in the pesticide solid preparation is detected by gas chromatography according to the requirements of 2.2 in GB/T19136-2003 and 2.2 in NY/T1427-2016 in general rules on testing stability of normal temperature storage of pesticides, and the decomposition rate of diethyl aminoethyl hexanoate is lower than 5% under the conditions of 14 days of hot storage and 2 years of normal temperature storage.
The foregoing is a detailed description of the invention and the following is an example of the invention.
Specifically, the following description is provided: the diethyl aminoethyl hexanoate citrate is prepared by the coordination reaction of diethyl aminoethyl hexanoate and citric acid, and the appearance form of the diethyl aminoethyl hexanoate citrate is converted from a liquid state to a solid state. In the formula table of the solid preparation containing diethyl aminoethyl hexanoate, the raw materials of the active ingredients are diethyl aminoethyl hexanoate citrate, and the active ingredient substances detected by gas chromatography are diethyl aminoethyl hexanoate, so that when the mass fraction of the active ingredients is calculated, the diethyl aminoethyl hexanoate citrate and the diethyl aminoethyl hexanoate need to be obtained through coefficient conversion, and the conversion coefficient is as follows: 407.46/215.33 is 1.89(407.46 is the relative molecular mass of diethyl aminoethyl citrate, 215.33 is the relative molecular mass of diethyl aminoethyl citrate). Examples are: if 100 g of 8% diethyl aminoethyl hexanoate soluble powder is prepared, the mass of diethyl aminoethyl hexanoate citrate is added as follows: 100 × 8% × 1.89 ═ 15.12 g.
Example one
1kg of 8% diethyl aminoethyl hexanoate soluble powder with different components is prepared, and the components in percentage by mass are shown in tables 1 and 2:
TABLE 18% diethyl aminoethyl hexanoate soluble powder (sugar alcohols) formulation composition
TABLE 28% soluble powder of diethyl aminoethyl hexanoate (non-sugar alcohol) formulation composition
The preparation method comprises the following steps: taking the components in the table 1 and the table 2 according to the mass ratio, and premixing → crushing → remixing to obtain the 8% diethyl aminoethyl hexanoate soluble powder.
The formula of the formula shown in the table 1 and the formula of the formula shown in the table 2 are used for forming samples, the quality indexes are detected according to the standard technical quality index of 8% diethyl aminoethyl hexanoate soluble powder Q/91510185MA68HDG804 & 25, and the specific control quality index is shown in the table 3. The heat storage stability of the effective components is determined according to 2.2 in the pesticide heat stability determination method GB/T19136-2003.
Quality control index of table 38% diethyl aminoethyl hexanoate soluble powder
Table 1 and table 2 the formula table shows the results of the quality index measurements in table 4.
Table 4 quality index test results of each technique
The following conclusions can be drawn from the above formulation examples No. 1-15 and the corresponding quality index test results: no. 1-15 except that the decomposition rate of the active ingredient (diethyl aminoethyl hexanoate) is changed, the other quality indexes all meet the requirements of enterprise standards; no. 1-9 with the gradual increase of the content of the sorbic alcohol , the decomposition rate of the diethyl aminoethyl hexanoate after heat storage is gradually reduced, but the decomposition rate of the diethyl aminoethyl hexanoate after heat storage is less than 5 percent; no. 10-15 adopts different inorganic salts as fillers, and the decomposition rate of the diethyl aminoethyl hexanoate after heat storage is more than 5 percent and even reaches more than 10 percent no matter which type of fillers.
The formula No. 1 and formula No. 9 in the formula table 1 are subjected to 2-year normal-temperature storage test according to the requirement of general rules on the storage stability of pesticides at normal temperature in NY/T1427-2016. And (3) detecting the content, the decomposition rate and other control indexes of the active ingredient diethyl aminoethyl hexanoate according to the quality standard (Q/91510185MA68HDG804 & 25) of 8% diethyl aminoethyl hexanoate soluble powder enterprises at the time points of the initial storage period, the 3 rd month, the 6 th month, the 12 th month and the 24 th month in the sample storage process. The results of the constant storage test are shown in tables 5 and 6.
Table 5 formula 1 test results of quality control indexes by room temperature storage
Table 6 quality control index test results of formula 9 storage at room temperature
From the detection indexes of the formulations 1 and 9 in the tables 5 and 6 at various time points of normal-temperature storage, the decomposition rate of the active ingredient diethyl aminoethyl hexanoate in the 8% diethyl aminoethyl hexanoate soluble powder (containing sugar alcohol) storage test at the normal temperature for 2 years is about 2% at most, and other quality control indexes are qualified. The formula shows that the decomposition rate of diethyl aminoethyl hexanoate is lower than 5% within 2 years of storage time, and all quality control indexes of the formula completely meet the standard requirement of 8% diethyl aminoethyl hexanoate soluble powder Q/91510185MA68HDG804 & 25.
Example two
1kg of 10% diethyl aminoethyl hexanoate soluble granules with different components are prepared, and the compositions in percentage by mass are shown in a table 7:
TABLE 710% diethyl aminoethyl hexanoate soluble granule (sugar alcohol containing) formulation
The preparation method comprises the following steps: the preparation method comprises the following steps: taking the components in the table 7 according to the mass ratio, and performing premixing → crushing → remixing → granulating to obtain the 10% diethyl aminoethyl hexanoate soluble granule.
The quality indexes of the formula samples are determined by referring to the public standard 10% diethyl aminoethyl hexanoate soluble granule (Q/PMB594) standard, and the specific control quality indexes are shown in a table 8. The heat storage stability of the effective components is determined according to 2.2 in the pesticide heat stability determination method GB/T19136-2003.
TABLE 810% quality control index of diethyl aminoethyl hexanoate soluble granules
The results of the quality index measurements in the formula table of table 7 are shown in table 9.
TABLE 910% quality index test results of diethyl aminoethyl hexanoate soluble granules
The following conclusions can be drawn from the above formulation examples No. 1-6 and the corresponding quality index test results: no. 1-6 except that the decomposition rate of the active ingredient (diethyl aminoethyl hexanoate) is changed, the other quality indexes all meet the technical standard requirements, and the thermal storage decomposition rate of the diethyl aminoethyl hexanoate is less than 2 percent.
Samples of formula I and formula VI in the formula table 8 are taken to carry out 2-year normal-temperature storage test according to the general rules of pesticide normal-temperature storage stability test (NY/T1427-2016). And detecting the content, the decomposition rate and other control indexes of the effective component diethyl aminoethyl hexanoate according to the technical index of 10 percent diethyl aminoethyl hexanoate soluble granules at the time points of the initial storage period, the 3 rd month, the 6 th month, the 12 th month and the 24 th month in the sample storage process. The results of the constant storage test are shown in tables 10 and 11.
TABLE 10 quality control index test results of formula I Normal temperature storage test
Table 11 quality control index test results of formula VI at room temperature storage
From the detection indexes of the formula I and the formula VI in the tables 10 and 11 at each time point of normal-temperature storage, the maximum decomposition rate of the active ingredient diethyl aminoethyl hexanoate in the 10 percent diethyl aminoethyl hexanoate soluble granule agent in the 2-year normal-temperature storage test is 2.39 percent, and other quality control indexes are qualified. The formula shows that the decomposition rate of the diethyl aminoethyl hexanoate is lower than 5% within 2 years of storage time, and all other quality control indexes completely meet the requirements of technical indexes.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and these modifications and adaptations should be considered within the scope of the invention.
Claims (8)
1. A pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate is characterized in that: the preservative comprises diethyl aminoethyl hexanoate citrate and sugar alcohol, wherein the weight ratio of the diethyl aminoethyl hexanoate citrate to the sugar alcohol is 1 (1-25).
2. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl hexanoate as claimed in claim 1, wherein: the sugar alcohol is at least one of sorbitol, mannitol, maltitol, lactitol and xylitol.
3. A pesticide solid preparation for reducing the decomposition rate of diethyl aminoethyl hexanoate is characterized in that: also comprises a pesticide adjuvant.
4. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl hexanoate as claimed in claim 3, wherein: the dosage form of the pesticide solid preparation is one of soluble powder and soluble granules.
5. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl hexanoate as claimed in claim 3, wherein: the pesticide auxiliary agent is at least one of a wetting agent, a dispersing agent, an anti-caking agent, a filler, a disintegrating agent and a synergist.
6. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl hexanoate in claim 5, wherein: the filler is a saccharide.
7. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl hexanoate as claimed in claim 6, wherein: the saccharide is at least one of glucose, sucrose, lactose, starch, cellulose and cyclodextrin.
8. The solid preparation of agricultural chemicals for reducing decomposition rate of diethyl aminoethyl ester according to claims 1 to 7, wherein: the content of diethyl aminoethyl hexanoate is detected by adopting a gas chromatography, and the decomposition rate of a sample stored for 14 days in a hot storage way and 2 years at normal temperature is less than 5 percent.
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| CN115669661A (en) * | 2023-01-05 | 2023-02-03 | 济南一农化工有限公司 | Diethyl aminoethyl hexanoate liquid preparation and preparation method and application thereof |
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