CN119345612A - 用于膀胱癌的光动力疗法(pdt)的方法 - Google Patents
用于膀胱癌的光动力疗法(pdt)的方法 Download PDFInfo
- Publication number
- CN119345612A CN119345612A CN202411499253.8A CN202411499253A CN119345612A CN 119345612 A CN119345612 A CN 119345612A CN 202411499253 A CN202411499253 A CN 202411499253A CN 119345612 A CN119345612 A CN 119345612A
- Authority
- CN
- China
- Prior art keywords
- light
- composition
- bladder
- use according
- flow rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 139
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 title claims abstract description 95
- 206010005003 Bladder cancer Diseases 0.000 title claims abstract description 89
- 201000005112 urinary bladder cancer Diseases 0.000 title claims abstract description 85
- 238000002428 photodynamic therapy Methods 0.000 title claims abstract description 82
- 239000000203 mixture Substances 0.000 claims abstract description 136
- -1 5-ALA hexyl ester Chemical class 0.000 claims abstract description 83
- 238000011282 treatment Methods 0.000 claims abstract description 72
- 150000003839 salts Chemical class 0.000 claims abstract description 50
- 238000009099 neoadjuvant therapy Methods 0.000 claims abstract description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 49
- 239000000243 solution Substances 0.000 claims description 40
- 238000009098 adjuvant therapy Methods 0.000 claims description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- 238000009799 cystectomy Methods 0.000 claims description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 239000012062 aqueous buffer Substances 0.000 claims description 19
- 238000002271 resection Methods 0.000 claims description 18
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 238000002512 chemotherapy Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 10
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 10
- 235000019800 disodium phosphate Nutrition 0.000 claims description 10
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 10
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 10
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 239000001488 sodium phosphate Substances 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000009169 immunotherapy Methods 0.000 claims description 7
- 239000008363 phosphate buffer Substances 0.000 claims description 7
- WVYWICLMDOOCFB-UHFFFAOYSA-N 4-methyl-2-pentanol Chemical group CC(C)CC(C)O WVYWICLMDOOCFB-UHFFFAOYSA-N 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 description 197
- 229960002749 aminolevulinic acid Drugs 0.000 description 45
- 230000003902 lesion Effects 0.000 description 45
- 206010028980 Neoplasm Diseases 0.000 description 43
- 239000003504 photosensitizing agent Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 14
- 229960004857 mitomycin Drugs 0.000 description 13
- 229930192392 Mitomycin Natural products 0.000 description 12
- 238000002574 cystoscopy Methods 0.000 description 10
- 238000001917 fluorescence detection Methods 0.000 description 9
- 210000004881 tumor cell Anatomy 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 230000004083 survival effect Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- 238000011179 visual inspection Methods 0.000 description 7
- 208000009458 Carcinoma in Situ Diseases 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 201000004933 in situ carcinoma Diseases 0.000 description 6
- 238000001959 radiotherapy Methods 0.000 description 6
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 230000001114 myogenic effect Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 238000002695 general anesthesia Methods 0.000 description 4
- 150000004032 porphyrins Chemical class 0.000 description 4
- 229950003776 protoporphyrin Drugs 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- ILBBNQMSDGAAPF-UHFFFAOYSA-N 1-(6-hydroxy-6-methylcyclohexa-2,4-dien-1-yl)propan-1-one Chemical compound CCC(=O)C1C=CC=CC1(C)O ILBBNQMSDGAAPF-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000007660 Residual Neoplasm Diseases 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 3
- 229960004316 cisplatin Drugs 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 230000005283 ground state Effects 0.000 description 3
- 150000003278 haem Chemical class 0.000 description 3
- 235000011167 hydrochloric acid Nutrition 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000011227 neoadjuvant chemotherapy Methods 0.000 description 3
- 239000013307 optical fiber Substances 0.000 description 3
- 231100000760 phototoxic Toxicity 0.000 description 3
- 238000009801 radical cystectomy Methods 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 229910052724 xenon Inorganic materials 0.000 description 3
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 3
- RYQOILLJDKPETL-UHFFFAOYSA-N 5-aminolevulinic acid hexyl ester Chemical compound CCCCCCOC(=O)CCC(=O)CN RYQOILLJDKPETL-UHFFFAOYSA-N 0.000 description 2
- 206010005063 Bladder pain Diseases 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- BUDAHACLEBPVOV-UHFFFAOYSA-N 2,2,3,3,5,5-hexaamino-4-oxopentanoic acid Chemical compound NC(N)C(=O)C(N)(N)C(N)(N)C(O)=O BUDAHACLEBPVOV-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 208000035346 Margins of Excision Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000011226 adjuvant chemotherapy Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 201000001531 bladder carcinoma Diseases 0.000 description 1
- 201000000545 bladder carcinoma in situ Diseases 0.000 description 1
- 208000029162 bladder disease Diseases 0.000 description 1
- 210000005068 bladder tissue Anatomy 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000009096 combination chemotherapy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- BACMENZMTITADY-UHFFFAOYSA-N hexyl 2-amino-4-oxopentanoate Chemical compound CCCCCCOC(=O)C(N)CC(C)=O BACMENZMTITADY-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000008629 immune suppression Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002632 myometrial effect Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 238000002693 spinal anesthesia Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 150000003458 sulfonic acid derivatives Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 208000026533 urinary bladder disease Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229960000653 valrubicin Drugs 0.000 description 1
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/307—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15200938 | 2015-12-17 | ||
| EP15200938.7 | 2015-12-17 | ||
| CN201680079638.6A CN108697800A (zh) | 2015-12-17 | 2016-12-19 | 用于膀胱癌的光动力疗法(pdt)的方法 |
| PCT/EP2016/081809 WO2017103285A1 (en) | 2015-12-17 | 2016-12-19 | Method of photodynamic therapy (pdt) for bladder cancer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680079638.6A Division CN108697800A (zh) | 2015-12-17 | 2016-12-19 | 用于膀胱癌的光动力疗法(pdt)的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119345612A true CN119345612A (zh) | 2025-01-24 |
Family
ID=55066354
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411499253.8A Pending CN119345612A (zh) | 2015-12-17 | 2016-12-19 | 用于膀胱癌的光动力疗法(pdt)的方法 |
| CN201680079638.6A Pending CN108697800A (zh) | 2015-12-17 | 2016-12-19 | 用于膀胱癌的光动力疗法(pdt)的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680079638.6A Pending CN108697800A (zh) | 2015-12-17 | 2016-12-19 | 用于膀胱癌的光动力疗法(pdt)的方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11235168B2 (enExample) |
| EP (1) | EP3389716B1 (enExample) |
| JP (1) | JP6995755B2 (enExample) |
| KR (1) | KR102787192B1 (enExample) |
| CN (2) | CN119345612A (enExample) |
| AU (1) | AU2016372575B2 (enExample) |
| BR (1) | BR112018011965A2 (enExample) |
| CA (1) | CA3008552C (enExample) |
| CL (1) | CL2018001612A1 (enExample) |
| DK (1) | DK3389716T3 (enExample) |
| ES (1) | ES2910034T3 (enExample) |
| IL (1) | IL259925B (enExample) |
| MX (1) | MX385912B (enExample) |
| PL (1) | PL3389716T3 (enExample) |
| RU (1) | RU2745194C2 (enExample) |
| SG (1) | SG11201805000RA (enExample) |
| WO (1) | WO2017103285A1 (enExample) |
| ZA (1) | ZA201804530B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119345612A (zh) * | 2015-12-17 | 2025-01-24 | 光治疗Asa公司 | 用于膀胱癌的光动力疗法(pdt)的方法 |
| CN110420326A (zh) * | 2019-09-17 | 2019-11-08 | 上海复旦张江生物医药股份有限公司 | 一种多替泊芬的应用 |
| JP7769015B2 (ja) * | 2021-08-17 | 2025-11-12 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 光活性剤を活性化するためのカテーテルシステム及びカテーテル |
| AU2024231397A1 (en) | 2023-03-07 | 2025-09-25 | Photocure Asa | Therapy for bladder cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7530461B2 (en) * | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| AU708076B2 (en) | 1995-03-10 | 1999-07-29 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US20050003154A1 (en) * | 2002-12-13 | 2005-01-06 | White Gary L. | Laminated building panels having preselected colors |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| GB0700580D0 (en) | 2007-01-11 | 2007-02-21 | Photocure Asa | Use |
| GB0724279D0 (en) | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| CN101891639A (zh) | 2009-05-20 | 2010-11-24 | 上海先导化学有限公司 | 一种制备5-氨基酮戊酸盐酸盐的方法 |
| PE20120858A1 (es) | 2009-06-11 | 2012-08-01 | Photocure Asa | Composiciones solidas que comprenden acido 5-aminolevulinico |
| EP2440199B1 (en) | 2009-06-11 | 2016-04-13 | Photocure ASA | Semi-solid compositions and pharmaceutical products |
| RU2448745C2 (ru) * | 2010-05-31 | 2012-04-27 | Олег Феликсович Каган | Способ лечения поверхностного рака мочевого пузыря |
| CN104244804B (zh) | 2011-12-19 | 2017-04-26 | 丹麦科技大学 | 用于内窥镜应用的照明系统 |
| RU2635563C2 (ru) | 2012-08-03 | 2017-11-14 | ФотоКьюэр АСА | Соединения |
| GB201221123D0 (en) * | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
| CN119345612A (zh) * | 2015-12-17 | 2025-01-24 | 光治疗Asa公司 | 用于膀胱癌的光动力疗法(pdt)的方法 |
-
2016
- 2016-12-19 CN CN202411499253.8A patent/CN119345612A/zh active Pending
- 2016-12-19 JP JP2018532037A patent/JP6995755B2/ja active Active
- 2016-12-19 CA CA3008552A patent/CA3008552C/en active Active
- 2016-12-19 MX MX2018007166A patent/MX385912B/es unknown
- 2016-12-19 CN CN201680079638.6A patent/CN108697800A/zh active Pending
- 2016-12-19 KR KR1020187020005A patent/KR102787192B1/ko active Active
- 2016-12-19 PL PL16810437T patent/PL3389716T3/pl unknown
- 2016-12-19 US US16/063,142 patent/US11235168B2/en active Active
- 2016-12-19 ES ES16810437T patent/ES2910034T3/es active Active
- 2016-12-19 EP EP16810437.0A patent/EP3389716B1/en active Active
- 2016-12-19 BR BR112018011965A patent/BR112018011965A2/pt not_active Application Discontinuation
- 2016-12-19 RU RU2018123834A patent/RU2745194C2/ru active
- 2016-12-19 SG SG11201805000RA patent/SG11201805000RA/en unknown
- 2016-12-19 WO PCT/EP2016/081809 patent/WO2017103285A1/en not_active Ceased
- 2016-12-19 DK DK16810437.0T patent/DK3389716T3/da active
- 2016-12-19 AU AU2016372575A patent/AU2016372575B2/en active Active
-
2018
- 2018-06-10 IL IL259925A patent/IL259925B/en unknown
- 2018-06-14 CL CL2018001612A patent/CL2018001612A1/es unknown
- 2018-07-06 ZA ZA2018/04530A patent/ZA201804530B/en unknown
-
2022
- 2022-01-31 US US17/588,978 patent/US11980772B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20220152411A1 (en) | 2022-05-19 |
| DK3389716T3 (da) | 2022-04-11 |
| RU2018123834A3 (enExample) | 2020-04-13 |
| IL259925A (en) | 2018-07-31 |
| NZ743697A (en) | 2024-10-25 |
| BR112018011965A2 (pt) | 2018-12-04 |
| AU2016372575B2 (en) | 2022-12-08 |
| IL259925B (en) | 2022-04-01 |
| SG11201805000RA (en) | 2018-07-30 |
| EP3389716A1 (en) | 2018-10-24 |
| CA3008552A1 (en) | 2017-06-22 |
| MX385912B (es) | 2025-03-18 |
| ZA201804530B (en) | 2019-09-25 |
| RU2745194C2 (ru) | 2021-03-22 |
| CN108697800A (zh) | 2018-10-23 |
| CA3008552C (en) | 2024-01-02 |
| US20190022404A1 (en) | 2019-01-24 |
| CL2018001612A1 (es) | 2019-01-11 |
| JP6995755B2 (ja) | 2022-01-17 |
| KR20180094986A (ko) | 2018-08-24 |
| PL3389716T3 (pl) | 2022-06-20 |
| US11235168B2 (en) | 2022-02-01 |
| ES2910034T3 (es) | 2022-05-11 |
| US11980772B2 (en) | 2024-05-14 |
| RU2018123834A (ru) | 2020-01-17 |
| EP3389716B1 (en) | 2022-03-23 |
| WO2017103285A1 (en) | 2017-06-22 |
| JP2019501161A (ja) | 2019-01-17 |
| KR102787192B1 (ko) | 2025-03-25 |
| AU2016372575A1 (en) | 2018-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11980772B2 (en) | Method of photodynamic therapy (PDT) for bladder cancer | |
| US11311620B2 (en) | Neoadjuvant therapy for bladder cancer | |
| CN104524576A (zh) | 氨基酮戊酸及其衍生物的应用 | |
| CN108699147A (zh) | 用于膀胱癌的膀胱内治疗 | |
| Ding et al. | Photogenetic‐Like Liposomes Disrupt Neuroligin‐3 Dependency to Enhance Glioma Treatment | |
| RU2783177C2 (ru) | Неоадъювантная терапия для рака мочевого пузыря | |
| HK1262650B (en) | Method of photodynamic therapy (pdt) for bladder cancer | |
| HK1262650A1 (en) | Method of photodynamic therapy (pdt) for bladder cancer | |
| Ma et al. | Synergizing photodynamic therapy and ethanol ablation: Light‐activatable sustained‐exposure ethanol injection technology for enhanced tumor ablation | |
| CA3008551C (en) | Neoadjuvant therapy for bladder cancer | |
| CN120957714A (zh) | 膀胱癌疗法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |