CN1192691A - 稳定的含tpo的冻干组合物 - Google Patents

稳定的含tpo的冻干组合物 Download PDF

Info

Publication number
CN1192691A
CN1192691A CN96196083A CN96196083A CN1192691A CN 1192691 A CN1192691 A CN 1192691A CN 96196083 A CN96196083 A CN 96196083A CN 96196083 A CN96196083 A CN 96196083A CN 1192691 A CN1192691 A CN 1192691A
Authority
CN
China
Prior art keywords
tpo
leu
ctg
pro
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96196083A
Other languages
English (en)
Chinese (zh)
Inventor
野村英昭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of CN1192691A publication Critical patent/CN1192691A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN96196083A 1995-06-08 1996-06-07 稳定的含tpo的冻干组合物 Pending CN1192691A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14207595 1995-06-08
JP142075/95 1995-06-08

Publications (1)

Publication Number Publication Date
CN1192691A true CN1192691A (zh) 1998-09-09

Family

ID=15306858

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196083A Pending CN1192691A (zh) 1995-06-08 1996-06-07 稳定的含tpo的冻干组合物

Country Status (8)

Country Link
EP (1) EP0841066A1 (enExample)
KR (1) KR19990022398A (enExample)
CN (1) CN1192691A (enExample)
AU (1) AU5911796A (enExample)
CA (1) CA2223749A1 (enExample)
MX (1) MXPA97009801A (enExample)
TW (1) TW497972B (enExample)
WO (1) WO1996041642A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100450542C (zh) * 2003-07-22 2009-01-14 比奥泰康医疗有限责任公司 不加人血清白蛋白(hsa)的蛋白质药物制剂
CN111588841A (zh) * 2019-02-21 2020-08-28 中国人民解放军军事科学院军事医学研究院 一种可气溶胶化的seb类毒素疫苗干粉吸入剂

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001501619A (ja) * 1996-10-04 2001-02-06 アムジェン インコーポレーテッド ｍｐｌリガンドを含有する医薬組成物
US20030104996A1 (en) * 2001-08-30 2003-06-05 Tiansheng Li L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
DE10204792A1 (de) * 2002-02-06 2003-08-14 Merck Patent Gmbh Lyophilisierte Zubereitung enthaltend Immuncytokine
CN102552184A (zh) * 2012-02-16 2012-07-11 山东泉港药业有限公司 一种血小板生成素拟肽冻干制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
AU641645B2 (en) * 1989-04-03 1993-09-30 Genetics Institute Inc. Megakaryocyte growth promoting activity
ATE139700T1 (de) * 1991-02-15 1996-07-15 Takeda Chemical Industries Ltd Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren
AU4190893A (en) * 1992-07-17 1994-01-20 Suntory Limited Megakaryocyte differentiation factor
SG47030A1 (en) * 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
WO1995021919A2 (en) * 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
NZ281482A (en) * 1994-02-14 2000-09-29 Univ Washington The stimulation of erythropoiesis using thrombopoietin and erythropoietin
FI963185A7 (fi) * 1994-02-14 1996-08-14 Zymogenetics Inc Hematopoieettinen proteiini ja materiaalit ja menetelmät sen valmistam iseksi
JP2996415B2 (ja) * 1994-03-31 1999-12-27 アムジエン・インコーポレーテツド 巨核球の成長と分化を刺激するモノｐｅｇ化ｍｇｄｆポリペプチド
US6790439B1 (en) * 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100450542C (zh) * 2003-07-22 2009-01-14 比奥泰康医疗有限责任公司 不加人血清白蛋白(hsa)的蛋白质药物制剂
CN111588841A (zh) * 2019-02-21 2020-08-28 中国人民解放军军事科学院军事医学研究院 一种可气溶胶化的seb类毒素疫苗干粉吸入剂

Also Published As

Publication number Publication date
WO1996041642A1 (en) 1996-12-27
KR19990022398A (ko) 1999-03-25
EP0841066A1 (en) 1998-05-13
CA2223749A1 (en) 1996-12-27
EP0841066A4 (enExample) 1998-06-03
TW497972B (en) 2002-08-11
MXPA97009801A (es) 2003-10-30
AU5911796A (en) 1997-01-09

Similar Documents

Publication Publication Date Title
CN1103782C (zh) 单聚乙二醇化的mgdf多肽
CN1309416C (zh) 新的药物组合物
CN1216992C (zh) 免疫调节剂
CN1189216C (zh) 含血浆蛋白的药物组合物
HK1046694A1 (zh) 干扰素-α蛋白作为FC融合蛋白的表达和运输
CN1902222A (zh) 具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质
CN1890371A (zh) 成纤维细胞生长因子的21突变蛋白
CN1527726A (zh) 红细胞生成素共轭物
CN1681527A (zh) 使用干扰素－β治疗肾衰竭
CN1370232A (zh) 利用二价金属离子制备Apo－2配体的方法
CN1764723A (zh) 白细胞介素－18突变体、其制品及应用
CN1993139A (zh) 稳定的干扰素液体制剂
CN1239480A (zh) 含有mpl配体的药物组合物
CN1282255A (zh) Ifnar2/1fn复合物
CN1214734A (zh) Scf类似物组合物和方法
CN1192691A (zh) 稳定的含tpo的冻干组合物
CN1182453A (zh) Mpl配体类似物
CN1802170A (zh) 利用IFN－β治疗慢性炎性脱髓鞘性多神经病
CN1861634A (zh) 犬干扰素α、制备方法和用途
CN1822852A (zh) 改良的重组人干扰素－β－1b多肽
HK1017844A (en) Stable freeze-dried composition containing tpo
CN1076356C (zh) 具有血小板生成素活性的蛋白质
CN1155404C (zh) 防止血小板生成素(tpo)吸附的方法及含tpo的稳定组合物
CN1169733A (zh) 角化细胞生长因子的类似物
CN1202129C (zh) Gdnf突变体及其治疗应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1017844

Country of ref document: HK