EP0466780A4 - Megakaryocyte growth promoting activity - Google Patents

Megakaryocyte growth promoting activity

Info

Publication number
EP0466780A4
EP0466780A4 EP19900906033 EP90906033A EP0466780A4 EP 0466780 A4 EP0466780 A4 EP 0466780A4 EP 19900906033 EP19900906033 EP 19900906033 EP 90906033 A EP90906033 A EP 90906033A EP 0466780 A4 EP0466780 A4 EP 0466780A4
Authority
EP
European Patent Office
Prior art keywords
growth promoting
promoting activity
megakaryocyte growth
megakaryocyte
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900906033
Other versions
EP0466780A1 (en
Inventor
Barbara Winslow Grant
Kenneth G. Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
University of Vermont and State Agricultural College
Original Assignee
Genetics Institute LLC
University of Vermont and State Agricultural College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC, University of Vermont and State Agricultural College filed Critical Genetics Institute LLC
Publication of EP0466780A1 publication Critical patent/EP0466780A1/en
Publication of EP0466780A4 publication Critical patent/EP0466780A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP19900906033 1989-04-03 1990-04-02 Megakaryocyte growth promoting activity Withdrawn EP0466780A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33265189A 1989-04-03 1989-04-03
US332651 1989-04-03

Publications (2)

Publication Number Publication Date
EP0466780A1 EP0466780A1 (en) 1992-01-22
EP0466780A4 true EP0466780A4 (en) 1992-08-26

Family

ID=23299216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900906033 Withdrawn EP0466780A4 (en) 1989-04-03 1990-04-02 Megakaryocyte growth promoting activity

Country Status (5)

Country Link
EP (1) EP0466780A4 (en)
JP (1) JPH04506513A (en)
AU (1) AU641645B2 (en)
CA (1) CA2050584A1 (en)
WO (1) WO1990012108A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433142B1 (en) * 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
AU8868891A (en) * 1990-10-12 1992-05-20 Amgen, Inc. Megakaryocyte maturation factors
ATE170559T1 (en) * 1991-05-31 1998-09-15 Genentech Inc TREATMENT OF HIV-ASSOCIATED IMMUNE THROMBOPENIA PURPURA
CA2112492A1 (en) * 1991-06-28 1993-01-07 Hava Avraham A differentiated megakaryocyte line producing novel megakaryocyte differentiation factors
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
CN1107891A (en) * 1994-03-04 1995-09-06 上海贝特生物技术有限公司 Human megacaryocyte auxin and its separating purification and gene clone method and application
SK166695A3 (en) * 1994-03-31 1997-02-05 Amgen Inc Mgdf polypeptide for stimulating growth and megakaryocyte differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
RU2482870C1 (en) * 2012-02-27 2013-05-27 Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) Agent inducing hemopoietic stem cell differentiation into thrombocytes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002001A1 (en) * 1989-08-08 1991-02-21 Genetics Institute, Inc. A megakaryocytopoietic factor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002001A1 (en) * 1989-08-08 1991-02-21 Genetics Institute, Inc. A megakaryocytopoietic factor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EXPERIMENTAL HEMATOLOGY vol. 13, no. 11, December 1985, NEW YORK, USA pages 1164 - 1172; MAZUR, E.M. ET AL.: 'Human megakaryocyte colony stimulating factor in sera from aplastic dogs : partial purification, characterization and determination of hematopoietic cell lineage specificty.' *
EXPERIMENTAL HEMATOLOGY vol. 14, no. 6, 1986, NEW YORK, USA page 490; SHIMIZU, T. ET AL.: 'Purification of human megakaryocyte colony stimulating factor.' *
EXPERIMENTAL HEMATOLOGY vol. 15, no. 5, 1987, NEW YORK, USA page 492; SHIMIZU, T.: 'Purification of human sialylated megakaryocyte colony stimulating factor.' *
See also references of WO9012108A1 *
THE JOURNAL OF CLINICAL INVESTIGATION vol. 75, no. 4, April 1985, THE AMERICAN SOCIETY FOR CLIN. INV. pages 1174 - 1182; HOFFMAN, R. ET AL.: 'Purification and partial characterization of a megakaryocyte colony-stimulating factor from human plasma.' *

Also Published As

Publication number Publication date
AU5405890A (en) 1990-11-05
WO1990012108A1 (en) 1990-10-18
AU641645B2 (en) 1993-09-30
EP0466780A1 (en) 1992-01-22
JPH04506513A (en) 1992-11-12
CA2050584A1 (en) 1990-10-04

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19911001

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A4 Supplementary search report drawn up and despatched

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18D Application deemed to be withdrawn

Effective date: 19940826