CN119095823A - 2,4,6-三碘苯酚衍生物的制备方法 - Google Patents

2,4,6-三碘苯酚衍生物的制备方法 Download PDF

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Publication number
CN119095823A
CN119095823A CN202380036849.1A CN202380036849A CN119095823A CN 119095823 A CN119095823 A CN 119095823A CN 202380036849 A CN202380036849 A CN 202380036849A CN 119095823 A CN119095823 A CN 119095823A
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CN
China
Prior art keywords
iodination
copper
silver
reaction
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380036849.1A
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English (en)
Chinese (zh)
Inventor
Z·巴拉尼艾
N·吉多林
F·拉扎里
F·尤吉里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of CN119095823A publication Critical patent/CN119095823A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202380036849.1A 2022-04-29 2023-04-28 2,4,6-三碘苯酚衍生物的制备方法 Pending CN119095823A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22170765 2022-04-29
EP22170765.6 2022-04-29
PCT/EP2023/061272 WO2023209165A1 (en) 2022-04-29 2023-04-28 Process for the preparation of 2,4,6-triiodophenol derivatives

Publications (1)

Publication Number Publication Date
CN119095823A true CN119095823A (zh) 2024-12-06

Family

ID=81448941

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380036849.1A Pending CN119095823A (zh) 2022-04-29 2023-04-28 2,4,6-三碘苯酚衍生物的制备方法

Country Status (6)

Country Link
US (1) US12269790B1 (https=)
EP (1) EP4514771B1 (https=)
JP (1) JP2025514326A (https=)
KR (1) KR20250006017A (https=)
CN (1) CN119095823A (https=)
WO (1) WO2023209165A1 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914294A (en) 1972-06-01 1975-10-21 Squibb & Sons Inc 3,5-Disubstituted-2,4,6-triiodobenzoic acids
CA1327600C (en) 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
IT1256248B (it) 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
IT1277339B1 (it) 1995-07-25 1997-11-10 Bracco Spa Processo per la produzione di agenti contrastografici iodurati
IT1303797B1 (it) 1998-11-27 2001-02-23 Bracco Spa Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2394984A1 (en) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives

Also Published As

Publication number Publication date
JP2025514326A (ja) 2025-05-02
US12269790B1 (en) 2025-04-08
KR20250006017A (ko) 2025-01-10
EP4514771A1 (en) 2025-03-05
WO2023209165A1 (en) 2023-11-02
US20250109094A1 (en) 2025-04-03
EP4514771B1 (en) 2026-04-15

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