CN119082301A - 癌症筛查方法及试剂盒、组合物和系统 - Google Patents
癌症筛查方法及试剂盒、组合物和系统 Download PDFInfo
- Publication number
- CN119082301A CN119082301A CN202411183327.7A CN202411183327A CN119082301A CN 119082301 A CN119082301 A CN 119082301A CN 202411183327 A CN202411183327 A CN 202411183327A CN 119082301 A CN119082301 A CN 119082301A
- Authority
- CN
- China
- Prior art keywords
- methylation
- sample
- dna
- nucleic acid
- dmr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962828948P | 2019-04-03 | 2019-04-03 | |
| US62/828,948 | 2019-04-03 | ||
| CN202080028382.2A CN113811622B (zh) | 2019-04-03 | 2020-04-03 | 在血浆中检测胰腺导管腺癌 |
| PCT/US2020/026581 WO2020206256A1 (en) | 2019-04-03 | 2020-04-03 | Detecting pancreatic ductal adenocarcinoma in plasma |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080028382.2A Division CN113811622B (zh) | 2019-04-03 | 2020-04-03 | 在血浆中检测胰腺导管腺癌 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119082301A true CN119082301A (zh) | 2024-12-06 |
Family
ID=72667410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411183327.7A Pending CN119082301A (zh) | 2019-04-03 | 2020-04-03 | 癌症筛查方法及试剂盒、组合物和系统 |
| CN202080028382.2A Active CN113811622B (zh) | 2019-04-03 | 2020-04-03 | 在血浆中检测胰腺导管腺癌 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080028382.2A Active CN113811622B (zh) | 2019-04-03 | 2020-04-03 | 在血浆中检测胰腺导管腺癌 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220162709A1 (https=) |
| EP (1) | EP3948292A4 (https=) |
| JP (2) | JP7680365B2 (https=) |
| KR (1) | KR20210146983A (https=) |
| CN (2) | CN119082301A (https=) |
| AU (1) | AU2020254760B2 (https=) |
| CA (1) | CA3132182A1 (https=) |
| WO (1) | WO2020206256A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2816122A1 (en) | 2008-02-15 | 2014-12-24 | Mayo Foundation For Medical Education And Research | Detecting neoplasm from a stool sample |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| ES2859645T3 (es) | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
| EP4234722A3 (en) | 2014-03-31 | 2023-09-20 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| CN108138235B (zh) | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| AU2016343937B2 (en) | 2015-10-30 | 2023-01-19 | Exact Sciences Corporation | Multiplex amplification detection assay and isolation and detection of DNA from plasma |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| US12584177B2 (en) | 2019-01-24 | 2026-03-24 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| CN112176419B (zh) * | 2019-10-16 | 2022-03-22 | 中国医学科学院肿瘤医院 | 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法 |
| CA3154354A1 (en) | 2019-10-31 | 2021-05-06 | William R. Taylor | Detecting ovarian cancer |
| US20220071605A1 (en) | 2020-04-17 | 2022-03-10 | Exact Sciences Development Company, Llc | Sampling device and analysis of methylated dna |
| AU2022213409A1 (en) * | 2021-01-29 | 2023-08-17 | Exact Sciences Corporation | Detecting the presence or absence of multiple types of cancer |
| WO2026055641A1 (en) | 2024-09-06 | 2026-03-12 | Exact Sciences Corporation | Methods and compositions for preparing biomolecule analytes from complex samples |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE437962T1 (de) * | 2002-10-01 | 2009-08-15 | Epigenomics Ag | Verfahren für die behandlung von proliferativen erkrankungen von brustzellen |
| AU2004237861B2 (en) * | 2003-12-11 | 2010-04-29 | Epigenomics Ag | Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients |
| US8158356B2 (en) * | 2006-10-16 | 2012-04-17 | Agrigenomics, Inc. | Screening for the genetic defect causing tibial hemimelia in bovines |
| DK2082745T3 (da) * | 2007-12-28 | 2013-03-25 | Deutsches Krebsforsch | Kræftterapi med en parvovirus kombineret med kemoterapi |
| WO2010083179A2 (en) * | 2009-01-16 | 2010-07-22 | Monsanto Technology Llc | Isolated novel nucleic acid and protein molecules from soybeans and methods of using those molecules to generate transgenic plants with enhanced agronomic traits |
| WO2013033213A1 (en) * | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| EP2900837A4 (en) * | 2012-09-26 | 2016-06-01 | Agency Science Tech & Res | BIOMARKERS FOR THE PRENATAL DIAGNOSIS OF THE DOWN SYNDROME |
| US20140274757A1 (en) * | 2013-03-14 | 2014-09-18 | Marie K. Kirby | Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer |
| ES2859645T3 (es) * | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
| CN106232833A (zh) * | 2014-01-30 | 2016-12-14 | 加利福尼亚大学董事会 | 用于非侵入性诊断的甲基化单体型分析(monod) |
| US10184154B2 (en) * | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10030272B2 (en) * | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| CN108138235B (zh) * | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CA3020628A1 (en) * | 2016-04-14 | 2017-10-19 | Mayo Foundation For Medical Education And Research | Detecting pancreatic high-grade dysplasia |
| CN116064796A (zh) * | 2016-05-05 | 2023-05-05 | 精密科学公司 | 通过分析甲基化dna来检测肺肿瘤 |
| CN109790198B (zh) * | 2016-09-02 | 2022-09-09 | 梅约医学教育与研究基金会 | 检测肝细胞癌 |
| KR102892245B1 (ko) * | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| US12584177B2 (en) * | 2019-01-24 | 2026-03-24 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
-
2020
- 2020-04-03 EP EP20782990.4A patent/EP3948292A4/en active Pending
- 2020-04-03 JP JP2021559250A patent/JP7680365B2/ja active Active
- 2020-04-03 CN CN202411183327.7A patent/CN119082301A/zh active Pending
- 2020-04-03 KR KR1020217035037A patent/KR20210146983A/ko not_active Ceased
- 2020-04-03 CA CA3132182A patent/CA3132182A1/en active Pending
- 2020-04-03 CN CN202080028382.2A patent/CN113811622B/zh active Active
- 2020-04-03 WO PCT/US2020/026581 patent/WO2020206256A1/en not_active Ceased
- 2020-04-03 AU AU2020254760A patent/AU2020254760B2/en active Active
- 2020-04-03 US US17/600,854 patent/US20220162709A1/en active Pending
-
2025
- 2025-01-16 JP JP2025006056A patent/JP2025063204A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025063204A (ja) | 2025-04-15 |
| CA3132182A1 (en) | 2020-10-08 |
| JP7680365B2 (ja) | 2025-05-20 |
| CN113811622B (zh) | 2024-09-17 |
| US20220162709A1 (en) | 2022-05-26 |
| EP3948292A4 (en) | 2023-01-18 |
| JP2022526415A (ja) | 2022-05-24 |
| EP3948292A1 (en) | 2022-02-09 |
| CN113811622A (zh) | 2021-12-17 |
| AU2020254760A1 (en) | 2021-10-28 |
| AU2020254760B2 (en) | 2025-10-23 |
| WO2020206256A1 (en) | 2020-10-08 |
| KR20210146983A (ko) | 2021-12-06 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |