AU2020254760B2 - Detecting pancreatic ductal adenocarcinoma in plasma - Google Patents

Detecting pancreatic ductal adenocarcinoma in plasma

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Publication number
AU2020254760B2
AU2020254760B2 AU2020254760A AU2020254760A AU2020254760B2 AU 2020254760 B2 AU2020254760 B2 AU 2020254760B2 AU 2020254760 A AU2020254760 A AU 2020254760A AU 2020254760 A AU2020254760 A AU 2020254760A AU 2020254760 B2 AU2020254760 B2 AU 2020254760B2
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AU
Australia
Prior art keywords
methylation
primers
sample
dna
nucleic acid
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AU2020254760A
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English (en)
Other versions
AU2020254760A1 (en
Inventor
David A. Ahlquist
Hatim T. Allawi
John B. Kisiel
Douglas W. Mahoney
William R. Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Mayo Clinic in Florida
Original Assignee
Mayo Foundation for Medical Education and Research
Exact Sciences Corp
Mayo Clinic in Florida
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Publication of AU2020254760A1 publication Critical patent/AU2020254760A1/en
Assigned to MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES CORPORATION reassignment MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Request for Assignment Assignors: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
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Publication of AU2020254760B2 publication Critical patent/AU2020254760B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Gastroenterology & Hepatology (AREA)
AU2020254760A 2019-04-03 2020-04-03 Detecting pancreatic ductal adenocarcinoma in plasma Active AU2020254760B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828948P 2019-04-03 2019-04-03
US62/828,948 2019-04-03
PCT/US2020/026581 WO2020206256A1 (en) 2019-04-03 2020-04-03 Detecting pancreatic ductal adenocarcinoma in plasma

Publications (2)

Publication Number Publication Date
AU2020254760A1 AU2020254760A1 (en) 2021-10-28
AU2020254760B2 true AU2020254760B2 (en) 2025-10-23

Family

ID=72667410

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020254760A Active AU2020254760B2 (en) 2019-04-03 2020-04-03 Detecting pancreatic ductal adenocarcinoma in plasma

Country Status (8)

Country Link
US (1) US20220162709A1 (https=)
EP (1) EP3948292A4 (https=)
JP (2) JP7680365B2 (https=)
KR (1) KR20210146983A (https=)
CN (2) CN119082301A (https=)
AU (1) AU2020254760B2 (https=)
CA (1) CA3132182A1 (https=)
WO (1) WO2020206256A1 (https=)

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EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
US20220071605A1 (en) 2020-04-17 2022-03-10 Exact Sciences Development Company, Llc Sampling device and analysis of methylated dna
AU2022213409A1 (en) * 2021-01-29 2023-08-17 Exact Sciences Corporation Detecting the presence or absence of multiple types of cancer
WO2026055641A1 (en) 2024-09-06 2026-03-12 Exact Sciences Corporation Methods and compositions for preparing biomolecule analytes from complex samples

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US20140274748A1 (en) * 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US20160090634A1 (en) * 2014-09-26 2016-03-31 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2017180886A1 (en) * 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

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AU2004237861B2 (en) * 2003-12-11 2010-04-29 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
US8158356B2 (en) * 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
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CN108138235B (zh) * 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
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KR102892245B1 (ko) * 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
US12584177B2 (en) * 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer

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US20160090634A1 (en) * 2014-09-26 2016-03-31 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2017180886A1 (en) * 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

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Also Published As

Publication number Publication date
JP2025063204A (ja) 2025-04-15
CA3132182A1 (en) 2020-10-08
JP7680365B2 (ja) 2025-05-20
CN113811622B (zh) 2024-09-17
US20220162709A1 (en) 2022-05-26
EP3948292A4 (en) 2023-01-18
CN119082301A (zh) 2024-12-06
JP2022526415A (ja) 2022-05-24
EP3948292A1 (en) 2022-02-09
CN113811622A (zh) 2021-12-17
AU2020254760A1 (en) 2021-10-28
WO2020206256A1 (en) 2020-10-08
KR20210146983A (ko) 2021-12-06

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Legal Events

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Owner name: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Owner name: EXACT SCIENCES CORPORATION

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

FGA Letters patent sealed or granted (standard patent)