CN118955675A - Iapp肽、包含其的药物组合物及其应用 - Google Patents
Iapp肽、包含其的药物组合物及其应用 Download PDFInfo
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- CN118955675A CN118955675A CN202410844356.7A CN202410844356A CN118955675A CN 118955675 A CN118955675 A CN 118955675A CN 202410844356 A CN202410844356 A CN 202410844356A CN 118955675 A CN118955675 A CN 118955675A
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- iapp
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US201962809167P | 2019-02-22 | 2019-02-22 | |
| US62/809,167 | 2019-02-22 | ||
| CN202080015845.1A CN113614101B (zh) | 2019-02-22 | 2020-02-24 | 淀粉样肽的变体 |
| PCT/US2020/019557 WO2020172686A1 (en) | 2019-02-22 | 2020-02-24 | Amyloid peptide variants |
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| CN202080015845.1A Division CN113614101B (zh) | 2019-02-22 | 2020-02-24 | 淀粉样肽的变体 |
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| CN202080015845.1A Active CN113614101B (zh) | 2019-02-22 | 2020-02-24 | 淀粉样肽的变体 |
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| JP (2) | JP7505713B2 (https=) |
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| IL (1) | IL285699A (https=) |
| WO (1) | WO2020172686A1 (https=) |
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| WO2021233942A1 (en) * | 2020-05-19 | 2021-11-25 | Empa Eidgenössische Materialprüfungs- Und Forschungsanstalt | Detection and imaging of amyloid aggregates in blood |
Family Cites Families (18)
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| SE454299B (sv) * | 1986-10-08 | 1988-04-18 | Westermark P | Sats innehallande polypeptid som finns i pankreasoamyloid och/eller antikroppar riktade mot polypeptiden |
| HU222249B1 (hu) * | 1991-03-08 | 2003-05-28 | Amylin Pharmaceuticals Inc. | Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| US5814600A (en) * | 1991-05-24 | 1998-09-29 | Amylin Pharmaceuticals Inc. | Method and composition for treatment of insulin requiring mammals |
| US7060670B1 (en) * | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| ATE514707T1 (de) * | 2002-04-19 | 2011-07-15 | Univ Toronto | Immunologisches verfahren und zusammensetzungen für die behandlung der krankheit von alzheimer |
| JP2007527365A (ja) * | 2003-03-18 | 2007-09-27 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | アミリン凝集阻害剤およびその使用 |
| DE102004051014A1 (de) * | 2004-10-20 | 2006-04-27 | Rwth Aachen | Chemisch modifizierte Peptidanaloga |
| GB0501348D0 (en) * | 2005-01-24 | 2005-03-02 | Zyentia Ltd | Compositions and methods |
| AU2006341375B2 (en) * | 2006-03-31 | 2013-03-21 | Amylin Pharmaceuticals, Llc | Amylin and amylin agonists for treating psychiatric diseases and disorders |
| EP2036923A1 (en) * | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Improved derivates of amylin |
| CA2812951A1 (en) | 2010-09-28 | 2012-04-19 | Amylin Pharmaceuticals, Llc | Engineered polypeptides having enhanced duration of action |
| US20130022620A1 (en) * | 2011-06-09 | 2013-01-24 | Ann Marie Schmidt | Assays and methods pertaining to pre-amyloid intermediates |
| JP6121992B2 (ja) * | 2011-06-10 | 2017-04-26 | ノヴォ ノルディスク アー／エス | ポリペプチド |
| US9475866B2 (en) * | 2012-09-12 | 2016-10-25 | Neurimmune Holding Ag | Human islet amyloid polypeptide (hIAPP) specific antibodies and uses thereof |
| WO2015062803A1 (en) * | 2013-10-29 | 2015-05-07 | Kapurniotu Aphrodite | Modified segments of islet amyloid polypeptide |
| CN108070075A (zh) * | 2016-11-09 | 2018-05-25 | 可口可乐公司 | 生物基meg和聚酯纤维组合物以及制造它们的方法 |
| WO2018144671A1 (en) * | 2017-02-01 | 2018-08-09 | The Research Foundation For The State University Of New York | Mutant islet amyloid polypeptides with improved solubility and methods for using the same |
| WO2019241628A1 (en) * | 2018-06-15 | 2019-12-19 | Proclara Biosciences, Inc. | General amyloid interaction motif (gaim) |
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| JP2024125307A (ja) | 2024-09-18 |
| JP2022521266A (ja) | 2022-04-06 |
| US20220119468A1 (en) | 2022-04-21 |
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| US12522635B2 (en) | 2026-01-13 |
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| US20260109744A1 (en) | 2026-04-23 |
| WO2020172686A9 (en) | 2020-11-12 |
| CN113614101B (zh) | 2024-07-16 |
| JP7825238B2 (ja) | 2026-03-06 |
| IL285699A (en) | 2021-10-31 |
| JP7505713B2 (ja) | 2024-06-25 |
| CN113614101A (zh) | 2021-11-05 |
| EP3927725A4 (en) | 2023-06-14 |
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