CN118922540A - 前激肽释放酶调节组合物及其使用方法 - Google Patents

前激肽释放酶调节组合物及其使用方法 Download PDF

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Publication number
CN118922540A
CN118922540A CN202280073696.3A CN202280073696A CN118922540A CN 118922540 A CN118922540 A CN 118922540A CN 202280073696 A CN202280073696 A CN 202280073696A CN 118922540 A CN118922540 A CN 118922540A
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compound
certain embodiments
modified oligonucleotide
modified
oligonucleotide
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CN202280073696.3A
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Chinese (zh)
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CN118922540A9 (zh
Inventor
李
朱瑞
周智清
金伯利·富尔茨
肖恩·斯蒂德
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Adalx Pharmaceutical Co ltd
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Adalx Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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    • C12N2310/3519—Fusion with another nucleic acid
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    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21034—Plasma kallikrein (3.4.21.34)

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  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202280073696.3A 2021-10-01 2022-09-30 前激肽释放酶调节组合物及其使用方法 Pending CN118922540A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202163251571P 2021-10-01 2021-10-01
US63/251,571 2021-10-01
US202163252554P 2021-10-05 2021-10-05
US63/252,554 2021-10-05
US202163270504P 2021-10-21 2021-10-21
US63/270,504 2021-10-21
US202163283175P 2021-11-24 2021-11-24
US63/283,175 2021-11-24
US202163287969P 2021-12-09 2021-12-09
US63/287,969 2021-12-09
PCT/US2022/077381 WO2023056440A1 (en) 2021-10-01 2022-09-30 Prekallikrein-modulating compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
CN118922540A true CN118922540A (zh) 2024-11-08
CN118922540A9 CN118922540A9 (zh) 2026-01-09

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US (3) US20250115915A1 (https=)
EP (1) EP4409003A4 (https=)
JP (1) JP2024536147A (https=)
KR (1) KR20240082351A (https=)
CN (1) CN118922540A (https=)
AU (1) AU2022357561A1 (https=)
CA (1) CA3233755A1 (https=)
CL (1) CL2024000931A1 (https=)
CO (1) CO2024004259A2 (https=)
IL (1) IL311518A (https=)
MX (1) MX2024004011A (https=)
PE (1) PE20241209A1 (https=)
TW (1) TW202322825A (https=)
WO (1) WO2023056440A1 (https=)

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