CN118878638A - 多黏菌素化合物及其药物组合物和用途 - Google Patents

多黏菌素化合物及其药物组合物和用途 Download PDF

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Publication number
CN118878638A
CN118878638A CN202410703525.5A CN202410703525A CN118878638A CN 118878638 A CN118878638 A CN 118878638A CN 202410703525 A CN202410703525 A CN 202410703525A CN 118878638 A CN118878638 A CN 118878638A
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CN
China
Prior art keywords
compound
formula
compounds
group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202410703525.5A
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English (en)
Chinese (zh)
Inventor
帕梅拉·布朗
迈克尔·道森
莫娜·西莫诺维克
史蒂文·博克斯
伊斯特·杜珀尔奇
迪恩·里弗斯
罗伊·莱斯特
斯科特·科尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yunding Xinyao Pharmaceutical Technology Co ltd
Original Assignee
Yunding Xinyao Pharmaceutical Technology Co ltd
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Application filed by Yunding Xinyao Pharmaceutical Technology Co ltd filed Critical Yunding Xinyao Pharmaceutical Technology Co ltd
Publication of CN118878638A publication Critical patent/CN118878638A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202410703525.5A 2018-06-25 2019-06-25 多黏菌素化合物及其药物组合物和用途 Pending CN118878638A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862689602P 2018-06-25 2018-06-25
US62/689,602 2018-06-25
PCT/EP2019/066819 WO2020002325A1 (en) 2018-06-25 2019-06-25 Compounds
CN201980041706.3A CN112789287B (zh) 2018-06-25 2019-06-25 化合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980041706.3A Division CN112789287B (zh) 2018-06-25 2019-06-25 化合物

Publications (1)

Publication Number Publication Date
CN118878638A true CN118878638A (zh) 2024-11-01

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN202410703525.5A Pending CN118878638A (zh) 2018-06-25 2019-06-25 多黏菌素化合物及其药物组合物和用途
CN201980041706.3A Active CN112789287B (zh) 2018-06-25 2019-06-25 化合物

Family Applications After (1)

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CN201980041706.3A Active CN112789287B (zh) 2018-06-25 2019-06-25 化合物

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EP (2) EP3810633B1 (enExample)
JP (2) JP7488774B2 (enExample)
KR (1) KR20210054500A (enExample)
CN (2) CN118878638A (enExample)
AR (1) AR116663A1 (enExample)
AU (2) AU2019294261B2 (enExample)
BR (1) BR112020026663A2 (enExample)
CA (1) CA3103158A1 (enExample)
CO (1) CO2020016080A2 (enExample)
DK (1) DK3810633T3 (enExample)
EA (1) EA202092819A1 (enExample)
ES (1) ES2971732T3 (enExample)
FI (1) FI3810633T3 (enExample)
HR (1) HRP20240028T1 (enExample)
HU (1) HUE065134T2 (enExample)
IL (2) IL279620B2 (enExample)
LT (1) LT3810633T (enExample)
MA (1) MA52946B1 (enExample)
MD (1) MD3810633T2 (enExample)
MX (1) MX2020013811A (enExample)
PH (1) PH12020552240A1 (enExample)
PL (1) PL3810633T3 (enExample)
PT (1) PT3810633T (enExample)
RS (1) RS65128B1 (enExample)
SG (1) SG11202012747VA (enExample)
SI (1) SI3810633T1 (enExample)
TW (2) TWI851584B (enExample)
UA (1) UA128162C2 (enExample)
WO (1) WO2020002325A1 (enExample)
ZA (1) ZA202301937B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120699105A (zh) * 2025-08-19 2025-09-26 中国药科大学 一种氘代抗菌肽及其组合物和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
DK3810633T3 (da) * 2018-06-25 2024-01-15 Spero Therapeutics Inc Forbindelser
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
CN120574287B (zh) * 2025-06-10 2026-07-03 中国药科大学 一种抗菌肽、组合物及应用
CN121159640A (zh) * 2025-07-24 2025-12-19 中国药科大学 一种抗菌肽、药物组合物及应用

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BRPI0715095B8 (pt) 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
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CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
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HUE059544T2 (hu) 2013-05-22 2022-11-28 Spero Therapeutics Inc Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal
KR20160135739A (ko) * 2014-03-11 2016-11-28 뉴 파마 라이센스 홀딩스 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
US10047126B2 (en) 2014-04-01 2018-08-14 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
BR112017010888A2 (pt) * 2014-12-17 2018-02-27 Hoffmann La Roche método para produzir um produto de conjugação enzimática de três polipeptídeos
WO2016166103A1 (en) * 2015-04-13 2016-10-20 Xellia Pharmaceuticals Aps Polymyxin derivatives
JP7367950B2 (ja) * 2015-09-29 2023-10-24 モナッシュ ユニバーシティ 抗菌性ポリミキシン誘導体化合物
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DK3810633T3 (da) * 2018-06-25 2024-01-15 Spero Therapeutics Inc Forbindelser
WO2020014501A1 (en) 2018-07-11 2020-01-16 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120699105A (zh) * 2025-08-19 2025-09-26 中国药科大学 一种氘代抗菌肽及其组合物和应用
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Also Published As

Publication number Publication date
MA52946A (fr) 2021-04-28
IL279620B1 (en) 2025-11-01
RS65128B1 (sr) 2024-02-29
WO2020002325A1 (en) 2020-01-02
US20230012121A1 (en) 2023-01-12
EA202092819A1 (ru) 2021-05-21
MX2020013811A (es) 2021-03-09
NZ771833A (en) 2024-09-27
JP2021528449A (ja) 2021-10-21
MD3810633T2 (ro) 2024-05-31
CA3103158A1 (en) 2020-01-02
HRP20240028T1 (hr) 2024-03-29
IL279620B2 (en) 2026-03-01
TWI851584B (zh) 2024-08-11
LT3810633T (lt) 2024-01-10
EP4316504A2 (en) 2024-02-07
IL323560A (en) 2025-11-01
US20260103491A1 (en) 2026-04-16
BR112020026663A2 (pt) 2021-03-23
CN112789287B (zh) 2024-06-21
US20210246169A1 (en) 2021-08-12
ZA202301937B (en) 2023-09-27
TW202446783A (zh) 2024-12-01
HUE065134T2 (hu) 2024-05-28
MA52946B1 (fr) 2024-03-29
FI3810633T3 (fi) 2024-02-09
AU2019294261A1 (en) 2021-02-04
SI3810633T1 (sl) 2024-04-30
CO2020016080A2 (es) 2021-01-18
PH12020552240A1 (en) 2021-08-16
EP3810633B1 (en) 2023-12-13
AU2024203362A1 (en) 2024-06-06
AR116663A1 (es) 2021-06-02
JP2024109664A (ja) 2024-08-14
DK3810633T3 (da) 2024-01-15
US11459357B2 (en) 2022-10-04
EP3810633A1 (en) 2021-04-28
ES2971732T3 (es) 2024-06-06
US12528837B2 (en) 2026-01-20
TW202019949A (zh) 2020-06-01
AU2019294261B2 (en) 2024-02-29
PT3810633T (pt) 2024-02-19
EP4316504A3 (en) 2024-04-17
SG11202012747VA (en) 2021-01-28
PL3810633T3 (pl) 2024-04-08
IL279620A (en) 2021-03-01
JP7488774B2 (ja) 2024-05-22
CN112789287A (zh) 2021-05-11
UA128162C2 (uk) 2024-04-24
KR20210054500A (ko) 2021-05-13

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