CN118829681A - 来自被屠宰动物的废弃组织的肝素以及天然蛋白质和肽的混合物 - Google Patents

来自被屠宰动物的废弃组织的肝素以及天然蛋白质和肽的混合物 Download PDF

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Publication number
CN118829681A
CN118829681A CN202380026054.2A CN202380026054A CN118829681A CN 118829681 A CN118829681 A CN 118829681A CN 202380026054 A CN202380026054 A CN 202380026054A CN 118829681 A CN118829681 A CN 118829681A
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China
Prior art keywords
peptides
proteins
fraction
supernatant
heparin
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Pending
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CN202380026054.2A
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English (en)
Chinese (zh)
Inventor
若泽·埃斯凯什·费勒
帕夫洛·拉米雷斯·鲁维奥
斯特法诺·卡利诺
卡洛斯·切特里特·鲁松
保罗·萨尔瓦特利亚·苏雷达
皮拉尔·达尔毛·普伊赫
朱迪思·普伊赫塞古拉·萨拉维亚
马克·蒙泰罗·帕迪略
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Holison Ip Co ltd
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Holison Ip Co ltd
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Publication date
Application filed by Holison Ip Co ltd filed Critical Holison Ip Co ltd
Publication of CN118829681A publication Critical patent/CN118829681A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L99/00—Compositions of natural macromolecular compounds or of derivatives thereof not provided for in groups C08L89/00 - C08L97/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Water Supply & Treatment (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
CN202380026054.2A 2022-03-08 2023-03-07 来自被屠宰动物的废弃组织的肝素以及天然蛋白质和肽的混合物 Pending CN118829681A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22382214 2022-03-08
EP22382214.9 2022-03-08
PCT/EP2023/055750 WO2023170064A1 (en) 2022-03-08 2023-03-07 Heparin and mixtures of native proteins and peptides from waste tissue of slaughtered animals

Publications (1)

Publication Number Publication Date
CN118829681A true CN118829681A (zh) 2024-10-22

Family

ID=80978811

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380026054.2A Pending CN118829681A (zh) 2022-03-08 2023-03-07 来自被屠宰动物的废弃组织的肝素以及天然蛋白质和肽的混合物

Country Status (10)

Country Link
US (1) US20250101140A1 (https=)
EP (1) EP4490233B1 (https=)
JP (1) JP2025509347A (https=)
CN (1) CN118829681A (https=)
CA (1) CA3249882A1 (https=)
CL (1) CL2024002692A1 (https=)
ES (1) ES3041746T3 (https=)
MX (1) MX2024010892A (https=)
PE (1) PE20241999A1 (https=)
WO (1) WO2023170064A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12565541B1 (en) 2025-09-03 2026-03-03 Camelx Biomedical & Research Method for extracting unfractionated heparin from camel intestinal mucosa

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
WO2003102132A2 (en) * 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
CN101182495B (zh) * 2007-11-21 2010-09-22 郑州市通源生物技术有限公司 以猪小肠为原料联产生产碱性磷酸酶和肝素钠的联产工艺
JP6046168B2 (ja) 2012-02-16 2016-12-14 イーライ リリー アンド カンパニー 動物排泄物の環境影響を減少させるための方法および組成物
CN102839162B (zh) 2012-09-26 2016-06-15 西藏天虹科技股份有限责任公司 一种碱性磷酸酶的制取方法
RU2610669C1 (ru) 2015-10-16 2017-02-14 Общество с ограниченной ответственностью "Научно-исследовательский институт средств противоожоговой терапии" Способ получения протеолитического препарата для медицинского применения
CN106035980B (zh) 2016-06-14 2019-06-07 江南大学 一种利用酶解法肝素吸附残液生产肠膜蛋白粉的方法
CN107345207A (zh) * 2017-06-29 2017-11-14 王德亮 用动物肠粘膜生产肠道微生物粉并联产小分子肽、肝素钠、碱性磷酸酶的方法及应用
CN107236059A (zh) 2017-08-10 2017-10-10 如皋市永兴肠衣有限公司 小肠粘膜副产物同步分离提取技术
US20200157161A1 (en) * 2018-11-19 2020-05-21 Gnubiotics Sciences Sa Compositions from gastrointestinal tract mucins and uses thereof
EP3924391A4 (en) * 2019-02-11 2022-10-05 Heptech Pesquisa E Desenvolvimento Ltda SAFE BOVINES HEPARIN, PROCESS OF MANUFACTURE AND USE
CN113999330B (zh) * 2021-12-07 2022-08-19 潢川县鹏升畜产品有限公司 一种低盐浓度肝素钠与活性肠蛋白肽分离联产工艺

Also Published As

Publication number Publication date
EP4490233B1 (en) 2025-05-21
PE20241999A1 (es) 2024-09-27
EP4490233C0 (en) 2025-05-21
CL2024002692A1 (es) 2025-02-07
WO2023170064A1 (en) 2023-09-14
MX2024010892A (es) 2024-09-17
CA3249882A1 (en) 2023-09-14
US20250101140A1 (en) 2025-03-27
EP4490233A1 (en) 2025-01-15
JP2025509347A (ja) 2025-04-11
ES3041746T3 (en) 2025-11-14

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