CN118829647A - 白介素-23受体的肽抑制剂及其药物组合物 - Google Patents

白介素-23受体的肽抑制剂及其药物组合物 Download PDF

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Publication number
CN118829647A
CN118829647A CN202380019940.2A CN202380019940A CN118829647A CN 118829647 A CN118829647 A CN 118829647A CN 202380019940 A CN202380019940 A CN 202380019940A CN 118829647 A CN118829647 A CN 118829647A
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CN
China
Prior art keywords
composition
amount
compound
formula
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380019940.2A
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English (en)
Chinese (zh)
Inventor
G·布洛克斯
D·T·布雷斯林
C·A·坎托
C·P·德多贝拉尔
G·德尼奥
G·迪普雷托罗
P·费尔南德斯
R·科拉科维奇
N·默滕斯
B·L·裴德森
G·拉詹
D·孙
S·帕特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN118829647A publication Critical patent/CN118829647A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202380019940.2A 2022-02-01 2023-01-31 白介素-23受体的肽抑制剂及其药物组合物 Pending CN118829647A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263305631P 2022-02-01 2022-02-01
US63/305631 2022-02-01
PCT/US2023/061651 WO2023150500A1 (en) 2022-02-01 2023-01-31 Peptide inhibitors of interleukin-23 receptor and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
CN118829647A true CN118829647A (zh) 2024-10-22

Family

ID=85556753

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380019940.2A Pending CN118829647A (zh) 2022-02-01 2023-01-31 白介素-23受体的肽抑制剂及其药物组合物

Country Status (13)

Country Link
EP (1) EP4472999A1 (https=)
JP (1) JP2025506374A (https=)
KR (1) KR20240137102A (https=)
CN (1) CN118829647A (https=)
AU (1) AU2023215245A1 (https=)
CA (1) CA3250172A1 (https=)
CL (1) CL2024002263A1 (https=)
IL (1) IL314629A (https=)
MX (1) MX2024009477A (https=)
PE (1) PE20241895A1 (https=)
TW (1) TW202342496A (https=)
UY (1) UY40135A (https=)
WO (1) WO2023150500A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL322423A (en) 2023-01-31 2025-09-01 Janssen Pharmaceutica Nv Methods for preparing crystalline peptide inhibitors of the interleukin-23 receptor
WO2025062347A1 (en) * 2023-09-21 2025-03-27 Janssen Pharmaceutica Nv Interleukin-23 receptor antagonist for use in the treatment of ulcerative colitis
WO2025151385A1 (en) * 2024-01-08 2025-07-17 Janssen Pharmaceutica Nv Peptide inhibitors of interleukin-23 receptor and uses thereof
WO2025163534A1 (en) * 2024-01-31 2025-08-07 Janssen Pharmaceutica Nv Crystal form of a peptide inhibitor of interleukin-23 receptor
WO2025243217A1 (en) * 2024-05-22 2025-11-27 Janssen Pharmaceutica Nv Crystal forms of peptide molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946150B2 (en) 2011-06-14 2015-02-03 Medical Diagnostic Laboratories, LLC. Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
CA3167751A1 (en) 2020-01-15 2021-07-22 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases

Also Published As

Publication number Publication date
TW202342496A (zh) 2023-11-01
UY40135A (es) 2023-08-31
IL314629A (en) 2024-09-01
CA3250172A1 (en) 2023-08-10
EP4472999A1 (en) 2024-12-11
KR20240137102A (ko) 2024-09-19
CL2024002263A1 (es) 2025-02-07
MX2024009477A (es) 2024-11-08
PE20241895A1 (es) 2024-09-19
WO2023150500A1 (en) 2023-08-10
JP2025506374A (ja) 2025-03-11
AU2023215245A1 (en) 2024-09-19

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