CN118632854A - 亚磷酰胺单体 - Google Patents

亚磷酰胺单体 Download PDF

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Publication number
CN118632854A
CN118632854A CN202280089516.0A CN202280089516A CN118632854A CN 118632854 A CN118632854 A CN 118632854A CN 202280089516 A CN202280089516 A CN 202280089516A CN 118632854 A CN118632854 A CN 118632854A
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CN
China
Prior art keywords
group
compound
hydrogen atom
general formula
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280089516.0A
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English (en)
Chinese (zh)
Inventor
浅沼浩之
加藤神谷由纪子
佐藤史经
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National University Corp Donghai National University
Original Assignee
National University Corp Donghai National University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corp Donghai National University filed Critical National University Corp Donghai National University
Publication of CN118632854A publication Critical patent/CN118632854A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Saccharide Compounds (AREA)
CN202280089516.0A 2022-01-21 2022-12-22 亚磷酰胺单体 Pending CN118632854A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022007792 2022-01-21
JP2022-007792 2022-01-21
PCT/JP2022/047371 WO2023140040A1 (ja) 2022-01-21 2022-12-22 アミダイトモノマー

Publications (1)

Publication Number Publication Date
CN118632854A true CN118632854A (zh) 2024-09-10

Family

ID=87348212

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280089516.0A Pending CN118632854A (zh) 2022-01-21 2022-12-22 亚磷酰胺单体

Country Status (5)

Country Link
US (1) US20250340585A1 (https=)
EP (1) EP4467644A4 (https=)
JP (1) JPWO2023140040A1 (https=)
CN (1) CN118632854A (https=)
WO (1) WO2023140040A1 (https=)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07252293A (ja) * 1994-03-12 1995-10-03 Hamamatsu Photonics Kk デオキシリボヌクレオシド誘導体およびその製造方法
AU2003269239A1 (en) * 2002-10-15 2004-05-04 Avecia Biotechnology Inc. Phosphitylation process
JP6704196B2 (ja) * 2015-01-09 2020-06-03 国立大学法人東海国立大学機構 オリゴヌクレオチド
CN110678447B (zh) * 2017-06-16 2023-12-12 卫材R&D管理有限公司 经修饰的核酸单体化合物及寡核酸类似物
EP4098746A4 (en) * 2020-01-31 2024-01-24 National University Corporation Tokai National Higher Education and Research System SINGLE-STRANDED POLYNUCLEOTIDE

Also Published As

Publication number Publication date
JPWO2023140040A1 (https=) 2023-07-27
WO2023140040A1 (ja) 2023-07-27
US20250340585A1 (en) 2025-11-06
EP4467644A4 (en) 2025-03-26
EP4467644A1 (en) 2024-11-27

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