CN118613239A - 用于制备凝血块的凝血模具、试剂盒和方法 - Google Patents
用于制备凝血块的凝血模具、试剂盒和方法 Download PDFInfo
- Publication number
- CN118613239A CN118613239A CN202380018300.XA CN202380018300A CN118613239A CN 118613239 A CN118613239 A CN 118613239A CN 202380018300 A CN202380018300 A CN 202380018300A CN 118613239 A CN118613239 A CN 118613239A
- Authority
- CN
- China
- Prior art keywords
- powder
- whole blood
- particle size
- coagulation
- calcium gluconate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005345 coagulation Methods 0.000 title claims abstract description 60
- 230000015271 coagulation Effects 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 48
- 208000007536 Thrombosis Diseases 0.000 title abstract description 19
- 239000008280 blood Substances 0.000 claims abstract description 133
- 210000004369 blood Anatomy 0.000 claims abstract description 133
- 239000002245 particle Substances 0.000 claims abstract description 82
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 17
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims description 138
- 229960004494 calcium gluconate Drugs 0.000 claims description 83
- 239000004227 calcium gluconate Substances 0.000 claims description 83
- 235000013927 calcium gluconate Nutrition 0.000 claims description 83
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 83
- 239000005995 Aluminium silicate Substances 0.000 claims description 79
- 235000012211 aluminium silicate Nutrition 0.000 claims description 79
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 79
- 238000009826 distribution Methods 0.000 claims description 58
- 206010053567 Coagulopathies Diseases 0.000 claims description 6
- 230000035602 clotting Effects 0.000 claims description 6
- 230000000630 rising effect Effects 0.000 claims description 2
- 239000003999 initiator Substances 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 3
- 206010040882 skin lesion Diseases 0.000 abstract description 3
- 231100000444 skin lesion Toxicity 0.000 abstract description 3
- 206010061245 Internal injury Diseases 0.000 abstract description 2
- 208000004680 Rectal Fistula Diseases 0.000 abstract description 2
- 206010002156 anal fistula Diseases 0.000 abstract description 2
- 239000000701 coagulant Substances 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000000725 suspension Substances 0.000 abstract description 2
- 210000002435 tendon Anatomy 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 108010074864 Factor XI Proteins 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006624 extrinsic pathway Effects 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Manufacturing & Machinery (AREA)
- Botany (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL290122 | 2022-01-25 | ||
| IL290122A IL290122B2 (en) | 2022-01-25 | 2022-01-25 | Clotting template, kit and method for making a blood clot |
| PCT/IL2023/050083 WO2023144818A1 (en) | 2022-01-25 | 2023-01-25 | A coagulation mold, a kit and a method for preparing a coagulated blood mass |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118613239A true CN118613239A (zh) | 2024-09-06 |
Family
ID=85238983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380018300.XA Pending CN118613239A (zh) | 2022-01-25 | 2023-01-25 | 用于制备凝血块的凝血模具、试剂盒和方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US12397018B2 (https=) |
| EP (1) | EP4447889A1 (https=) |
| JP (1) | JP2025504710A (https=) |
| KR (1) | KR20240144143A (https=) |
| CN (1) | CN118613239A (https=) |
| AU (1) | AU2023214201A1 (https=) |
| CA (1) | CA3242778A1 (https=) |
| IL (1) | IL290122B2 (https=) |
| MX (1) | MX2024009036A (https=) |
| WO (1) | WO2023144818A1 (https=) |
| ZA (1) | ZA202406452B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025243305A1 (en) | 2024-05-23 | 2025-11-27 | Reddress Ltd. | Controlled drug delivery |
| EP4686486A1 (en) * | 2024-07-30 | 2026-02-04 | Paul Hartmann AG | Gel composition comprising whole blood |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2381969T3 (en) * | 2009-01-27 | 2016-09-05 | Reddress Ltd | METHODS OF MAKING wound dressings AND A BANK wound dressings |
| IL254636A0 (en) | 2017-09-24 | 2017-11-30 | Reddress Ltd | System and method for preparing a wound dressing |
| IL257229B (en) | 2018-01-30 | 2022-07-01 | Reddress Ltd | Blood applicator for tissue treatment |
-
2022
- 2022-01-25 IL IL290122A patent/IL290122B2/en unknown
-
2023
- 2023-01-25 EP EP23705316.0A patent/EP4447889A1/en active Pending
- 2023-01-25 MX MX2024009036A patent/MX2024009036A/es unknown
- 2023-01-25 WO PCT/IL2023/050083 patent/WO2023144818A1/en not_active Ceased
- 2023-01-25 AU AU2023214201A patent/AU2023214201A1/en active Pending
- 2023-01-25 CN CN202380018300.XA patent/CN118613239A/zh active Pending
- 2023-01-25 CA CA3242778A patent/CA3242778A1/en active Pending
- 2023-01-25 JP JP2024539932A patent/JP2025504710A/ja active Pending
- 2023-01-25 KR KR1020247024731A patent/KR20240144143A/ko active Pending
-
2024
- 2024-07-24 US US18/783,156 patent/US12397018B2/en active Active
- 2024-08-22 ZA ZA2024/06452A patent/ZA202406452B/en unknown
- 2024-12-16 US US18/983,077 patent/US20250114399A1/en active Pending
-
2025
- 2025-01-21 US US19/032,762 patent/US12599629B2/en active Active
- 2025-02-20 US US19/058,528 patent/US12364713B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4447889A1 (en) | 2024-10-23 |
| US12397018B2 (en) | 2025-08-26 |
| IL290122B2 (en) | 2023-08-01 |
| WO2023144818A1 (en) | 2023-08-03 |
| US20250161353A1 (en) | 2025-05-22 |
| AU2023214201A2 (en) | 2024-08-15 |
| MX2024009036A (es) | 2024-08-06 |
| US20250114399A1 (en) | 2025-04-10 |
| KR20240144143A (ko) | 2024-10-02 |
| IL290122B1 (en) | 2023-04-01 |
| US20240374636A1 (en) | 2024-11-14 |
| US20250186488A1 (en) | 2025-06-12 |
| IL290122A (https=) | 2022-03-01 |
| AU2023214201A1 (en) | 2024-08-08 |
| ZA202406452B (en) | 2025-04-30 |
| JP2025504710A (ja) | 2025-02-17 |
| US12364713B2 (en) | 2025-07-22 |
| US12599629B2 (en) | 2026-04-14 |
| CA3242778A1 (en) | 2023-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |