CN118576699A - Hbv疫苗 - Google Patents

Hbv疫苗 Download PDF

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Publication number
CN118576699A
CN118576699A CN202410387306.0A CN202410387306A CN118576699A CN 118576699 A CN118576699 A CN 118576699A CN 202410387306 A CN202410387306 A CN 202410387306A CN 118576699 A CN118576699 A CN 118576699A
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Prior art keywords
hbv
seq
sequence
immunogen
viral vector
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Pending
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CN202410387306.0A
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English (en)
Chinese (zh)
Inventor
E·巴恩斯
S·钦纳坎南
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Oxford University Innovation Ltd
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Oxford University Innovation Ltd
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
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    • C12N9/10—Transferases (2.)
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    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y301/26004—Ribonuclease H (3.1.26.4)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202410387306.0A 2017-04-10 2018-04-10 Hbv疫苗 Pending CN118576699A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1705765.4 2017-04-10
GBGB1705765.4A GB201705765D0 (en) 2017-04-10 2017-04-10 HBV vaccine
CN201880028408.6A CN110913899B (zh) 2017-04-10 2018-04-10 Hbv疫苗
PCT/GB2018/050948 WO2018189522A1 (en) 2017-04-10 2018-04-10 Hbv vaccine

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880028408.6A Division CN110913899B (zh) 2017-04-10 2018-04-10 Hbv疫苗

Publications (1)

Publication Number Publication Date
CN118576699A true CN118576699A (zh) 2024-09-03

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ID=58744773

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Application Number Title Priority Date Filing Date
CN202410387306.0A Pending CN118576699A (zh) 2017-04-10 2018-04-10 Hbv疫苗
CN201880028408.6A Active CN110913899B (zh) 2017-04-10 2018-04-10 Hbv疫苗

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CN201880028408.6A Active CN110913899B (zh) 2017-04-10 2018-04-10 Hbv疫苗

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US (2) US20200113998A1 (https=)
EP (1) EP3609535B1 (https=)
JP (1) JP7326157B2 (https=)
KR (1) KR102700586B1 (https=)
CN (2) CN118576699A (https=)
AU (1) AU2018251241B2 (https=)
CA (1) CA3059290A1 (https=)
DK (1) DK3609535T3 (https=)
ES (1) ES3036962T3 (https=)
GB (1) GB201705765D0 (https=)
MX (1) MX2019012101A (https=)
MY (1) MY202396A (https=)
PH (1) PH12019502310A1 (https=)
SG (1) SG11201909353VA (https=)
WO (1) WO2018189522A1 (https=)

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US11389531B2 (en) 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
TW202102256A (zh) * 2019-03-05 2021-01-16 比利時商葛蘭素史密斯克藍生物品公司 B型肝炎免疫法及組合物
CA3143679A1 (en) * 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
US20220313815A1 (en) * 2019-06-20 2022-10-06 Janssen Sciences Ireland Unlimited Company Self-replicating rna molecules for hepatitis b virus (hbv) vaccines and uses thereof
EP4021923A1 (en) 2019-08-29 2022-07-06 VIR Biotechnology, Inc. Hepatitis b virus vaccines
CN119770638A (zh) 2019-09-30 2025-04-08 吉利德科学公司 Hbv疫苗和治疗hbv的方法
WO2021243149A2 (en) * 2020-05-28 2021-12-02 President And Fellows Of Harvard College Protein covariance networks reveal interactions important to the emergence of sars coronaviruses as human pathogens
CN116367854A (zh) * 2020-07-08 2023-06-30 杨森科学爱尔兰无限公司 针对hbv的rna复制子疫苗
TW202229556A (zh) 2020-10-02 2022-08-01 國立大學法人大阪大學 針對SARS-CoV-2之改良型DNA疫苗
TW202245809A (zh) * 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
CN115595312A (zh) * 2021-06-28 2023-01-13 中国农业大学（Cn） 一种重组腺病毒及其应用
WO2023086961A1 (en) * 2021-11-12 2023-05-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sars-cov-2 spike fused to a hepatitis b surface antigen
EP4444347A1 (en) 2021-12-07 2024-10-16 Barinthus Biotherapeutics (UK) Limited Vaccine boost methods and compositions
EP4680277A1 (en) * 2023-03-17 2026-01-21 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Hbv antigen formulation for treating hepatitis b
GB202317925D0 (en) 2023-11-23 2024-01-10 Spybiotech Ltd Vaccines
CN118593695B (zh) * 2024-08-07 2024-10-22 山东兴瑞生物科技有限公司 一种用于治疗HBV感染的siRNA和mRNA联合疫苗

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CN101573449A (zh) * 2006-08-14 2009-11-04 浦项工大产学协力团 用于治疗慢性乙型肝炎的dna疫苗及其制备方法
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CN103173492A (zh) * 2013-03-12 2013-06-26 中国人民解放军白求恩国际和平医院 携带外源基因的复制型hbv载体、其转染后产生的重组hbv，和相应的制备方法与应用
WO2015082922A1 (en) * 2013-12-04 2015-06-11 Isis Innovation Limited Molecular adjuvant

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JP2006526409A (ja) * 2003-06-03 2006-11-24 セル ジェネシス インコーポレイテッド ペプチド開裂部位を用いた単一ベクターからの組換えポリペプチドの高められた発現のための構成と方法
CN101573449A (zh) * 2006-08-14 2009-11-04 浦项工大产学协力团 用于治疗慢性乙型肝炎的dna疫苗及其制备方法
WO2011015656A2 (en) * 2009-08-07 2011-02-10 Transgene Sa Composition for treating hbv infection
WO2012109404A1 (en) * 2011-02-12 2012-08-16 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis b infection
WO2013007772A1 (en) * 2011-07-12 2013-01-17 Transgene Sa Hbv polymerase mutants
CN103173492A (zh) * 2013-03-12 2013-06-26 中国人民解放军白求恩国际和平医院 携带外源基因的复制型hbv载体、其转染后产生的重组hbv，和相应的制备方法与应用
WO2015082922A1 (en) * 2013-12-04 2015-06-11 Isis Innovation Limited Molecular adjuvant

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US20200113998A1 (en) 2020-04-16
SG11201909353VA (en) 2019-11-28
DK3609535T3 (da) 2025-08-18
US12521431B2 (en) 2026-01-13
AU2018251241B2 (en) 2025-04-17
JP2020516264A (ja) 2020-06-11
EP3609535A1 (en) 2020-02-19
KR102700586B1 (ko) 2024-08-30
AU2018251241A1 (en) 2019-10-31
ES3036962T3 (en) 2025-09-25
JP7326157B2 (ja) 2023-08-15
CN110913899A (zh) 2020-03-24
KR20200024130A (ko) 2020-03-06
PH12019502310A1 (en) 2020-09-21
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