CN1185322A - Qi-tonifying and diuresis decoction of Chinese medicine and preparation method thereof - Google Patents
Qi-tonifying and diuresis decoction of Chinese medicine and preparation method thereof Download PDFInfo
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- CN1185322A CN1185322A CN96114264A CN96114264A CN1185322A CN 1185322 A CN1185322 A CN 1185322A CN 96114264 A CN96114264 A CN 96114264A CN 96114264 A CN96114264 A CN 96114264A CN 1185322 A CN1185322 A CN 1185322A
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Abstract
The present invention relates to a Chinese medicine for curing prostatitis-Yiqi Tonglin Tang and its preparation method. Said invention uses 8 Chinese medicinal materials of smooth greenbrier root, eucommia bark, forsythia fruit, dandelion, plantago seed, fish poison yam, astragalus root and moutan rot bark as main raw material, and according to state of illness also can add the Chinese medicinal materials of corydalis tuber, polyporus and lindera root as auxiliary medicinal ingredients. Its preparation method includes the following steps: distilling forsythia fruit and moutan root bark by using water, collecting distillate; decocting medicine residue and other medicinal materials twice, concentrating filtrate, extracting with ethyl alcohol, concentrating extract; combining said concentrated extract and said distillate, adding auxiliary materials, filtering, filling and sterilizing. Its effective rate is 86% and curative rate is 73%.
Description
Chinese medicine qi-tonifying and diuresis decoction of the present invention is to belong to the Chinese herbal medicine class for the treatment of chronic prostatitis.
Chronic prostatitis is Urology Surgery adult male's the disease of seeing more, is especially again the susceptible disease of male adults, accounts for according to statistics and secretes about 25% of outer outpatient service.Because its course of disease is different in size, symptom performance variation, and easily outbreak are repeatedly given in the treatment and have been brought certain difficulty.The method of foreign treatment chronic prostatitis mainly contains 2 kinds at present: (one) antibiotic therapy; (2) physical therapy.But therefore the disease pathogen body is complicated and changeable, and the accuracy that antibiotics is selected and the generation of Resistant strain can't effectively solve.And the per urethra radio-frequency (RF) therapy prostatitis of carrying out recently also has obvious deficiency, the one, easily cause urinary tract repeated infection, and increase the weight of prostatitic symptom, the 2nd, only symptomatic treatment can not be dealt with problems from the cause of disease.The domestic Chinese medicine prostatitis of carrying out recently only limits to the auxiliary treatment to bacterial prostatitis.Given this, a kind of to treat prostatitic method with Chinese medicine for principal agent be the direction that the Urology Surgery doctor makes great efforts always in development.The prostatitic principle of treatment by Chinese herbs is heat-clearing and toxic substances removing, sharp apparent treating stranguria, promoting blood circulation and stopping pain, and regulates the human body endocrine rhythm, strengthens people's immunity.The prostatitic Chinese medicine of treatment has QIANLIEKANG, NANKANG PIAN, LIUWEI DIHUANG WAN plus-minus etc. both at home and abroad at present, it is reported that this type of medicine all has the inflammatory reaction that alleviates prostata tissue, and certain curative effect is arranged.Learned that from patent documentation existing is that raw material is made the prostatitic medicine of various treatments and filed an application to Patent Office of the People's Republic of China with Chinese medicine before the present patent application patent, for example: a kind of Chinese medicine and production method for the treatment of the prostatitis urine retention, [CN1085098A (1994)]; A kind of prescription and manufacturing process [CN1083368A (1994)] for the treatment of prostatitis Chinese medicine; Powder for curing prostatosis [CN1113802A (1995)] etc.
From the disclosed content of above-mentioned document as can be known, their common advantage is that pain relieving, logical urine, preparation are easy.But obvious weak point is also arranged: (1) is failed to illustrate theoretically mechanism, is resembled pills for prostate disease, only illustrates that it has therapeutical effect to prostatitis and prostate hyperplasia, yet both are in the order of onset peak year, and the pathogenesis difference is very big; (2) be used for not carrying out animal experiment before the clinical observation, thereby the screening of concentration, dosage and the understanding of toxicity, side effect are lacked persuasion; (3) clinical observation material is owed comprehensively, and the clinical observation of above-mentioned existing three kinds of Chinese medicine preparation is not all compared with matched group, lacks the dimension transverse contrast; (4) clinical efficacy is relatively poor, and the treatment effective percentage of prostate pill only is about 70%.
Chinese medicine qi-tonifying and diuresis decoction of the present invention is different from above-mentioned Chinese medicine on prescription and composition.Advantage is: (1) prescription combo becomes rationally, not only by the apolegamy of traditional Chinese medical science mechanism, and has carried out animal experiment, and the effect and the consumption of medicine carried out repeatedly experiment repeatedly, and its safety is more reliable; (2) clinical data is more complete, and it is many to be applied to clinical case, and establishes matched group and carried out the statistical data processing, and its therapeutic effect obviously is better than the report of prostate pill, powder for curing prostatosis.Chinese medicine qi-tonifying and diuresis decoction of the present invention, clinical efficacy prove that effective percentage is 86%, and cure rate is 73%, and taking convenience does not have secondary toxic action; (3) processing technology is reasonable, advanced, detects fully by company standard.
The objective of the invention is to provides a kind of curative effect height, few side effects, safe and reliable, low-cost Chinese medicine preparation for prostatitis patient.
Main contents of the present invention are as follows:
Chinese medicine qi-tonifying and diuresis decoction of the present invention, its basic design philosophy is to select energy human body immunity improving power, regulate the human body endocrine rhythm, energy antiinflammatory, analgesia, the hemorrhage Chinese herbal medicine of minimizing are that raw material is formed, and, research and analyse and draft out corresponding proportion of composing and process for producing flow process thereof according on probation.
The composition and the part by weight thereof of Chinese medicine qi-tonifying and diuresis decoction of the present invention are as follows:
Qi-tonifying and diuresis decoction of the present invention is made up of Rhizoma Smilacis Glabrae, the Cortex Eucommiae, Fructus Forsythiae, Herba Taraxaci, Semen Plantaginis, castor , the Radix Astragali, Cortex Moutan eight flavor principal agents, and looks state of an illness symptom and add other accessory drugs composition.For example work as the patient for deficiency of vital energy pain is main person, add the Rhizoma Corydalis stasis of blood alive; Vexed expand is main person, adds Polyporus diuretic and health invigorating and adds the Radix Linderae.Thereby aspect the Comprehensive Treatment acute and chronic prostatitis, combining becomes following multiple prescription or prescription: prescription one,
Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g
Semen Plantaginis 70-90g castor 70-90g Radix Astragali 110-150g Cortex Moutan 50-70g prescription two, also can add Rhizoma Corydalis and live the stasis of blood, pain relieving in above-mentioned prescription one:
Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g
Semen Plantaginis 70-90g castor 70-90g Radix Astragali 110-150g Cortex Moutan 50-70g
Rhizoma Corydalis 50-70g prescription three, also Polyporus is added and diuretic in the right side in above-mentioned prescription two:
Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g
Semen Plantaginis 70-90g castor 70-90g Radix Astragali 110-150g Cortex Moutan 50-70g
Rhizoma Corydalis 50-70g Polyporus 110-130g prescription four, also can add the Radix Linderae and strengthen the empty patient's of body body constitution in above-mentioned prescription three:
Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g
The yellow late-maturing 110-150g of Semen Plantaginis 70-90g castor 70-90g Cortex Moutan 50-70g
Rhizoma Corydalis 50-70g Polyporus 110-130g Radix Linderae 50-70g
Chinese medicine qi-tonifying and diuresis decoction of the present invention is step method preparation in the following order: above ten Chinese medicines simply, with Fructus Forsythiae, Cortex Moutan water distillation, collect distillation liquid, nine flavors (Semen Plantaginis is used bundle) such as medicinal residues and all the other Rhizoma Smilacis Glabraes decoct with water secondary, 2h for the first time, 1h for the second time, collecting decoction, filtration, solution concentration is to relative density 1.2 (50 ℃ of heat are surveyed).Add ethanol and make concentration of alcohol reach 65-70%, leave standstill extraction, get supernatant and reclaim ethanol, be concentrated into about 200ml, add water and stir evenly; Leave standstill, the receipts supernatant filters, and filtrate is concentrated into an amount of and above-mentioned distillate and merges, and adding stevioside and antiseptic are an amount of, adjust total amount to 1000ml, stir evenly, filter, and fill, sterilization, promptly.
In addition, the Chinese medicine qi-tonifying and diuresis decoction should detect by technical standard of enterprise.
According to above-mentioned technical process, can provide manufacturing process flow diagram, shown in accompanying drawing after the description.
The specification requirement of Chinese medicine qi-tonifying and diuresis decoction oral liquid (" Li Qianning ") is as follows:
(1) sense organ requires: brown gas-liquid, it is sweet to distinguish the flavor of.
(2) physical and chemical index:
Relative density: should be not less than 1.01.
PH value: should be 4.0-6.0.
Other: the pertinent regulations that should meet agent.
(3) sanitary standard:
Arsenic (ppm/ml)≤5
Heavy metal (ppm/ml)≤1
(4) microbiological indicator:
Antibacterial＜10
Mycete＜10
Enzyme is because of bacterium＜10
Escherichia coli must not detect
Dirty cocoon bacterium must not detect
According to the technique scheme design, can make the sharp preceding peaceful oral liquid of Chinese medicine qi-tonifying and diuresis decoction.
Embodiment 1
Rhizoma Smilacis Glabrae 110g Cortex Eucommiae 50g Fructus Forsythiae 120g Herba Taraxaci 130g
Semen Plantaginis 70g
70g Radix Astragali 110g Cortex Moutan 65g
Radix Linderae 70g Polyporus 115g
With the prescription of this embodiment 1, be prepared according to the above-mentioned steps method, can obtain finished product Chinese medicine qi-tonifying and diuresis decoction, or the medicine of drafting " Li Qianning " oral liquid.
Embodiment 2 (optimum formula):
Rhizoma Smilacis Glabrae 125g Cortex Eucommiae 65g Fructus Forsythiae 125g Herba Taraxaci 135g
Semen Plantaginis 85g
90g Radix Astragali 150g Cortex Moutan 70g
Radix Linderae 70g Polyporus 125g
With above-mentioned enforcement 2 prescriptions, be prepared according to the above-mentioned steps method, can obtain " Li Qianning " oral liquid of finished product Chinese medicine qi-tonifying and diuresis decoction.
Embodiment 3
Rhizoma Smilacis Glabrae 120g Cortex Eucommiae 65g Fructus Forsythiae 115g Herba Taraxaci 135g
Semen Plantaginis 80g
80g Radix Astragali 140g Cortex Moutan 60g
Rhizoma Corydalis 65g Radix Linderae 60g
With present embodiment 3 prescriptions, be prepared according to the above-mentioned steps method, can obtain another kind of finished product Chinese medicine qi-tonifying and diuresis decoction oral liquid " Li Qianning ".
For the feasibility of verifying the technical scheme that the present invention is designed is compared the beneficial effect that is had with effectiveness and it with the prostatitic medicine of existing treatment.The inventor once carried out multinomial experimentation under the cooperation of relevant R﹠D institution, now this research project content and result thereof are summarized as follows:
(1) antiinflammatory experiment.
1, to the influence of mice dimethylbenzene auricular concha swelling
Get 30 of mices, be divided into three groups at random, one group of normal saline is irritated stomach, and two groups and three groups gavage medicine, continuous several days, once a day, administration in the 4th day is after 1 hour, and each is organized mice and causes inflammation 3 of hard of hearing melted paraxylenes, put to death animal after 30 minutes, cut two ears, weigh about same position is laid respectively with diameter 8mm card punch, the difference heavy with two ear amounts is to make the index of inflammation swelling degree.The result shows that administration group weight obviously alleviates, and there were significant differences compared with the control for it.
2, to the influence of mice capillary permeability
Get 21 of mices, the grouping administration, successive administration 7 days, once a day, the last administration is after 1 hour, and every mouse peritoneal is injected 0.5% acetic acid 0.2ml.Tail vein injection 1% ivens is blue 0.2ml/ immediately, dead animal after 20 minutes.Cut open the belly, with the distilled water flushing abdominal cavity of 5ml, washing liquid is surveyed its trap in 590mm place colorimetric, and the result shows that the administration group can obviously suppress mice permeability capillaceous.
3, to the granulomatous influence of mice agar
Get 24 of mices, etherization, from the autoclaved 2% agar 0.2ml/ of mouse back subcutaneous injection only, it is consistent that make every effort to each Mus injection site, and the administration group gavages medicine every day from injecting the same day, control group administered physiological saline, 2 weeks of administration altogether.The 15th day, two treated animals under drunkenness,ether, were peeled off ball fat granuloma respectively, weighed, and the result shows, this medicine has obvious inhibitory action to granuloma due to the agar.
(2) analgesic activity (writhing method)
Get mice and be divided into four groups at random, the administration group gavages 20 respectively, the qi-tonifying and diuresis decoction of 40g/kg and the aspirin of 0.1g/kg, the blank group is given the normal saline of the capacity of grade, continuous three days, after the last administration 1 hour, lumbar injection 1% acetum 0.1ml/10g observes the writhing response number of every group of mice then.The result shows that administration group mouse writhing reaction times obviously reduces, and the analgesia percentage rate obviously increases.
(3) bacteriostatic test
Make 1: 4 sample solution with fluid medium, take tube dilution method, serial dilution under aseptic condition (2 times of dilutions), inoculation 10-2 bacterium liquid is an amount of, through 37 ℃ of cultivations 24 hours, observes judgement.Test shows that qi-tonifying and diuresis (1: 32) within the specific limits has certain inhibitory action to staphylococcus aureus, Candida albicans, escherichia coli, bacillus pyocyaneus.
(4) acute toxic reaction
Get 10 of healthy mices, nearly 37g/kg, gastric infusion (0.25ml/10g, 3 times/day, concentration 500%) was observed 7 days continuously, 10 none death of mice as a result, and activity, behavior, ingest, hair color is all normal, this dosage is equivalent to 220.5 times of people's dosage.Show that this medicine does not have acute toxic reaction.
On zooperal basis, carried out clinical experimental study
The inventor once used Chinese medicine qi-tonifying and diuresis decoction treatment patients with chronic prostatitis 400 (comprise matched group 100 examples, followed up a case by regular visits to 3 months-1 year that the first group is given oral qi-tonifying and diuresis decoction, the second group in contrast, the result shows, the first group is cured 123 examples, 39 examples that take a turn for the better, invalid 42 examples.The second group is cured 3 examples, 16 examples that take a turn for the better, invalid 47 examples.Follow up a case by regular visits to after 3 months, the first group recurs 17 examples, and the second group recurs 18 examples, statistical result first group cure rate 73%, effective percentage 86%; Second group cure rate is 37%, and effective percentage is 53%; First group relapse rate 5.6%, second group relapse rate 18%.Above result shows that the Chinese medicine qi-tonifying and diuresis decoction is compared with existing commercially available similar medicine, and the former is tangible to treating prostatitic effect, and there be not secondary the use, safe and reliable, low price, taking convenience calculated by 1 course of treatment, and its price only is a thirtieth of a Western medicine.
Accompanying drawing: Chinese medicine qi-tonifying and diuresis decoction manufacturing process flow diagram
Claims (10)
1. prostatitic Chinese medicine qi-tonifying and diuresis decoction of treatment, it is characterized in that by Rhizoma Smilacis Glabrae, the Cortex Eucommiae, Fructus Forsythiae, Herba Taraxaci, Semen Plantaginis,
, the Radix Astragali, Cortex Moutan eight flavor Chinese medicinal herbs principal agents and other accessory drugss are formed.
2. treatment prostatitis Chinese medicine as claimed in claim 1 is characterized in that the prescription and the consumption of eight flavor Chinese herbal medicine principal agents is: Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g Semen Plantaginis 70-90g
70-90g Radix Astragali 110-150g Cortex Moutan 50-70g
3. treatment prostatitis Chinese medicine as claimed in claim 2 is characterized in that also containing the prescription of accessory drugs Rhizoma Corydalis: Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g Semen Plantaginis 70-90g
70-90g Radix Astragali 110-150g Cortex Moutan 50-70g Rhizoma Corydalis 50-70g
4. treatment prostatitis Chinese medicine as claimed in claim 3 is characterized in that wherein also containing the prescription of Polyporus: Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g Semen Plantaginis 70-90g
70-90g Radix Astragali 110-150g Cortex Moutan 50-70g Rhizoma Corydalis 50-70g Polyporus 110-130g
5. treatment prostatitis Chinese medicine as claimed in claim 4 is characterized in that wherein also containing the prescription of the Radix Linderae: Rhizoma Smilacis Glabrae 110-130g Cortex Eucommiae 50-65g Fructus Forsythiae 110-130g Herba Taraxaci 110-135g Semen Plantaginis 70-90g
70-90g Radix Astragali 110-150g Cortex Moutan 50-70g Rhizoma Corydalis 50-70g Polyporus 110-130g Radix Linderae 50-70g
6. treatment prostatitis Chinese medicine as claimed in claim 1 or 2 is characterized in that best prescription prescription is: Rhizoma Smilacis Glabrae 125g Cortex Eucommiae 65g Fructus Forsythiae 125g Herba Taraxaci 135g Semen Plantaginis 85g
90g Radix Astragali 150g Cortex Moutan 70g Polyporus 125g Radix Linderae 70g
7. the method for making of the prostatitic Chinese medicine qi-tonifying and diuresis decoction of treatment is characterized in that adopting following process sequences step: (1) distillation Fructus Forsythiae and Cortex Moutan, collection distillate; (2) decoct: add in all the other Chinese herbal medicine of respectively distinguishing the flavor of that medicinal residues after Fructus Forsythiae and the Cortex Moutan distillation decoct together, filtration and filtrate concentrates; (3) in concentrated solution, add ethanol and make concentration of alcohol reach 65-70%, effective component extracting, supernatant concentration; (4) prescription preparation: in concentrated solution, add Fructus Forsythiae and Cortex Moutan distillate and the sweet glucose of other adjuvants, antiseptic, and (5) are refining, comprise fine straining, fill, sterilization.
8. the method for making of Chinese medicine as claimed in claim 7 is characterized in that wherein (2) decoct: the medicinal residues of all the other Chinese herbal medicine of respectively distinguishing the flavor of after with Fructus Forsythiae and Cortex Moutan distillation decoct together, fry in shallow oil secondary altogether, and 2 hours for the first time, 1 hour for the second time; The relative density of concentrated solution is 1.2 (50 ℃ of heat are surveyed).
9. the method for making of Chinese medicine as claimed in claim 7, it is characterized in that wherein (3) with the ethanol extraction supernatant concentration to 200ml.
10. as the method for making of claim 7 or 9 described Chinese medicines, it is characterized in that (4) prescription ingredients: adding entry to total amount during the finished product preparation is 1000ml, and adjusting PH is 4.0-6.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96114264A CN1185322A (en) | 1996-12-19 | 1996-12-19 | Qi-tonifying and diuresis decoction of Chinese medicine and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN96114264A CN1185322A (en) | 1996-12-19 | 1996-12-19 | Qi-tonifying and diuresis decoction of Chinese medicine and preparation method thereof |
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| CN1185322A true CN1185322A (en) | 1998-06-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96114264A Pending CN1185322A (en) | 1996-12-19 | 1996-12-19 | Qi-tonifying and diuresis decoction of Chinese medicine and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
| CN101244149B (en) * | 2008-03-03 | 2010-06-23 | 河南中医学院 | Chinese medicine pill for treating hypertrophy of the prostate and acute or chronic prostatitis |
| CN107007734A (en) * | 2017-05-26 | 2017-08-04 | 毛里夏里甫·哈帕 | A kind of medicine for treating gynaecological disease, prostatic disorders and preparation method thereof and application method |
-
1996
- 1996-12-19 CN CN96114264A patent/CN1185322A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
| CN101244149B (en) * | 2008-03-03 | 2010-06-23 | 河南中医学院 | Chinese medicine pill for treating hypertrophy of the prostate and acute or chronic prostatitis |
| CN107007734A (en) * | 2017-05-26 | 2017-08-04 | 毛里夏里甫·哈帕 | A kind of medicine for treating gynaecological disease, prostatic disorders and preparation method thereof and application method |
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