CN118460616A - 腺病毒载体 - Google Patents

腺病毒载体 Download PDF

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Publication number
CN118460616A
CN118460616A CN202410243409.XA CN202410243409A CN118460616A CN 118460616 A CN118460616 A CN 118460616A CN 202410243409 A CN202410243409 A CN 202410243409A CN 118460616 A CN118460616 A CN 118460616A
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vector
adenovirus
antigen
adenoviral vector
virus
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Chinese (zh)
Inventor
S·C·吉尔伯特
A·维艾斯·希尔
M·G·科廷厄姆
M·迪克斯
S·J·莫里斯
A·道格拉斯
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Oxford University Innovation Ltd
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Oxford University Innovation Ltd
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Publication of CN118460616A publication Critical patent/CN118460616A/zh
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CN202410243409.XA 2016-06-23 2017-06-23 腺病毒载体 Pending CN118460616A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1610967.0A GB2549809C (en) 2016-06-23 2016-06-23 Vector
GB1610967.0 2016-06-23
PCT/GB2017/051851 WO2017221031A1 (en) 2016-06-23 2017-06-23 Adenoviral vector
CN201780039028.8A CN109790548B (zh) 2016-06-23 2017-06-23 腺病毒载体

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CN201780039028.8A Division CN109790548B (zh) 2016-06-23 2017-06-23 腺病毒载体

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CN118460616A true CN118460616A (zh) 2024-08-09

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CN201780039028.8A Active CN109790548B (zh) 2016-06-23 2017-06-23 腺病毒载体
CN202410243409.XA Pending CN118460616A (zh) 2016-06-23 2017-06-23 腺病毒载体

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US (3) US11306325B2 (enExample)
EP (2) EP3943604A1 (enExample)
JP (2) JP7187451B2 (enExample)
KR (1) KR102205908B1 (enExample)
CN (2) CN109790548B (enExample)
AU (1) AU2017282102B2 (enExample)
CA (1) CA3027686A1 (enExample)
DK (1) DK3475433T3 (enExample)
ES (1) ES2883354T3 (enExample)
GB (1) GB2549809C (enExample)
MX (1) MX2018016074A (enExample)
SG (1) SG11201811178UA (enExample)
WO (1) WO2017221031A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6576326B2 (ja) 2013-03-14 2019-09-18 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍溶解性アデノウイルス組成物
AU2017222568B2 (en) 2016-02-23 2020-09-10 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
KR20220163505A (ko) 2016-02-23 2022-12-09 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
SG11201910101SA (en) 2017-05-08 2019-11-28 Gritstone Oncology Inc Alphavirus neoantigen vectors
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
GB201812647D0 (en) * 2018-08-03 2018-09-19 Chancellor Masters And Scholars Of The Univ Of Oxford Viral vectors and methods for the prevention or treatment of cancer
GB201814141D0 (en) * 2018-08-30 2018-10-17 Univ Oxford Innovation Ltd Method and compositions for producing a virus
GB201818084D0 (en) 2018-11-06 2018-12-19 Univ Oxford Innovation Ltd Compositions and methods
CN109602901B (zh) * 2019-01-08 2022-05-27 成都迈科康生物科技有限公司 一种带状疱疹病毒疫苗及其制备方法和应用
CN114072516B (zh) * 2019-05-30 2025-01-14 磨石生物公司 经修饰的腺病毒
US11497808B2 (en) 2019-09-30 2022-11-15 Gilead Sciences, Inc. HBV vaccines and methods treating HBV
CN113088530A (zh) * 2020-01-08 2021-07-09 怡道生物科技(苏州)有限公司 一种基于黑猩猩ChAd63型腺病毒的表达载体及其构建方法
CN113088538A (zh) * 2020-01-08 2021-07-09 怡道生物科技(苏州)有限公司 一种基于黑猩猩ChAd3型腺病毒的表达载体及其构建方法
US20230065376A1 (en) * 2020-02-05 2023-03-02 New York Blood Center, Inc. Zika virus immunogenic compositions
US12023376B1 (en) 2020-04-17 2024-07-02 Triad National Security, Llc Conserved region T cell vaccines for coronavirus and methods of use
RU2720614C9 (ru) * 2020-04-23 2021-02-09 федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Министерства здравоохранения Российской Федерации Иммунобиологическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
EA037291B9 (ru) * 2020-08-22 2021-11-24 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты)
WO2022122036A1 (zh) * 2020-12-10 2022-06-16 武汉博沃生物科技有限公司 一种SARS-CoV-2病毒的免疫原、药物组合物及其应用
CN112552380B (zh) * 2020-12-10 2021-12-24 武汉博沃生物科技有限公司 一种SARS-CoV-2病毒的免疫原及其应用
CN112831524B (zh) * 2021-02-20 2023-06-13 苏州相奕生物技术有限公司 人工改造的重组腺病毒载体、由其包装的病毒及其应用
WO2023069926A1 (en) 2021-10-18 2023-04-27 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
CN116103242B (zh) * 2023-01-10 2024-08-02 潍坊医学院 一种靶向治疗结核病的esat6-car-t细胞及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2163260B1 (en) * 2004-01-23 2017-03-15 MSD Italia S.r.l. Chimpanzee adenovirus vaccine carriers
EP3385387B1 (en) * 2009-02-02 2021-08-25 GlaxoSmithKline Biologicals SA Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
GB201108879D0 (en) * 2011-05-25 2011-07-06 Isis Innovation Vector
CN103987726B (zh) * 2011-10-05 2017-10-03 金维克有限公司 猴(大猩猩)腺病毒或腺病毒载体及其使用方法
GB201318084D0 (en) * 2013-10-11 2013-11-27 Isis Innovation Malaria vaccination
MY196581A (en) * 2013-11-01 2023-04-19 Pfizer Vectors for Expression of Prostate-Associated Antigens
GB201413530D0 (en) * 2014-07-30 2014-09-10 Isis Innovation Treatment and prevention of malaria
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector

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