CN118451076A - 经取代的哌啶化合物的晶体、经取代的哌啶化合物的盐及其晶体 - Google Patents

经取代的哌啶化合物的晶体、经取代的哌啶化合物的盐及其晶体 Download PDF

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Publication number
CN118451076A
CN118451076A CN202380015529.8A CN202380015529A CN118451076A CN 118451076 A CN118451076 A CN 118451076A CN 202380015529 A CN202380015529 A CN 202380015529A CN 118451076 A CN118451076 A CN 118451076A
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CN
China
Prior art keywords
azabicyclo
methoxypiperidin
fluoropyrimidin
cyclopropyl
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380015529.8A
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English (en)
Chinese (zh)
Inventor
栉田郁雄
伊藤洋子
安井崇
福山尚
佐藤信明
浅羽太郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanitary Material R&d Management Co ltd
Original Assignee
Sanitary Material R&d Management Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanitary Material R&d Management Co ltd filed Critical Sanitary Material R&d Management Co ltd
Publication of CN118451076A publication Critical patent/CN118451076A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN202380015529.8A 2022-01-14 2023-01-12 经取代的哌啶化合物的晶体、经取代的哌啶化合物的盐及其晶体 Pending CN118451076A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-004608 2022-01-14
JP2022004608 2022-01-14
PCT/JP2023/000561 WO2023136279A1 (ja) 2022-01-14 2023-01-12 置換ピペリジン化合物の結晶並びに置換ピペリジン化合物の塩及びそれらの結晶

Publications (1)

Publication Number Publication Date
CN118451076A true CN118451076A (zh) 2024-08-06

Family

ID=87279104

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380015529.8A Pending CN118451076A (zh) 2022-01-14 2023-01-12 经取代的哌啶化合物的晶体、经取代的哌啶化合物的盐及其晶体

Country Status (10)

Country Link
US (1) US20250051322A1 (https=)
EP (1) EP4438602A4 (https=)
JP (1) JPWO2023136279A1 (https=)
KR (1) KR20240134870A (https=)
CN (1) CN118451076A (https=)
AU (1) AU2023206823A1 (https=)
CA (1) CA3243267A1 (https=)
MX (1) MX2024008024A (https=)
TW (1) TW202334120A (https=)
WO (1) WO2023136279A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7591592B2 (ja) * 2022-01-14 2024-11-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 置換ピペリジン化合物を含有する医薬

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG34208A1 (en) 1995-03-01 1996-12-06 Guy Andrew Vaz Blast and fragment resistant polyurethane boot sole for safety footwear
EP0828751A4 (en) 1995-05-05 1999-01-20 Human Genome Sciences Inc HUMAN NEUROPEPTIDE RECEPTOR
US6309854B1 (en) 1996-12-17 2001-10-30 Smithkline Beecham Corporation Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
US6159605A (en) 1997-02-18 2000-12-12 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Ink-jet recording sheet
US5935814A (en) 1997-04-30 1999-08-10 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72Y receptor
US6020157A (en) 1997-04-30 2000-02-01 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72X receptor
US6166193A (en) 1997-07-25 2000-12-26 Board Of Regents, University Of Texas System Polynucleotides encoding MY1 receptor
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템
TW201444849A (zh) * 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
EP3896060B1 (en) * 2018-12-12 2023-08-16 Takeda Pharmaceutical Company Limited Heterocyclic compound
TWI888599B (zh) * 2020-07-17 2025-07-01 日商衛材R&D企管股份有限公司 取代哌啶化合物及其用途

Also Published As

Publication number Publication date
EP4438602A1 (en) 2024-10-02
TW202334120A (zh) 2023-09-01
CA3243267A1 (en) 2025-04-10
US20250051322A1 (en) 2025-02-13
KR20240134870A (ko) 2024-09-10
WO2023136279A1 (ja) 2023-07-20
AU2023206823A1 (en) 2024-07-11
MX2024008024A (es) 2024-07-15
JPWO2023136279A1 (https=) 2023-07-20
EP4438602A4 (en) 2025-11-19

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