KR20240134870A - 치환된 피페리딘 화합물의 결정, 치환된 피페리딘 화합물의 염, 및 이의 결정 - Google Patents

치환된 피페리딘 화합물의 결정, 치환된 피페리딘 화합물의 염, 및 이의 결정 Download PDF

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Publication number
KR20240134870A
KR20240134870A KR1020247020975A KR20247020975A KR20240134870A KR 20240134870 A KR20240134870 A KR 20240134870A KR 1020247020975 A KR1020247020975 A KR 1020247020975A KR 20247020975 A KR20247020975 A KR 20247020975A KR 20240134870 A KR20240134870 A KR 20240134870A
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KR
South Korea
Prior art keywords
ppm
chemical formula
azabicyclo
methoxypiperidin
fluoropyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247020975A
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English (en)
Korean (ko)
Inventor
이쿠오 구시다
요코 이토
소 야스이
다카시 후쿠야마
노부아키 사토
다로 아사바
Original Assignee
에자이 알앤드디 매니지먼트 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에자이 알앤드디 매니지먼트 가부시키가이샤 filed Critical 에자이 알앤드디 매니지먼트 가부시키가이샤
Publication of KR20240134870A publication Critical patent/KR20240134870A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020247020975A 2022-01-14 2023-01-12 치환된 피페리딘 화합물의 결정, 치환된 피페리딘 화합물의 염, 및 이의 결정 Pending KR20240134870A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022004608 2022-01-14
JPJP-P-2022-004608 2022-01-14
PCT/JP2023/000561 WO2023136279A1 (ja) 2022-01-14 2023-01-12 置換ピペリジン化合物の結晶並びに置換ピペリジン化合物の塩及びそれらの結晶

Publications (1)

Publication Number Publication Date
KR20240134870A true KR20240134870A (ko) 2024-09-10

Family

ID=87279104

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247020975A Pending KR20240134870A (ko) 2022-01-14 2023-01-12 치환된 피페리딘 화합물의 결정, 치환된 피페리딘 화합물의 염, 및 이의 결정

Country Status (10)

Country Link
US (1) US20250051322A1 (https=)
EP (1) EP4438602A4 (https=)
JP (1) JPWO2023136279A1 (https=)
KR (1) KR20240134870A (https=)
CN (1) CN118451076A (https=)
AU (1) AU2023206823A1 (https=)
CA (1) CA3243267A1 (https=)
MX (1) MX2024008024A (https=)
TW (1) TW202334120A (https=)
WO (1) WO2023136279A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7591592B2 (ja) * 2022-01-14 2024-11-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 置換ピペリジン化合物を含有する医薬

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034877A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
JPH11178588A (ja) 1997-07-25 1999-07-06 Smithkline Beecham Corp 新規なヒト７−トランスメンブランレセプターをコードするｃＤＮＡクローンＭＹ１
KR100229887B1 (ko) 1995-03-01 1999-11-15 구이 앤드류 바즈 폭발 및 파편화에 저항성을 갖는 안전화용의 폴리우레탄 신발창
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템
KR100327889B1 (ko) 1997-02-18 2002-08-21 다이니치 세이카 고교 가부시키가이샤 잉크젯용기록시트

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309854B1 (en) 1996-12-17 2001-10-30 Smithkline Beecham Corporation Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
US5935814A (en) 1997-04-30 1999-08-10 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72Y receptor
US6020157A (en) 1997-04-30 2000-02-01 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72X receptor
TW201444849A (zh) * 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
EP3896060B1 (en) * 2018-12-12 2023-08-16 Takeda Pharmaceutical Company Limited Heterocyclic compound
TWI888599B (zh) * 2020-07-17 2025-07-01 日商衛材R&D企管股份有限公司 取代哌啶化合物及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100229887B1 (ko) 1995-03-01 1999-11-15 구이 앤드류 바즈 폭발 및 파편화에 저항성을 갖는 안전화용의 폴리우레탄 신발창
WO1996034877A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
KR100327889B1 (ko) 1997-02-18 2002-08-21 다이니치 세이카 고교 가부시키가이샤 잉크젯용기록시트
JPH11178588A (ja) 1997-07-25 1999-07-06 Smithkline Beecham Corp 新規なヒト７−トランスメンブランレセプターをコードするｃＤＮＡクローンＭＹ１
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
[비특허 문헌 1] Sakurai T.et al, Cell, 1998,92,573-585
[비특허 문헌 2] Lin L. et al, Cell, 1999,98,365-376
[비특허 문헌 3] Chemelli R.M.et al, Cell, 1999,98,437-451
[비특허 문헌 4] Mieda M.et al, Proc. Natl. Acad. Sci. USA, 2004,101,4649-4654
[비특허 문헌 5] Willie J.T. et al, Neuron, 2003,38,715-730
[비특허 문헌 6] Thannickal T.C.et al, Brain 2007,130,1586-1595
[비특허 문헌 7] Busquets X.et al, Respiration, 2004,71,575-579
[비특허 문헌 8] Mieda M.et al, CNS Drugs, 2013,27,83-90

Also Published As

Publication number Publication date
CN118451076A (zh) 2024-08-06
EP4438602A1 (en) 2024-10-02
TW202334120A (zh) 2023-09-01
CA3243267A1 (en) 2025-04-10
US20250051322A1 (en) 2025-02-13
WO2023136279A1 (ja) 2023-07-20
AU2023206823A1 (en) 2024-07-11
MX2024008024A (es) 2024-07-15
JPWO2023136279A1 (https=) 2023-07-20
EP4438602A4 (en) 2025-11-19

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