CN118340726A - 含有西罗莫司或其盐的水性混悬组合物 - Google Patents
含有西罗莫司或其盐的水性混悬组合物 Download PDFInfo
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- CN118340726A CN118340726A CN202410500671.8A CN202410500671A CN118340726A CN 118340726 A CN118340726 A CN 118340726A CN 202410500671 A CN202410500671 A CN 202410500671A CN 118340726 A CN118340726 A CN 118340726A
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- China
- Prior art keywords
- aqueous suspension
- suspension composition
- sirolimus
- salt
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title claims abstract description 147
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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| PCT/JP2020/048738 WO2021132565A1 (ja) | 2019-12-26 | 2020-12-25 | シロリムスまたはその塩を含有する水性懸濁組成物 |
| CN202080089390.8A CN114845714B (zh) | 2019-12-26 | 2020-12-25 | 含有西罗莫司或其盐的水性混悬组合物 |
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| US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| ES2507078T3 (es) * | 2007-08-16 | 2014-10-14 | Santen Pharmaceutical Co., Ltd | Formulaciones de rapamicina para tratamiento de la degeneración macular relacionada con la edad |
| ES2667945T3 (es) | 2007-10-08 | 2018-05-16 | Aurinia Pharmaceuticals Inc. | Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR |
| CN105073112B (zh) | 2013-03-13 | 2017-12-29 | 参天制药株式会社 | 睑板腺功能障碍的治疗剂 |
| JP6279395B2 (ja) * | 2014-05-01 | 2018-02-14 | 東亜薬品株式会社 | ブリンゾラミド懸濁性点眼液組成物の製造方法 |
| CN105833344B (zh) * | 2016-04-26 | 2019-04-26 | 青岛慧生惠众生物科技有限公司 | 一种可注射水凝胶在制备眼内填充物中的应用 |
| CN106420607B (zh) | 2016-11-02 | 2019-06-28 | 北京诺康达医药科技股份有限公司 | 一种西罗莫司纳米混悬剂及其制备方法 |
| EP3565520B1 (en) * | 2017-01-06 | 2026-02-25 | Palvella Therapeutics, Inc. | Anhydrous compositions of mtor inhibitors and methods of use |
| CN107334734B (zh) | 2017-07-10 | 2020-03-17 | 浙江大学 | 一种西罗莫司或其衍生物的眼用制剂 |
| US20200261427A1 (en) * | 2019-02-20 | 2020-08-20 | Al Therapeutics, Inc. | Topical rapamycin formulations and their use in treating facial angiofibromas and other skin disorders |
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| EP4082544A4 (en) | 2024-01-10 |
| JP2025111828A (ja) | 2025-07-30 |
| TW202135806A (zh) | 2021-10-01 |
| CN114845714A (zh) | 2022-08-02 |
| CN114845714B (zh) | 2024-05-14 |
| EP4082544A1 (en) | 2022-11-02 |
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