CN118203527A - Composition for preventing hair disulfide bond oxidative damage as well as preparation method and application thereof - Google Patents
Composition for preventing hair disulfide bond oxidative damage as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN118203527A CN118203527A CN202410241984.6A CN202410241984A CN118203527A CN 118203527 A CN118203527 A CN 118203527A CN 202410241984 A CN202410241984 A CN 202410241984A CN 118203527 A CN118203527 A CN 118203527A
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- CN
- China
- Prior art keywords
- hair
- composition
- oxidative damage
- disulfide bonds
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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Abstract
The invention discloses a composition for preventing oxidative damage of disulfide bonds of hair, and a preparation method and application thereof. The photo-thermal damage pre-protection composition comprises the following components in parts by weight: 10-25 parts of ginkgo leaf extract, 0.1-5 parts of tremella polysaccharide extract, 20-40 parts of microalgae oil, 0.5-3 parts of emulsion stabilizer and 27-69.4 parts of water. The invention forms a layer of biological protection film on the hair surface through ginkgo extract, absorbs a part of ultraviolet rays, supplements lost amino acid, protein and other moisturizing factors through tremella polysaccharide fermentation products, and quenches singlet oxygen free radicals generated in a fur layer due to heat, light and the like through vegetable oil, thereby greatly weakening the attack of the free radicals produced by photo-thermal production on disulfide bonds, avoiding disulfide bond fracture and further oxidation of free sulfhydryl groups, and preventing the degradation of hair lipid. Experiments prove that the three components have synergistic effect, and the hair conditioner is particularly applied to the hair care film/conditioner without washing or flushing, really realizes internal and external double protection, improves the strength and the glossiness of hair, and enhances the capability of the hair to resist external damage.
Description
Technical Field
The invention relates to the technical field of washing and caring products, and particularly discloses a composition for preventing oxidative damage of disulfide bonds of hair caused by light and heat, and a preparation method and application thereof.
Background
Hair does not have self-repairing ability, and once the hair is damaged from the outside, the damage is spread, and at present, the hair damage mainly comprises physical (mechanical combing and pulling) damage, sunlight pollution damage, thermal damage, chemical damage (permanent wave, hair straightening, hair dyeing, color bleaching and the like). Among them, solar pollution and thermal injury are injury modes which most people can contact every day, the main principal of solar injury is ultraviolet rays, the ultraviolet rays can excite the triplet ground state of O 2 into the excited singlet state, and the ultraviolet rays interact with various intracellular structures, such as disulfide bonds, such as cleavage of disulfide bonds, oxidation of cystine into cysteic acid, lipid oxidation, amino acid degradation and slight decomposition of melanin particles, and the disulfide bonds are one of the most critical and easily destroyed chemical bonds for maintaining the mechanical properties of hair, and finally the surface properties and mechanical properties of hair are reduced.
After the hair is washed every day, the hot air blower can accelerate the generation of singlet oxygen free radicals, and can also cause the light loss of CMC (cell membrane complex), the light decomposition of keratin and the light decomposition of melanin particles, so that the hair surface is easy to be hydrophilic, and the glossiness, smoothness and strength of the hair are reduced.
At present, the conventional hair care mode is that small molecular cations/protein modified cations are added to neutralize negative charge sites exposed on the surface of hair, a silicone oil film forming agent smoothes the lifted hair scales, the comb property is improved, and a humectant, small molecular keratin and the like are added to supplement lost moisture and CMC, such as patent CN 106580858B and CN103301032A.
The other is to add raw materials or combinations capable of entering into hair core to repair disulfide bonds, such as CN116924912A, CN116120180A, CN115737498AN and European Leya CN 110461341A, based on the first category, and the composition is used for improving the toughness of hair and realizing the blocking of pigment deposition polymer by respectively adding two free sulfhydryl groups to the composition by means of the principle of establishing stable covalent bonds through classical Michael addition reaction.
Both of these ideas are to repair the hair scales from the outside as much as possible after injury, and to form new covalent bonds from the inside instead of broken disulfide bonds.
The hair damage caused by photo aging can cause degradation and loss of various molecules in the hair, and further the problems of dryness, easy breakage, difficult carding and the like are apparent, so that many people are plagued, and the main effect of most hair care products at present is to repair damaged hair, restore partial performance of the damaged hair, and not protect and repair the damaged hair from root sources.
Disclosure of Invention
The invention aims to provide a composition for preventing oxidative damage of hair disulfide bonds caused by light and heat, which can protect disulfide bonds from being more oxidatively degraded, effectively strengthen the capability of hair for resisting external damage from root sources, strengthen self-strengthening and toughening, reduce hair pigment loss, and prevent and repair hair damage.
Another object of the present invention is to provide a method for preparing the composition for preventing oxidative damage of disulfide bonds of hair caused by light and heat.
It is still another object of the present invention to provide an application of the composition for preventing oxidative damage of disulfide bonds of hair caused by photo-heat, which is added into a leave-on hair care or rinse-off hair care film/conditioner, and the strength and glossiness of the hair are improved by internal and external double protection, and the hair resistance to external damage is enhanced.
The aim of the invention is achieved by the following technical means:
Further, the composition mainly comprises, in parts by weight: ginkgo leaf extract, tremella polysaccharide extract, vegetable oil and emulsion stabilizer; wherein, the mass gram weight ratio of the first three raw materials is (10-25): (0.1-5): (20-40), emulsion stabilizer (0.5-3), and residual water (27-69.4).
Further, the preparation method of the ginkgo leaf extract comprises the following steps:
1) Drying 10-30 parts of ginkgo leaves until the water content remains less than 5%, crushing, sieving, taking 70-130 meshes, adding 70% ethanol aqueous solution which is 7-14 times of the powder, and mixing;
2) Extracting at 75-85 deg.c for 5-8 hr, ageing for 1-4 hr, filtering to obtain supernatant, extracting the residue again for 1-2 hr, vacuum evaporating the supernatant to eliminate solvent, vacuum drying, and detecting the content of flavone, terpene lactone and ginkgolic acid.
Furthermore, the tremella polysaccharide extract is tremella heteropolysaccharide and the tremella heteropolysaccharide extract, as long as the following structure, composition and molecular weight are satisfied, the structure takes alpha- (1-3) mannose as a main chain, the content of the tremella polysaccharide extract is more than 30%, the content of glucuronic acid is more than 10%, and the average molecular weight is 100+/-30 ten thousand daltons.
Furthermore, the vegetable oil mainly contains high content of monounsaturated fatty acid, in particular vegetable oil rich in oleic acid (C18:1) and more than 40%, and has strong compatibility with silicone oil, synthetic oil and nonpolar oil, including but not limited to microalgae oil, olive oil, avocado oil and Morocco nut oil.
Further, the emulsion stabilizer is a thickening type emulsifier selected from the group consisting of, but not limited to, polyacrylamides, sodium acrylate/sodium acryloyldimethyl taurate copolymers, acrylamide/ammonium acrylate copolymers, polyacrylate-13, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylate crosslinked polymer 6, acrylate/C10-30 alkyl acrylate crosslinked copolymers, and the like.
In addition, the invention also discloses a preparation method of the composition for preventing oxidative damage of disulfide bonds of hair caused by light and heat, which comprises the following process steps:
1) Heating water and emulsion stabilizer to 80-85deg.C;
2) Adding microalgae oil, stirring for 2 min, homogenizing, stirring, and cooling after emulsification;
3) And (3) adding the tremella polysaccharide water solution and the ginkgo leaf extract when the temperature is reduced to 45 ℃, and adding a small amount of phenoxyethanol based on the anti-corrosion requirement.
In addition, the invention also discloses application of the composition for preventing hair disulfide bond oxidative damage caused by light and heat, which is added into a washing-free or flushing type hair mask/conditioner/essence, wherein the addition amount is 15% -45%.
Further, the shampoo-free film is mainly prepared from the following components in percentage by weight: 1-3% of emulsifying agent, 1-10% of skin feel regulator, 15-45% of composition for preventing disulfide bond oxidative damage, 1-5% of thickening agent, 0.2-0.8% of preservative, 0.1-0.5% of essence, 0.05-0.5% of PH regulator and the balance of deionized water.
Further, the rinse-off hair mask is prepared from the following components in percentage by weight:
1-5% of cationic emulsifier, 0-1.5% of auxiliary emulsifier, 4-10% of higher fatty alcohol, 5-10% of composition for preventing disulfide bond oxidative damage, 0.5-4% of amino/alkyl modified silicone oil, 0.5-5% of linear or emulsified polydimethylsiloxane, 0.1-0.5% of chelating agent, 0.02-0.5% of PH regulator, 0-2% of quaternary ammonium salt-n (n=7, 10, 22, 37, 39, 64, 91), 0-2% of stabilizer, 1-5% of polyalcohol (sorbitol, glycerin, propylene glycol, butanediol and the like), 0.2-0.8% of preservative, 0.1-0.5% of essence, 0.00001-0.0001% of pigment and the balance of deionized water.
Compared with the prior art, the invention has the beneficial effects that:
1) The invention is compounded by ginkgo leaf extract, tremella polysaccharide and microalgae oil, and is added into a washing-free or flushing-free hair care product, firstly, oxygen radicals and peroxide ROS are radically removed, disulfide bonds are prevented from being oxidized and degraded, lipid and moisturizing factors lost among cells are supplemented, the strengthening and toughening ability of hair is improved, the ultraviolet resistance of the hair is enhanced, photooxidation is weakened, and thirdly, a natural soft protective film is formed to resist heat energy damage, the natural soft protective film is protected from inside to outside and the inner layer is protected from outside, and healthy hair is nourished.
2) The hair care composition of the present invention may further contain various active ingredients such as various synthetic oils, conditioners, natural/synthetic moisturizing factors, etc., which may be added so long as the properties of the hair care composition of the present invention are not affected.
3) Based on the method, the invention provides a new thought and method, mainly aims at preventing protection and repairing, removes peroxides such as oxygen free radicals, lipid and the like from the root of the hair core, prevents oxidation and rupture of disulfide bonds and peptide bonds, and protects healthy hair in a mode of weakening damage of ultraviolet rays and heat energy to the hair on the external source.
Based on the technical scheme, the invention has the following beneficial technical effects:
1) According to the composition for preventing disulfide bond injury, a layer of biological protection film is formed on the surface of hair through the ginkgo extract, a part of ultraviolet rays are absorbed, meanwhile, the tremella polysaccharide fermentation product is used for supplementing lost amino acid, protein moisturizing factors and vegetable oil to quench singlet oxygen free radicals generated by the hair cortex, so that the attack of the free radicals produced by photo-thermal production on disulfide bonds is greatly weakened, the breakage of the disulfide bonds and the further oxidation of free sulfhydryl are avoided, and the degradation of hair lipid is prevented.
2) Experiments prove that the three components have synergistic effect, and especially are applied to the hair care film/conditioner without washing or flushing, through internal and external double protection, the strength and the glossiness of the hair are improved, and the capability of the hair for resisting external damage is enhanced.
Drawings
FIG. 1 is a view of an ultraviolet radiation treatment beam set;
FIG. 2 is an infrared spectrum of samples 1-11 combined;
FIG. 3 is a graph of the peak of the oxidation characteristic of the disulfide bond as shown in the partial enlarged IR spectrum of samples 1-11;
FIGS. 4A-4K are the IR spectra of samples 1-11, respectively.
Detailed Description
The invention is further illustrated by the following specific examples in conjunction with efficacy testing examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention.
The invention discloses a composition for preventing oxidative damage of disulfide bonds of hair caused by light and heat, which comprises the following components in parts by weight: 10-25 parts of ginkgo leaf extract, 0.1-5 parts of tremella polysaccharide extract, 20-40 parts of microalgae oil, 0.5-3 parts of emulsion stabilizer and 27-69.4 parts of water; water, polyols, humectants, cationic conditioning agents, keratin modifiers, and the like may also be incorporated to provide new compositions.
Wherein, the efficacy of the main raw materials is expressed as follows:
① Ginkgo leaf extract
The flavonoid substances in the ginkgo leaf are scavenging free radicals, can protect cell layers, prevent cells from being oxidized, can obviously absorb light waves within the range of 280-300 nm and 360-400 nm, can resist long-wave ultraviolet rays and medium-wave ultraviolet rays, can weaken excitation energy of ultraviolet rays to triplet state oxygen when being smeared on hair in a detention type hair mask/conditioner, has superoxide dismutase (SOD) activity, can remove a part of superoxygen free radicals on the surface layer, weakens damage to pigments, cells and chemical bonds, and is equivalent to applying a layer of natural sun-screening agent and antioxidant on the hair.
② Tremella polysaccharide extract
The tremella polysaccharide is composed of plant-seaweed-animal held sugar, polysaccharide body with unique space network structure, mannose is taken as skeleton (main chain), and side chains are xylose, fucose, glucuronic acid and glucose, so that the tremella polysaccharide is a natural plant humectant, and sugar chains are opened to form a huge and complex space network structure after absorbing 500 times of water of the tremella polysaccharide.
The tremella polysaccharide has the moisture-preserving effect equivalent to that of hyaluronic acid, is known as 'plant hyaluronic acid', has more unique performance than hyaluronic acid, forms a film hydrophilic group which is inwards arranged and has certain hydrophobicity, particularly selects tremella polysaccharide with the molecular weight of 100+/-30 ten thousand daltons to be applied to hair care products, can form a layer of moistened soft hydrophobic film on the surface of hair to help the hair to lock moisture in a high-heat energy environment, can replace the film-forming effect of traditional synthetic silicone oil, and can resist heat, and the hair upper epidermal layer is biomimetically repaired, which is equivalent to putting on a layer of natural heat-insulating coat on the hair.
③ Microalgae oil
The human hair contains 1.9% -5% of lipids, and the lipid layer is important for maintaining the integrity of the hair, and is called a "hair barrier". The natural oil is especially microalgae oil (such as Algapur TM HSHO of Lu Borun), has C18:1 content higher than 90%, is an effective singlet oxygen scavenger, can inactivate ROS at a higher rate than other oils, can inactivate singlet oxygen and bring it back to its triplet ground state, can prevent lipid degradation of outer beta layer (18 MEA layer), outer angular cortex, inner epidermal layer and other layers of hair fiber under ultraviolet irradiation, can prevent further degradation of disulfide bonds by oxygen free radicals and lipid peroxide, and can supplement intercellular lipid lost by hair cores due to its strong permeability, and can prevent and further repair damaged hair strands.
④ Emulsion stabilizer
The viscosity of the composition can be increased, the stability is improved, the oil-water separation is prevented, the smearing skin feel is enhanced, and the composition is more stable and easy to apply. The thickening emulsifier is selected from: polyacrylamides, sodium acrylate/sodium acryloyldimethyltaurate copolymers, acrylamide/ammonium acrylate copolymers, polyacrylate-13, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymers, polyacrylate crosslinked polymer 6, acrylate/C10-30 alkyl acrylate crosslinked copolymers.
According to the composition for preventing disulfide bond injury, a layer of biological protective film is formed on the surface of hair through the ginkgo extract, a part of ultraviolet rays are absorbed, ultraviolet ray injury is reduced, meanwhile, the tremella polysaccharide fermentation product is used for supplementing lost amino acid, protein moisturizing factors and vegetable oil to quench singlet oxygen free radicals generated by the hair layer, so that the attack of the free radicals produced by photo-thermal production on disulfide bonds is greatly weakened, disulfide bond breakage and further free sulfhydryl oxidation are avoided, and hair lipid degradation is prevented.
Experiments prove that the three components have synergistic effect, and especially are applied to the hair care film/conditioner without washing or flushing, through internal and external double protection, the strength and the glossiness of the hair are improved, and the capability of the hair for resisting external damage is enhanced.
The experimental methods, in which specific conditions are not noted in the following examples, are generally conducted under conventional conditions or under conditions recommended by the manufacturer.
Percentages and parts are by weight unless otherwise indicated.
A composition for preventing photo-thermal induced oxidative damage to hair disulfide bonds comprising the weight components shown in table 1:
TABLE 1 composition formulation of examples 1-4 and comparative examples 1-5 (wt.%)
The preparation method of the composition for preventing oxidative damage of hair disulfide bonds caused by light and heat in the embodiment comprises the following process steps:
1) Heating water and emulsion stabilizer to 80-85deg.C;
2) Adding microalgae oil, stirring for 2 min, homogenizing for 2-3 min, and stirring and cooling after emulsification;
3) And (3) adding the tremella polysaccharide water solution and the ginkgo leaf extract when the temperature is reduced to 45 ℃, and adding a small amount of phenoxyethanol based on the anti-corrosion requirement.
Application examples and comparative examples (leave-in shampoo film)
The above-mentioned compositions for preventing oxidative damage of disulfide bonds of hair caused by light and heat, examples 1-4 and comparative examples 1-5, were added to the shampoo-free film in an amount of 40 parts.
The shampoo-free film is mainly prepared from the following components in percentage by weight:
2.5% of emulsifying agent (behenyl trimethyl ammonium chloride), 0.2% of skin feel modifier (hydroxyethyl cellulose), 4% of thickening agent (cetostearyl alcohol) in terms of 40% of example and comparative example compositions (see table 2), 1% of preservative (octanoyl hydroxamic acid, glycerol caprylate and 1,3 propylene glycol), 0.3% of essence, and a proper amount of pH modifier (citric acid) and a proper amount of deionized water.
Table 2 shampoo free film formulation additive composition
The shampoo free film of the composition for preventing oxidative damage of disulfide bonds of hair caused by light and heat of the embodiment comprises the following process steps:
1) Phase A: adding hydroxyethyl cellulose into normal-temperature deionized water, starting to heat to 85 ℃, adding behenyl trimethyl ammonium chloride into hot water, dissolving at 85 ℃, and then preserving heat and stirring for 5 minutes.
1) And B phase: heating cetostearyl alcohol alone until it is dissolved, adding phase A under stirring, stirring at high speed for 1 min, homogenizing for 2-3 min, and cooling.
2) Cooling to 40-45deg.C, adding the composition of examples or comparative examples or silicone oil, antiseptic, essence and pH regulator, and stirring.
The following are the contents of the efficacy test examples.
The experimental method comprises the following steps:
Experiment one: infrared spectroscopy testing
The infrared light can be absorbed by various chemical bonds in the hair to generate absorption peaks, the absorption peaks form the infrared spectrum of the hair, and the infrared spectrum (Infrared Spectrum, IR) containing a large amount of abundant structural information is the most common spectrum characterization means. Because the disulfide bond has poor stability, the disulfide bond is broken by daily hair ironing and dyeing, sunlight irradiation, oxidation environment and the like, and the property of the hair is influenced, so the characterization of the disulfide bond and the oxidized derivative thereof has practical significance. The treated expanded beam is crushed into powder for conventional tabletting in an experiment, and the absorption peak of 500-4000nm is tested in the experiment by using total reflection Fourier transform infrared spectrum.
Experiment II: hair gloss test
The gloss of hair is understood to be the degree of reflection of light by the hair. When the hair is changed in structure due to various improper treatments, light is diffusely reflected on the epidermis, and scattering in the fur or hair pith causes a decrease in reflected light intensity. When light is irradiated onto hair, the hair tends to give out natural luster if the surface structure of the hair fiber is more regular.
Otherwise, the damaged hair quality is shown as dark and dull, the hair is flattened by the glossiness tester Skin-Glossymeter GL for experiments before use, the glossiness of the hair is measured, each hair is uniformly measured for 10 times from top to bottom, the average value is taken as an initial value, 5 hair bundles are tested in total, the hair bundle deviating from the maximum is removed, and 3 hair bundles are taken.
After the hair bundle is treated according to a heat and ultraviolet treatment method, measuring the glossiness of the hair bundle again, adopting SPSS 25.0 statistical analysis software to carry out statistical analysis on data, and carrying out double-tail inspection, wherein the significance level is P < 0.1; p < 0.05, P < 0.001.
Experiment III: thermal damage treatment procedure
Slightly damaged hair bundles (length 12cm x 5 g) were taken, numbered, following hair mask: hair bundles=0.5:1, rubbing for 5 minutes, washing-free without washing, washing with clear water for 1 minute, standing for 24 hours at 25 ℃ in 45+/-5%, airing, placing in a constant temperature oven at 150 ℃ for heat blowing treatment for 2 hours, treating a hair straightening rod at 160 ℃ for 110 times, taking out, marking numbers, and paralleling 5 groups each time, and waiting to be detected.
Experiment IV: ultraviolet injury treatment procedure
Slightly damaged hair bundles (length 12cm x 5 g) were taken, numbered, following hair mask: the hair bundle=0.5:1 is smeared, rubbed for 5 minutes, no washing is needed, washing is carried out for 1 minute, standing is carried out for 24 hours in 45+/-5% environment at 25 ℃ for airing, the light intensity is 500W/m < 2 >, the environment temperature is regulated to 70 ℃ (simulating hot blast), and the hair bundle is taken out, is taken out for 5 groups in parallel each time, and is ready to be detected.
Experimental results:
1. gloss of hair
As shown in tables 3 and 4 and figure 1, the composition of the invention can effectively prevent the change of glossiness caused by pigment degradation and hair structure oxidation of ultraviolet rays, and the degree of glossiness weakening is less than 15% as a whole, wherein the effects of examples 2 and 4 are better than those of examples 1 and 3, the effects of examples 1-4 are better than those of comparative examples 1-5, the comparative blank has obvious protection effect, and meanwhile, the three core efficacy substances have synergistic effect.
Examples 2 and 4 are more preferable, mainly the microalgae oil has the effects of directly quenching free radicals or scavenging ROS, delaying lipid oxidation, reducing protein degradation and the ginkgo extract has stronger absorption to ultraviolet light, and tremella polysaccharide has more films to defend high-temperature heat energy, so that the effect on photoprotection is not obvious.
The control group adopts the common washing-free silicone oil-containing hair conditioner, and compared with the blank group silicone oil film forming agent, the control group can also prevent degradation of pigment lipid and the like caused by ultraviolet oxidation to a certain extent, has a light protection effect, but compared with examples 1-4, the control group has far less protection effect. The composition of the embodiment not only can form a film, but also can prevent the hair from further damage, and can more effectively realize the protection and repair of the hair.
TABLE 3 ultraviolet irradiation treatment sample set
Table 4 table of statistical analysis of ultraviolet irradiation treated sample group
Note 1: the larger the measurement, the higher the gloss of the hair strand;
And (2) injection: rate of change/% = (pre-treatment mean-post-treatment mean)/pre-treatment mean 100%;
And (3) injection: the smaller the rate of change, the better the hair protection, the less gloss damage.
2. Degree of hair disulfide bond change
The internal structure of the hair is researched by adopting a total reflection Fourier transform infrared spectrum technology, disulfide bonds are difficult to form peaks in the infrared spectrum due to heavier sulfur atoms, and derivative groups sulfinic acid and sulfonic acid groups after disulfide bonds are damaged by oxidation are easier to be detected by infrared appearance due to the fact that S=O bonds are contained. The s=o characteristic peak was barely visible in healthy hair, whereas the signal was very pronounced in oxidatively damaged hair.
FIG. 2 is an infrared spectrum of hair of samples 1-11; FIG. 3 is an enlarged view of a portion of the infrared spectrum 1039 cm-1 of the hair; FIGS. 4A-4K are the IR spectra of samples 1-11, respectively, and FIG. 2 is a graph.
The purity is disturbed during the test, the blind test is carried out, and the test samples corresponding to the numbers are as follows:
the infrared spectrum of the sample group is shown in fig. 2, the lower the absorbance is, the better the generated sulfur-oxygen bond is, and the tested example group can prevent disulfide bond damage, and the result is shown in fig. 2 and a partially enlarged fig. 3:
1039cm -1 results: example 4 > example 2 > example 3 > example 4 > comparative example 3 > comparative example 1 > comparative example 5> control group > comparative example 2 > blank group.
Among them, comparative examples 3 and 4 are superior to comparative examples 1/2/5, demonstrating that the effect of protecting the microalgae oil against ultraviolet-induced disulfide bond damage is superior to ginkgo biloba extract and tremella polysaccharide extract.
Examples 1-4 are better than comparative examples 1-3 and also better than comparative examples 4-5, demonstrating the synergistic effect of the three.
TABLE 5 sample numbers (1-11) and ordering
| Sample numbering | Corresponding sample | Ordering of |
| 2401181854-1 | Comparative example 5 | 8 |
| 2401181854-2 | Comparative example 4 | 5 |
| 2401181854-3 | Control group | 9 |
| 2401181854-4 | Blank group | 11 |
| 2401181854-5 | Example 2 | 2 |
| 2401181854-6 | Example 4 | 1 |
| 2401181854-7 | Comparative example 2 | 10 |
| 2401181854-8 | Comparative example 3 | 6 |
| 2401181854-9 | Comparative example 1 | 7 |
| 2401181854-10 | Example 3 | 3 |
| 2401181854-11 | Example 1 | 4 |
TABLE 6 Infrared spectral characteristics of hair
The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.
Claims (10)
1. A composition for preventing oxidative damage to hair disulfide bonds, comprising: the composition mainly comprises the following components in parts by weight: ginkgo leaf extract, tremella polysaccharide extract, vegetable oil and emulsion stabilizer; wherein, the mass gram weight ratio of the first three raw materials is (5-30): (0.05-10): (10-50), emulsion stabilizer (0.5-3), water (20-84.45).
2. A composition for preventing oxidative damage to hair disulfide bonds as recited in claim 1 wherein: the composition mainly comprises the following components in parts by weight: ginkgo leaf extract, tremella polysaccharide extract, vegetable oil and emulsion stabilizer; wherein, the mass gram weight ratio of the first three raw materials is (10-25): (0.1-5): (20-40), emulsion stabilizer 0.5-3, and residual water 27-69.4.
3. A composition for preventing oxidative damage to hair disulfide bonds as recited in claim 2 wherein:
The preparation method of the ginkgo leaf extract comprises the following steps:
Drying 10-30 parts of ginkgo leaves until the water content remains less than 5%, crushing, sieving, taking 70-130 meshes, adding 70% ethanol aqueous solution which is 7-14 times of the powder, and mixing;
Extracting at 75-85 deg.c for 5-8 hr, ageing for 1-4 hr, filtering to obtain supernatant, extracting the residue again for 1-2 hr, vacuum evaporating the supernatant to eliminate solvent, vacuum drying, and detecting the content of flavone, terpene lactone and ginkgolic acid.
4. A composition for preventing oxidative damage to hair disulfide bonds as recited in claim 2 wherein: the tremella polysaccharide extract is tremella heteropolysaccharide and tremella heteropolysaccharide extract, and the tremella heteropolysaccharide extract can meet the following structure, composition and molecular weight, the structure takes alpha- (1-3) mannose as a main chain, the content of the tremella polysaccharide extract is more than 30%, the content of glucuronic acid is more than 10%, and the average molecular weight is 100+/-30 ten thousand daltons.
5. A composition for preventing oxidative damage to hair disulfide bonds as recited in claim 1 wherein:
The vegetable oil mainly contains high content of monounsaturated fatty acid, in particular vegetable oil which is rich in oleic acid (C18:1) and has the content of more than 40 percent and has strong compatibility with silicone oil, synthetic oil and nonpolar oil, including but not limited to microalgae oil, olive oil, avocado oil and argan nut oil.
6. A composition for preventing oxidative damage to hair disulfide bonds as recited in claim 2 wherein:
The emulsion stabilizer is a thickening type emulsifier selected from the group consisting of, but not limited to, polyacrylamides, sodium acrylate/sodium acryloyldimethyl taurate copolymers, acrylamide/ammonium acrylate copolymers, polyacrylate-13, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylate crosslinked polymer 6, acrylate/C10-30 alkyl acrylate crosslinked copolymers and the like.
7. A method for preparing the composition for preventing oxidative damage to hair disulfide bonds as recited in any one of claims 1 to 6, comprising the following process steps:
1) Heating water and emulsion stabilizer to 80-85deg.C;
2) Adding microalgae oil, stirring for 2 min, homogenizing, stirring, and cooling after emulsification;
3) Adding tremella polysaccharide water solution and ginkgo leaf extract when the temperature is reduced to 45 ℃, and adding a small amount of phenoxyethanol preservative based on the preservative requirement.
8. Use of a composition for preventing oxidative damage to hair disulfide bonds as claimed in any one of claims 1 to 6, characterized in that: the hair mask/hair conditioner is applied to the hair mask/hair conditioner/essence which is free of washing or flushing, and the addition amount is 5-10% or 15-45%.
9. Use of a composition for preventing oxidative damage to hair disulfide bonds as recited in claim 8 wherein: the shampoo-free film is mainly prepared from the following components in percentage by weight: 1-3% of emulsifying agent, 1-10% of skin feel regulator, 15-45% of composition for preventing disulfide bond oxidative damage, 1-5% of thickening agent, 0.2-1% of preservative, 0.1-0.5% of essence, 0.05-0.5% of PH regulator and the balance of deionized water.
10. Use of a composition for preventing oxidative damage to hair disulfide bonds as recited in claim 8 wherein: the rinse-off hair mask is prepared from the following components in percentage by weight:
1-5% of cationic emulsifier, 0-1.5% of auxiliary emulsifier, 4-10% of higher fatty alcohol, 5-10% of composition for preventing disulfide bond oxidative damage, 0.5-4% of amino/alkyl modified silicone oil, 0.5-5% of linear or emulsified polydimethylsiloxane, 0.1-0.5% of chelating agent, 0.02-0.5% of PH regulator, 0-2% of quaternary ammonium salt-n (n=7, 10, 22, 37, 39, 64, 91), 0-2% of stabilizer, 1-5% of polyalcohol (sorbitol, glycerin, propylene glycol, butanediol and the like), 0.2-0.8% of preservative, 0.1-0.5% of essence, 0.00001-0.0001% of pigment and the balance of deionized water.
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| CN202410241984.6A CN118203527A (en) | 2024-03-04 | 2024-03-04 | Composition for preventing hair disulfide bond oxidative damage as well as preparation method and application thereof |
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| CN202410241984.6A CN118203527A (en) | 2024-03-04 | 2024-03-04 | Composition for preventing hair disulfide bond oxidative damage as well as preparation method and application thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10287531A (en) * | 1997-04-14 | 1998-10-27 | Kose Corp | Cosmetic for hair |
| CN105616292A (en) * | 2016-02-03 | 2016-06-01 | 九沪（上海）生物科技有限公司 | Tea saponin shampoo containing traditional Chinese medicine extracts and preparation method thereof |
| CN109864913A (en) * | 2019-03-21 | 2019-06-11 | 湖南科技学院 | A kind of ginkgo leaf shampoo and preparation method thereof |
| CN113730297A (en) * | 2021-06-17 | 2021-12-03 | 广州市衡拓贸易有限公司 | Pearlescent no-wash hair care essence |
| CN114028276A (en) * | 2021-12-17 | 2022-02-11 | 上海蜂花日用品有限公司 | Hair care composition with multiple-effect repairing effect and application thereof |
-
2024
- 2024-03-04 CN CN202410241984.6A patent/CN118203527A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10287531A (en) * | 1997-04-14 | 1998-10-27 | Kose Corp | Cosmetic for hair |
| CN105616292A (en) * | 2016-02-03 | 2016-06-01 | 九沪（上海）生物科技有限公司 | Tea saponin shampoo containing traditional Chinese medicine extracts and preparation method thereof |
| CN109864913A (en) * | 2019-03-21 | 2019-06-11 | 湖南科技学院 | A kind of ginkgo leaf shampoo and preparation method thereof |
| CN113730297A (en) * | 2021-06-17 | 2021-12-03 | 广州市衡拓贸易有限公司 | Pearlescent no-wash hair care essence |
| CN114028276A (en) * | 2021-12-17 | 2022-02-11 | 上海蜂花日用品有限公司 | Hair care composition with multiple-effect repairing effect and application thereof |
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