CN118150410A - 孔芯片及微粒测定系统 - Google Patents
孔芯片及微粒测定系统 Download PDFInfo
- Publication number
- CN118150410A CN118150410A CN202311427005.8A CN202311427005A CN118150410A CN 118150410 A CN118150410 A CN 118150410A CN 202311427005 A CN202311427005 A CN 202311427005A CN 118150410 A CN118150410 A CN 118150410A
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- CN
- China
- Prior art keywords
- hole
- chip
- membrane
- insulating layer
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000005259 measurement Methods 0.000 title claims abstract description 19
- 239000011859 microparticle Substances 0.000 title claims description 7
- 239000012528 membrane Substances 0.000 claims abstract description 29
- 239000000758 substrate Substances 0.000 claims description 9
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims description 4
- 239000011810 insulating material Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 description 34
- 239000010410 layer Substances 0.000 description 28
- 230000005684 electric field Effects 0.000 description 17
- 239000011148 porous material Substances 0.000 description 16
- 238000010586 diagram Methods 0.000 description 9
- 238000004088 simulation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000003792 electrolyte Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G01N15/132—Circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/13—Details pertaining to apertures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0266—Investigating particle size or size distribution with electrical classification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1029—Particle size
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022-195237 | 2022-12-06 | ||
| JP2022195237A JP2024081540A (ja) | 2022-12-06 | 2022-12-06 | ポアチップおよび微粒子測定システム |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118150410A true CN118150410A (zh) | 2024-06-07 |
Family
ID=89429027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311427005.8A Pending CN118150410A (zh) | 2022-12-06 | 2023-10-31 | 孔芯片及微粒测定系统 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240183769A1 (https=) |
| JP (1) | JP2024081540A (https=) |
| CN (1) | CN118150410A (https=) |
| DE (1) | DE102023133432A1 (https=) |
| GB (1) | GB2626420A (https=) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2569477B1 (fr) * | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | Appareil et procede pour la determination de la deformabilite des globules rouges du sang |
| WO2001069202A2 (en) * | 2000-03-16 | 2001-09-20 | Ulrik Darling Larsen | Sensor units for particle characterisation apparatus |
| KR100594074B1 (ko) | 2001-04-13 | 2006-06-30 | 스미토모덴키고교가부시키가이샤 | 콘택트 프로브 |
| DE602004021033D1 (de) * | 2003-12-19 | 2009-06-18 | Harvard College | Analyse von molekülen durch translokation durch eine beschichtete öffnung |
| ITTO20080104A1 (it) * | 2008-02-08 | 2009-08-09 | Silicon Biosystems Spa | Apparato e metodo per il conteggio e l'identificazione di particelle di interesse in un fluido |
| IT1398771B1 (it) * | 2009-09-04 | 2013-03-18 | Istituto Naz Per La Ricerca Sul Cancro | Chip nanoforato di nitruro di silicio per l'analisi di profili di espressione genica e relativi biosensori. |
| US9121823B2 (en) * | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| CN102621214B (zh) * | 2012-03-13 | 2014-10-29 | 美国哈佛大学 | 一种基于固态纳米孔对核酸分子进行减速及单分子捕获的方法 |
| JP2014219235A (ja) | 2013-05-02 | 2014-11-20 | 山一電機株式会社 | 電気部品検査用ソケット |
| JP6484514B2 (ja) | 2015-06-30 | 2019-03-13 | 株式会社エンプラス | 電気部品用ソケット |
| JP6688881B2 (ja) * | 2016-04-28 | 2020-04-28 | 株式会社日立製作所 | メンブレンデバイス、計測装置、メンブレンデバイス製造方法 |
| JP2018054594A (ja) | 2016-09-26 | 2018-04-05 | セイコーインスツル株式会社 | 接触式プローブ |
| US10976233B2 (en) * | 2018-08-15 | 2021-04-13 | Taiwan Semiconductor Manufacturing Company, Ltd. | Particle detector |
| KR102176130B1 (ko) * | 2018-11-13 | 2020-11-10 | 고려대학교 산학협력단 | 마이크로 포어를 이용한 생체 분자 검출 장치 |
| KR102514030B1 (ko) * | 2021-03-31 | 2023-03-24 | 고려대학교 산학협력단 | 마이크로 포어를 이용한 단일 세포 분석 장치 |
-
2022
- 2022-12-06 JP JP2022195237A patent/JP2024081540A/ja active Pending
-
2023
- 2023-10-31 CN CN202311427005.8A patent/CN118150410A/zh active Pending
- 2023-11-29 DE DE102023133432.8A patent/DE102023133432A1/de active Pending
- 2023-11-29 GB GB2318250.4A patent/GB2626420A/en active Pending
- 2023-11-30 US US18/524,722 patent/US20240183769A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB202318250D0 (en) | 2024-01-10 |
| DE102023133432A1 (de) | 2024-06-06 |
| JP2024081540A (ja) | 2024-06-18 |
| US20240183769A1 (en) | 2024-06-06 |
| GB2626420A (en) | 2024-07-24 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |