GB2626420A - Pore chip and microparticle measurement system - Google Patents
Pore chip and microparticle measurement system Download PDFInfo
- Publication number
- GB2626420A GB2626420A GB2318250.4A GB202318250A GB2626420A GB 2626420 A GB2626420 A GB 2626420A GB 202318250 A GB202318250 A GB 202318250A GB 2626420 A GB2626420 A GB 2626420A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pore
- membrane
- chip
- layer
- pore chip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011148 porous material Substances 0.000 title claims abstract description 115
- 238000005259 measurement Methods 0.000 title claims abstract description 23
- 239000011859 microparticle Substances 0.000 title claims description 7
- 239000012528 membrane Substances 0.000 claims abstract description 42
- 239000011810 insulating material Substances 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 abstract description 36
- 239000010410 layer Substances 0.000 description 36
- 238000010586 diagram Methods 0.000 description 26
- 230000005684 electric field Effects 0.000 description 19
- 238000004088 simulation Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 6
- 239000008151 electrolyte solution Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 238000005336 cracking Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 230000002902 bimodal effect Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G01N15/132—Circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/13—Details pertaining to apertures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0266—Investigating particle size or size distribution with electrical classification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1029—Particle size
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022195237A JP2024081540A (ja) | 2022-12-06 | 2022-12-06 | ポアチップおよび微粒子測定システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB202318250D0 GB202318250D0 (en) | 2024-01-10 |
| GB2626420A true GB2626420A (en) | 2024-07-24 |
Family
ID=89429027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2318250.4A Pending GB2626420A (en) | 2022-12-06 | 2023-11-29 | Pore chip and microparticle measurement system |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240183769A1 (https=) |
| JP (1) | JP2024081540A (https=) |
| CN (1) | CN118150410A (https=) |
| DE (1) | DE102023133432A1 (https=) |
| GB (1) | GB2626420A (https=) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835457A (en) * | 1984-08-24 | 1989-05-30 | Universite Rene Descartes | Apparatus and process for determining the deformability of the red corpuscles in the blood |
| WO2001069202A2 (en) * | 2000-03-16 | 2001-09-20 | Ulrik Darling Larsen | Sensor units for particle characterisation apparatus |
| EP1708957B1 (en) * | 2003-12-19 | 2009-05-06 | The President and Fellows of Harvard College | Analysis of molecules by translocation through a coated aperture |
| US20110050200A1 (en) * | 2008-02-08 | 2011-03-03 | Silicon Biosystems S.P.A. | Apparatus and Method for Counting and Identifying Particles of Interest in a Fluid |
| EP2473849B1 (en) * | 2009-09-04 | 2014-10-29 | Universita' Degli Studi Di Genova | Nanopored silicon nitride chip for the analysis of gene expression profiles |
| US9121823B2 (en) * | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| US20220011231A1 (en) * | 2018-11-13 | 2022-01-13 | Korea University Research And Business Foundation | Biomolecule detection apparatus using micropore |
| US20220314219A1 (en) * | 2021-03-31 | 2022-10-06 | Korea University Research And Business Foundation | Device for analyzing single cell using micropores |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100594074B1 (ko) | 2001-04-13 | 2006-06-30 | 스미토모덴키고교가부시키가이샤 | 콘택트 프로브 |
| CN102621214B (zh) * | 2012-03-13 | 2014-10-29 | 美国哈佛大学 | 一种基于固态纳米孔对核酸分子进行减速及单分子捕获的方法 |
| JP2014219235A (ja) | 2013-05-02 | 2014-11-20 | 山一電機株式会社 | 電気部品検査用ソケット |
| JP6484514B2 (ja) | 2015-06-30 | 2019-03-13 | 株式会社エンプラス | 電気部品用ソケット |
| JP6688881B2 (ja) * | 2016-04-28 | 2020-04-28 | 株式会社日立製作所 | メンブレンデバイス、計測装置、メンブレンデバイス製造方法 |
| JP2018054594A (ja) | 2016-09-26 | 2018-04-05 | セイコーインスツル株式会社 | 接触式プローブ |
| US10976233B2 (en) * | 2018-08-15 | 2021-04-13 | Taiwan Semiconductor Manufacturing Company, Ltd. | Particle detector |
-
2022
- 2022-12-06 JP JP2022195237A patent/JP2024081540A/ja active Pending
-
2023
- 2023-10-31 CN CN202311427005.8A patent/CN118150410A/zh active Pending
- 2023-11-29 DE DE102023133432.8A patent/DE102023133432A1/de active Pending
- 2023-11-29 GB GB2318250.4A patent/GB2626420A/en active Pending
- 2023-11-30 US US18/524,722 patent/US20240183769A1/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835457A (en) * | 1984-08-24 | 1989-05-30 | Universite Rene Descartes | Apparatus and process for determining the deformability of the red corpuscles in the blood |
| WO2001069202A2 (en) * | 2000-03-16 | 2001-09-20 | Ulrik Darling Larsen | Sensor units for particle characterisation apparatus |
| EP1708957B1 (en) * | 2003-12-19 | 2009-05-06 | The President and Fellows of Harvard College | Analysis of molecules by translocation through a coated aperture |
| US20110050200A1 (en) * | 2008-02-08 | 2011-03-03 | Silicon Biosystems S.P.A. | Apparatus and Method for Counting and Identifying Particles of Interest in a Fluid |
| EP2473849B1 (en) * | 2009-09-04 | 2014-10-29 | Universita' Degli Studi Di Genova | Nanopored silicon nitride chip for the analysis of gene expression profiles |
| US9121823B2 (en) * | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| US20220011231A1 (en) * | 2018-11-13 | 2022-01-13 | Korea University Research And Business Foundation | Biomolecule detection apparatus using micropore |
| US20220314219A1 (en) * | 2021-03-31 | 2022-10-06 | Korea University Research And Business Foundation | Device for analyzing single cell using micropores |
Also Published As
| Publication number | Publication date |
|---|---|
| GB202318250D0 (en) | 2024-01-10 |
| DE102023133432A1 (de) | 2024-06-06 |
| JP2024081540A (ja) | 2024-06-18 |
| US20240183769A1 (en) | 2024-06-06 |
| CN118150410A (zh) | 2024-06-07 |
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