CN118105372A - 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 - Google Patents
小分子PI4KIIIα抑制剂组合物、其制备方法及用途 Download PDFInfo
- Publication number
- CN118105372A CN118105372A CN202311755839.1A CN202311755839A CN118105372A CN 118105372 A CN118105372 A CN 118105372A CN 202311755839 A CN202311755839 A CN 202311755839A CN 118105372 A CN118105372 A CN 118105372A
- Authority
- CN
- China
- Prior art keywords
- pao
- pharmaceutical composition
- alkyl
- oil
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/285—Arsenic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2019/094831 | 2019-07-05 | ||
| CN2019094831 | 2019-07-05 | ||
| PCT/CN2020/100377 WO2021004422A1 (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
| CN202080049288.5A CN114555056B (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080049288.5A Division CN114555056B (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118105372A true CN118105372A (zh) | 2024-05-31 |
Family
ID=74115038
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311755839.1A Pending CN118105372A (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
| CN202080049288.5A Active CN114555056B (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080049288.5A Active CN114555056B (zh) | 2019-07-05 | 2020-07-06 | 小分子PI4KIIIα抑制剂组合物、其制备方法及用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230115711A1 (https=) |
| EP (1) | EP3995134A4 (https=) |
| JP (1) | JP2022538505A (https=) |
| KR (1) | KR20220071175A (https=) |
| CN (2) | CN118105372A (https=) |
| AU (1) | AU2020309681A1 (https=) |
| BR (1) | BR112022000155A2 (https=) |
| CA (1) | CA3149104A1 (https=) |
| CO (1) | CO2022001218A2 (https=) |
| IL (1) | IL289586A (https=) |
| MX (1) | MX2022000287A (https=) |
| PE (1) | PE20220942A1 (https=) |
| PH (1) | PH12022550254A1 (https=) |
| TW (1) | TW202126294A (https=) |
| WO (1) | WO2021004422A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114685566A (zh) * | 2020-12-31 | 2022-07-01 | 江苏挪贝肽医药科技有限公司 | 氧化苯砷晶型i、晶型ii和晶型iii及其制备方法 |
| JP2024537837A (ja) * | 2021-09-30 | 2024-10-16 | ヌオ－ベータ・ファーマシューティカル・テクノロジー（シャンハイ）カンパニー・リミテッド | ハロゲン化フェニルアルシンオキシド化合物およびその用途 |
| CN116478954B (zh) * | 2023-02-14 | 2025-06-10 | 中国农业大学 | 水稻基因OsPI4K及其在水稻抗稻瘟病中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002365110A1 (en) * | 2001-07-10 | 2003-07-15 | Massachusetts Institute Of Technology | Small molecule microarrays |
| EP2316943B1 (en) * | 2007-07-05 | 2013-06-19 | Novartis AG | DSRNA for treating viral infection |
| WO2016172952A1 (zh) * | 2015-04-30 | 2016-11-03 | 江苏挪贝肽医药科技有限公司 | PI4KIIIα蛋白及相关的膜蛋白复合体在治疗阿尔茨海默病中的应用 |
| CN112437674A (zh) * | 2018-04-11 | 2021-03-02 | 新墨西哥科技大学研究园公司 | 用于药物递送的脂质前药 |
| BR112022019864A2 (pt) * | 2020-03-31 | 2022-11-16 | Nuo Beta Pharmaceutical Tech Shanghai Co Ltd | Composto de oxofenilarsina deuterada e uso do mesmo |
| JP2024537837A (ja) * | 2021-09-30 | 2024-10-16 | ヌオ－ベータ・ファーマシューティカル・テクノロジー（シャンハイ）カンパニー・リミテッド | ハロゲン化フェニルアルシンオキシド化合物およびその用途 |
-
2020
- 2020-07-03 TW TW109122503A patent/TW202126294A/zh unknown
- 2020-07-06 KR KR1020227003749A patent/KR20220071175A/ko not_active Ceased
- 2020-07-06 CA CA3149104A patent/CA3149104A1/en active Pending
- 2020-07-06 BR BR112022000155A patent/BR112022000155A2/pt not_active Application Discontinuation
- 2020-07-06 JP JP2022526849A patent/JP2022538505A/ja active Pending
- 2020-07-06 PH PH1/2022/550254A patent/PH12022550254A1/en unknown
- 2020-07-06 CN CN202311755839.1A patent/CN118105372A/zh active Pending
- 2020-07-06 AU AU2020309681A patent/AU2020309681A1/en not_active Abandoned
- 2020-07-06 EP EP20836327.5A patent/EP3995134A4/en active Pending
- 2020-07-06 CN CN202080049288.5A patent/CN114555056B/zh active Active
- 2020-07-06 US US17/624,850 patent/US20230115711A1/en active Pending
- 2020-07-06 WO PCT/CN2020/100377 patent/WO2021004422A1/zh not_active Ceased
- 2020-07-06 MX MX2022000287A patent/MX2022000287A/es unknown
- 2020-07-06 PE PE2022000005A patent/PE20220942A1/es unknown
-
2022
- 2022-01-03 IL IL289586A patent/IL289586A/en unknown
- 2022-02-07 CO CONC2022/0001218A patent/CO2022001218A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020309681A1 (en) | 2022-02-24 |
| KR20220071175A (ko) | 2022-05-31 |
| CO2022001218A2 (es) | 2022-05-20 |
| IL289586A (en) | 2022-03-01 |
| WO2021004422A1 (zh) | 2021-01-14 |
| CA3149104A1 (en) | 2021-01-14 |
| JP2022538505A (ja) | 2022-09-02 |
| EP3995134A4 (en) | 2023-07-12 |
| MX2022000287A (es) | 2022-06-16 |
| US20230115711A1 (en) | 2023-04-13 |
| EP3995134A1 (en) | 2022-05-11 |
| CN114555056B (zh) | 2024-01-05 |
| TW202126294A (zh) | 2021-07-16 |
| PE20220942A1 (es) | 2022-05-31 |
| PH12022550254A1 (en) | 2023-06-26 |
| CN114555056A (zh) | 2022-05-27 |
| BR112022000155A2 (pt) | 2022-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |