CN118078885A - Externally applied medicine containing radix notoginseng for treating arthralgia - Google Patents
Externally applied medicine containing radix notoginseng for treating arthralgia Download PDFInfo
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Abstract
The invention discloses an external medicine containing pseudo-ginseng for treating arthralgia, which is prepared from the following components in parts by weight: 20-30 parts of pseudo-ginseng, 15-25 parts of angelica, 20-30 parts of ligusticum wallichii, 5-15 parts of aconite, 25-35 parts of mulberry twig, 10-20 parts of radix clematidis, 20-30 parts of notopterygium root, 15-25 parts of cassia twig, 15-25 parts of gentiana macrophylla, 20-30 parts of astragalus root, 15-25 parts of ginseng, 20-30 parts of poria cocos, 15-25 parts of epimedium, 10-20 parts of rhizoma cibotii, 15-25 parts of eucommia bark, 1-3 parts of musk, 15-25 parts of auxiliary materials of honey, 5-10 parts of sesame oil and 150-250 parts of water.
Description
Technical Field
The invention belongs to the field of pharmacy, and in particular relates to an external medicine containing pseudo-ginseng for treating arthralgia.
Background
Joint pain is a common chronic disease, which is common to the elderly, severely affects joint function and reduces quality of life. According to the traditional Chinese medicine, joint pain belongs to arthralgia, and arthralgia is mainly caused by invasion of exogenous evils such as wind cold, damp and heat into human meridians, cold or damp in the human body is heavier, joint pathology is easy to cause, joint pain and limited movement are likely to occur, and phenomena such as numbness and joint deformation are also caused if the joint pain is serious, so that normal work or life is influenced, and a doctor needs to be matched for positive conditioning, and recovery can be promoted. The traditional Chinese medicine also considers that the arthralgia syndrome is caused by wind, cold, dampness, heat evil, blockage of channels and collaterals and influence on qi and blood circulation. Therefore, it can be clinically classified into four types of wind-cold-dampness arthralgia in the acute stage, wind-damp-heat arthralgia, phlegm-stasis arthralgia in the chronic stage and deficiency of liver and kidney, and wind-cold-dampness arthralgia can be classified into migratory arthralgia, arthralgia and pain arthralgia according to the difference of the pathogenic factors perceived by wind-cold-dampness arthralgia. The arthralgia is caused by wind evil, and is characterized in that pain wander is used as a hot spot, arthralgia is caused by damp evil, acid pain is mainly caused by severe pain, and arthralgia is caused by cold evil, severe pain and fixed pain position. According to the course of the disease, it is divided into wind-cold-dampness arthralgia and wind-damp-heat arthralgia in the acute stage and also in the remission stage, or phlegm-stasis arthralgia in the sequelae stage, or liver and kidney deficiency type, and it is easy to transform into qi-blood deficiency arthralgia after long-term disease.
Disclosure of Invention
In order to overcome the defects of the prior art and solve the technical problems, the invention provides an external medicine containing pseudo-ginseng for treating arthralgia and a preparation method thereof. The external medicine of the invention adopts a pure traditional Chinese medicine formula, can be directly applied to joints, and the medicine effect directly reaches the joint injury part, thereby having the effects of activating blood circulation, reducing swelling and relieving pain.
In order to achieve the first object of the invention, the invention provides an external medicine containing radix notoginseng for treating arthralgia.
An external medicine containing pseudo-ginseng for treating arthralgia is prepared from the following components in parts by weight: 20-30 parts of pseudo-ginseng, 15-25 parts of angelica sinensis, 20-30 parts of ligusticum wallichii, 5-15 parts of aconite, 25-35 parts of mulberry twig, 10-20 parts of radix clematidis, 20-30 parts of notopterygium root, 15-25 parts of cassia twig, 15-25 parts of large-leaf gentian root, 20-30 parts of astragalus root, 15-25 parts of ginseng, 20-30 parts of poria cocos, 15-25 parts of epimedium, 10-20 parts of rhizoma cibotii, 15-25 parts of eucommia bark and 1-3 parts of musk.
The external medicine containing pseudo-ginseng for treating arthralgia is prepared from the following components in parts by weight: 25 parts of pseudo-ginseng, 20 parts of angelica sinensis, 25 parts of ligusticum wallichii, 10 parts of aconite, 30 parts of mulberry twig, 15 parts of radix clematidis, 25 parts of notopterygium root, 20 parts of cassia twig, 20 parts of large-leaf gentian root, 25 parts of astragalus root, 20 parts of ginseng, 25 parts of poria cocos, 20 parts of epimedium herb, 15 parts of rhizoma cibotii, 20 parts of eucommia ulmoides and 2 parts of musk.
The external medicine containing pseudo-ginseng for treating arthralgia is prepared from the following components in parts by weight: 20 parts of pseudo-ginseng, 25 parts of Chinese angelica, 20 parts of szechuan lovage rhizome, 15 parts of aconite root, 25 parts of mulberry twig, 20 parts of Chinese clematis, 20 parts of incised notopterygium rhizome, 25 parts of cassia twig, 15 parts of large-leaf gentian root, 30 parts of astragalus root, 15 parts of ginseng, 30 parts of Indian buead, 15 parts of epimedium herb, 20 parts of east Asian tree fern rhizome, 15 parts of eucommia bark and 3 parts of musk.
The second object of the present invention is to provide an external medicine for treating arthralgia containing pseudo-ginseng, the preparation method comprises the following steps:
(1) Weighing Chinese medicinal decoction pieces of radix Notoginseng, radix Angelicae sinensis, rhizoma Chuanxiong, radix Aconiti lateralis Preparata, ramulus Mori, radix Clematidis, rhizoma Et radix Notopterygii, ramulus Cinnamomi, radix Gentianae Macrophyllae, radix astragali, radix Ginseng, poria, herba Epimedii, rhizoma Cibotii, and cortex Eucommiae according to the weight ratio, mixing, placing into a container, adding oleum Sesami into the container, soaking for seven days, heating to boil, keeping boiling until the medicinal materials are golden yellow, removing the fire, removing the residues, placing the oil at room temperature, adding Moschus of the fine powder, mixing, and stirring;
(2) Taking a certain amount of vaseline, heating and melting the vaseline, and cooling for later use;
(3) And (3) adding the mixture obtained in the step (1) into the cooled Vaseline obtained in the step (2) according to the principle of a small amount of a plurality of times, stirring uniformly, and then continuously cooling to obtain the ointment.
The externally applied medicine containing pseudo-ginseng for treating arthralgia is in the form of ointment.
The externally applied medicine containing pseudo-ginseng for treating arthralgia belongs to qi-blood deficiency arthralgia.
Notoginseng radix is a plant of Panax of Araliaceae, is a special rare Chinese medicinal material, and is one of the earliest medicinal and edible plants in China. Pseudo-ginseng has been recognized as having remarkable effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain since ancient times, and has the reputation of 'Stephania sinica Diels' and 'Nanguo Shencao'. Because the branches are divided into three branches and seven pieces, the branches are called pseudo-ginseng, stephania sinica Diels and the like, and the branches are also called Zhaoshen, xueshen, ginseng radix pseudo-ginseng, tianqi, shan Cao, sanqi ginseng and the like in ancient times. It is usually collected in two seasons of spring and winter, and is classified into "spring seven" and "winter seven". The pseudo-ginseng has special requirements on the growing environment conditions, and is suitable for the ecological environment which is warm in winter and cool in summer, is not resistant to severe cold and heat, and is loving in half a yin and moist. The notoginseng has good hemostatic effect, and can obviously shorten bleeding and blood coagulation time, and researches show that the hemostatic component of the notoginseng is mainly Dencichine (DENCICHINE).
Notoginseng radix is a traditional Chinese medicinal material, and has the main chemical components of triterpenes and polysaccharides, and has effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and removing toxic substances. Notoginseng radix has effects of relieving pain and detumescence by promoting blood circulation, improving microcirculation, and reducing inflammatory reaction.
Radix Angelicae sinensis is dry root of Angelica sinensis ANGELICA SINENSIS (Oliv.) Diels of Umbelliferae. The main production of Gansu southeast is rich in Min county yield and good in quality, and the second is Yunnan, sichuan, shaanxi, hubei and other provinces, which are all cultivated. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. It is commonly used for sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, pyocutaneous disease, and constipation due to intestinal dryness.
Ligusticum wallichii is a plant cultivated in Ligusticum of Umbelliferae, and has developed rhizome to form irregular nodular fist-shaped lump; the stem is upright, cylindrical and provided with longitudinal stripes; the upper part is multi-branched, and the lower stem node is expanded to be disc-shaped; the flowering period is 7-8 months, and the young fruit period is 9-10 months. The Ligusticum wallichii has strong and special fragrance, bitter and pungent taste, slightly sweet taste and tingling tongue feeling. Chuan Xiong is mainly produced in Sichuan and cultivated in Yunnan, guizhou, guangxi and other places. Ligusticum wallichii is not cold-resistant, generally grows in a mild and moist environment, and is suitable for being planted in loose, fertile, well-drained neutral or slightly acidic sandy loam rich in humus; mainly depends on the breeding of poria cocos. Ligusticum wallichii is firstly carried in decoction Ben Cao (herbal medicine), and is recorded in decoction Ben Cao (herbal medicine) of Ben Jing (pharmacopoeia), and can be used for activating blood and promoting qi, dispelling wind and relieving pain, and has certain curative effects on symptoms such as headache, irregular menstruation, activating blood and promoting qi.
Radix Aconiti lateralis is processed product of radix Aconiti lateralis Aconitum carmichaelii Debx of Ranunculaceae. Digging in the last ten days of 6 to 8 months to remove mother root, fibrous root and sediment, known as "mud Fuzi". Pungent and sweet in flavor, and big in heat. It enters heart, kidney and spleen meridians. The composition has effects of restoring yang, rescuing collapse, nourishing fire, supporting yang, dispelling cold and relieving pain. Can be used for treating yang depletion, deficiency of cold limbs, heart yang deficiency, chest pain, emesis and diarrhea due to deficiency-cold, abdominal pain, kidney yang deficiency, sexual impotence, cold womb, edema due to cold, yang deficiency exogenous pathogenic factor, and cold-dampness arthralgia.
Ramulus Mori is dry tender branch of Morus alba L. Collected in the early spring and summer, removed from leaves, dried in the sun, or sliced and dried in the sun. Slightly bitter in flavor and neutral in nature. Enter liver meridian. Has effects in dispelling pathogenic wind and dampness, and benefiting joint. Can be used for treating rheumatalgia, and soreness and numbness of shoulder and arm and joint.
Radix Clematidis is dried root and rhizome of radix Clematidis CLEMATIS CHINENSIS Osbeck, clematis (Leptoradix Clematidis) Clematis hexapetala pall, or clematis chinensis Clematis manshurica rupr. Collected in autumn, removed the silt, dried in the sun. Pungent and salty in flavor and warm in nature. Enter bladder meridian. Dispel wind-damp, and unblock the channels and collaterals. Can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexing and extending.
Notopterygium incisum is an umbrella-type plant of Notopterygium, perennial herb, 60-120 cm high, strong in rhizome, and bamboo-shaped in elongation. The root neck is provided with a wilt leaf sheath. The stem is upright, cylindrical, hollow, has vertical fine stripes and is purple. It has warm nature, and can be used for relieving exterior syndrome, dispelling cold, and eliminating cold dampness, and can be used for treating wind cold, headache, perspiration, arthralgia due to cold dampness, and rheumatalgia of upper limbs.
Ramulus Cinnamomi belongs to Cinnamomum, lauraceae, and is a medium-sized arbor; annual branches are cylindrical, the terminal buds are in a scale wide oval shape, green leaves grow mutually, and the shape of each annual branch is oblong to be nearly in a needle shape; white flower, about 4.5mm long; the fruits are oval, black and purple when ripe, and have no hair; flowering period is 6-8 months, and fruit period is 10-12 months. Mainly produced in Guangxi, guangdong and Yunnan provinces. Cutting off tender branch in spring and summer, sun drying or drying in shade, and cutting into slices or segments. Pungent, sweet and warm. It enters heart, lung and bladder meridians. Has effects of inducing sweat, relieving muscle, warming and activating meridian, supporting yang, activating qi-flowing, and calming the pulse. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, etc.
The radix Gentianae Marcrophyllae is dry root of Gentiana Marcrophyllae Gentiana macroph μlla pall. Of Gentianaceae, gentiana Marcrophyllae GENTIANA STRAMINEA maxim. Of Gentiana Marcrophyllae GENTIANA CRAS-sicaulis Duthie ex Burk. Or Gentiana Marcrophyllae Gentiana dahurica Fisch. Pungent and bitter in flavor and neutral in nature. It enters stomach, liver and gallbladder meridians. Dispel wind-damp, clear damp-heat, stop arthralgia, dispel deficiency-heat. Can be used for treating rheumatalgia, apoplexy, hemiplegia, spasm of tendons and vessels, joint pain, jaundice due to damp-heat, hectic fever due to bone steaming, infantile malnutrition, and fever.
The radix astragali is root of Astragalus mongholicus Astragalus memeranaceus (Fisch.) bge. Var. Mongholicus (bge.) Hsiao or Astragalus membranaceus A.membrane aceus (Fisch.) bge. In Astragalus of Leguminosae. Has effects of invigorating spleen, invigorating middle warmer, invigorating yang, consolidating superficial resistance, promoting urination, removing toxic substances, and promoting granulation. It is indicated for spleen qi deficiency, lung qi deficiency, spontaneous perspiration due to qi deficiency, qi and blood deficiency, and sores and ulcers, or chronic ulcer.
The Ginseng radix is root of Ginseng radix of Araliaceae. The root contains various ginsenosides. Warm nature, sweet, slightly bitter and slightly warm. Enter spleen and lung meridian. Warm nature, sweet, slightly bitter and slightly warm. Enter spleen and lung meridian. To strengthen primordial qi, recover pulse, arrest excessive loss, invigorate spleen, benefit lung, promote fluid production and tranquilize the mind. Can be used for treating asthenia, listlessness, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, asthma, cough, and thirst due to body fluid deficiency.
Poria is the dry sclerotium of Wolf, a fungus of the Polyporaceae family, poria cocos (Schw.) co. Digging for more than 7-9 months, removing sediment after digging out, piling up for "sweating", spreading out and airing until the surface is dry, then "sweating", repeating for several times until most of internal moisture is lost, and drying in the shade, namely "Fuling Zhi"; or cutting fresh Poria into pieces according to different parts, and drying in the shade, which are called "Poria block" and "Poria tablet", respectively. Sweet and light in taste and neutral in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and excrete dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Herba Epimedii, also known as herba Epimedii, just before, is listed as a middle energizer product in Shennong Ben Cao Jing, has effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness, and can be used for treating sexual impotence, spermatorrhea, flaccidity of tendons and bones, rheumatalgia, numbness and contracture caused by deficiency of kidney yang, and is a common clinical traditional Chinese medicine.
The rhizoma Cibotii is a perennial large fern plant of Cibotium of Umbelliferae. The rhizome can be used as medicine. According to the description of "herbal Renewness": "Jianshenxue, tonify Qi". It has bitter and sweet taste, warm nature, and has effects of nourishing liver and kidney, strengthening waist and knee, dispelling pathogenic wind and dampness, and can be used for treating lumbago, strong ridge, joint discomfort, soreness of waist and back, urinary incontinence, female leukorrhagia, etc. caused by liver and kidney deficiency and pathogenic wind-cold-dampness.
Eucommia ulmoides is bark of eucommia ulmoides Oliver belonging to family Eucommiaceae. To protect resources, a local peeling method is generally used. Selecting plants growing for more than 15-20 years from Qingming to summer, peeling off bark, peeling off coarse bark, and sun drying according to the specification and size of medicinal materials. And (5) placing the product at a ventilation drying place. The main functions are as follows: liver and kidney tonifying, tendons and bones strengthening, miscarriage preventing. For soreness and pain of waist and knees, weakness of feet and knees, dribbling urine, itching of yin, abortion, fetal movement, and hypertension. ① Book of changes: pain in the back, strengthening the middle-jiao, replenishing vital essence, strengthening tendons and bones, strengthening the mind, removing itching and dampness, and removing dribbling urine. ② The miscellaneous records: soreness and pain in the main foot, not to trample the ground. ③ Drug Property theory (L): for kidney cold and hip lumbago, the patient with waist deficiency with body rigidity and wind. It is used for treating lumbar dysplasia. ④ Japanese Sunji (Japanese Subtu) grass: for kidney fatigue and lumbar spinal contracture. It is used after being stir-baked. ⑤ Wang Haogu: moisten liver and dry, nourish liver meridian and wind deficiency. ⑥ Ben Cao Zheng (Ben Cao Zheng): stop nocturnal emission, warm uterus, an Taiqi. ⑦ Medicine solution of Aronia melanocarpa: has effects in invigorating liver and kidney, nourishing tendons and bones, and eliminating joint dampness. For soreness of waist and knees, contracture of legs and feet. ⑧ Materia medica re-establishment: the muscles and tendons are filled and the yang channel is strengthened.
Musk is the dried secretion of deer in the natural musk MoschusberezovskiiFlerov, ma She M.sifaniacus Przewalski or raw musk M.Moschifferus Linnaeus mature male body sachet. Has effects of inducing resuscitation, refreshing mind, promoting blood circulation, dredging channels, and relieving swelling and pain. Is mainly used for treating the symptoms of closed form unconsciousness, sores and ulcers, swelling and toxicity, scrofula, phlegm nodule, sore throat, blood stasis, amenorrhea, abdominal pain, heart and abdomen sudden pain, headache, traumatic injury, wind-cold-dampness arthralgia, difficult delivery, stillbirth and no loss of cell cover.
The arthralgia due to qi and blood deficiency is caused by the long-term cure of arthralgia, light and heavy time, and severe time when flexing and stretching or the convulsion and jumping of tendons and flesh. Pale complexion, heart beat, debilitation, short breath, spontaneous perspiration, lean muscle, anorexia, loose stool. A pale tongue with white or no coating and a soft or weak or fine pulse. And (3) pathogenesis analysis: the arthralgia syndrome is long-term, the deficiency of qi and blood, the lingering of pathogenic qi and tendons and bones, and the aching pain and the muscle and muscle being vigilant. At this time, joint muscle pain is not severe, but soreness remains. Meanwhile, because of deficiency of both qi and blood, invasion of exogenous evil is easy to occur, or wind-cold-dampness evil is seriously felt due to careless protection, wind-cold-dampness evil is caused, arthralgia recurs, and the pain is a syndrome of excess of pathogenic factors of vital qi deficiency. The qi-blood deficiency arthralgia is mainly formed by deficiency of qi and blood of a body, or blood loss, or yang deficiency of spleen and kidney, or after long-term illness, or after long-term arthralgia.
"Yizongbi read-Bi: for arthralgia syndrome, wind dispelling is mainly used, cold and dampness resisting and damp eliminating are not wasted, and blood replenishing agents are mainly used for treating wind, and blood is treated first, and blood is self-killed; for pain arthralgia, it is mainly dispelling cold, but not necessary to dispel wind and dry dampness, and is mainly used as a fire-replenishing agent, not being Xin Dawen, but failing to release the harm of congealing cold; for arthralgia syndrome, it is essential to dispel wind and cold for diuresis, and mainly takes as the recipe for tonifying spleen and qi, so that the earth can dispel dampness, and qi and foot are not stubborn. "Zhang Lu" Zhang Shi Yitong "also describes: "gout-treating" means "Ling Pi" means "Equisetum wind", "su-Wen" means "Bi-syndrome", and "jin Kui" means "Ming Jie and" Ji Jie ", and" Ji Bai Hu Jie "means" for the later generation. While the etiology and pathogenesis of the Chinese medicinal composition are basically the same, the "disease is caused by wind-cold-dampness, deficiency and attack on the channels and collaterals and stagnation of qi and blood". The first method of the invention adopts the methods of removing blood stasis, stopping bleeding, relieving swelling and pain, nourishing blood and activating blood. Meanwhile, due to qi and blood deficiency arthralgia accompanied with yang deficiency, traditional Chinese medicines for warming channels to dispel cold and dredging and opening arthralgia are adopted to release congealing cold. The body's wei yang is not fixed, so that the striae and striae are empty and dredged, wind evil is in deficiency and enters fur, muscle and channels and collaterals, wind nature is in a series, and the wind evil is also in a yang evil, so that the channels are not communicated, qi and blood are blocked, joint pain occurs, and the movement is inconvenient, so that the effects of dispelling wind, dispelling cold and eliminating dampness are adopted. Because spleen and stomach are the acquired root, spleen and earth are strong to remove dampness, and the spleen is used for invigorating qi and strengthening spleen. The chronic disease has the defects of yang qi deficiency, weak superficial and defensive qi and easy invasion of exogenous evil, so the bone joint is painful, and the time is light and rapid; the long-term retention of pathogenic qi and blood failing to nourish, so that the joints are hard and deformed, the joints are painful, the waist is painful, and the tendons and bones are atrophic; waist is the house of kidney, knee is the house of tendons, soreness and weakness of waist and knee, even hunchback, and prolonged disease with liver and kidney deficiency, liver and kidney deficiency should be treated by warming and nourishing liver and kidney.
The invention adopts pseudo-ginseng, angelica and szechuan lovage rhizome for removing blood stasis and stopping bleeding, relieving swelling and pain, nourishing blood and activating blood, and the aconite root, mulberry twig and clematis root for dredging and removing arthralgia, and warming channel and dispelling cold, which are all monarch drugs; notopterygii rhizoma, ramulus Cinnamomi, and radix Gentianae Marcrophyllae for dispelling pathogenic wind, dispelling cold and eliminating dampness; astragalus root, ginseng and poria cocos are used as ministerial drugs for tonifying qi and strengthening spleen; herba Epimedii, rhizoma Cibotii, and Eucommiae cortex can warm and nourish liver and kidney; the musk is used as a guiding drug for warming the blood, and the musk is used as an external preparation for treating joint pain caused by qi and blood deficiency arthralgia, and the external preparation is prepared from the whole formula of pseudo-ginseng, angelica, ligusticum wallichii, aconite, mulberry twig, clematis root, notopterygium root, cassia twig, gentiana macrophylla, astragalus root, ginseng, poria cocos, epimedium, rhizoma cibotii, eucommia ulmoides and musk.
Detailed Description
The application is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. Further, it is understood that various changes and modifications of the present application may be made by those skilled in the art after reading the description of the present application, and that such equivalents are intended to fall within the scope of the application as defined in the appended claims.
Example 1:
250g of pseudo-ginseng, 200g of Chinese angelica, 250g of szechuan lovage rhizome, 100g of aconite, 300g of mulberry twig, 150g of clematis root, 250g of notopterygium root, 200g of cassia twig, 200g of large-leaf gentian root, 250g of astragalus root, 200g of ginseng, 250g of poria cocos, 200g of epimedium herb, 150g of rhizoma cibotii, 200g of eucommia bark and 20g of musk are taken, and the preparation method comprises the following steps:
(1) Weighing Chinese medicinal decoction pieces of radix Notoginseng, radix Angelicae sinensis, rhizoma Chuanxiong, radix Aconiti lateralis Preparata, ramulus Mori, radix Clematidis, rhizoma Et radix Notopterygii, ramulus Cinnamomi, radix Gentianae Macrophyllae, radix astragali, radix Ginseng, poria, herba Epimedii, rhizoma Cibotii, and cortex Eucommiae according to the weight ratio, mixing, placing into a container, adding oleum Sesami into the container, soaking for seven days, heating to boil, keeping boiling until the medicinal materials are golden yellow, removing the fire, removing the residues, placing the oil at room temperature, adding Moschus of the fine powder, mixing, and stirring;
(2) Taking a certain amount of vaseline, heating and melting the vaseline, and cooling for later use;
(3) And (3) adding the mixture obtained in the step (1) into the cooled Vaseline obtained in the step (2) according to the principle of a small amount of a plurality of times, stirring uniformly, and then continuously cooling to obtain the ointment.
Example 2:
200g of pseudo-ginseng, 250g of angelica, 200g of ligusticum wallichii, 150g of aconite, 250g of mulberry twig, 200g of radix clematidis, 200g of notopterygium root, 250g of cassia twig, 150g of large-leaf gentian root, 300g of astragalus root, 150g of ginseng, 300g of poria cocos, 150g of epimedium herb, 200g of rhizoma cibotii, 150g of eucommia bark and 30g of musk are taken, and the preparation method comprises the following steps:
(1) Weighing Chinese medicinal decoction pieces of radix Notoginseng, radix Angelicae sinensis, rhizoma Chuanxiong, radix Aconiti lateralis Preparata, ramulus Mori, radix Clematidis, rhizoma Et radix Notopterygii, ramulus Cinnamomi, radix Gentianae Macrophyllae, radix astragali, radix Ginseng, poria, herba Epimedii, rhizoma Cibotii, and cortex Eucommiae according to the weight ratio, mixing, placing into a container, adding oleum Sesami into the container, soaking for seven days, heating to boil, keeping boiling until the medicinal materials are golden yellow, removing the fire, removing the residues, placing the oil at room temperature, adding Moschus of the fine powder, mixing, and stirring;
(2) Taking a certain amount of vaseline, heating and melting the vaseline, and cooling for later use;
(3) And (3) adding the mixture obtained in the step (1) into the cooled Vaseline obtained in the step (2) according to the principle of a small amount of a plurality of times, stirring uniformly, and then continuously cooling to obtain the ointment.
Example 3:
300g of pseudo-ginseng, 150g of Chinese angelica, 300g of szechuan lovage rhizome, 50g of aconite, 350g of mulberry twig, 100g of Chinese clematis, 300g of incised notopterygium rhizome, 150g of cassia twig, 250g of large-leaf gentian root, 200g of astragalus root, 250g of ginseng, 200g of Indian buead, 250g of epimedium herb, 100g of east Asian tree fern rhizome, 250g of eucommia bark and 10g of musk are taken, and the preparation method comprises the following steps:
(1) Weighing Chinese medicinal decoction pieces of radix Notoginseng, radix Angelicae sinensis, rhizoma Chuanxiong, radix Aconiti lateralis Preparata, ramulus Mori, radix Clematidis, rhizoma Et radix Notopterygii, ramulus Cinnamomi, radix Gentianae Macrophyllae, radix astragali, radix Ginseng, poria, herba Epimedii, rhizoma Cibotii, and cortex Eucommiae according to the weight ratio, mixing, placing into a container, adding oleum Sesami into the container, soaking for seven days, heating to boil, keeping boiling until the medicinal materials are golden yellow, removing the fire, removing the residues, placing the oil at room temperature, adding Moschus of the fine powder, mixing, and stirring;
(2) Taking a certain amount of vaseline, heating and melting the vaseline, and cooling for later use;
(3) And (3) adding the mixture obtained in the step (1) into the cooled Vaseline obtained in the step (2) according to the principle of a small amount of a plurality of times, stirring uniformly, and then continuously cooling to obtain the ointment.
Example 4: anti-swelling test
The inhibition of ear swelling in mice by each example group was determined using a model of ear swelling caused by mouse xylene, and the specific method was as follows:
100 healthy Kunming mice are taken, the male and female mice are half, 0.1mL of dimethylbenzene is uniformly coated on the front and rear sides of the left auricle of the mice to cause inflammation, the swelling condition of the left auricle of the mice is observed after 1h, and after successful modeling, the 100 mice are randomly divided into five groups, including an example 1 group, an example 2 group, an example 3 group, a blank control group and a positive control group (white vein ointment), and each group comprises 20 mice. The corresponding ointments are respectively smeared on the mouse inflammatory auricles of the corresponding groups, the blank control group is smeared with normal saline, and the positive control group is smeared on the mouse inflammatory auricles after 0.5g of white vein ointment (produced by Tibet Qizhen Tibetan medicine Co., ltd.) is evenly mixed. After 3 hours, the cervical vertebrae of the mice were dislocation and death, two ears were cut off along the auricle base line, one ear piece was respectively punched out at the same position with a punch with a diameter of 7mm, immediately weighed on an analytical balance, the difference (Δmg) between the weights of the two ear pieces was calculated to reflect the swelling degree, and the swelling inhibition rate was calculated.
The results of ear swelling inhibition% = (average swelling degree of control group-average swelling degree of administration group)/average swelling degree of control group x 100% are shown in table 1.
TABLE 1 Effect of the invention on model of ear swelling due to mouse xylene
Group of | n | Swelling degree (mg) | Swelling inhibition ratio (%) |
Blank control group | 20 | 7.28±3.12 | --- |
Positive control group | 20 | 5.36±2.47 | 26.37 |
Example 1 group | 20 | 3.49±2.18** | 52.06 |
Example 2 group | 20 | 4.12±2.43** | 43.40 |
Example 3 group | 20 | 3.76±2.67** | 48.35 |
P <0.05, P <0.01 compared to the placebo group
From the above experiments, the ear swelling caused by the paraxylene in examples 1-3 has a remarkable inhibiting effect, which shows that the Chinese medicinal ointment has anti-swelling and anti-inflammatory effects, and the inhibiting rate is obviously higher than that of a positive control group.
Example 5: clinical study
1. Clinical study subjects: 200 patients, 96 men and 104 women. Age 45-81 years, mean 61 years. The course of the disease ranges from 8 months to 20 years, and is on average 6.5 years, and all cases suffer from joint pain. The symptoms of the arthralgia are manifested by joint pain, mild and severe symptoms, severe symptoms of the arthralgia, or convulsions and jumping of the muscles and tendons. Pale complexion, heart beat, debilitation, short breath, spontaneous perspiration, lean muscle, anorexia, loose stool. A pale tongue with white or no coating and a soft or weak or fine pulse. The treatment effect on joint pain was observed by randomly dividing the ointment of the present invention (example 1) and the positive control ointment (white vein ointment (tibetan-Tibetan medicine Co., ltd.)). The white vein ointment contains turmeric, rhizoma nardostachyos, artificial musk and other components, has the effects of promoting blood circulation, relaxing tendons, activating collaterals, promoting qi circulation, relieving pain, eliminating dampness and detumescence, and can obviously improve local pain and swelling or symptoms such as skin bluish purple, limb joint flexion and extension discomfort and the like.
2. The treatment method comprises the following steps: the ointment is uniformly applied to the joint for 1 time a day and 15 days as a treatment course.
3. Standard of efficacy: is formulated according to the traditional Chinese medicine diagnostic curative effect standard formulated by the national administration of medicine.
(1) And (3) healing: symptoms such as pain disappear, joint movement is normal, and main physical and chemical examination indexes are normal;
(2) Has obvious effect of relieving pain at joints within 1 week, and eliminating partial symptoms or main symptoms;
(3) The pain at the joint is relieved within 1 month, and the main symptoms are improved;
(4) It is ineffective that pain at the joint cannot be relieved, and the main symptoms and joint movement are not obviously improved.
4. The treatment results are shown in Table 2.
Table 2 statistical table of clinical efficacy for each trial group
Group of | Healing of the wound | Has obvious effect | Effective and effective | Invalidation of | Total effective rate (%) |
Example 1 group | 32 | 27 | 32 | 9 | 91 |
Positive control group | 12 | 18 | 38 | 32 | 68 |
As can be seen from Table 2, after 15 days of treatment, the total effective rate of the ointment of the present invention for patients is 91% higher than that of the positive medicine, which indicates that the traditional Chinese medicine ointment of the present invention has better effect in treating osteoarthritis.
Typical cases: some men, 60 years old, had repeated episodes of general joint pain for 5 years, heavy limbs, morning stiffness, impaired flexion and extension of joints, and exacerbation with cold. Clinically, it is indicated for arthralgia due to deficiency of qi and blood, with symptoms of mild and severe symptoms, and with symptoms of muscle and tendon with symptoms of convulsion, pale complexion, heart beat, debilitation, short breath, spontaneous perspiration, lean muscle, anorexia, and loose stool. A pale tongue with white coating and a soft and weak pulse. The ointment of the embodiment 1 of the invention has no obvious effect for more than one year after taking the traditional Chinese medicine, and has the advantages of one treatment course, arthralgia, disappearance of symptoms of morning stiffness, recovery of functions, and continuous consolidation of the medicine for two treatment courses, and no recurrence after follow-up.
Somewhere left, women, age 48. The lower limb joint pain and swelling are aggravated in the case of overcast and rainy days, the disease is repeatedly caused, the clinical diagnosis is that the qi and blood deficiency is arthralgia, the symptoms are that the joint pain is light and heavy, the bending and stretching are very serious, the face is yellow and shiny, the heart is hypodynamia, short qi, spontaneous perspiration, lean muscle, poor appetite, loose stool, pale tongue, no fur and fine pulse, and the joint pain of a patient is relieved and the swelling disappears after the external ointment of the embodiment 1 of the invention is used for treating for one month later. With two courses of treatment, all symptoms disappear and the patient is cured.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. An externally applied medicine containing pseudo-ginseng for treating arthralgia is characterized by comprising the following components in parts by weight: 20-30 parts of pseudo-ginseng, 15-25 parts of angelica sinensis, 20-30 parts of ligusticum wallichii, 5-15 parts of aconite, 25-35 parts of mulberry twig, 10-20 parts of radix clematidis, 20-30 parts of notopterygium root, 15-25 parts of cassia twig, 15-25 parts of large-leaf gentian root, 20-30 parts of astragalus root, 15-25 parts of ginseng, 20-30 parts of poria cocos, 15-25 parts of epimedium, 10-20 parts of rhizoma cibotii, 15-25 parts of eucommia bark and 1-3 parts of musk.
2. The external medicine containing pseudo-ginseng for treating arthralgia according to claim 1, which is characterized by comprising the following components in parts by weight: 25 parts of pseudo-ginseng, 20 parts of angelica sinensis, 25 parts of ligusticum wallichii, 10 parts of aconite, 30 parts of mulberry twig, 15 parts of radix clematidis, 25 parts of notopterygium root, 20 parts of cassia twig, 20 parts of large-leaf gentian root, 25 parts of astragalus root, 20 parts of ginseng, 25 parts of poria cocos, 20 parts of epimedium herb, 15 parts of rhizoma cibotii, 20 parts of eucommia ulmoides and 2 parts of musk.
3. The external medicine containing pseudo-ginseng for treating arthralgia according to claim 1, which is characterized by comprising the following components in parts by weight: 20 parts of pseudo-ginseng, 25 parts of Chinese angelica, 20 parts of szechuan lovage rhizome, 15 parts of aconite root, 25 parts of mulberry twig, 20 parts of Chinese clematis, 20 parts of incised notopterygium rhizome, 25 parts of cassia twig, 15 parts of large-leaf gentian root, 30 parts of astragalus root, 15 parts of ginseng, 30 parts of Indian buead, 15 parts of epimedium herb, 20 parts of east Asian tree fern rhizome, 15 parts of eucommia bark and 3 parts of musk.
4. The external medicine containing pseudo-ginseng for treating arthralgia as set forth in claim 1, wherein the preparation method comprises the following steps:
(1) Weighing Chinese medicinal decoction pieces of radix Notoginseng, radix Angelicae sinensis, rhizoma Chuanxiong, radix Aconiti lateralis Preparata, ramulus Mori, radix Clematidis, rhizoma Et radix Notopterygii, ramulus Cinnamomi, radix Gentianae Macrophyllae, radix astragali, radix Ginseng, poria, herba Epimedii, rhizoma Cibotii, and cortex Eucommiae according to the weight ratio, mixing, placing into a container, adding oleum Sesami into the container, soaking for seven days, heating to boil, keeping boiling until the medicinal materials are golden yellow, removing the fire, removing the residues, placing the oil at room temperature, adding Moschus of the fine powder, mixing, and stirring;
(2) Taking a certain amount of vaseline, heating and melting the vaseline, and cooling for later use;
(3) And (3) adding the mixture obtained in the step (1) into the cooled Vaseline obtained in the step (2) according to the principle of a small amount of a plurality of times, stirring uniformly, and then continuously cooling to obtain the ointment.
5. The topical formulation for treating joint pain comprising Panax notoginseng of claim 1, wherein the topical formulation is an ointment.
6. The external medicine for treating arthralgia containing pseudo-ginseng according to claim 1, wherein the arthralgia is a qi-blood deficiency arthralgia.
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