CN118059177A - A Chinese medicinal composition, acupoint patch for treating peripheral facial paralysis, and its preparation method - Google Patents
A Chinese medicinal composition, acupoint patch for treating peripheral facial paralysis, and its preparation method Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 208000004929 Facial Paralysis Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 239000011505 plaster Substances 0.000 claims abstract description 37
- 239000003814 drug Substances 0.000 claims abstract description 25
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 244000107975 Strychnos nux-vomica Species 0.000 claims abstract description 20
- 235000012907 honey Nutrition 0.000 claims abstract description 11
- 241000746716 Typhonium Species 0.000 claims abstract description 4
- 239000002674 ointment Substances 0.000 claims description 24
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- 241000316658 Sauromatum giganteum Species 0.000 claims 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00446—Plasters use for oriental medicine
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
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Abstract
The invention discloses a traditional Chinese medicine composition, an acupoint plaster for treating peripheral facial paralysis and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: equal amount of nux vomica and giant typhonium tuber, and proper amount of white honey. The traditional Chinese medicine composition has simple composition, the nux vomica has the effects of dredging collaterals, dissipating heat, removing blood stasis and relieving pain, the rhizoma typhonii has the effects of dispelling wind phlegm, arresting convulsion, removing toxin, resolving masses and relieving pain, and the white honey is used as a harmonizing agent on one hand and also has the effects of removing toxin on the other hand; after the three are combined, the effects of activating collaterals and relieving pain are achieved, and the Chinese medicinal composition has good effect on paralysis. When the Chinese medicinal composition is prepared into an acupoint plaster, the acupoint plaster is attached to at least one of Yifeng acupoint and Hegu acupoint; the external application is more convenient than the direct external application on the affected side surface part, and the trouble to the daily life is avoided; and the curative effect on peripheral facial paralysis is greatly improved.
Description
Technical Field
The invention belongs to the technical field of medicines, and in particular relates to a traditional Chinese medicine composition, an acupoint plaster for treating peripheral facial paralysis and a preparation method thereof.
Background
Facial paralysis, also known as facial paralysis, can be clinically divided into two types, peripheral facial paralysis and central facial paralysis. The peripheral facial nerve paralysis is generally injury of lower motor neurons, and is characterized in that forehead lines on one side become shallow or disappear, facial muscles on the whole same side are paralyzed, a patient cannot be wrinkled, eye fission is large, a mouth angle is sagged and is inclined to a healthy side, air leakage is obvious when the user wears a cheek, whistles cannot be blown, liquid flows out when the user eats, solids are easy to remain between cheeks and gums, and the patient is always accompanied with pain under the same side ears and at the angles of lower jaw.
The method for treating peripheral facial paralysis comprises external plaster, acupuncture, oral administration (including Chinese medicine and western medicine), etc. Among them, the topical plaster is popular because of small side effects.
The Chinese patent application with publication number CN114796324A discloses an external application traditional Chinese medicine ointment for treating facial paralysis, which comprises, by mass, 40-60 parts of rhizoma typhonii, 20-50 parts of stiff silkworm, 40-60 parts of scorpion, 40-80 parts of roasted nux vomica, 10-30 parts of cinnamon, 20-60 parts of bighead atractylodes rhizome, 10-35 parts of cassia twig, 10-35 parts of rhizoma corydalis, 15-40 parts of borneol, 30-60 parts of castor bean, 90-110 parts of sesame oil and 280-320 parts of honey.
The traditional Chinese medicine ointment is an improved prescription of Qianzheng powder (rhizoma typhonii, stiff silkworm and scorpion) and the use method is as follows: after the face is cleaned before sleeping every night, the ointment is externally applied to the affected side (namely the facial paralysis position), and the face is cleaned with clear water after the morning.
The traditional Chinese medicine ointment has the following defects: (1) The ointment is required to be directly applied to the side of a patient, and inconvenience is brought to the life of the patient no matter the patient takes medicine at night or takes medicine in the daytime; (2) The single use effect is not colorful, and acupuncture treatment is needed to be matched, however, the patient cannot perform acupuncture at home.
It is required to develop an ointment with good therapeutic effect and convenient use for treating peripheral facial paralysis.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition and an acupoint plaster for treating peripheral facial paralysis, the traditional Chinese medicine composition has good curative effect on the peripheral facial paralysis, and the traditional Chinese medicine composition is prepared into the acupoint plaster with better curative effect and more convenient use.
In order to achieve the above object, the present invention has the following technical scheme:
A traditional Chinese medicine composition consists of the following components: equal amount of nux vomica and giant typhonium tuber, and proper amount of white honey.
The traditional Chinese medicine composition only comprises nux vomica, rhizoma typhonii and white honey, and the prescription composition is simple; wherein, semen Strychni has effects of dredging collaterals, dispelling heat, removing blood stasis, and relieving pain, rhizoma Typhonii has effects of dispelling pathogenic wind phlegm, arresting convulsion, removing toxic substance, resolving hard mass, and relieving pain, and white Mel is used as harmonizing agent on one hand, and also has toxic substance removing effect on the other hand; after the three are combined, the effects of activating collaterals and relieving pain are achieved, and the Chinese medicinal composition has good effect on paralysis.
As a further preference, the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of nux vomica, 1 part of rhizoma typhonii and 1 part of white honey.
The invention also provides an acupoint plaster for treating peripheral facial paralysis, which is prepared from the traditional Chinese medicine composition; when in use, the Chinese medicinal composition is applied to Yifeng acupoint and Hegu acupoint. The invention discovers that when the traditional Chinese medicine composition is prepared into an acupoint plaster and is stuck to nebula acupoint and Hegu acupoint on the affected side, the plaster is more convenient than being directly externally applied to the affected side, and does not cause trouble to daily life; and the curative effect is greatly improved, and the traditional Chinese medicine takes effect in one week generally, and 90% of patients recover within 2 weeks.
The invention also provides a preparation method of the acupoint plaster, which comprises the following steps:
(1) Placing semen Strychni in water, boiling for 15-25min, removing skin, cleaning kernel, slicing, baking with slow fire, and grinding to obtain semen Strychni fine powder;
Preferably, boiling for 20min;
preferably, the particle size of the nux vomica powder is 50-100 mesh, more preferably 80 mesh;
(2) Mixing semen Strychni fine powder with white Mel to give a thin paste, decocting with slow fire for 10-20min to obtain thick paste, and air-drying;
Preferably, the mixture is decocted with slow fire for 15min;
(3) Pulverizing rhizoma Typhonii into powder, mixing with thick paste, and making into unguent; the ointment is coated on the ointment cloth, and the acupoint plaster is obtained;
preferably, the particle size of the rhizoma typhonii powder is 50-100 mesh, more preferably 80 mesh;
Preferably, each patch is coated with 0.1-0.3g of ointment.
Compared with the prior art, the invention has the beneficial effects that:
(1) The traditional Chinese medicine composition only comprises nux vomica, rhizoma typhonii and white honey, and the prescription composition is simple; wherein, semen Strychni has effects of dredging collaterals, dissipating heat and removing blood stasis, rhizoma Typhonii has effects of dispelling pathogenic wind phlegm, arresting convulsion, removing toxic substance and resolving hard mass, and relieving pain, while white Mel is used as harmonizing agent on one hand, and has toxic substance removing effect on the other hand; after the three are combined, the effects of activating collaterals and relieving pain are achieved, and the Chinese medicinal composition has good effect on paralysis.
(2) When in use, the acupoint plaster is attached to Yifeng acupoint and Hegu acupoint; the invention discovers that when the traditional Chinese medicine composition is prepared into an acupoint plaster and is stuck to nebula acupoint and Hegu acupoint on the affected side, the plaster is more convenient than being directly externally applied to the affected side, and does not cause trouble to daily life; and the curative effect on peripheral facial paralysis is greatly improved, and generally takes effect in one week, and 90% of patients recover in 2 weeks.
Drawings
FIG. 1 is a schematic diagram of the application of the acupoint plaster of the invention to Yifeng acupoint to treat peripheral facial paralysis;
fig. 2 is a schematic diagram of the application of the acupoint plaster of the present invention to the Hegu acupoint to treat peripheral facial paralysis.
Detailed Description
The technical scheme of the invention is further described in detail below with reference to the attached drawings and the detailed description.
Example 1
The acupoint plaster for treating peripheral facial paralysis is prepared by the following steps:
(1) Placing 500g of nux vomica in 3600mL of water, boiling for 20min, scraping off the outer skin while the nux vomica is hot, taking clean kernels, slicing, baking with slow fire, grinding, and sieving to obtain nux vomica fine powder with the particle size of 80 meshes;
(2) Mixing semen Strychni fine powder with 500 white Mel to obtain thin paste, decocting with slow fire for 15min to obtain thick paste, and air drying;
(3) Preparing 500g of rhizoma typhonii into powder with the particle size of 80 meshes, mixing into thick paste, and preparing into ointment; the acupoint plaster for treating peripheral facial paralysis of this example was obtained by applying 0.2g of the plaster to the center of the plaster.
Comparative example 1
The preparation method of the acupoint plaster in the embodiment is as follows:
(1) Placing 500g of nux vomica in 3600mL of water, boiling for 20min, scraping off the outer skin while the nux vomica is hot, taking clean kernels, slicing, baking with slow fire, grinding, and sieving to obtain nux vomica fine powder with the particle size of 80 meshes;
(2) Mixing semen Strychni fine powder with 500g white Mel to obtain thin paste, decocting with slow fire for 20min to obtain unguent, air-drying, and applying 0.2g unguent to the center of the plaster cloth to obtain the acupoint plaster of this comparative example.
Comparative example 2
The preparation method of the acupoint plaster in the embodiment is as follows:
Preparing 500g of rhizoma typhonii into powder with the particle size of 80 meshes, preparing into paste by using 500g of white honey, and coating 0.2g of paste in the center of paste cloth to obtain the acupoint plaster of the comparative example.
Comparative example 3
200G of giant typhonium rhizome, 200g of stiff silkworm and 100g of scorpion are dried to prepare powder with the particle size of 80 meshes, then 500g of white honey is used for preparing into paste, and 0.2g of paste is taken and coated in the center of paste cloth, thus obtaining the acupoint plaster of the comparative example.
Comparative example 4
The preparation method of the external ointment for treating peripheral facial paralysis is as follows:
(1) Placing 500g of nux vomica in 3600mL of water, boiling for 20min, scraping off the outer skin while the nux vomica is hot, taking clean kernels, slicing, baking with slow fire, grinding, and sieving to obtain nux vomica fine powder with the particle size of 80 meshes;
(2) Mixing semen Strychni fine powder with 500g white Mel to give a thin paste, decocting with slow fire for 15min to obtain a thick paste, and air-drying;
(3) 500g of rhizoma typhonii is prepared into powder with the particle size of 80 meshes, and then mixed into thick paste to prepare the ointment of the comparative example.
28 Patients with peripheral facial paralysis (patients aged between 35 and 75 years) were treated by using the acupoint pastes prepared in example 1 and comparative examples 1-3, respectively, according to the following treatment methods: the acupoint plaster is applied to the affected Yifeng acupoint and Hegu acupoint for 2 times per week, each time for 72 hours, 7 days is a treatment course.
Treatment of 28 patients with peripheral facial paralysis (patients aged between 39 and 72 years) with the ointment of comparative example 4: the ointment is applied to the affected side face before sleeping every day, and is cleaned next morning, and 7 days is a treatment course.
The treatment of all patients was counted and the results are shown in tables 1 and 2.
Table 1 treatment of the acupoint plaster of example 1 and the plaster of comparative example 4
As can be seen from Table 1, when the ointment is applied to the nebula and the Hegu acupoints, the effective rate and the cure rate are both greatly improved and the recurrence rate within 2 years is also greatly reduced, compared with the case that the ointment is directly applied to the face. Especially when the ointment is simultaneously applied to the nebula acupoint and the valley-closing acupoint, not only the obvious efficiency and the cure rate reach 100%, but also 92.9% of patients can be cured within two courses of treatment, and the course of the disease is short; the recurrence rate was only 3.7% within 2 years.
Table 2 treatment of the acupoint plaster of comparative examples 1-3 (applied to Yifeng acupoint and Hegu acupoint)
As can be seen from table 2, the therapeutic effects of the prescriptions of comparative examples 1, 2 and 3 are all greatly reduced compared with the prescription of example 1, the highest effective rate is only 50% and the highest recovery rate is only 42.9% after treatment for six courses of treatment; of the patients who heal, up to 50% of the patients relapse within 2 years, and the treatment is incomplete.
Claims (10)
1. A Chinese medicinal composition is characterized by comprising the following components: equal amount of nux vomica and giant typhonium tuber, and proper amount of white honey.
2. The traditional Chinese medicine composition according to claim 1, which comprises the following components in parts by weight: 1 part of nux vomica, 1 part of rhizoma typhonii and 1 part of white honey.
3. An acupoint plaster for treating peripheral facial paralysis, characterized by being prepared from the traditional Chinese medicine composition according to claim 1 or 2.
4. The acupoint plaster of claim 3, wherein the plaster is applied to at least one of the nebula acupoint and the Hegu acupoint in use.
5. A method of preparing an acupoint plaster according to claim 3, comprising the steps of:
(1) Placing semen Strychni in water, boiling for 15-25min, removing skin, cleaning kernel, slicing, baking with slow fire, and grinding to obtain semen Strychni fine powder;
(2) Mixing semen Strychni fine powder with white Mel to give a thin paste, decocting with slow fire for 10-20min to obtain thick paste, and air-drying;
(3) Pulverizing rhizoma Typhonii into powder, mixing with thick paste, and making into unguent; and (3) coating the ointment on an ointment cloth to obtain the acupoint plaster.
6. The method according to claim 5, wherein in the step (1), the mixture is boiled for 20 minutes.
7. The method of claim 5, wherein in step (1), the particle size of the fine powder of nux vomica is 50 to 100 mesh.
8. The method according to claim 5, wherein in the step (2), the mixture is decocted with slow fire for 15min.
9. The process according to claim 5, wherein in step (3), the particle size of the typhonium giganteum powder is 50-100 mesh.
10. The method of claim 5, wherein in step (4), each patch is coated with 0.1-0.3g of ointment.
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