CN117925383A - Microorganism separation device for drug microorganism detection - Google Patents

Abstract

The invention provides a microbial separation device for drug microbial inspection, which relates to the technical field of microbial inspection, wherein a separation device body comprises a centrifugal mechanism, a separation assembly and a dialysis assembly, a top plate is arranged at the top of the centrifugal mechanism, a transmission box is arranged on the surface of the top plate, stand columns are connected to the bottoms of two sides of the top plate, a bottom plate is arranged at the bottoms of the stand columns, a collection bin is arranged in the middle of the bottom plate, a discharge pipeline is arranged at the bottom of the separation assembly, the bottom of the centrifugal mechanism is inserted into an embedded groove, and a plurality of dialysis assemblies are arranged at the edge of the centrifugal mechanism in an inclined state.

Description

Microorganism separation device for drug microorganism detection

Technical Field

The invention relates to the technical field of microorganism detection, in particular to a microorganism separation device for drug microorganism detection.

Background

The microbial detection of medicines mainly comprises sterility test and microbial limit test, and microbial detection plays an important role in product quality control and product research and development, and relates to the fields and fields, and has an important role in laboratory detection, and the microbial detection generally measures the microbial quantity from indexes such as weight, volume, density or concentration of samples, and the like, and the microbial detection of medicines needs to be carried out before separation treatment.

In the prior art, a microorganism separation device for drug microorganism detection separates a solution containing drug microorganisms by a filter membrane in a direct filtration mode, but the filter membrane in the scheme has low filtration speed, so that the separation efficiency is low, and a large number of microorganisms cannot be effectively separated; or after centrifugal sedimentation, the microorganism after sedimentation is separated, the scheme improves the separation efficiency, but the supernatant liquid part and the sedimentation part still need to be separated manually after centrifugal sedimentation, the operation difficulty of the process is high, and the separated supernatant liquid still needs to be repeatedly centrifuged for a plurality of times to thoroughly separate the microorganism inside.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a microorganism separation device for drug microorganism detection, so as to solve the problems in the prior art.

In order to achieve the above object, the present invention is realized by the following technical scheme: the utility model provides a microorganism separator for medicine microbiological inspection, includes the separator body, the separator body includes centrifuge, separation subassembly and dialysis subassembly, the roof is installed at centrifuge's top, the surface mounting of roof has the transmission case, the both sides bottom of roof is connected with the stand, the bottom plate is installed to the bottom of stand, collection storehouse has been placed to the centre of bottom plate, separation subassembly's bottom is provided with discharge pipe, discharge pipe's end embeds the inside of collecting the storehouse, the embedded groove has been seted up on separation subassembly's top, centrifuge's bottom inserts the inside of embedded groove, centrifugal dish is installed to centrifuge's bottom, dialysis subassembly installs the inside at centrifugal dish, and dialysis subassembly outwards wears out from centrifugal dish's top.

Further, the centrifugal mechanism comprises a driven shaft and a centrifugal disc, wherein the bottom of the driven shaft is fixedly connected with the middle of the surface of the centrifugal disc, a centrifugal channel is formed in the centrifugal disc, and a supernatant discharging channel and a microorganism discharging channel are arranged at the tail end of the centrifugal channel.

Further, the centrifugal channels are provided with a plurality of, each centrifugal channel is uniformly distributed around the middle position of the centrifugal disc, the inside of the driven shaft is of a hollow structure, the inside of the driven shaft is mutually communicated with the inside of each centrifugal channel, the supernatant discharging channel and the centrifugal channels are positioned on the same horizontal straight line, and the whole microorganism discharging channel is inclined downwards.

Further, the motor is installed at the top of transmission case, the drive shaft is installed to the output of motor, the surface cover of drive shaft is equipped with the driving gear, the top cover of driven shaft is equipped with injection pipeline, the circulating pump has been placed on the surface of roof.

Further, one side of the circulating pump is connected with a backflow pipeline, the tail end of the backflow pipeline is communicated with the side edge of the injection pipeline, and an injection port is formed in the top of the injection pipeline.

Further, the surface mounting of driven shaft has driven gear, driving gear and driven gear mesh mutually, injection pipe's bottom and the top swing joint of driven shaft, the side of circulating pump is connected with and draws out the pipeline, the end of drawing out the pipeline is linked together with the inside bottom of collecting the storehouse, the top of driven shaft is connected with the roof through the bearing.

Further, the dialysis subassembly includes frame and dialysis membrane, the dialysis membrane is installed in the bottom of frame, the top of frame is connected with the fixed plate, the inside of centrifugal disk is all embedded with the state of slope to frame and dialysis membrane whole.

Further, the end of the centrifugal channel is provided with a shunt opening, the frame and the dialysis membrane pass through from the inside of the shunt opening, the surface of the fixing plate is provided with a pull ring, and the fixing plate is fixed on the surface of the centrifugal disc by using screws.

Further, the separation assembly comprises a butt joint bin and an electric lifting rod, the bottom of the butt joint bin is connected with a diversion bin, the side edge of the diversion bin is provided with a supporting plate, the top of the electric lifting rod is fixed below the supporting plate, an embedded groove is formed in the butt joint bin, and an annular butt joint port is formed in the inner wall of the embedded groove.

Further, the discharge pipeline is connected to the bottom end of the diversion bin, the edge of the centrifugal disk is attached to the inner wall of the embedded groove, and the annular opposite joint is aligned with the supernatant discharge channel or the microorganism discharge channel.

The invention has the beneficial effects that:

1. According to the microbial separation device for drug microbial inspection, the plurality of dialysis components are arranged at the edge of the centrifugal mechanism in an inclined state, so that in the subsequent high-speed rotation process of the centrifugal disk, the microbial precipitation part can be directly guided to the lower part by means of the dialysis components, and finally, the primary separation process of microbial precipitation and the supernatant part can be completed in the centrifugal process, and the subsequent separation steps are simplified.

2. This a microorganism separator for medicine microorganism inspection installs separation subassembly in centrifugal mechanism's side, through separation subassembly's elevating movement, can carry out circulation flow with the inside supernatant part of centrifugal mechanism, consequently under the condition that does not stop centrifugal movement, carries out multiple circulation dialysis treatment to the supernatant fast, has further improved the microorganism separation effect to in the microorganism solution.

3. This a little biological separation device for medicine microorganism inspection accomplishes the centrifugation processing of supernatant part after the centrifugation many times, can directly collect the back with the help of the collection storehouse of bottom and discharge, then continue to move down with the help of the separation subassembly, can lead into the inside of collection storehouse with the microorganism part after the sediment and collect the processing, whole separation process microorganism solution is in the inside of centrifuge constructs and separation subassembly all the time, need not carry out extra separation processing after taking out, the risk of being polluted has been reduced, and the efficiency of separation has been improved, the degree of difficulty of manual operation has been reduced.

Drawings

FIG. 1 is a schematic structural view showing the outline of a microorganism separating apparatus for drug microorganism test according to the present invention;

FIG. 2 is a schematic illustration of the connection between the centrifuge mechanism and the interior of the power case of the present invention;

FIG. 3 is a side cross-sectional view of a centrifuge disk of the present invention;

FIG. 4 is a schematic view of a portion of a separator assembly according to the present invention;

FIG. 5 is an internal cross-sectional view of the separation assembly of the present invention;

FIG. 6 is a split view of a dialysis assembly portion of the present invention;

in the figure: 1. a bottom plate; 2. a column; 3. a top plate; 4. a transmission case; 5. a circulation pump; 6. a centrifugal mechanism; 7. a separation assembly; 8. a dialysis assembly; 9. a motor; 10. a drive shaft; 11. a drive gear; 12. a driven shaft; 13. a driven gear; 14. an injection conduit; 15. an injection port; 16. a return line; 17. a centrifugal disc; 18. a supernatant discharge channel; 19. a microorganism discharge passage; 20. a centrifugal channel; 21. a shunt port; 22. a butt joint bin; 23. an embedding groove; 24. a ring-shaped interface; 25. a supporting plate; 26. an electric lifting rod; 27. a diversion bin; 28. a discharge pipe; 29. a collecting bin; 30. drawing out the pipeline; 31. a fixing plate; 32. a pull ring; 33. a frame; 34. and (3) dialyzing the membrane.

Detailed Description

The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.

Referring to fig. 1 to 6, the present invention provides the following technical solutions: a microorganism separating device for drug microorganism inspection comprises a separating device body, wherein the separating device body comprises a centrifugal mechanism 6, a separating component 7 and a dialysis component 8, a top plate 3 is arranged at the top of the centrifugal mechanism 6, a transmission case 4 is arranged on the surface of the top plate 3, stand columns 2 are connected to the bottoms of two sides of the top plate 3, a bottom plate 1 is arranged at the bottom of the stand columns 2, a collecting bin 29 is arranged in the middle of the bottom plate 1, a discharge pipeline 28 is arranged at the bottom of the separating component 7, the tail end of the discharge pipeline 28 is embedded into the collecting bin 29, an embedded groove 23 is formed at the top end of the separating component 7, the bottom of the centrifugal mechanism 6 is inserted into the embedded groove 23, a centrifugal disc 17 is arranged at the bottom end of the centrifugal mechanism 6, the dialysis component 8 is arranged in the centrifugal disc 17, and the dialysis component 8 outwards penetrates out from the top end of the centrifugal disk 17, when the microbial separation device for drug microbial detection is used, liquid medicine is partially conveyed into the centrifugal mechanism 6 from the injection port 15 at the top of the injection pipeline 14, then the motor 9 at the top is started, the whole centrifugal mechanism 6 can be driven to rotate at a high speed by means of the transmission case 4, in the rotating process, centrifugal treatment of the liquid medicine storage part in the centrifugal disk 17 is realized, microorganisms in the liquid medicine are further precipitated, the precipitation part and the supernatant part are separated by means of the supernatant liquid discharge channel 18 and the microbial discharge channel 19 at the tail end of the centrifugal channel 20, and finally the supernatant liquid and the precipitation part are independently led out by means of the cooperation of the separation component 7 until the subsequent repeated separation process is completed.

In this embodiment, the centrifugal mechanism 6 includes a driven shaft 12 and a centrifugal disk 17, the bottom of the driven shaft 12 is fixedly connected with the middle of the surface of the centrifugal disk 17, a centrifugal channel 20 is provided in the interior of the centrifugal disk 17, a supernatant discharge channel 18 and a microorganism discharge channel 19 are provided at the end of the centrifugal channel 20, the centrifugal channels 20 are provided in a plurality, each centrifugal channel 20 is uniformly distributed around the middle position of the centrifugal disk 17, the interior of the driven shaft 12 is in a hollow structure, the interior of the driven shaft 12 is mutually communicated with the interior of each centrifugal channel 20, the supernatant discharge channel 18 and the centrifugal channel 20 are positioned on the same horizontal straight line, and the microorganism discharge channel 19 is integrally inclined downwards. By mounting the plurality of dialysis members 8 in an inclined state at the edge of the centrifugal mechanism 6, the microbial precipitation portion can be directed to the lower side by means of the dialysis members 8 in the subsequent high-speed rotation of the centrifugal disk 17, and finally the preliminary separation process of the microbial precipitation and the supernatant portion can be completed in the centrifugation process, simplifying the subsequent separation steps.

Specifically, after the liquid medicine is injected into the centrifugal channel 20 inside the centrifugal disc 17 through the driven shaft 12, the liquid medicine is centrifugally treated inside the centrifugal channel 20 along with the high-speed rotation of the centrifugal disc 17, the centrifugal action precipitates the microorganism part, and after the microorganism part is accumulated on the surface of the dialysis component 8, the microorganism precipitation part can be blocked, and then the microorganism discharge channel 19 part facing the bottom is collected, while the supernatant part enters the supernatant discharge channel 18 and the centrifugal channel 20, and then the supernatant and the precipitate are sequentially separated by controlling the separation component 7.

In this embodiment, motor 9 is installed at the top of transmission case 4, drive shaft 10 is installed to the output of motor 9, drive shaft 10's surface cover is equipped with driving gear 11, driven shaft 12's top cover is equipped with injection pipeline 14, circulating pump 5 has been placed on the surface of roof 3, one side of circulating pump 5 is connected with backflow pipeline 16, backflow pipeline 16's end is linked together with injection pipeline 14's side, injection port 15 has been seted up at injection pipeline 14's top, driven shaft 12's surface mounting has driven gear 13, driving gear 11 meshes with driven gear 13, injection pipeline 14's bottom and driven shaft 12's top swing joint, circulating pump 5's side is connected with and draws pipeline 30, draw pipeline 30's end and collection bin 29's inside bottom are linked together, driven shaft 12's top is connected with roof 3 through the bearing. The separation assembly 7 is arranged on the side edge of the centrifugal mechanism 6, and the supernatant liquid part inside the centrifugal mechanism 6 can be circularly flowed through the lifting movement of the separation assembly 7, so that the supernatant liquid can be rapidly subjected to repeated circulating dialysis treatment under the condition that the centrifugal movement is not stopped, and the microbial separation effect on a microbial solution is further improved.

Specifically, after the motor 9 is started, the motor 9 drives the driving shaft 10 to rotate, the driving shaft 10 drives the driving gear 11 on the surface to rotate, the driven gear 13 on the driven shaft 12 is matched with the driving gear 11 to rotate, and then the centrifugal disc 17 at the bottom can be rotated at a high speed, and the top end of the driven shaft 12 is supported by the top plate 3 through the bearing, so that only the rotation movement is performed, and the liquid medicine injected from the injection port 15 can flow into the driven shaft 12 downwards from the inside of the injection pipeline 14.

In this embodiment, the dialysis unit 8 includes a frame 33 and a dialysis membrane 34, the dialysis membrane 34 is attached to the bottom of the frame 33, the top end of the frame 33 is connected with a fixing plate 31, the whole of the frame 33 and the dialysis membrane 34 is embedded into the centrifugal disk 17 in an inclined state, the end of the centrifugal channel 20 is provided with a shunt opening 21, the frame 33 and the dialysis membrane 34 pass through the shunt opening 21, the surface of the fixing plate 31 is provided with a pull ring 32, and the fixing plate 31 is fixed on the surface of the centrifugal disk 17 by using screws.

Specifically, through the above-mentioned centrifugation process, after pushing the liquid medicine towards the end in the inside of centrifugal passageway 20, can contact with dialysis subassembly 8 part, insert dialysis membrane 34 to the end of centrifugal passageway 20 through the form of slope insertion in the dialysis subassembly 8, therefore the liquid medicine can block microorganism sediment part by dialysis membrane 34 to enter into the microorganism discharge channel 19 of slope, and dialysis membrane 34 can carry out synchronous rotation along with centrifugal disk 17, can realize carrying out separation treatment to the liquid medicine in the in-process of centrifugation.

In this embodiment, the separation assembly 7 includes butt joint storehouse 22 and electric lift pole 26, the bottom of butt joint storehouse 22 is connected with water conservancy diversion storehouse 27, the side of water conservancy diversion storehouse 27 is provided with layer board 25, the below at layer board 25 is fixed at the top of electric lift pole 26, embedded groove 23 has been seted up to the inside of butt joint storehouse 22, annular butt joint mouth 24 has been seted up to the inner wall of embedded groove 23, discharge tube 28 connects in the bottom of water conservancy diversion storehouse 27, the edge of centrifugal disk 17 laminates with the inner wall of embedded groove 23 mutually, annular butt joint mouth 24 is aligned with supernatant discharge channel 18 or microorganism discharge channel 19 part. After the centrifugal separation treatment of the supernatant liquid part for many times is completed, the supernatant liquid can be directly collected by the collecting bin 29 at the bottom and then discharged, and then the precipitated microorganism part can be continuously led into the collecting bin 29 to be collected by the downward movement of the separating component 7, so that the microorganism solution in the whole separating process is always in the centrifugal mechanism 6 and the separating component 7, and the additional separating treatment is not needed after the separation is carried out, so that the pollution risk is reduced, the separating efficiency is improved, and the manual operation difficulty is reduced.

Specifically, in the centrifugal state, the annular opposite port 24 is located at the top of the supernatant discharge channel 18, at this time, the ends of the supernatant discharge channel 18 and the microorganism discharge channel 19 are plugged, after centrifugation is completed, the electric lifting rod 26 is controlled to move downwards, the annular opposite port 24 can be aligned with the end of the supernatant discharge channel 18, at this time, the supernatant filtered by the dialysis component 8 enters the inside of the diversion bin 27 from the annular opposite port 24, finally flows into the collection bin 29 at the bottom, and the collected supernatant flows into the centrifugal mechanism 6 again by means of the circulating pump 5 to repeat the centrifugal separation process, so that the separation effect on microorganisms in the liquid medicine can be improved, at last, the circulating pump 5 is stopped, the bottom of the collection bin 29 is opened, the flung supernatant can be discharged, the bottom of the collection bin 29 can be sealed after the supernatant is completely discharged, the annular opposite port 24 is controlled to move downwards again until the annular opposite port 24 is aligned with the microorganism discharge channel 19, at this time, the supernatant discharge channel 18 at the top is flung into the annular opposite port 19, and finally deposited in the annular opposite port 19 into the collection bin 29, and finally the microorganism discharge channel 19 is flung into the collection bin.

While the fundamental and principal features of the invention and advantages of the invention have been shown and described, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (10)

1. A microbial separation device for drug microbiological inspection, includes separator body, its characterized in that: the utility model provides a separating device body includes centrifuge constructs (6), separation subassembly (7) and dialysis subassembly (8), roof (3) are installed at the top of centrifuge constructs (6), the surface mounting of roof (3) has transmission case (4), both sides bottom of roof (3) is connected with stand (2), bottom plate (1) are installed to the bottom of stand (2), collection storehouse (29) have been placed in the centre of bottom plate (1), the bottom of separation subassembly (7) is provided with discharge pipe (28), the inside of collection storehouse (29) is inlayed to the end of discharge pipe (28), embedded groove (23) have been seted up on the top of separation subassembly (7), the inside of embedded groove (23) is inserted to the bottom of centrifuge constructs (6), centrifugal dish (17) are installed to the bottom of centrifuge constructs (6), dialysis subassembly (8) are installed in the inside of centrifugal dish (17), and outwards wear out from the top of centrifugal dish (17) dialysis subassembly (8).

2. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 1, wherein: the centrifugal mechanism (6) comprises a driven shaft (12) and a centrifugal disc (17), wherein the bottom of the driven shaft (12) is fixedly connected with the middle of the surface of the centrifugal disc (17), a centrifugal channel (20) is formed in the centrifugal disc (17), and a supernatant discharge channel (18) and a microorganism discharge channel (19) are arranged at the tail end of the centrifugal channel (20).

3. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 2, wherein: the centrifugal channels (20) are arranged in a plurality, each centrifugal channel (20) is uniformly distributed around the middle position of the centrifugal disc (17), the inside of the driven shaft (12) is of a hollow structure, the inside of the driven shaft (12) is mutually communicated with the inside of each centrifugal channel (20), the supernatant discharging channel (18) and the centrifugal channels (20) are positioned on the same horizontal line, and the microorganism discharging channel (19) is integrally inclined downwards.

4. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 2, wherein: the top of transmission case (4) is installed motor (9), drive shaft (10) are installed to the output of motor (9), the surface cover of drive shaft (10) is equipped with driving gear (11), the top cover of driven shaft (12) is equipped with injection pipe (14), circulating pump (5) have been placed on the surface of roof (3).

5. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 4, wherein: one side of the circulating pump (5) is connected with a backflow pipeline (16), the tail end of the backflow pipeline (16) is communicated with the side edge of the injection pipeline (14), and an injection port (15) is formed in the top of the injection pipeline (14).

6. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 5, wherein: the surface mounting of driven shaft (12) has driven gear (13), driving gear (11) and driven gear (13) mesh mutually, the bottom of injection pipeline (14) is connected with the top swing joint of driven shaft (12), the side of circulating pump (5) is connected with and takes out pipeline (30), the end of taking out pipeline (30) is linked together with the inside bottom of collecting bin (29), the top of driven shaft (12) is connected with roof (3) through the bearing.

7. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 2, wherein: the dialysis assembly (8) comprises a frame (33) and a dialysis membrane (34), the dialysis membrane (34) is attached to the bottom of the frame (33), the top end of the frame (33) is connected with a fixing plate (31), and the whole of the frame (33) and the dialysis membrane (34) is embedded into the centrifugal disc (17) in an inclined state.

8. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 7, wherein: the end of the centrifugal channel (20) is provided with a shunt opening (21), the frame (33) and the dialysis membrane (34) penetrate through the shunt opening (21), the surface of the fixing plate (31) is provided with a pull ring (32), and the fixing plate (31) is fixed on the surface of the centrifugal disc (17) by using screws.

9. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 7, wherein: the separation assembly (7) comprises a butt joint bin (22) and an electric lifting rod (26), a diversion bin (27) is connected to the bottom of the butt joint bin (22), a supporting plate (25) is arranged on the side edge of the diversion bin (27), the top of the electric lifting rod (26) is fixed below the supporting plate (25), an embedded groove (23) is formed in the butt joint bin (22), and an annular butt joint port (24) is formed in the inner wall of the embedded groove (23).

10. A microbiological separation device for microbiological testing of pharmaceuticals according to claim 9, wherein: the discharge pipeline (28) is connected to the bottom end of the diversion bin (27), the edge of the centrifugal disc (17) is attached to the inner wall of the embedded groove (23), and the annular opposite joint (24) is partially aligned with the supernatant discharge channel (18) or the microorganism discharge channel (19).