CN117898395A - Fermented composition and application thereof in preparation of product with bowel relaxing effect - Google Patents
Fermented composition and application thereof in preparation of product with bowel relaxing effect Download PDFInfo
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Abstract
The invention relates to the technical field of health-care food, in particular to a fermentation composition and application thereof in preparing products with the effect of relaxing bowel. The composition is prepared by taking peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice as raw materials and fermenting the raw materials by hericium erinaceus. The composition can obviously improve the propulsion rate of ink in intestinal tracts, obviously shorten the first granule black stool discharging time, obviously increase the number of black stool discharging granules for 6 hours and the weight of black stool discharging for 6 hours, and has obviously better cathartic effect than a hericium erinaceus fermented short formula composition 2 (compared with the raw materials of the invention, peach blossom and bitter apricot kernel are absent) and a hericium erinaceus fermented composition 3 (compared with the composition of the invention, the composition is not fermented), which indicates that all components in the composition have obvious synergism.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to a fermentation composition and application thereof in preparing products with the effect of relaxing bowel.
Background
With the rapid development of social economy, the life rhythm of the whole society is gradually accelerated, and the working pressure of people is increased. The daily diet and work and rest time of office workers are extremely irregular, so that sub-health phenomena such as gastrointestinal dysfunction and the like are more and more common, and particularly functional constipation seriously affects the life quality of people. Constipation refers to a condition in which feces is retained in the intestines for too long, the defecation period is prolonged, or the period is not long, but the feces is dry and hard to discharge, or the feces is not hard, but the feces is not smooth although the feces is intentional. The long-term dryness can be accompanied with symptoms such as abdominal distention, dry mouth, debilitation, listlessness and the like, and can also cause hemorrhoids, anal fissure, intestinal bleeding and polyp, and severe rectal neoplasm can also be caused. Other diseases such as hypertension, acute myocardial infarction, cerebrovascular accident, etc. can also be aggravated by difficult defecation. Currently, the main medicine adopted by Western medicine for treating constipation is an external dredging medicine, and the medicine is multipurpose enema. Enema is glycerol with high osmotic pressure, which can permeate water in intestinal wall into intestinal cavity, and glycerol has lubricating effect, so that it can relieve constipation. However, the side effect is that the intestinal wall is dry, and habitual constipation is caused by frequent use. The traditional Chinese medicine preparation for treating constipation in the market often contains purgative medicines such as rheum officinale, folium sennae, semen cassiae and the like, and as the medicines contain various anthraquinone glycoside components and tannin components, the anthraquinone glycoside components have purgative effects, and the tannin components have astringents and antidiarrheal effects, secondary constipation can be caused after long-term administration. Meanwhile, the medicine is bitter and cold, and can easily damage spleen and stomach after long-term administration, so that more side effects are caused, and diarrhea, abdominal pain, intestinal diseases and the like are even caused. Therefore, there is an urgent need to provide a composition which can effectively improve constipation symptoms, does not cause dependency, and has little side effects.
Disclosure of Invention
In view of this, the present invention provides a fermentation composition and its use in the preparation of a product having a bowel relaxing effect. The fermented composition has remarkable effect of relaxing bowel, can obviously improve constipation symptoms, can normally relieve constipation in a short time without dependence, and has small side effect.
In order to achieve the above object, the present invention provides the following technical solutions:
The fermentation composition is prepared by fermenting raw materials including peach blossom, rose, bitter apricot seed, red bean, polished round-grained rice and oat rice with edible fungi.
According to the medical and clinical experience of traditional Chinese medicine for treating constipation, peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice with the function of relaxing the bowels are combined, and hericium erinaceus with the digestion function is inoculated for fermentation, so that the fermentation composition is obtained. The fermented composition improves intestinal flora balance, and has effects of loosening bowel to relieve constipation.
Peach blossom is bitter in flavor and flat in nature. Has the effects of relieving constipation, inducing diuresis and relieving edema. Can be used for treating edema, ascites, constipation, and dryness. The Sheng Hui Fang is recorded in the book for dry feces blocking intestines and distending pain.
The flos Rosae Rugosae is dry bud of Rosa rugosa Thunb. Sweet and slightly bitter in flavor and warm in nature. Enter liver and spleen meridians. Has effects of strengthening liver, nourishing stomach, promoting blood circulation, regulating menstruation, loosening bowel to relieve constipation, resolving stagnation, and tranquilizing. Can relieve emotion, balance endocrine, supplement blood and qi, and treat constipation.
Semen Armeniacae amarum is dry mature seed of Prunus armeniaca L.var. Ansu maxim. Of Rosaceae, prunus sibirica Prunus sibirica L, prunus northwest Prunus mandshurica (maxim.) Koehne or Prunus armeniaca L. Has effects in lowering qi, relieving cough and asthma, and loosening bowel to relieve constipation. Can be used for treating cough, asthma, chest fullness, excessive phlegm, blood deficiency, fluid dryness, constipation, and intestinal dryness.
The semen Phaseoli is dry mature seed of semen Phaseoli Phaseolus calcaratus Roxb. Or semen Phaseoli Phaseolus angularisWight of Leguminosae. Sweet in flavor and neutral in nature. Has effects in invigorating spleen, promoting diuresis, dispelling blood stasis, and removing toxic substances.
The semen oryzae sativae L is seeds of grass plant of Gramineae. The Tang Dynasty medicine Jia Suo Simiao emphasizes in Qian jin Fang and Yi Zhi, polished round-grained rice can nourish stomach qi and grow muscles; the food-grade herbal medicine written in Qing dynasty Chai Yi also considers that the polished round-grained rice has good effects of tonifying spleen and stomach, nourishing five viscera and strengthening strength. Japonica rice is sweet in flavor and neutral in nature. Has effects in invigorating spleen and stomach, and relieving polydipsia. Modern researches have proved that the crude fiber molecules of the rice bran layer of the polished round-grained rice are helpful for gastrointestinal peristalsis and have good curative effects on stomach diseases, constipation, hemorrhoids and the like; semen oryzae Sativae can improve immunity, promote blood circulation, and reduce hypertension. In the invention, the polished round-grained rice is mainly produced in northeast China, and is also called northeast China rice.
Oat is the seed of the family Gramineae, oat (latin brand name: AVENA SATIVA l.). It is called brome and wild wheat in Ben Cao gang mu. Sweet and neutral in nature. Has effects in invigorating spleen, nourishing heart, and arresting sweating. The nutritional value is very high, and the water-soluble dietary fibers in oat are 4.7 times and 7.7 times that of wheat and corn respectively. The fat content is 4 times of that of rice, and the content of 8 amino acids and vitamin E required by human body is higher than that of rice and white flour. The nutritionist finds that oat is an ideal food for preventing atherosclerosis, hypertension and coronary heart disease. The health care food contains rich linoleic acid accounting for 35% -52% of total unsaturated fatty acid, has auxiliary curative effects on diabetes, fatty liver, constipation, edema, cardiovascular and cerebrovascular diseases and the like, and is beneficial to improving physical strength and prolonging life of middle-aged and elderly people.
The peach blossom and the rose flower contain a large amount of volatile oil, flavone, coumarin, trefoil, various vitamins and other nutrient substances, and the bitter apricot seed contains oil and fat components, so that the three foods and medicines can stimulate gastrointestinal peristalsis, promote defecation, discharge toxin in the body, relax bowels and reduce swelling. The red bean contains a large amount of proteins, polypeptides, fats and amino acids; semen oryzae Sativae and oat rice contain starch, protein, fat, dietary fiber, and B vitamins; the three foods have effects in invigorating spleen and stomach, promoting diuresis, relieving polydipsia, and preventing diabetes, tinea pedis, senile plaque, constipation, etc. Peach blossom is cold in nature, and can not be taken for a long time, and spleen and stomach can be injured after long-term taking; the rose is warm in nature and can alleviate bitter and cold property when combined with peach blossom; the rice flour, the polished round-grained rice and the oat rice are sweet in taste and flat in nature, can benefit spleen and stomach, the polished round-grained rice and the oat rice can provide carbon sources and vitamins for hericium erinaceus, the red bean can provide nitrogen sources for the hericium erinaceus, and after six medicinal and edible homologous substances are combined, the hericium erinaceus is inoculated for biological conversion, and saccharifying enzyme is produced to hydrolyze starch into nutrient substances such as glucose, so that the balance of intestinal flora can be improved, and the fermented product of the composition is pleasant in fragrance, can effectively regulate the digestion function of a human body, and can prevent and treat intractable constipation.
The invention takes peach blossom, rose, bitter apricot kernel, polished round-grained rice, oat rice and red bean as raw materials, and uses edible fungus (such as hericium erinaceus) with stomach strengthening and digestion promoting effects to carry out bioconversion to obtain the fermentation composition. After continuous oral gavage administration of the fermented composition to mice for one week, the constipation-relieving effect on constipation model mice was studied. The results show that the fermented composition has obvious effects of relaxing bowel, can obviously improve constipation symptoms, can normally relieve constipation in a short time, and has small side effects.
In the invention, the edible fungi comprise hericium erinaceus. The invention is not particularly limited to the specific source of the hericium erinaceus, and is edible and commonly used in the art. In a specific embodiment of the invention, hericium erinaceus is purchased from Fuzhdao (Jilin) biotechnology Co.
In the invention, the polished round-grained rice is soaked polished round-grained rice, and the oat rice is soaked oat rice.
In some embodiments, the dry weight mass ratio of peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice is (2-4): (2-4): (5-6): (5-6): (10-15): (68-74).
In some embodiments, the edible fungi are added in an amount of 10-12% of the total weight of the peach blossom, the rose, the bitter apricot kernel, the red bean, the polished round-grained rice and the oat rice, and the specific mass percentages can be 10%, 10.5%, 11%, 11.5% and 12%.
In some embodiments, the edible fungus is Hericium erinaceus, and the mass ratio of the peach blossom to the rose flower to the almond to the red bean to the rice to the oat to the Hericium erinaceus is 3:3:5:5:10:74:10.
In some embodiments, the edible fungus is Hericium erinaceus, and the mass ratio of the peach blossom to the rose flower to the almond to the red bean to the rice to the oat to the Hericium erinaceus is 4:4:6:6:12:68:10.
In some embodiments, the edible fungus is Hericium erinaceus, and the mass ratio of the peach blossom to the rose flower to the almond to the red bean to the rice to the oat to the Hericium erinaceus is 2:2:6:6:15:69:12.
The invention also provides a preparation method of the fermentation composition, which comprises the following steps:
Pulverizing flos persicae, flos Rosae Rugosae, semen Armeniacae amarum and semen Phaseoli, mixing with soaked semen oryzae Sativae and oat rice, sterilizing, cooling to room temperature, inoculating Hericium Erinaceus, and fermenting;
collecting fermentation products, drying and crushing to obtain the fermentation composition.
In some embodiments, the soaking is with water, to the extent that it is lightly crushed by hand;
The fermentation culture temperature is 28-32 ℃, and the culture time is 20-30 d generally until hyphae grow fully.
In some embodiments, the drying temperature is 50 ℃ to 75 ℃, specifically 50 ℃, 55 ℃, 60 ℃, 65 ℃, 70 ℃, 75 ℃.
The invention also provides application of the fermentation composition or the fermentation composition prepared by the preparation method in preparation of products with the effect of relaxing bowel.
The invention also provides a health food which comprises an effective amount of the fermentation composition and auxiliary materials acceptable in food.
The invention has no special requirement on auxiliary materials acceptable in food science, and can be added according to actual requirements by people in the field, wherein the common or common types can be used in the field, such as edible essence, sweetener, acidulant, filler, preservative and the like.
The health food can be any dosage form in the current health food field, including but not limited to pills, capsules, tablets, powder, granules, oral liquid or ointment and the like.
Each dosage form can be prepared by selecting proper acceptable auxiliary materials according to the actual requirement of the dosage form, which belongs to the conventional preparation technology of dosage forms in the field.
The invention takes peach blossom, rose, bitter apricot kernel, polished round-grained rice, oat rice and red bean as raw materials, and uses edible fungus (such as hericium erinaceus) with stomach strengthening and digestion promoting effects to carry out bioconversion to obtain the fermentation composition. The fermented composition is healthy and nutritious, has a certain health care effect, can relieve constipation through diet therapy, is safe and effective, improves the sub-health state of people, and is suitable for the masses to eat.
Detailed Description
The invention provides a fermentation composition and application thereof in preparing a product with the effect of relaxing bowel. Those skilled in the art can, with the benefit of this disclosure, suitably modify the process parameters to achieve this. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included in the present invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the invention can be practiced and practiced with modification and alteration and combination of the methods and applications herein without departing from the spirit and scope of the invention.
The raw materials adopted by the invention are all common commercial products and can be purchased in the market.
The invention is further illustrated by the following examples:
Example 1 preparation of fermentation composition
Screening flos persicae, flos Rosae Rugosae, semen Armeniacae amarum, semen Phaseoli, cleaning impurities such as dirt on surface with water, drying, and pulverizing into coarse powder. The northeast rice and oat rice are selected and washed with water, and soaked to the extent that they are lightly crushed by hand. Peach blossom: rose: bitter apricot kernel: red bean: polished round-grained rice: the oat rice is prepared from the following components in percentage by weight: 3:5:5:10:74, and sterilizing 50 min at 121 ℃. After cooling to room temperature 10% of the Hericium erinaceus strain was added. Placing the mixed raw materials into a sterile container, and sealing. Fermenting at 28deg.C until mycelia grow fully, collecting fermentation product, drying at 60deg.C, and pulverizing to obtain fermented composition.
Example 2 preparation of fermentation composition
Screening flos persicae, flos Rosae Rugosae, semen Armeniacae amarum, semen Phaseoli, cleaning impurities such as dirt on surface with water, drying, and pulverizing into coarse powder. The northeast rice and oat rice are selected and washed with water, and soaked to the extent that they are lightly crushed by hand. Peach blossom: rose: bitter apricot kernel: red bean: polished round-grained rice: the oat rice is prepared from the following components in percentage by weight: 4:6:6:12:68, and sterilizing at 126 deg.c for 40 min. After cooling to room temperature 10% of the Hericium erinaceus strain was added. Placing the mixed raw materials into a sterile container, and sealing. Fermenting at 30deg.C until mycelium grows fully, collecting fermentation product, drying at 70deg.C, and pulverizing to obtain fermented composition.
Example 3 preparation of fermentation composition
Screening flos persicae, flos Rosae Rugosae, semen Armeniacae amarum, semen Phaseoli, cleaning impurities such as dirt on surface with water, drying, and pulverizing into coarse powder. The northeast rice and oat rice are selected and washed with water, and soaked to the extent that they are lightly crushed by hand. Peach blossom: rose: bitter apricot kernel: red bean: polished round-grained rice: the oat rice is prepared from the following components in percentage by weight: 2:6:6:15:69, and sterilizing at 126 deg.c for 30 min. Cooling to room temperature, and adding 12% Hericium Erinaceus strain. Placing the mixed raw materials into a sterile container, and sealing. Fermenting at 32deg.C until mycelium grows, collecting fermentation product, drying at 75deg.C, and pulverizing to obtain fermented composition.
Test example 1 composition experiments on small intestine movement of mice
1. Method of
1.1 Composition and preparation thereof
Preparation of composition 1: a fermentation composition was prepared as in example 1 to give composition 1.
Preparation of composition 2: taking rose, red bean, polished round-grained rice and oat rice, and mixing the following components: red bean: polished round-grained rice: the dry weight mass ratio of oat rice is 3:5:10:74, sterilizing at 121deg.C for 50 min, cooling to room temperature, adding 10% Hericium Erinaceus strain, placing the mixed raw materials into a sterile container, sealing, culturing at 28deg.C until mycelium grows completely, collecting fermentation product, drying at 60deg.C, and pulverizing to obtain composition 2. Wherein the Hericium erinaceus strain is the same as in example 1.
Preparation of composition 3: peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice are taken according to the following weight percent: rose: bitter apricot kernel: red bean: polished round-grained rice: the oat rice mass ratio is 3:3:5:5:10:74, and pulverizing to obtain composition 3.
1.2 Small intestine exercise experiment
According to the "health food functional test and technical evaluation Specification" (2003 edition) laxative function test method. Mice were divided into 5 groups of 6 mice each, and divided into a blank control group, a model control group, an HF1 group (composition 1,3.32 g/kgBW), an HF2 group (composition 2,3.32 g/kgBW), and a ZH group (composition 3,3.32/kgBW) (corresponding to 10 times daily human dose) 3 administration groups. Samples of different concentrations were prepared daily with distilled water and given to animals by gavage at 20mL/kgBW, the blank and model controls were given the same volume of distilled water. Samples were continuously administered for 7 days. After 7 days of administration of the test sample, each group of mice fasted without water for 16 hours. The model control group and the three administration groups were given 5mg/kgBW (10 mL/kgBW) of compound diphenoxylate by intragastric administration, and the blank control group was given distilled water. After 0.5 hour of compound diphenoxylate administration, each administration group was respectively intragastrically administered with ink (containing 5% active carbon powder, 10% gum arabic) containing the corresponding test sample, and the blank control group and the model control group were administered with ink. Immediately removing cervical vertebrae to kill animals after 25 minutes, opening abdominal cavity to separate mesentery, cutting off the intestinal canal from the pylorus and the lower end to the ileocecum part, placing on a tray, gently pulling the small intestine into a straight line, measuring the length of the intestinal canal to be the total length of the small intestine, taking the front edge from the pylorus to the ink to be the pushing length of the ink, and calculating the pushing rate of the ink according to the following formula:
1.3 Statistical method
Statistical analysis using SPSS18.0 software, metering data results toThe expression, the comparison between the groups adopts a one-factor analysis of variance and the comparison between the groups adopts a t-test. The difference of P <0.05 is statistically significant.
1.4 Result determination
On the premise that the model is established, when the ink propelling rate of the mice in the test sample group is obviously higher than that of the mice in the model control group, the test result can be judged to be positive.
2. Results
As can be seen from table 1, compared with the blank control group, the ink propulsion length of the model control group is obviously shortened, the ink propulsion rate is obviously reduced (P < 0.05), and the small intestine peristalsis inhibition model is established; compared with the model control group, the ink propulsion length and the propulsion rate of each administration group of the tested sample are increased, wherein the ink propulsion rate of the HF1 group is extremely obviously different from that of the model control group (P < 0.01), the ink propulsion rate of the HF2 group is obviously different from that of the model control group (P < 0.05), and the ink propulsion rate and the ink propulsion length of the ZH group are not obviously different from those of the model control group (P > 0.05). And judging that the small intestine movement experiment result is positive according to the result judgment standard.
Table 1: effect of the composition on intestinal motility
Note that: # was P <0.05 with significant difference compared to the blank, ## was P <0.01 with very significant difference.
* Is significant difference P <0.05 compared to model group; ** P <0.01 is very significant for the difference.
3. Conclusion(s)
Mice were given once daily gavage by three dosing groups, HF1, HF2 and ZH, with gavage volumes of 20mL/kgBW, and the same volumes of distilled water by the blank and model control groups for 7 consecutive days. Under the experimental conditions, the result of the small intestine movement experiment is positive.
The higher the ink propelling rate is, the better the laxative effect is. The ink propulsion of both the HF1 and HF2 groups was significantly improved compared to the model group, with the HF1 group having a very significant difference (P < 0.01) from the model group and the HF2 group having a significant difference (P < 0.05) from the model group. While the ZH group was not significantly different from the model group (P > 0.05). The results show that the cathartic effect of the HF1 group is obviously better than that of the HF2 group and the ZH group.
Test example 2 measurement of the composition for the defecation time, the number of black bowel movement and the weight of black bowel movement in mice
1. Method of
1.1 Preparation of the composition
Preparation of composition 1: prepared as in example 1 to obtain composition 1.
Preparation of composition 2: taking rose, red bean, polished round-grained rice and oat rice, and mixing the following components: red bean: polished round-grained rice: the dry weight mass ratio of oat rice is 3:5:10:74, sterilizing at 121deg.C for 50 min, cooling to room temperature, adding 10% Hericium Erinaceus strain, placing the mixed raw materials into a sterile container, sealing, culturing at 28deg.C until mycelium grows completely, collecting fermentation product, drying at 60deg.C, and pulverizing to obtain composition 2. Wherein the Hericium erinaceus strain is the same as in example 1.
Preparation of composition 3: peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice are taken according to the following weight percent: rose: bitter apricot kernel: red bean: polished round-grained rice: the oat rice mass ratio is 3:3:5:5:10:74, and pulverizing to obtain composition 3.
1.2 Measurement of defecation time, number of black bowel movement particles and weight of black bowel movement
Mice were divided into 5 groups of 6 mice each, and divided into a blank control group, a model control group, an HF1 group (composition 1,3.32 g/kgBW), an HF2 group (composition 2,3.32 g/kgBW), and a ZH group (composition 3,3.32/kgBW) (corresponding to 10 times daily human dose) 3 administration groups. Samples of different concentrations were prepared daily with distilled water and given to animals by gavage at 20mL/kgBW, the blank and model controls were given the same volume of distilled water. Samples were continuously administered for 7 days. After 7 days of administration of the test sample, each group of mice was fasted without water withdrawal for 16 hours, the blank group was given distilled water, and the model control group and the three administration groups were given the compound diphenoxylate 10mg/kgBW (10 mL/kgBW) by intragastric administration. After 0.5h of compound diphenoxylate administration, each administration group was respectively gastrically administered with ink (containing 5% of activated carbon powder and 10% of gum arabic) containing the corresponding test sample, and the blank control group and the model control group were administered with ink, and animals were fed in single cages with normal drinking water. From the beginning of ink filling, black stool discharge time of the first grains of each animal, black stool discharge grain number in 6 hours and weight are recorded.
1.3 Statistical method
Statistical analysis using SPSS18.0 software, metering data results toThe expression, the comparison between the groups adopts a one-factor analysis of variance and the comparison between the groups adopts a t-test. The difference of P <0.05 is statistically significant.
1.4 Result determination
On the premise that the constipation model of the small intestine is established, the first grain of the mice in the test sample group has obviously shorter defecation time than the model control group, and the result of the index can be judged to be positive. The number of the black discharge excrement grains is obviously higher than that of a model control group within 6 hours, and the result of the index can be judged to be positive. The weight of the black stool discharged within 6 hours is obviously higher than that of a model control group, and the result of the index can be judged to be positive.
2. Results
As can be seen from table 2, the model control group had significantly longer first-grain urination time (P < 0.05) and significantly lower urination grain number and weight (P < 0.01) compared with the blank control group, indicating that the small intestine constipation model was established. Compared with the model control group, each administration group can obviously shorten the first granule of black stool discharging time and increase the number and weight of black stool discharging in 6 hours. Wherein, the first granule of the HF1 group has significant difference (P < 0.01) compared with the model control group, the black stool number and weight of the 6h group have significant difference (P < 0.05) compared with the model control group, and the ZH group has significant difference (P < 0.05) only in the first granule of the black stool number and weight of the HF2 group compared with the model control group. And judging that the results of the three indexes of the first black stool discharging time, the black stool discharging grain number and the black stool discharging weight are positive according to the result judging standard.
Table 2: influence of the composition on the first granule discharge time, the granule number and the weight of the black feces）
Note that: # was P <0.05 with significant difference compared to the blank, ## was P <0.01 with very significant difference.
* Is significant difference P <0.05 compared to model group; ** P <0.01 is very significant for the difference.
3. Conclusion(s)
The three administration groups of the composition, namely an HF1 group, an HF2 group and a ZH group, are administered to mice by intragastric administration once a day, the intragastric volume is 20mL/kgBW, and the same volume of distilled water is given to a blank control group and a model control group for 7 days. Under the experimental condition, the result of the index of the first granule of black stool discharging time is positive; the result of the index of the number of the black discharge particles is positive; the result of the index of the weight of the black stool is positive.
As can be seen from Table 2, composition 1 (HF 1 group) of the present invention significantly shortened the first-shot black stool time and significantly increased the 6-h black stool number and 6-h black stool weight, both with very significant differences (P < 0.01) compared to the model group. And compared with a model group, the composition 2 (HF 1 group) of the hericium erinaceus fermented lacking peach blossom and bitter apricot kernel has the advantages that the number of black discharge grains is increased remarkably only for 6 hours, the weight of black discharge grains is increased remarkably (P < 0.05), and the time for first grain black discharge is not obviously different (P > 0.05). The first granule of the composition 3 (ZH group) can significantly shorten the defecation time (P < 0.05), and the number of the 6h black stool particles and the weight of the 6h black stool are improved but have no significant difference (P > 0.05) compared with the model group. It is demonstrated that the cathartic effect of composition 1 of the present invention is significantly better than compositions 2 and 3.
From the results, the composition prepared by fermenting peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice serving as raw materials through hericium erinaceus can obviously improve the propulsion rate of ink in intestinal tracts, obviously shorten the black stool time of first grains, and obviously increase the black stool grain number and the black stool weight of 6 hours. The composition has the advantages that the cathartic effect of the composition is obviously better than that of a hericium erinaceus fermented short formula composition 2 (compared with the raw materials of the invention, peach blossom and bitter apricot kernel are absent), and a hericium erinaceus fermented composition 3 (compared with the composition of the invention, the composition is not fermented), and the composition has reasonable compatibility of all components, generates good synergistic effect and is indispensable.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (10)
1. The fermentation composition is characterized by being prepared by fermenting raw materials comprising peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice through edible fungi.
2. The fermentation composition of claim 1, wherein the polished round-grained rice is soaked polished round-grained rice and the oat rice is soaked oat rice.
3. The fermentation composition of claim 1, wherein the edible fungus comprises hericium erinaceus.
4. The fermented composition according to claim 1, wherein the dry weight mass ratio of peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice is (2-4): (2-4): (5-6): (5-6): (10-15): (68-74).
5. The fermented composition according to claim 1, wherein the edible fungi is added in an amount of 10-12% of the total weight of the peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice and oat rice.
6. The fermented composition according to any one of claims 1 to 5, wherein the edible fungus is hericium erinaceus, and the dry weight mass ratio of peach blossom, rose, bitter apricot kernel, red bean, polished round-grained rice, oat rice and hericium erinaceus is 3:3:5:5:10:74:10, or 4:4:6:6:12:68:10, or 2:2:6:6:15:69:12.
7. The method for producing a fermented composition according to any one of claims 1 to 6, comprising:
Pulverizing flos persicae, flos Rosae Rugosae, semen Armeniacae amarum and semen Phaseoli, mixing with soaked semen oryzae Sativae and oat rice, sterilizing, cooling to room temperature, inoculating Hericium Erinaceus, and fermenting;
collecting fermentation product, drying, pulverizing to obtain fermentation composition.
8. The method of claim 7, wherein the soaking is with water to the extent of lightly grinding by hand;
The temperature of the fermentation culture is 28-32 ℃ and the time is 20-30 d;
The drying temperature is 50-75 ℃.
9. Use of a fermentation composition as claimed in any one of claims 1 to 6 or a fermentation composition as obtainable by a process as claimed in any one of claims 7 to 8 in the preparation of a product having bowel relaxing properties.
10. A health food comprising the fermented composition of any one of claims 1 to 6 and a pharmaceutically acceptable adjuvant.
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