CN1218745C - Health food for protecting liver and adjusting blood fat and method for preparing the same - Google Patents
Health food for protecting liver and adjusting blood fat and method for preparing the same Download PDFInfo
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Abstract
The present invention relates to health food for protecting liver and regulating blood fat, which is composed of red sage root, peach kernels, Gynostemma pentaphylla, fermentation cordycepin fungus powder, chitosan, starch and dextrin; the present invention is a complex prescription of traditional Chinese medicine, which are used for realizing the organic combination of two health functions of protecting the liver and regulating the blood fat. The preparation method of the health food comprises the following steps: extracting the red sage root, the peach kernels and the Gynostemma pentaphylla by dynamic sub-boiling water, adding the chitosan so as to carry out flocculating sedimentation, and minutely filtering micropores; adding and mixing the fermentation cordycepin fungus powder, carrying out spray drying so as to obtain spraying drymeal, and adding the starch and the dextrin; carrying out mixing, granulation, desiccation, particle preforming and film coating so as to obtain tablets. The preparation method synthetically uses various kinds of advanced technology; compared with the tradition preparation method, the preparation method has the advantages of short production period, energy saving, environmental protection, high labour intensity, good product quality, etc., and the production period is shortened by more than one half.
Description
Technical field
The present invention relates to the health food of a kind of hepatoprotective and blood lipid regulation, especially about a kind of be the hepatoprotective of raw material and health food of blood lipid regulation and preparation method thereof with the Chinese medicine medicine.
Background technology
Along with China's rapid economic development, the raising of national life level, the adjustment of dietary structure, excessive consumption of alcohol and because in the food excessive albumen, lipid, saccharide to take in the disease and the potential hazard that bring more and more serious, as alcoholic liver, fatty liver, medicine liver etc.The patient of these diseases is more and more with relevant sub-health population, according to statistics, the pathogenesis of fatty liver rate has reached 10%, the alcoholic liver sickness rate has reached 1.92%, hyperlipidemia then is 3.84%, because chemical liver injury and hyperlipidemia to liver that factors such as ethanol, medicine, environmental pollution cause become a harm greatly that hinders people healthy.
Though the health food of some hepatoprotective and the medicine of some treatment hepatitis are also arranged, and these health foods and medicine exist many deficiencies.They are not strong to the health care of the chemical liver injury of liver, do not have the health care of blood lipid regulation exactly, and medicine and be not suitable for the situation that non-hepatitis is taken for a long time can not be applicable to for a long time and take.Disclosed a kind of medicine for the treatment of chronic hepatopathy of Chinese patent CN1243743 (2000) and preparation method thereof for example, it is a treatment hepatic fibrosis effect new Chinese medicine preferably, but owing to be medicine, constituent content wherein is not suitable for taking for a long time that people keep healthy and need.All these are difficult to satisfy the healthy health care needs of people.Exploitation in conjunction with the health food of hepatoprotective and two kinds of health cares of blood lipid regulation is very urgent.
Summary of the invention
The invention provides health food of a kind of hepatoprotective and blood lipid regulation and preparation method thereof.
The present invention is according to traditional Chinese medicine theory and the theoretical health food that proposes of health care, is with Radix Salviae Miltiorrhizae, Semen Persicae, Herb Gynostemmae Pentaphylli, and fermented Cordyceps powder is a raw materials of effective components, that joins forms with adjuvant chitosan, starch and dextrin again.
Health food of the present invention is to be made by the raw material of following weight parts: Radix Salviae Miltiorrhizae 6-10; Semen Persicae 1-3; Herb Gynostemmae Pentaphylli 4-8; Fermented Cordyceps powder 1-3; Chitosan 0.02-0.06; Starch 0.8-2; Dextrin 0.5-1.5.
Optimum weight part content of health food of the present invention is: Radix Salviae Miltiorrhizae 8; Semen Persicae 2; Herb Gynostemmae Pentaphylli 6; Fermented Cordyceps powder 2; Chitosan 0.05; Starch 0.9; Dextrin 0.6.
Fermented Cordyceps powder in the prescription, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli and Semen Persicae show through modern pharmacology and clinical research; the effect that all has blood fat reducing and improve liver SOD content; suit to take good care of food and take for a long time, play the health care that chemical liver injury is had auxiliary protection function and blood lipid regulation as health care.Below set forth the compound basis of health food of the present invention respectively by health care classification.
The compound basis that chemical liver injury is had auxiliary protection function: 1. fermented Cordyceps powder system carries out purebred cultivation by the inventor's separating obtained Cordyceps peacilomyce hepiahi from natural cordyceps (Cordyceps Sinensis (Berk) Sace) by microbial engineering; vegetative hyphae; processing makes; basic identical with the natural cordyceps main component, all contain compositions such as crude protein, aminoacid, adenine, ribosidoadenine.In addition, also contain potassium, sodium, calcium, magnesium, ferrum, copper, manganese, zinc, phosphorus, selenium and other trace elements and vitamin B
1, B
2, E etc.Relevant studies show that, fermented Cordyceps powder can improve the content of murine liver tissue SOD.2. Radix Salviae Miltiorrhizae has significant protective effect to hepatic injury due to the carbon tetrachloride, can reduce the decline of serum and hepatic tissue SOD vigor; Also have anti peroxidation of lipid and the hepatocellular effect of protection.3. Herb Gynostemmae Pentaphylli can obviously reduce rat liver lipid peroxide content, strengthens the cell SOD vigor.4. Semen Persicae has some improvement to the liver surface microcirculation.In sum, this prescription should have the health care that chemical liver injury is had auxiliary protection function.
The compound basis of blood lipid regulation: 1. fermented Cordyceps powder can significantly reduce hyperlipidemia mice serum cholesterol and content of triglyceride.2. Radix Salviae Miltiorrhizae has effect for reducing blood fat, can reduce serum total cholesterol, triglyceride and low density lipoprotein, LDL in the rabbit regulating liver-QI.3. Herb Gynostemmae Pentaphylli can reduce hyperlipidemia patient T-CHOL, triglyceride, low density lipoprotein, LDL.In sum, this prescription should have the health care of blood lipid regulation.
Theory of Chinese medical science thinks that fatty liver is that dampness-heat of the liver pents up, and the suffocating of liver and gall imbalance causes in the phlegm-damp gives birth to qi depression to blood stasis; Stasis of blood heat-transformation of a specified duration causes taste, and expectorant heat is stopped up Sheng; Injure one's stomach and kidney for a long time, cause hepatic and renal YIN deficiency.Alcoholic liver injury is to accumulate in the damp and hot alcoholism to cause liver and lose bar and reach, dysfunction of the spleen in transportation, and phlegm-damp stasis of blood knot hinders in the liver network and forms.Should use depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, invigorating qi and benefiting blood, the method for dissipating phlegm and resolving masses.
The present invention carries out prescription according to the above-mentioned Chinese medical discrimination rule of treatment, is monarch with the Radix Salviae Miltiorrhizae activating blood circulation and dissipating phlegm, and " herbal classic " said: " Radix Salviae Miltiorrhizae master trusted subordinate pathogen, borborygmus silk silk is as leaking water, cold and heat gather ， Po wei and remove abdominal mass, end stuffy sensation with restlessness, QI invigorating ".Cordyceps tool tonifying deficiency, benefit vital essence effect, because of fatty liver, alcoholic liver injury are all due to cloudy two void of gas, the liver spleen kidney three dirty deficiencies, The liver and the kidney have a common source, kidney for it this, so Cordyceps the kidney invigorating and essence nourishing and effect a permanent cure (the present invention is with composition and act on close Cordyceps powder for it); Semen Persicae " main blood stasis, blood Bi ， WEIJIA " (" herbal classic ") helps the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, with Cordyceps be minister altogether; The Herb Gynostemmae Pentaphylli bitter in the mouth, cold in nature, heat-clearing and toxic substances removing is with the pyretic toxicity of Xie Weijing, be to be assistant.All flavor compatibilities gather blood circulation promoting and blood stasis dispelling altogether, the merit of beneficial intensive culture liver.
Recipe ingredient of the present invention, its dosage is to be foundation with tradition each component modern pharmacology and clinical research in proved recipe and prescription, and the consumption of reference treatment senile disease and defying age body-building again is by repeatedly prescription test, overall merit and decide the dosage of active component as shown in table 1 below.
The consumption reference value of active component and the dosage of Comprehensive Assessment in table 1 prescription
Obviously, active component dosage is purpose with the health body-building all in the prescription, is starkly lower than the Drug therapy consumption.
Chitosan in the prescription is a kind of natural macromolecule amylose, is used for the refining and edulcoration behind Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli and the Semen Persicae water extraction.Chitosan itself also has many-sided health care, can reduce the cholesterol in liver and the serum effectively, strengthen liver function, regulate body immune system etc., therefore containing certain amount of chitosan in finished product of the present invention is very useful to strengthening health care.
Starch in the prescription and dextrin are the required adjuvant of press sheet formulation, all meet national standard.
Above-mentioned each component is made the preparation method of health food of the present invention, comprise the following steps:
1. take by weighing Radix Salviae Miltiorrhizae, Semen Persicae, Herb Gynostemmae Pentaphylli, the water that adds 8-15 times of weight, heat 90-99 ℃ and be the Asia state that boils, dynamic circulation water extraction 1.5-4 hour, extracting solution filters with 60 order filter clothes, filtrate is at 50-80 ℃, under the vacuum 0.04-0.09Mpa, carry out vacuum concentration, reach 1.01-1.20 (50 ℃) to the concentrated solution relative density;
2. adding concentration in concentrated solution is the chitosan of 500-1000ppm, flocculation sediment 0.5-2 hour;
3. flocculation sediment liquid at 50-80 ℃, under the vacuum 0.04-0.09Mpa, carries out vacuum concentration with fine straining liquid with 200 order micropore fine filtrations, reaches 1.05-1.30 (50 ℃) to the concentrated solution relative density;
4. take by weighing fermented Cordyceps powder, mix with concentrated solution, spray drying gets spray powder, adds starch and dextrin again in spray powder, mixes, and granulates, and drying gets granule;
5. with the granule tabletting, film coating promptly gets finished tablet of the present invention.
Control of product quality of the present invention adopts advanced high-efficient liquid phase chromatogram technology, its effective component is monitored quantitative analysis, be about 2.1mg/g as content of Danshensu, adenosine content is about 0.71g/kg, polysaccharide (in glucosan) content is about 20mg/g, thereby guarantees the reliability and stability of product quality.
The outward appearance of finished product of the present invention is a film coating tablet, and content is a chocolate brown powder, Chinese medicine fragrance flavor is arranged, the little sweet little hardship of its taste.
To health product of the present invention sampling carrying out acute toxicity test, sample all greater than 21500mg/kg, with acute toxicity median lethal dose(LD 50) toxicity grading, belongs to nontoxic grade of material to the acute oral LD50 of male and female white mice.
Health product sample of the present invention is the fruit green coated tablet, and the human body recommended dose is 5.4g/60kg every day, experimentizes to establish basic, normal, high three dosage groups, is equivalent to 5 times, 10 times and 30 times of human body recommended dose respectively.Specify the functional evaluation experiment of inspection body to show through country; per os gave animal sample after 30 days; promptly have blood fat reducing and liver-protective effect; sample can suppress the serum cholesterol of the high nutrient fodder rat of high fat and the rising of triglyceride; can obviously reduce carbon tetrachloride poisoning mice serum glutamate pyruvate transaminase GPT, glutamic oxaloacetic transaminase, GOT GOT, hepatic lesions obviously alleviates.The health care evaluation conclusion is the health care with the liver protecting and blood fat reducing, and suitable health care is taken good care of food and taken for a long time, is a kind of pure natural health-care.
Advantage of the present invention: the effective ingredient fermented Cordyceps powder in the health food formula for a product of the present invention, Radix Salviae Miltiorrhizae, Semen Persicae, Herb Gynostemmae Pentaphylli etc. all have the effect that improves liver SOD content and vigor.These components can realize the combination of hepatoprotective and two kinds of health cares of blood lipid regulation as a Chinese medicine compound, rather than only are to realize a function by several components wherein, and several components realize another function in addition.This existing product on market is unique.Chitosan in the prescription is a kind of natural macromolecule amylose, is used for the refining and edulcoration after Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli and Semen Persicae water are carried.And chitosan itself also has many-sided health care, can reduce the cholesterol in liver and the serum effectively, strengthen liver function, regulate body immune system etc., therefore containing certain amount of chitosan in this product is very useful to strengthening health care.The alcohol-free flavor of product of the present invention again, and owing to adopt the sugar-free film coating, so product also is suitable for diabetics.
Preparation method of the present invention combines the Asia multiple advanced technologies such as dynamic extraction, flocculation sediment, micropore fine filtration, spray drying, film-coated preparation of boiling, and compares with the traditional preparation process method, innovation is all arranged and improves.Adopt the Asia dynamic extraction technology of boiling, the static extract phase ratio with traditional not only makes extractive technique be further enhanced, and all improves significantly at aspects such as energy-saving and environmental protection, labor intensity and extraction time and efficient.Flocculation sediment adopts good flocculating agent chitosan, and it is dissolved in the water extract with charge neutrality and the electronegative particle of suction type sedimentation such as impurity and does not reach the polysaccharide composition, can reach the purpose of purification after filtration.Like this, add constituent of chitosan and both can realize purpose refining and that purify, also as the above-mentioned function that improves product.Flocculation sediment has changed the length consuming time brought by traditional ethanol, has reached 24 hours, the consumption grain alcohol, and to the specific (special) requirements of environment, polysaccharide active component, volatile ingredient and the various trace elements that can improve immunologic function in the product have been kept simultaneously, improve the quality of product, the anti-mildew moisture resistance performance of product also improves greatly simultaneously.The microporous filter technology that adopts, wherein the microporous pipe of Cai Yonging meets hygienic requirements, and use can be washed repeatedly according to wanting filtering particle size to select in the aperture, and occupation area of equipment is little.Spray drying technology makes material obtain drying in moment, reduced the loss of polysaccharide active component, volatile ingredient, and the quality of product is improved.Film-coated coating is a water solublity in the film-coated preparation, has advantages such as moisture-resisting, lucifuge, screening flavor, sheet type be good; Make the product tablet not easily broken, can preserve for a long time, and not contain ethanol, production technology has been saved explosion-proof needs, and is safer, also meets environmental protection requirement; Do not contain sugar, meet modern's living needs.The application of multiple advanced technology makes whole technology smoothness, and the production cycle shortens over half.Can form a modern production line.
The specific embodiment
Embodiment 1, the experiment of health food blood lipid regulation of the present invention effect
Sample treatment and preparation: with the tablet samples grind into powder, sample thief 2.25g, 4.5g, 13.5g, adding distil water makes into even suspension to 100ml respectively, is the test liquid of basic, normal, high three dosage groups.
Laboratory animal: the SD rat, male, body weight 150-190 gram.
The dosage design:
Sample human body recommended dose is 5.4g/60kg every day, and basic, normal, high three dosage groups are established in this experiment, is respectively 0.45,0.9,2.7g/kg, is equivalent to 5,10,30 times of human body recommended dose respectively, and matched group gives distilled water.
The high nutrient fodder of high fat: add cholesterol 1g in every 100g normal feedstuff, cholate 0.5g, Adeps Sus domestica 10g, yolk powder 10g.
Give the sample approach: irritate stomach, irritating stomach dosage is the 2ml/100g body weight.
Experimental technique and result: get 40 of rat, after 5 days, weigh with the normal diet feed, get tail blood, survey the normal value of serum triglycerides, cholesterol, high density lipoprotein, according to basic blood lipid level rat is divided into four groups at random then, 10 every group, be respectively sample three dosage group and matched groups, design according to dosage gives sample, respectively organizes equal feed high lipid food simultaneously, feed 30 days continuously after, weigh, get rathole blood and survey every blood lipids index.
Table 2 sample is to the influence of rat body weight
| Group | Number of animals (only) | Body weight (gram) | Weightening finish (gram) | |
| Before giving sample | After giving sample | |||
| Dosage high dose in the contrast low dosage | 10 10 10 10 | 172±8.8 172±9.2 170±10.2 172±9.6 | 297±14.8 286±16.3 282±19.8 288±16.5 | 125±9.2 114±12.3 112±14.8 116±13.2 |
By table 2 as seen, each dosage treated animal body weight gain of sample is compared difference that there are no significant with matched group.
Table 3 suppresses the effect that rat fat raises
| Group | Number of animals (only) | Cholesterol (mmol/l) | Triglyceride (mmol/l) | High density lipoprotein (mmol/l) | |||
| Before the test | After the test | Before the test | After the test | Before the test | After the test | ||
| Dosage high dose in the contrast low dosage | 10 10 10 10 | 1.93±0.05 1.92±0.05 1.92±0.06 1.94±0.06 | 3.86±0.31 3.53±0.11 3.32±0.13 2.69±0.08 * | 1.31±0.11 1.29±0.13 1.28±0.11 1.29±0.12 | 2.22±1.16 2.18±0.12 2.11±0.13 1.70±0.07 * | 0.52±0.03 0.52±0.03 0.54±0.02 0.53±0.02 | 0.62±0.10 0.61±0.05 0.62±0.04 0.65±0.06 |
*(through variance analysis) compared in P＜0.05 with matched group
By table 3 as seen, for the rat of the high nutrient fodder of the high fat of feed, simultaneously per os gives the sample 30 days of various dose, can suppress the rising of rat blood serum cholesterol and triglyceride, credit is analysed by statistics, and the cholesterol of sample high dose group is compared with matched group with triglyceride, and significant difference is all arranged.
The influence of table 4 pair rat fat level
| Group | Number of animals (only) | Cholesterol (%) | Triglyceride (%) | High density lipoprotein (mmol/l) |
| Dosage high dose in the contrast low dosage | 10 10 10 10 | -8.5 -14.0 -30.3 | -1.8 -5.0 -23.4 | +0.03 |
By table 4 as seen, the high, medium and low dosage group of sample cholesterol is compared with matched group with triglyceride all decline, and especially high dose group has descended 30.3% and 23.4% respectively, high density lipoprotein rising 0.03mmol/l (1.2mg/dl).
This experiment conclusion: per os gave animal sample after 30 days, had the blood lipid regulation effect.
Embodiment 2, and health food of the present invention is to the experiment of the protective effect of hepatic injury due to the chemicals
Sample treatment: with the tablet samples grind into powder, sample thief 2.25g, 4.5g, 13.5g adding distil water respectively make into even suspension to 100ml, are the test liquid of high, medium and low three dosage groups.
The dosage design: sample human body recommended dose is 5.4g/60kg every day.0.45,0.9,0.27g/kg basic, normal, high three dosage groups are established in this experiment:, be equivalent to 5,10,30 times of human body recommended dose respectively, other establishes liver injury model group and normal control group (giving distilled water).
Laboratory animal: Kunming kind white mice, the 18-22 gram, female.
Give the sample approach: irritate stomach, irritating the stomach volume is 0.4ml/20g.
Experimental technique and result:
Each dosage group is given sample, and matched group and model group give to drink distilled water, continuous 30 days.The 30th day each dosage group and model group CCl
4Contamination, dosage 24ml/kg, lumbar injection (i.p).The 31st day, 5 treated animals are plucked eyeball and got blood, and be centrifugal, gets serum.Measure following biochemical indicator: serum glutamic pyruvic transminase (GPT), glutamic oxaloacetic transaminase, GOT (GOT), white/globulin ratio (A/G); And get liver and carry out histopathologic examination.Experimental result Spss software statistics.
1. body weight
Table 5 sample is to the influence of the weight of animals
| Group | Number of animals | Initial body weight | Mid-term body weight | Final body weight |
| Normal control CCl 4Dosage high dose in the model low dosage | 10 10 10 10 10 | 19±0.7 19±0.5 19±0.6 19±0.7 19±0.7 | 32±0.7 32±0.7 32±0.7 32±0.8 32±0.7 | 41±0.5 41±2.2 42±0.6 41±1.1 41±0.7 |
By table 5 as seen, each dosage group of sample is compared difference that there are no significant with matched group.
2. biochemistry detection result
Table 6 sample is to GPT, GOT of white mice and the influence of A/G
| Group | Number of animals (only) | Glutamate pyruvate transaminase (IU/L) | Glutamic oxaloacetic transaminase, GOT (IU/L) | In vain/the globulin ratio |
| Normal control CCl 4Dosage high dose in the model low dosage | 10 10 10 10 10 | 33±19 * 3334±1852 2160±1684 1267±1356 * 1919±1338 * | 70±38 * 3258±1593 2105±1642 1278±1735 * 1532±1422 * | 1.78±0.34 1.54±0.11 1.74±0.16 1.52±0.23 1.79±0.38 |
*P＜0.05 and CCl
4Model group compares, through variance analysis
By table 6 as seen, the glutamate pyruvate transaminase of normal control group, glutamic oxaloacetic transaminase, GOT content are starkly lower than CCl
4There is significant difference in model group, and the model establishment is described.Middle and high dosage group of sample and CCl
4Model group compares, and glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT obviously reduce, and all have significant difference.
3. pathological examination results
Table 7 pathologic finding total mark
| Group | Number of animals | Granular degeneration | Hydropic degeneration | The balloon degeneration | Steatosis | The endochylema cohesion | Necrocytosis | Inflammatory cell infiltration | Total points | Average mark |
| Normal control CCl 4Dosage high dose in the model low dosage | 10 10 10 10 10 | 14 15 16 15 13 | 2 27 24 20 10 | 0 27 22 17 9 | 1 0 0 0 3 | 1 21 19 23 17 | 0 48 39 41 24 | 6 21 18 21 12 | 24 159 138 137 88 | 2.4±1.5 * 15.9±4.0 13.8±3.9 13.7±4.2 8.8±4.1 * |
*P＜0.05 and CCl
4Model group is (through variance analysis) relatively
As shown in table 7, by check substantially and the microscopy result as seen, the pathology integration of normal control group is starkly lower than CCl
4There is significant difference in model group, and the model establishment is described.Sample high dose group and CCl
4Model control group is compared, and the pathology integration obviously descends, and has significant difference.
This experiment conclusion: the animal per os was fed sample after 30 days, had the protective effect to hepatic injury due to the chemicals.
The manufacturing of embodiment 3 fermented Cordyceps powder
From natural cordyceps, separate cordyceps species peacilomyce hepiahi (Paecilomyces hepialiChen ﹠amp; Dai, list of references: Jiang Wenxia etc., the edible fungi journal, 1999,6 (2) pp38-40) at first carrying out slant strains and cultivate, is culture medium with peptone, glucose, cattle cream etc., sterilized 30 minutes for 115 ℃, inoculation was placed on 25 ℃ of constant temperature culture 7 days, and after mycelia was evenly covered with the inclined-plane, cryopreservation was standby.Shake-flask seed is cultivated again, is culture medium with peptone, glucose, Carnis Bovis seu Bubali cream etc., adopts 300ml dress 100ml culture medium, sterilizes 30 minutes for 115 ℃, and inoculation vibration (100rpm) is cultivated, and 25～30 ℃, 3 days time.Seed tank seed culture again will be shaken seed that bottle cultivated in 3 days behind purity test, in aseptic condition down and plant jar (100L).25～30 ℃ of jar temperature, tank pressure 0.05Mpa, speed of agitator 200rpm cultivated 3 days.The seed tank culture base is sucrose, beef extract, analysis for soybean powder etc.Fermentation culture again, the 1000L fermentation tank, 25～30 ℃ of jar temperature, tank pressure 0.05Mpa, speed of agitator 140rpm cultivated 3 days.Fermentation tank culture medium is with the seed tank culture medium.After the fermentation culture, jar is put in no microbiological contamination, and vegetative hyphae filters, and collects mycelium.In 80 ℃ with the mycelium drying, the control water content is lower than 7%, crushing screening is controlled the following fine powder of 60 orders greater than 80% then, must fermented Cordyceps powder.Measuring the adenosine value is 0.30%, and measured value conforms to Ministry of Health of the People's Republic of China's ministerial level standard (November nineteen ninety-five), and packing is placed on aeration-drying place and preserves.
The preparation method of embodiment 4 health foods of the present invention
1. take by weighing Radix Salviae Miltiorrhizae 400 gram, Semen Persicae 100 grams, Herb Gynostemmae Pentaphylli 300 grams drop into extraction pot, add 8 liters in water, are heated to the 95-98 ℃ of Asia state that boils, and dynamic circulation water extraction 2 hours is isolated extracting solution, and slag is left away.Extracting solution is filtered with 60 order filter clothes, and elimination impurity gets filtrate.Filtrate at 65 ℃, is carried out vacuum concentration under the vacuum 0.08Mpa, reach 1.04 (50 ℃) to the concentrated solution relative density;
2. in concentrated solution, add 25 gram chitosans (adding), carried out flocculation sediment 0.5 hour with 800ppm concentration;
3. flocculation sediment liquid is with 200 order microporous filter, fine straining liquid, it at 65 ℃, under the vacuum 0.08Mpa, is carried out vacuum concentration, reach 1.10 (50 ℃) to the concentrated solution relative density;
4. take by weighing fermented Cordyceps powder 100 grams, mix with concentrated solution, spray drying gets spray powder, and adding starch 45 grams and dextrin 30 grams in spray powder mix again, granulation, and drying gets granule 270 grams;
5. with the granule tabletting, the sugar-free film coating, 300 in health food tablet gets product.Every contains 0.9 gram dosage.
Instructions about how to take medicine: obey every day 3 times, each 2, (adult's recommended dose is 5.4g/60kg, day).
Claims (4)
1. the health food of hepatoprotective and blood lipid regulation is characterized in that it is to be made by the raw material of following weight parts: Radix Salviae Miltiorrhizae 6-10; Semen Persicae 1-3; Herb Gynostemmae Pentaphylli 4-8; Fermented Cordyceps powder 1-3; Chitosan 0.02-0.06; Starch 0.8-2; Dextrin 0.5-1.5.
2. health food as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight parts: Radix Salviae Miltiorrhizae 8; Semen Persicae 2; Herb Gynostemmae Pentaphylli 6; Fermented Cordyceps powder 2; Chitosan 0.05; Starch 0.9; Dextrin 0.6.
3. health food as claimed in claim 1 is characterized in that described health food is to make tablet.
4. the manufacture method of the health food of described hepatoprotective of claim 1 and blood lipid regulation is characterized in that this method comprises the following steps:
(1) takes by weighing Radix Salviae Miltiorrhizae, Semen Persicae, Herb Gynostemmae Pentaphylli, the water that adds 8-15 times of weight, heat 90-99 ℃ and be the Asia state that boils, dynamic circulation water extraction 1.5-4 hour, extracting solution filters with 60 order filter clothes, filtrate is at 50-80 ℃, and vacuum 0.04-0.09Mpa concentrates down, reaches 1.01-1.20 50 ℃ the time to the concentrated solution relative density;
(2) adding concentration in concentrated solution is the chitosan of 500-1000ppm, flocculation sediment 0.5-2 hour;
(3) flocculation sediment liquid is with 200 order micropore fine filtrations, and at 50-80 ℃, vacuum 0.04-0.09Mpa concentrates down with fine straining liquid, reaches 1.05-1.30 50 ℃ the time to the concentrated solution relative density;
(4) take by weighing fermented Cordyceps powder, mix with concentrated solution, spray drying gets spray powder, adds starch and dextrin again, mixes, and granulates, and drying gets granule;
(5) granule tabletting, film coating promptly gets tablet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9161959B2 (en) | 2007-04-29 | 2015-10-20 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd | Use of a vegetable drug composition in the manufacturing of pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101334386B (en) | 2007-04-27 | 2012-07-11 | 上海现代中医药股份有限公司 | Determination method for plant medicine blood plasma amygdalin for strengthening the body resistance |
| CN103191188B (en) * | 2013-04-01 | 2014-12-10 | 上海现代中医药股份有限公司 | Six-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof |
| CN103191189B (en) * | 2013-04-01 | 2015-02-18 | 上海现代中医药股份有限公司 | Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof |
| CN103191173B (en) * | 2013-04-01 | 2015-02-18 | 上海现代中医药股份有限公司 | Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof |
| CN105495605A (en) * | 2016-02-03 | 2016-04-20 | 聊城大学 | Health-care product for regulating blood lipids and preparation method of health-care product |
| CN108157972A (en) * | 2017-08-01 | 2018-06-15 | 楼良水 | With the cordyceps sinensis compound and solid beverage for improving immunity |
-
2002
- 2002-07-12 CN CNB021360022A patent/CN1218745C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9161959B2 (en) | 2007-04-29 | 2015-10-20 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd | Use of a vegetable drug composition in the manufacturing of pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis |
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| Publication number | Publication date |
|---|---|
| CN1466990A (en) | 2004-01-14 |
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