CN114681535A - Machilus aquilaria sinensis and agilawood wine and making method thereof - Google Patents
Machilus aquilaria sinensis and agilawood wine and making method thereof Download PDFInfo
- Publication number
- CN114681535A CN114681535A CN202210286714.8A CN202210286714A CN114681535A CN 114681535 A CN114681535 A CN 114681535A CN 202210286714 A CN202210286714 A CN 202210286714A CN 114681535 A CN114681535 A CN 114681535A
- Authority
- CN
- China
- Prior art keywords
- parts
- agilawood
- wine
- white spirit
- machi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 23
- 241001533085 Aquilaria sinensis Species 0.000 title description 8
- 241001337998 Machilus Species 0.000 title description 4
- -1 gilawood Species 0.000 title description 2
- 241000222336 Ganoderma Species 0.000 claims abstract description 43
- 239000000843 powder Substances 0.000 claims abstract description 38
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 24
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 238000000605 extraction Methods 0.000 claims abstract description 16
- 238000005325 percolation Methods 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 239000000796 flavoring agent Substances 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 6
- 240000004668 Valerianella locusta Species 0.000 claims description 5
- 235000003560 Valerianella locusta Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000002791 soaking Methods 0.000 abstract description 22
- 238000000227 grinding Methods 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 16
- 238000002360 preparation method Methods 0.000 abstract description 15
- 208000024891 symptom Diseases 0.000 abstract description 15
- 230000036541 health Effects 0.000 abstract description 13
- 238000002386 leaching Methods 0.000 abstract description 13
- 206010062519 Poor quality sleep Diseases 0.000 abstract description 11
- 239000008280 blood Substances 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 abstract description 11
- 206010016256 fatigue Diseases 0.000 abstract description 10
- 208000031975 Yang Deficiency Diseases 0.000 abstract description 9
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 5
- 239000002023 wood Substances 0.000 abstract description 5
- 241000984061 Aquilaria Species 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 240000008397 Ganoderma lucidum Species 0.000 description 9
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 9
- 238000010298 pulverizing process Methods 0.000 description 9
- 229930004725 sesquiterpene Natural products 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 8
- 208000027906 leg weakness Diseases 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- 230000003860 sleep quality Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 241000271309 Aquilaria crassna Species 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 150000003648 triterpenes Chemical class 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- VNZNWFQJBFLELF-UHFFFAOYSA-N 2-(2-phenylethyl)chromone Chemical compound O1C2=CC=CC=C2C(=O)C=C1CCC1=CC=CC=C1 VNZNWFQJBFLELF-UHFFFAOYSA-N 0.000 description 2
- 241000219312 Chenopodium Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000002137 ultrasound extraction Methods 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 244000205574 Acorus calamus Species 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 235000011996 Calamus deerratus Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- VGAJNILINWUWOP-UHFFFAOYSA-N Eudesmane Natural products COC(=O)C(=C)C1C(O)C2C(=O)CCC(O)C2(C)CC1OC(=O)C(=C)CO VGAJNILINWUWOP-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- MCNAURNYDFSEML-UHFFFAOYSA-N Guaiane Natural products CC1CCC(C(C)=C)C(O)C2=C(C)C(=O)CC12 MCNAURNYDFSEML-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- 241001096707 Machilus chinensis Species 0.000 description 1
- 241001666357 Machilus yunnanensis Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000283222 Physeter catodon Species 0.000 description 1
- 241000283249 Physeteridae Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000986020 Thymelaea Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- LKBQARGGDFBGFF-UHFFFAOYSA-N eremophilane Natural products CC1C(O)CCC2C(=O)CC(CC12C)C(=C)C LKBQARGGDFBGFF-UHFFFAOYSA-N 0.000 description 1
- AJWBFJHTFGRNDG-GBJTYRQASA-N eremophilane Chemical compound C1CC[C@H](C)[C@@]2(C)C[C@H](C(C)C)CC[C@H]21 AJWBFJHTFGRNDG-GBJTYRQASA-N 0.000 description 1
- DYEQPYSFRWUNNV-APIJFGDWSA-N eudesmane Chemical compound C1CC[C@@H](C)[C@@H]2C[C@H](C(C)C)CC[C@]21C DYEQPYSFRWUNNV-APIJFGDWSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- QAQCPAHQVOKALN-RMEBNNNOSA-N guaiane Chemical compound C1[C@H](C(C)C)CC[C@H](C)[C@@H]2CC[C@H](C)[C@@H]21 QAQCPAHQVOKALN-RMEBNNNOSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000002011 intestinal secretion Anatomy 0.000 description 1
- ZQIOPEXWVBIZAV-ZKYCIREVSA-N lanostane Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@@H]2[C@]2(C)CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 ZQIOPEXWVBIZAV-ZKYCIREVSA-N 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
- C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
- C12G3/055—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides extracted from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of health care wine, and provides a machia nanensis and agilawood wine and a preparation method thereof, wherein the wine is prepared from the following raw materials in parts by weight: 1.0-1.5 parts of machi aquilaria wood, 2.0-4.5 parts of lucid ganoderma, 2.5-5.5 parts of longan and 88.5-94.5 parts of white spirit. The preparation method comprises the following steps: firstly, preparing agilawood and lucid ganoderma into superfine powder, then adding the agilawood superfine powder, the lucid ganoderma superfine powder, longan and white spirit into a percolation device for extraction, collecting an extracting solution after the extraction is finished, and blending to obtain the machi agilawood wine. The invention takes easily obtained and cheap traditional Chinese medicines as raw materials, and obtains a simplified formula which has obvious effects on symptoms such as soreness and weakness of waist and legs, poor sleep, lassitude and the like caused by kidney-yang deficiency and essence and blood loss through the compatibility principle of the traditional Chinese medicines; and the superfine grinding technology and the percolation method are combined and used, so that the leaching rate of the effective components can be greatly improved and the soaking time can be reduced by extracting at room temperature, and the overall effect of the formula is greatly improved.
Description
Technical Field
The invention relates to the technical field of health care wine, and particularly relates to a machi-nanmu agilawood wine and a preparation method thereof.
Background
In recent years, with the rapid development of economy, people generally have big working pressure, living habits such as staying up all night and lack of physical exercise, more and more people have symptoms such as soreness and weakness of waist and legs, poor sleep quality, lassitude and the like due to kidney yang deficiency and loss of essence and blood, and the symptoms seriously affect the life quality of people and even seriously harm the life safety of people. In order to adjust physiological functions such as soreness of waist, leg weakness, poor sleep quality and the like, the health care wine for health care, health preservation and body building is deeply favored by people due to the unique characteristics of simple manufacture, convenient storage, convenient use, internal and external use, safety, reliability, few side effects and the like.
The agilawood is resin-containing wood formed by injuring plants of Aquilaria spp of Thymelaea in the growing process, and is a traditional rare medicinal material and a natural spice in China and south-east Asia countries. The agilawood is pungent, slightly warm and nontoxic, has the effects of promoting qi circulation, relieving pain, warming middle energizer, stopping vomiting, absorbing qi, relieving asthma and the like, is used for treating diseases related to pain and inflammation such as rheumatism, arthritis, angina, gout and the like, and has obvious curative effects on abdominal distension, stomach cold, kidney deficiency, male sperm cold and asthma. Research shows that the main active ingredients of the agilawood are 2- (2-phenylethyl) chromone and sesquiterpene compounds, and the sesquiterpenes found in the agilawood are mainly divided into eudesmane type sesquiterpenes, eremophilane type sesquiterpenes, agarofuran type sesquiterpenes, agarofilarine type sesquiterpenes, guaiane type sesquiterpenes, juniper alkane type sesquiterpenes, calamus type sesquiterpenes and the like according to the types of carbon skeletons. At present, 21 agilawood plants and 9 pseudo-agilawood plants are reported all over the world and are mainly distributed in China and parts of southeast Asia, and the Machilus chinensis is known as top-grade agilawood spice due to high oil content, cool and refreshing fragrance and rich abundance. At present, the artificial planting of the aquilaria sinensis has been successful greatly, and the planting area of the aquilaria sinensis in northern Guangxi city exceeds one hundred thousand acres, so that the aquilaria sinensis becomes an easily-obtained and relatively-cheap traditional Chinese medicine.
Ganoderma lucidum is the king of fungus, is known as 'immortal grass', is one of the most widely used and safe Chinese medicinal materials, and is also a medicinal and edible test material. Recorded in the compendium of materia medica, the ganoderma lucidum has the efficacies of benefiting heart qi, benefiting lung qi, benefiting spleen qi, benefiting essence qi, nourishing liver qi, benefiting joints, strengthening bones and muscles, treating consumptive disease, losing weight and being not aged after long-term taking, and prolonging life. Ganoderma lucidum has complex and various chemical components, mainly comprises polysaccharide, triterpene, sterol, protein, polypeptide, amino acid, nucleoside, furan derivatives and the like, wherein the polysaccharide and triterpene are the two most important active components in the ganoderma lucidum, and the ganoderma lucidum polysaccharide has the activities of resisting tumor, regulating immunity, reducing blood sugar and blood fat and the like. Triterpenes found in ganoderma lucidum are mainly highly oxidized lanostane type triterpenes, and have remarkable effects on protecting liver, reducing cholesterol and the like.
On one hand, the existing health care wine generally has the defects of complex formula, heavy traditional Chinese medicine taste and the like, for example, the published CN112494604A Chinese invention patent application discloses a preparation method of nourishing, health preserving and kidney tonifying wine, the formula comprises 12 traditional Chinese medicines such as ganoderma lucidum spores, cistanche, agilawood, ambergris and the like, wherein 1g of ambergris is needed for every 300 plus 400mL of white spirit, and the ambergris is a dried product of intestinal secretion of sperm whale family, is the most famous and precious traditional Chinese medicine and is extremely rare. Data show that along with the human killing of a large amount of sperm whales, the ambergris resource is reduced year by year, the current annual trade volume of natural ambergris is reduced to 100 kilograms, so that the wine is difficult to realize large-scale production due to the scarcity of raw materials, and the ultrasonic extraction is adopted in the patent, and along with the extraction, the temperature of an extracting solution can be increased, volatile components are easily lost, and the heat-unstable components are easily damaged. On the other hand, most of the existing health-care wine is produced by adopting a traditional room-temperature soaking method, the dissolution rate of active ingredients of medicinal materials is low, and the soaking time is long, for example, the soaking time required by the preparation method of the agilawood health-care wine and the agilawood wine disclosed by the Chinese patent application with the publication number of CN 103571704A is 80-110 days, the fermentation time of the agilawood wine and the preparation method thereof disclosed by the Chinese patent application with the publication number of CN 106978307A is three months, and the soaking time of the agilawood wine disclosed by the Chinese patent application with the publication number of CN 108865612A is 10 days. The agilawood and the lucid ganoderma are superior traditional Chinese medicinal materials with obvious health care functions, but the agilawood is solid wood, the lignification degree of the lucid ganoderma is higher, the two medicinal materials are hard and solid, and the problem of low leaching rate of effective components is more prominent.
The invention is especially provided in view of the low dissolution rate of the agilawood and the ganoderma lucidum and the rare and rare raw materials of the traditional tonic health-preserving kidney-tonifying wine.
Disclosure of Invention
The invention aims to: aiming at the problems, the invention provides a chess-nan agilawood wine and a preparation method thereof, which take easily-obtained and cheap traditional Chinese medicines as raw materials, and obtain a simplified formula with obvious effects on symptoms such as kidney-yang deficiency, waist soreness and leg weakness, poor sleep quality, lassitude and the like caused by essence and blood loss by a traditional Chinese medicine compatibility principle; and the superfine grinding technology and the percolation method are combined and used, so that the leaching rate of the effective components can be greatly improved and the soaking time can be reduced by extracting at room temperature, and the overall effect of the formula is greatly improved.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the machi nanchuang wine is prepared from the following raw materials in parts by weight: 1.0-1.5 parts of machi nanmu agilawood, 2.0-4.5 parts of lucid ganoderma, 2.5-5.5 parts of longan and 88.5-94.5 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
In the invention, preferably, the machi lewood health care wine is prepared from the following raw materials in parts by weight: 1.2 parts of Chinese eaglewood, 3.0 parts of lucid ganoderma, 3.5 parts of longan and 92.3 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
In the invention, preferably, the machi nanchuang wine is prepared from the following raw materials in parts by weight: 1.3 parts of machi nanmu agilawood, 4.0 parts of lucid ganoderma, 4.5 parts of longan and 90.2 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
The manufacturing method of the machi naughty agilawood wine comprises the following steps: firstly, preparing medicinal materials such as lignum aquilariae sinensis and lucid ganoderma into superfine powder with the granularity of more than 100 meshes, then adding the lignum aquilariae sinensis superfine powder, the lucid ganoderma superfine powder, longan and white spirit into a percolation device for extraction, collecting extracting solution after the extraction is finished, blending the degrees, bottling and sealing to obtain the lignum aquilariae sinensis agilawood wine.
In the above preparation method, the extraction time is preferably 20-36 h.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the formula of the invention takes three traditional Chinese medicines of the Chinese eaglewood, the lucid ganoderma and the longan which are easily available and relatively cheap as raw materials, the formula is simple, but the effective rate of the prepared wine on symptoms of kidney-yang deficiency and loss of essence and blood, such as soreness of waist and legs, poor sleep, lassitude and the like reaches more than 97 percent, the formula obtains remarkable health care efficacy with less medicine types, and the bitter taste of the medicinal materials is corrected by the longan, so that the wine is suitable for the taste of the public.
2. According to the invention, the lignum aquilariae sinensis and the lucid ganoderma are crushed into ultrafine powder with more than 100 meshes, and then are percolated, and only 24 hours of extraction are needed at room temperature, so that the leaching rate of the effective components of the main drug can reach 29.4%, compared with the traditional soaking method, the extraction time is greatly shortened, and the leaching rate of the effective components is greatly improved; compared with ultrasonic extraction method, the method only needs to be carried out at room temperature, and can not cause the loss of volatile components and the damage to thermally unstable components. Therefore, the process can effectively reduce the dosage of the medicinal materials, thereby protecting the resources of the Chinese medicinal materials.
In conclusion, the raw materials of the formula provided by the invention are simple in components and reasonable in proportion, the pharmacological effects of the components can be fully exerted, the preparation process is simple, the realization is easy, the production efficiency is high, the Chinese mache and mache naughty eaglewood wine with good health care effect can be quickly prepared, the wide popularization and application are facilitated, and no relevant report for preparing the Chinese mache and mache leying wine by adopting the formula exists at present.
Detailed Description
In order to make the technical solutions in the embodiments of the present application better understood, the technical solutions in the embodiments of the present application are clearly and completely described below, and it is obvious that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
First, preparation example
Example 1
The machi nanchuang wine is prepared from the following raw materials in parts by weight: 1.0 part of Chinese eaglewood, 2.0 parts of lucid ganoderma, 2.5 parts of longan and 94.5 parts of white spirit, wherein the white spirit is 53-degree Maotai-flavor white spirit. The preparation method comprises the following steps:
(1) pulverizing lignum Aquilariae Resinatum meeting medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into 100 mesh above lignum Aquilariae Resinatum superfine powder;
(2) pulverizing Ganoderma conforming to medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into Ganoderma superfine powder of more than 100 meshes;
(3) adding 0.2Kg of lignum Aquilariae Resinatum micropowder, 0.4Kg of Ganoderma micropowder and 0.5Kg of arillus longan into a percolating cylinder, and soaking in 18.9Kg of 53% (v/v) Maotai-flavor Chinese liquor for 20 hr.
(4) Collecting percolate, blending the percolate to 53 degrees, inspecting, bottling, sealing, and sterilizing to obtain the final product.
Example 2
The machi nanchuang wine is prepared from the following raw materials in parts by weight: 1.2 parts of machi nanmu agilawood, 3.0 parts of lucid ganoderma, 3.5 parts of longan and 92.3 parts of white spirit, wherein the white spirit is 53-degree Maotai-flavor white spirit. The preparation method comprises the following steps:
(1) pulverizing lignum Aquilariae Resinatum meeting medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into 100 mesh above lignum Aquilariae Resinatum superfine powder;
(2) pulverizing Ganoderma conforming to medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into Ganoderma superfine powder of more than 100 meshes;
(3) adding 0.24Kg of lignum Aquilariae Resinatum micropowder, 0.6Kg of Ganoderma micropowder and 0.7Kg of arillus longan into a percolating cylinder, and soaking with 18.5Kg of 53% (v/v) Maotai-flavor Chinese liquor for 24 hr.
(4) Collecting percolate, blending the percolate to 53 degrees, inspecting, bottling, sealing, and sterilizing to obtain the final product.
Example 3
The machi nanchuang wine is prepared from the following raw materials in parts by weight: 1.3 parts of machi nanmu agilawood, 4.0 parts of lucid ganoderma, 4.5 parts of longan and 90.2 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 56 degrees. The preparation method comprises the following steps:
(1) pulverizing lignum Aquilariae Resinatum meeting medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into 100 mesh above lignum Aquilariae Resinatum superfine powder;
(2) pulverizing Ganoderma conforming to medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into Ganoderma superfine powder of more than 100 meshes;
(3) adding 0.26Kg of lignum Aquilariae Resinatum micropowder, 0.8Kg of Ganoderma micropowder and 0.9Kg of arillus longan into a percolating cylinder, and soaking with 18.4Kg of 56% (v/v) Maotai-flavor Chinese liquor for 24 hr.
(4) Collecting percolate, blending the percolate to 56 degree, inspecting, bottling, sealing, and sterilizing to obtain final product.
Example 4
The machilus sinense wine is prepared from the following raw materials in parts by weight: 1.5 parts of machi nanmu agilawood, 4.5 parts of lucid ganoderma, 5.5 parts of longan and 88.5 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 60 degrees. The preparation method comprises the following steps:
(1) pulverizing lignum Aquilariae Resinatum meeting medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into 100 mesh above lignum Aquilariae Resinatum superfine powder;
(2) pulverizing Ganoderma conforming to medicinal material standard into coarse powder by common pulverizer, grinding in ultramicro physical pulverizer for 20min, and grinding into Ganoderma superfine powder of more than 100 meshes;
(3) adding 0.3Kg of lignum Aquilariae Resinatum micropowder, 0.9Kg of Ganoderma micropowder and 1.1Kg of arillus longan into a percolating cylinder, and soaking with 17.7Kg of 60 degree Maotai-flavor Chinese liquor for 36 h.
(4) Collecting percolate, blending the percolate to 60 degrees, inspecting, bottling, sealing, and sterilizing to obtain the Machilus sinkiang Lenzi wine.
II, extraction test:
respectively making lignum Aquilariae Resinatum from Liujing Zhenhui of Guangxi Bei Liu city and Ganoderma purchased from Yulin Chinese medicinal harbor into coarse powder and superfine powder of more than 100 meshes; then mixed into samples of different compositions:
sample one: mixing 10g lignum Aquilariae Resinatum coarse powder and 20g Ganoderma coarse powder,
sample two: mixing lignum Aquilariae Resinatum micropowder 10g and Ganoderma micropowder 20 g.
Then extracting respectively by percolation and room temperature solvent cold soaking, wherein the solvent is ethanol, the dosage is 100mL, and the extraction time is 24 h. The results of the experiment are shown in table 1 below:
TABLE 1
| Sample (I) | Leaching rate of room temperature solvent cold leaching method | Leaching rate by percolation method |
| Sample No | 13.2％ | 18.3％ |
| Sample No. 2 | 20.5％ | 29.4％ |
As can be seen from Table 1, the leaching rate of the effective components is obviously improved after the medicinal materials are prepared into the ultrafine powder, and the leaching rate of the effective components is obviously superior to that of the room-temperature solvent cold leaching method by adopting the percolation method for extraction. The extraction rate of the effective components is improved by 16.2 percent compared with the extraction rate of the effective components which are prepared into coarse powder and extracted by adopting a room-temperature solvent cold-leaching method by combining the superfine powder technology and the percolation method. The invention can obtain higher leaching rate in a short time by crushing the aquilaria sinensis and the lucid ganoderma into superfine powder with more than 100 meshes and then percolating. Not only reduces the usage amount of medicinal materials, but also improves the production efficiency.
Thirdly, efficacy test:
clinical tests prove that the Chenxiang wine has obvious curative effects on symptoms such as kidney-yang deficiency and essence and blood loss, such as soreness of waist, leg weakness, poor sleep quality, lassitude and the like, and partial test conditions are as follows:
1. preparing the Machilus yunnanensis wine:
the machi nakai agilawood wine (set as one group to four groups) prepared in examples 1-4 is provided with a blank control and three comparative test groups at the same time, and the concrete steps are as follows:
blank control group: the raw materials used are only 53-degree Maotai-flavor liquor and longan, the dosage is 0.25Kg of longan and 9.75Kg of 53-degree Maotai-flavor liquor, and the soaking method and the soaking time are carried out according to the embodiment 1;
comparative experiment 1 (group five): the raw materials only comprise 53-degree Maotai-flavor liquor and Machilus aquilaria sinensis, the dosage of the Maotai-flavor liquor is 0.1Kg of fine aquilaria sinensis powder, and the dosage of the 53-degree Maotai-flavor liquor is 9.5Kg, and the treatment method, the soaking method and the soaking time of the aquilaria sinensis are carried out according to the embodiment 1;
comparative experiment 2 (group six): the raw materials are 53-degree Maotai-flavor liquor and lucid ganoderma, the dosage of the lucid ganoderma superfine powder is 0.2Kg, and the dosage of the 53-degree Maotai-flavor liquor is 9.5Kg, and the lucid ganoderma treatment method, the soaking method and the soaking time are carried out according to the embodiment 1;
comparative experiment 3 (group seven): the raw materials, the proportions, the qualities and the soaking time of the raw materials are the same as those of the example 1, but the agilawood and the lucid ganoderma are coarse powder which is only crushed commonly and extracted for 24 hours by a room temperature cold soaking method.
2. The test method comprises the following steps:
240 patients suffering from symptoms of kidney-yang deficiency, waist soreness and leg weakness caused by essence and blood loss, poor sleep, lassitude and the like are selected, a drug effect experiment is completed through a hospital, the screening and the effect after medication of the patients are judged by professional doctors, and the selected patients are 35 years in minimum age, 65 years in maximum age, 120 men and 120 women;
randomly distributing the patients into 8 groups, each group comprises 30 patients, each group correspondingly takes the blank control group and one to seven groups of the Chenopodium aquilaria wood wine, and takes 2 two after each dinner every day, and takes the patients for 45 days to carry out conditioning curative effect statistics. Wherein the curative effect judgment standard is as follows:
and (3) curing: the symptoms of waist soreness and leg weakness disappear, and the sleep is stable and good at night;
improvement: the symptoms of waist soreness and leg weakness are relieved, the sleep quality at night is improved, the sleep time is prolonged, and the spirit is improved;
and (4) invalidation: soreness of waist and legs, poor sleep and lassitude.
The test results are shown in table 2:
TABLE 2
The experimental results in table 2 show that when agilawood and ganoderma lucidum are coarse powder and the agilawood wine prepared by the room temperature cold soaking method has the effective rate of 60.0% (group seven), the effective rate of the agilawood wine prepared by combining the ultramicro-pulverization technology and the percolation method reaches over 96.7%, the effective rate is improved by about 36.7%, and the health-care wine has the effect of increasing the dosage of the medicine from the group one to the group four. When only longan is used for soaking the wine, the effective rate of the obtained wine is 0 (blank control group); when only agilawood is used as the raw material to prepare the agilawood wine, the effective rate is only 40% (group five); when the wine is prepared by only using the lucid ganoderma as the raw material, the effective rate is only 30 percent (group six); the compatibility of the agilawood, the lucid ganoderma and the longan proves that the effect of the formula can be obviously improved.
Typical cases
1. Wu-chi, male, 45 years old, farm workers, due to long-term work in the field, had extremely irregular living habits, which resulted in symptoms of kidney yang deficiency, loss of essence and blood, such as soreness of the waist and legs, poor sleep, lassitude, etc., and after taking the health wine prepared in example 1 for 45 days, the symptoms disappeared.
2. Wangzhi, male, 49 years old, scientific research staff rarely do physical training due to high working pressure, which causes symptoms such as soreness and weakness of waist and legs, poor sleep, lassitude and the like caused by kidney-yang deficiency and essence and blood loss, and after taking the health wine prepared in example 1 for 45 days, the symptoms basically disappear and return to normal.
3. In plum, male and 51-year-old drivers, the drivers of large trucks, who sit and drive for a long time, do irregular work and rest and do little outdoor exercises, cause symptoms such as kidney-yang deficiency, waist soreness and leg weakness caused by essence and blood loss, poor sleep, lassitude and the like, and the symptoms disappear after taking the health wine prepared in example 1 for 45 days.
The above description is intended to describe in detail the preferred embodiments of the present invention, but the embodiments are not intended to limit the scope of the claims of the present invention, and all equivalent changes and modifications made within the technical spirit of the present invention should fall within the scope of the claims of the present invention.
Claims (5)
1. The machi nakai agilawood wine is characterized by being prepared from the following raw materials in parts by weight: 1.0-1.5 parts of machi nanmu agilawood, 2.0-4.5 parts of lucid ganoderma, 2.5-5.5 parts of longan and 88.5-94.5 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
2. The mache agilawood wine of claim 1, wherein: the feed is prepared from the following raw materials in parts by weight: 1.2 parts of machi naughty agilawood, 3.0 parts of lucid ganoderma, 3.5 parts of longan and 92.3 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
3. The macha agilawood wine of claim 1, wherein: the feed is prepared from the following raw materials in parts by weight: 1.3 parts of machi nanmu agilawood, 4.0 parts of lucid ganoderma, 4.5 parts of longan and 90.2 parts of white spirit, wherein the white spirit is Maotai-flavor white spirit with the alcohol content of 50-60 degrees.
4. The method for making a machi cheng xiang wine as claimed in any one of claims 1-3, characterized by comprising the following steps: firstly, preparing medicinal materials such as lignum aquilariae sinensis and lucid ganoderma into superfine powder with the granularity of more than 100 meshes, then adding the lignum aquilariae sinensis superfine powder, the lucid ganoderma superfine powder, longan and white spirit into a percolation device for extraction, collecting extracting solution after the extraction is finished, blending the degrees, bottling and sealing to obtain the lignum aquilariae sinensis agilawood wine.
5. The method of manufacturing according to claim 1, wherein: the extraction time is 20-36 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210286714.8A CN114681535A (en) | 2022-03-23 | 2022-03-23 | Machilus aquilaria sinensis and agilawood wine and making method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210286714.8A CN114681535A (en) | 2022-03-23 | 2022-03-23 | Machilus aquilaria sinensis and agilawood wine and making method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114681535A true CN114681535A (en) | 2022-07-01 |
Family
ID=82139133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210286714.8A Pending CN114681535A (en) | 2022-03-23 | 2022-03-23 | Machilus aquilaria sinensis and agilawood wine and making method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114681535A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116855340A (en) * | 2023-08-02 | 2023-10-10 | 四川农业大学 | Photinia wine and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103571704A (en) * | 2012-07-31 | 2014-02-12 | 苗丽荣 | Preparation method of agilawood health-care wine and agilawood wine thereof |
| CN104178398A (en) * | 2013-05-27 | 2014-12-03 | 廖少波 | Natural Chinese herbal health care wine and making method thereof |
| CN109762709A (en) * | 2017-11-10 | 2019-05-17 | 雷艳丽 | A kind of aloe wine and preparation method thereof |
| CN111363655A (en) * | 2020-04-21 | 2020-07-03 | 深圳市华斌润丰生物科技有限公司 | Production method of Kyara agilawood white spirit |
| CN113599452A (en) * | 2021-07-27 | 2021-11-05 | 海南娜古芳沉香科技有限公司 | Kyara agilawood wine and preparation method thereof |
-
2022
- 2022-03-23 CN CN202210286714.8A patent/CN114681535A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103571704A (en) * | 2012-07-31 | 2014-02-12 | 苗丽荣 | Preparation method of agilawood health-care wine and agilawood wine thereof |
| CN104178398A (en) * | 2013-05-27 | 2014-12-03 | 廖少波 | Natural Chinese herbal health care wine and making method thereof |
| CN109762709A (en) * | 2017-11-10 | 2019-05-17 | 雷艳丽 | A kind of aloe wine and preparation method thereof |
| CN111363655A (en) * | 2020-04-21 | 2020-07-03 | 深圳市华斌润丰生物科技有限公司 | Production method of Kyara agilawood white spirit |
| CN113599452A (en) * | 2021-07-27 | 2021-11-05 | 海南娜古芳沉香科技有限公司 | Kyara agilawood wine and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 关天增,等: "浅谈超微粉碎", 《中国中药杂志》 * |
| 刘玉杰: "几款抗衰老药膳", 《药膳食疗》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116855340A (en) * | 2023-08-02 | 2023-10-10 | 四川农业大学 | Photinia wine and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107496701B (en) | Formula for producing sperms and treating impotence and premature ejaculation | |
| CN100394859C (en) | Health tea | |
| WO2021114586A1 (en) | Immune response-improving composition, preparation method and application thereof | |
| CN108159262A (en) | A kind of preparation method and application of the composition of warm kidney kidney tonifying, the composition | |
| CN104383259A (en) | Bitter gourd and mulberry leaf chromium-rich capsule and preparation method thereof | |
| CN105029568A (en) | Black garlic beverage and preparation method thereof | |
| CN114681535A (en) | Machilus aquilaria sinensis and agilawood wine and making method thereof | |
| CN102309615B (en) | Small water turtle, ginseng and pilose antler wine | |
| CN108143974A (en) | Relieving alcoholism and protecting liver ball | |
| CN111838433A (en) | Composition for promoting digestion of pig feed and preparation method thereof | |
| AU2021103674A4 (en) | Preparation method of healthcare wine for dispelling cold and tonifying kidney | |
| CN107158299B (en) | Composition with function of enhancing learning memory and preparation method thereof | |
| CN105560386A (en) | Cactus tablet and preparation method thereof | |
| CN104799118A (en) | Dog food and preparation method thereof | |
| CN108315185A (en) | A kind of health liquor and preparation method thereof of cold extermination kidney tonifying | |
| CN112998257A (en) | Dietetic therapy composition and preparation method thereof | |
| CN102626471B (en) | Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration | |
| CN101612254A (en) | A kind of pharmaceutical composition and preparation method thereof with resisting fatigue, immunoregulation effect | |
| CN111218370A (en) | Health-care medicinal liquor with anti-fatigue effect and preparation method thereof | |
| CN110507707A (en) | A kind of Chinese medicine composition and preparation method thereof for treating type II diabetes | |
| CN107737259A (en) | A kind of Chinese prescription for improving male's sexual | |
| CN116459314B (en) | Aging-delaying spray | |
| CN113383956B (en) | Kidney-tonifying formula of black truffle and preparation method thereof | |
| CN102631487B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN107811907A (en) | A kind of body lotion for promoting subcutaneous fat to decompose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220701 |