CN1178919C - 用于制备三环化合物的中间体的合成方法及其中的中间体 - Google Patents

用于制备三环化合物的中间体的合成方法及其中的中间体 Download PDF

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Publication number
CN1178919C
CN1178919C CNB988052997A CN98805299A CN1178919C CN 1178919 C CN1178919 C CN 1178919C CN B988052997 A CNB988052997 A CN B988052997A CN 98805299 A CN98805299 A CN 98805299A CN 1178919 C CN1178919 C CN 1178919C
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CN
China
Prior art keywords
formula
compound
alkyl
aryl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988052997A
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English (en)
Chinese (zh)
Other versions
CN1257484A (zh
Inventor
陈星�
�Ү��
M·普瓦里耶
黄以诚
吴光中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1257484A publication Critical patent/CN1257484A/zh
Application granted granted Critical
Publication of CN1178919C publication Critical patent/CN1178919C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CNB988052997A 1997-03-25 1998-03-23 用于制备三环化合物的中间体的合成方法及其中的中间体 Expired - Fee Related CN1178919C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82392897A 1997-03-25 1997-03-25
US08/823928 1997-03-25
US08/823,928 1997-03-25

Publications (2)

Publication Number Publication Date
CN1257484A CN1257484A (zh) 2000-06-21
CN1178919C true CN1178919C (zh) 2004-12-08

Family

ID=25240156

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988052997A Expired - Fee Related CN1178919C (zh) 1997-03-25 1998-03-23 用于制备三环化合物的中间体的合成方法及其中的中间体

Country Status (13)

Country Link
EP (1) EP0977739B1 (enExample)
JP (1) JP3476838B2 (enExample)
CN (1) CN1178919C (enExample)
AR (1) AR012147A1 (enExample)
AT (1) ATE253052T1 (enExample)
AU (1) AU6441498A (enExample)
CA (1) CA2284646C (enExample)
DE (1) DE69819316T2 (enExample)
ES (1) ES2209121T3 (enExample)
IN (1) IN186464B (enExample)
TW (1) TW513410B (enExample)
WO (1) WO1998042676A1 (enExample)
ZA (1) ZA982453B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
CN1162404C (zh) * 1998-11-20 2004-08-18 先灵公司 合成用于制备三环化合物的中间体的方法
DK1274688T3 (da) 2000-04-18 2007-02-05 Schering Corp Syntese af mellemprodukter, der er nyttige ved fremstilling af tricykliske forbindelser
WO2024011415A1 (zh) * 2022-07-12 2024-01-18 苏州大学 一种邻碘苯基化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011858B1 (en) * 1978-11-29 1983-05-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Radioiodine containing amines, their preparation and their use as brain imaging agents
GB2094790B (en) * 1981-03-13 1985-10-09 Spofa Vereinigte Pharma Werke Tricycle compounds
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
DE69819316D1 (de) 2003-12-04
EP0977739A1 (en) 2000-02-09
EP0977739B1 (en) 2003-10-29
AR012147A1 (es) 2000-09-27
AU6441498A (en) 1998-10-20
JP2001507715A (ja) 2001-06-12
ZA982453B (en) 1998-09-23
CN1257484A (zh) 2000-06-21
DE69819316T2 (de) 2004-07-22
JP3476838B2 (ja) 2003-12-10
IN186464B (enExample) 2001-09-08
CA2284646C (en) 2004-04-06
CA2284646A1 (en) 1998-10-01
ATE253052T1 (de) 2003-11-15
TW513410B (en) 2002-12-11
HK1023773A1 (en) 2000-09-22
ES2209121T3 (es) 2004-06-16
WO1998042676A1 (en) 1998-10-01

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C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP01 Change in the name or title of a patent holder

Address after: new jersey

Patentee after: Schering Corporation

Address before: new jersey

Patentee before: SCHERING CORP (US)

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041208

Termination date: 20140323