CN1178687C - Compound seabuckthorn fruit oil suppository - Google Patents
Compound seabuckthorn fruit oil suppository Download PDFInfo
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- CN1178687C CN1178687C CNB021145121A CN02114512A CN1178687C CN 1178687 C CN1178687 C CN 1178687C CN B021145121 A CNB021145121 A CN B021145121A CN 02114512 A CN02114512 A CN 02114512A CN 1178687 C CN1178687 C CN 1178687C
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- cervical erosion
- suppository
- colpitis
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Abstract
The present invention provides a compound hippophae rhamnoides fruit oil suppository for treating cervical erosion and vaginitis caused by the downward flow of damp and heat. The present invention is composed of hippophae rhamnoides fruit oil, cnidium fruit, flavescent sophora root, myrrh, etc. The present invention has the functions of regulating qi and blood, combining the inner and the outer, removing stasis and promoting new, treating surface diseases and inner diseases, drying damp, killing insects, relieving itching, removing swelling, stopping pains, activating blood and generating muscle by matching the medicine. The rate for curing cervical erosion is 49.3% by the certification of clinic observation, and the total effective rate is 94.9%; the rate for curing mycotic colpitis is 88.6%, the rate for curing trichomonas vaginitis is 89.5%, and the rate for curing senile vaginitis is 97.5%. The present invention has obvious promoting action for the cicatrization of the damaged position caused by after operations for sexually transmitted diseases, cervical erosion (the cervical erosion is treated by laser and electricity cautery) and abortion are carried out.
Description
One, technical field
The invention belongs to a kind of cervical erosion, colpitic suppository medicine---a kind of suppository for the treatment of cervical erosion and colpitis that is used for the treatment of due to the damp invasion of lower energizer.
Two, background technology
Cervical erosion, senile vaginitis are common gynecological disease, frequently-occurring disease.Cervical erosion can not get curing easy generation canceration for a long time, has a strong impact on women's physical and mental health.The gynopathic medicine of treatment is more on city's field boundary, as oral medicine, topical agent, health care protective pad, Western medicine suppository, Chinese medicine lotion and operative treatment etc.Though oral medicine is effective in cure, its medicine must take orally, and oral medicine easily produces ill effect to liver, kidney; Health care protective pad, topical agent are also effective in cure to the treatment gynaecopathia, but it is relatively poor to cervical erosion, senile vaginitis curative effect, fry in shallow oil water demibain or rinsing vulva with Chinese medicine, effect is very undesirable, developed into afterwards with laser, micro-wave therapeutic freezing and that adopt at present etc., and all existed wound big, easily hemorrhage, the expense height, and influence work and life.Western medicine suppository has certain curative effect to treatment cervical erosion, senile vaginitis, Chinese patent communique and various documents and materials by retrieval, and the medicament composing prescription of its suppository is not seen the publicity report.
Three, summary of the invention
The object of the present invention is to provide a kind of cervical erosion due to the damp invasion of lower energizer, suppository medicine of senile vaginitis for the treatment of, it is evident in efficacy, and dosage form is easy to use, safety, a kind of suppository for the treatment of cervical erosion and colpitis that side effect is little.
The present invention is the medicament of being made by following proportion raw material medicine, makes 1000 finished product needed raw material medicine content to be:
Fructrs Hippophae seed oil 400---600g Fructus Cnidii 130---180g Radix Sophorae Flavescentis 60---100g
Calamina 140---160g Olibanum 35---60g Myrrha 35---60g
Borneolum Syntheticum 15---25g.
The preferred weight proportioning of each raw material wherein, the content of making 1000 each crude drug of finished product is:
Fructrs Hippophae seed oil 450---550g Fructus Cnidii 140---165g Radix Sophorae Flavescentis 65---85g
Calamina 145---155g Olibanum 40---55g Myrrha 45---55g
Borneolum Syntheticum 18---24g.
The weight proportion of optimum feed stock of the present invention, the content of composition is in per 1000 finished products:
Fructrs Hippophae seed oil 500g Fructus Cnidii 150g Radix Sophorae Flavescentis 80g
Calamina 150g Olibanum 50g Myrrha 50g
Borneolum Syntheticum 20g.
A kind of suppository for the treatment of cervical erosion and colpitis of the present invention, its preparation method: get Fructus Cnidii, Radix Sophorae Flavescentis, Calamina, Olibanum, Myrrha five kinds of Chinese medicine and be ground into fine powder; Get the Borneolum Syntheticum porphyrize, with above-mentioned powder facing-up, mixing.Other gets glycerol gelatin matrix 1550g, puts heating and melting in 75 ℃ of water-baths, adds the Fructrs Hippophae seed oil and the water 150ml of uniform temp, and thickness is gluey to add above-mentioned powder to being in emulsifying rapidly, and mixing treats that bubble collapse promptly pours into a mould in the bolt mould, cooling, promptly.
A kind of suppository for the treatment of cervical erosion and colpitis provided by the invention is to be basis with the Basic Theories of Chinese Medicine, press Chinese medicine monarch compatibility rule, through strictness screening prescription, [monarch drug] Fructrs Hippophae seed oil wherein: anti-inflammation, human body immunity improving function, promote rotten to the corn face reparation and wound healing, suppress growth of tumour cell.[ministerial drug] Fructus Cnidii: dampness, parasite killing, antipruritic.Radix Sophorae Flavescentis: heat clearing and damp drying, killing parasites for relieving itching suppresses anaphylaxis.[adjuvant drug] Calamina: removing dampness is antipruritic, skin ulcer is held back in detoxifcation, suppresses bacterial reproduction.Olibanum: promoting blood circulation and stopping pain, detumescence and promoting granulation.Myrrha: stasis-dispelling and pain-killing, evacuation of pus detumescence.[messenger drug] Borneolum Syntheticum: repelling foulness with aromatics, Xin Xiang walk to scurry, eliminating stasis to stop pain, antipyretic and itching-stopping.Monarch, all medicines cooperate, QI and blood regulating, the combination of inner and outside, giving birth to dispels lays equal stress on treating both the principal and secondary aspects of a disease.Messenger drug through mucous membrane myocutaneous junction, site where the skin and muscle are joined is gone into the skin reason, is advanced internal organs, venting QI-blood, putrefaction-removing granulation-promoting, killing parasites for relieving itching, the turbid detoxifcation of row.With can make qi and blood circulation, evil malicious loss, metabolism are vigorous, and the merit that removing dampness removes, poison looses, worm is dead, pain disappears, skin ulcer is closed.
A kind of suppository for the treatment of cervical erosion and colpitis provided by the invention is 49.3% through the clinical observation proof to treatment cervical erosion cure rate, total effective rate 94.95%; Colpitis mycotica cure rate 88.6%; Cure rate of trichomonal vaginitis 89.5%; Senile vaginitis cure rate 60%, total effective rate 97.5%.And the healing at sexually transmitted disease (STD) postoperative, cervical erosion postoperative (behind laser and the electric cautery), artificial abortion's postoperative damage position there is obvious facilitation.
A kind of suppository for the treatment of cervical erosion and colpitis provided by the invention, proof after deliberation:
One, pharmacological action:
1, antiinflammatory action: show that according to white mice Oleum Tiglii ear inflammation method and the test of rat chondrus ocellatus Holmes pedal swelling inflammation a kind of suppository for the treatment of cervical erosion and colpitis provided by the invention has tangible antiinflammatory action.
2, analgesic activity: show that according to reaction of white mice acetic acid twisting and hot plate method test a kind of suppository for the treatment of cervical erosion and colpitis provided by the invention has certain suppression to act on bitterly.
3, human body immunity improving function: measure according to the serum agglutinin, the spleen hemolysis plaque forms cell (PFC) and measures, peripheral blood ANAE measures and E---and tests such as Flos Rosae Rugosae open form one-tenth show that a kind of immunity of suppository pair cell and humoral immunization for the treatment of cervical erosion and colpitis provided by the invention all has obvious facilitation.
4, antibacterium: adopt the evidence of dull and stereotyped antibacterial paper method, a kind of suppository for the treatment of cervical erosion and colpitis provided by the invention all has killing action to staphylococcus aureus, Staphylococcus albus, shigella flexneri, bacillus subtilis etc. when the 12----100 concentration.
5, antifungal: adopt the bacteriostatic test plate paper disk method to prove that a kind of suppository for the treatment of cervical erosion and colpitis provided by the invention all has killing action to candida albicans, Cryptococcus histolyticus and black aspergillosis etc. when the 12----150 concentration.
6, kill infusorian: anti-trichomonas vaginitis test method(s) shows that a kind of suppository for the treatment of cervical erosion and colpitis provided by the invention was cultivated 24 hours at the 40----80mg/6ml concentration in the laboratory, and the infusorian mortality rate is 98----100%.Illustrate that a kind of suppository for the treatment of cervical erosion and various colpitis provided by the invention has brute force to kill the infusorian effect.
7, recover the intravaginal environment: make the intravaginal pH value recover normal, adsorb too much secretions, protect its weak acid characteristic and cleanliness factor.
Two, animal toxicity test
1, anxious toxicity: heavy dose of (quite the 180----360 of patient's vagina medicinal dosage doubly) gives rabbit skin coating 7 days, and once a day, local no red and swollen inflammatory stimulus symptom is not seen and is poisoned to death.
2, long term toxicity: behavior, hemogram and the main organs function of animal are not had obvious influence for the long-term vagina medicinal of new zealand rabbit (quite the 8------16 of patient's vagina medicinal dosage times, continuous use 30 days), find to poison and the variation of infringement sexually transmitted disease (STD) reason.
3, anaphylaxis: do not find part and systemic anaphylaxis.
Three, antimicrobial spectrum
1, antibacterial: staphylococcus aureus, Staphylococcus albus, dysentery bacterium, bacillus subtilis, Hemophilus vaginalis(Hemophilus vaginalis), escherichia coli, aerobacteria, bacillus pyocyaneus, Diplococcus pneumoniae, Streptococcus.
2, fungus: aspergillosis, read coccus family, Cryptococcus histolyticus.
3, protozoon and other: trichomonas vaginitis etc.
A kind of suppository for the treatment of cervical erosion and colpitis provided by the invention has heat clearing and damp drying, killing parasites for relieving itching, reducing swelling and alleviating pain, blood activating and promoting tissue regeneration.
Four, description of drawings
Accompanying drawing is a kind of process chart for the treatment of the suppository of cervical erosion and colpitis of the present invention.
Claims (4)
1, a kind of suppository for the treatment of cervical erosion and colpitis is characterized in that: it is by the medicament that following proportion raw material medicine is made, and makes 1000 required crude drug content of finished product and is:
Fructrs Hippophae seed oil 400---600g Fructus Cnidii 130---180g Radix Sophorae Flavescentis 60---100g
Calamina 140---160g Olibanum 35---60g Myrrha 35---60g
Borneolum Syntheticum 15---25g.
2, a kind of suppository for the treatment of cervical erosion and colpitis as claimed in claim 1, the content of wherein making 1000 each crude drug of finished product is:
Fructrs Hippophae seed oil 450---550g Fructus Cnidii 140---165g Radix Sophorae Flavescentis 65---85g
Calamina 145---155g Olibanum 40---55g Myrrha 45---55g
Borneolum Syntheticum 18---24g.
3, a kind of suppository for the treatment of cervical erosion and colpitis as claimed in claim 1, the content of wherein making 1000 each crude drug of finished product is:
Fructrs Hippophae seed oil 500g Fructus Cnidii 150g Radix Sophorae Flavescentis 80g
Calamina 150g Olibanum 50g Myrrha 50g
Borneolum Syntheticum 20g.
4,, it is characterized in that getting Fructus Cnidii, Radix Sophorae Flavescentis, Calamina, Olibanum, Myrrha five kinds of Chinese medicine and be ground into fine powder as claim 1,2 or 3 described a kind of preparation methoies for the treatment of the suppository of cervical erosion and colpitis; Get the Borneolum Syntheticum porphyrize, with above-mentioned powder facing-up, mixing.Other gets glycerol gelatin matrix 1550g, puts heating and melting in 75 ℃ of water-baths, adds the Fructrs Hippophae seed oil and the water 150ml of uniform temp, and thickness is gluey to add above-mentioned powder to being in emulsifying rapidly, and mixing treats that bubble collapse promptly pours into a mould in the bolt mould, cooling, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021145121A CN1178687C (en) | 2002-04-11 | 2002-04-11 | Compound seabuckthorn fruit oil suppository |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021145121A CN1178687C (en) | 2002-04-11 | 2002-04-11 | Compound seabuckthorn fruit oil suppository |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1387896A CN1387896A (en) | 2003-01-01 |
| CN1178687C true CN1178687C (en) | 2004-12-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021145121A Expired - Lifetime CN1178687C (en) | 2002-04-11 | 2002-04-11 | Compound seabuckthorn fruit oil suppository |
Country Status (1)
| Country | Link |
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| CN (1) | CN1178687C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224237B (en) * | 2008-01-31 | 2011-01-26 | 陕西海天制药有限公司 | Novel uses of compound seabuckthorn seed oil in preparing medicine |
| CN101455715B (en) * | 2008-11-13 | 2011-02-16 | 陕西东泰制药有限公司 | Suppository for treating gynecologic diseases and preparation method thereof |
| CN103520261B (en) * | 2013-10-11 | 2015-08-19 | 哈尔滨欧替药业有限公司 | Compound seabuckthorn fruit oil vaginal expansion plug and preparation method thereof and detection method |
| CN107213177A (en) * | 2017-06-15 | 2017-09-29 | 陕西海天制药有限公司 | A kind of preparation method for the Chinese medicine composition and its gel for treating cervical erosion |
-
2002
- 2002-04-11 CN CNB021145121A patent/CN1178687C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1387896A (en) | 2003-01-01 |
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