CN117838695A - 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 - Google Patents
用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 Download PDFInfo
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862657540P | 2018-04-13 | 2018-04-13 | |
| US201862657563P | 2018-04-13 | 2018-04-13 | |
| US62/657,540 | 2018-04-13 | ||
| US62/657,563 | 2018-04-13 | ||
| US201862743469P | 2018-10-09 | 2018-10-09 | |
| US62/743,469 | 2018-10-09 | ||
| US201862753025P | 2018-10-30 | 2018-10-30 | |
| US201862753023P | 2018-10-30 | 2018-10-30 | |
| US62/753,023 | 2018-10-30 | ||
| US62/753,025 | 2018-10-30 | ||
| PCT/US2019/027217 WO2019200254A1 (en) | 2018-04-13 | 2019-04-12 | Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer |
| CN201980037795.4A CN112236139A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980037795.4A Division CN112236139A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
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| Publication Number | Publication Date |
|---|---|
| CN117838695A true CN117838695A (zh) | 2024-04-09 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311324993.3A Pending CN117838695A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| CN202311331258.5A Pending CN117959303A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| CN201980037795.4A Pending CN112236139A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311331258.5A Pending CN117959303A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| CN201980037795.4A Pending CN112236139A (zh) | 2018-04-13 | 2019-04-12 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20210113562A1 (https=) |
| EP (1) | EP3773560A4 (https=) |
| JP (2) | JP2021521170A (https=) |
| KR (2) | KR20260036611A (https=) |
| CN (3) | CN117838695A (https=) |
| AU (2) | AU2019252793A1 (https=) |
| CA (1) | CA3095580A1 (https=) |
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| EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
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| EP4611753A1 (en) * | 2022-10-31 | 2025-09-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
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2019
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| KR20200143454A (ko) | 2020-12-23 |
| EP3773560A4 (en) | 2022-01-19 |
| CA3095580A1 (en) | 2019-10-17 |
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| JP2021521170A (ja) | 2021-08-26 |
| JP2024038485A (ja) | 2024-03-19 |
| CN117959303A (zh) | 2024-05-03 |
| CN112236139A (zh) | 2021-01-15 |
| AU2019252793A1 (en) | 2020-10-15 |
| MX2023001425A (es) | 2023-03-03 |
| AU2025201505A1 (en) | 2025-03-20 |
| KR20260036611A (ko) | 2026-03-17 |
| MX2020010556A (es) | 2021-03-02 |
| EP3773560A1 (en) | 2021-02-17 |
| US20250082634A1 (en) | 2025-03-13 |
| WO2019200254A1 (en) | 2019-10-17 |
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