CN117801066A - 用于癌症疗法的免疫原性化合物 - Google Patents

用于癌症疗法的免疫原性化合物 Download PDF

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Publication number
CN117801066A
CN117801066A CN202311807705.XA CN202311807705A CN117801066A CN 117801066 A CN117801066 A CN 117801066A CN 202311807705 A CN202311807705 A CN 202311807705A CN 117801066 A CN117801066 A CN 117801066A
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CN
China
Prior art keywords
seq
peptide
amino acid
acid sequence
antigenic
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Pending
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CN202311807705.XA
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English (en)
Chinese (zh)
Inventor
L·钱
A·马修
M·披查德
F·斯特罗兹
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Enterome SA
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Enterome SA
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Publication of CN117801066A publication Critical patent/CN117801066A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202311807705.XA 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物 Pending CN117801066A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP16192948 2016-10-07
EP16192948.4 2016-10-07
PCT/EP2017/075673 WO2018065623A2 (en) 2016-10-07 2017-10-09 Immunogenic compounds for cancer therapy
CN201780074774.0A CN110022893B (zh) 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780074774.0A Division CN110022893B (zh) 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物

Publications (1)

Publication Number Publication Date
CN117801066A true CN117801066A (zh) 2024-04-02

Family

ID=57123864

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311807705.XA Pending CN117801066A (zh) 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物
CN201780074774.0A Active CN110022893B (zh) 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780074774.0A Active CN110022893B (zh) 2016-10-07 2017-10-09 用于癌症疗法的免疫原性化合物

Country Status (9)

Country Link
US (2) US11478537B2 (https=)
EP (1) EP3522915A2 (https=)
JP (3) JP7116278B2 (https=)
KR (2) KR102622188B1 (https=)
CN (2) CN117801066A (https=)
AU (3) AU2017339577B2 (https=)
CA (1) CA3039322A1 (https=)
IL (3) IL302345B2 (https=)
WO (1) WO2018065623A2 (https=)

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WO2018065628A2 (en) 2016-10-07 2018-04-12 Enterome Microbiota sequence variants of tumor-related antigenic epitopes
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FI4021487T3 (fi) * 2019-11-15 2024-02-06 Enterome S A Antigeenisiä peptidejä b-solun pahanlaatuisuuden ehkäisyyn ja hoitoon
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CN112010960A (zh) * 2020-09-10 2020-12-01 热休(厦门)细胞生物科技有限公司 一种肿瘤抗原复合物体外致敏dc、t细胞获得肿瘤特异性杀伤细胞ctl及其制备方法
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Also Published As

Publication number Publication date
JP7331207B2 (ja) 2023-08-22
KR20190066028A (ko) 2019-06-12
JP2022120137A (ja) 2022-08-17
WO2018065623A3 (en) 2018-05-31
KR102622188B1 (ko) 2024-01-05
JP7648311B2 (ja) 2025-03-18
IL296165B1 (en) 2023-06-01
CN110022893B (zh) 2023-12-29
CA3039322A1 (en) 2018-04-12
AU2023222999A1 (en) 2023-09-21
IL302345B2 (en) 2024-12-01
EP3522915A2 (en) 2019-08-14
KR20240007316A (ko) 2024-01-16
JP2023156414A (ja) 2023-10-24
AU2017339577B2 (en) 2021-12-02
WO2018065623A2 (en) 2018-04-12
US11478537B2 (en) 2022-10-25
AU2023222999B2 (en) 2025-07-24
JP2019534884A (ja) 2019-12-05
CN110022893A (zh) 2019-07-16
US20200113983A1 (en) 2020-04-16
IL302345B1 (en) 2024-08-01
IL296165A (en) 2022-11-01
US12263210B2 (en) 2025-04-01
KR102686875B1 (ko) 2024-07-19
AU2022200872A1 (en) 2022-03-03
JP7116278B2 (ja) 2022-08-10
IL265751A (en) 2019-05-30
IL302345A (en) 2023-06-01
IL296165B2 (en) 2023-10-01
AU2017339577A1 (en) 2019-05-02
IL265751B (en) 2022-10-01
AU2022200872B2 (en) 2023-06-29
US20230201322A1 (en) 2023-06-29
IL265751B2 (en) 2023-02-01

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