CN117797232A - 一种用于手部湿疹的中药组合物 - Google Patents
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Abstract
本发明公开了一种用于手部湿疹的中药组合物,它是含有如下重量配比的原料制备而成:桂花5~15份,乌梅20~40份、丹参10~30份、马齿苋5~15份、姜黄5~15份、冰片2~7份、白矾5~15份,猪油5‑35份。本发明中药组合物能改善手掌湿疹反复发作,手部皲裂带来的痛苦,滋润手部肌肤的作用,且味道芳香自然,具备实际推广应用价值。
Description
技术领域
本发明具体涉及一种用于手部湿疹的中药组合物。
背景技术
手部湿疹是指主要发生在手部不累及或很少累及体其他部位的皮炎,常与手部皮炎作为同义词。发病率高、女性多见、病因复杂、治疗困难。流行病学研究反复证实手部湿疹是一时常发生的皮肤病,一年患病率约10%,一生患病率约20%。症状轻微到严重影响生活和工作质量,慢性趋势是一特点,症状或持续很多年或者好转后复发。
临床上大部分手部湿疹患者都能通过皮肤保护措施和局部治疗来处理。目前西医治疗手部湿疹仍以外用皮质类固醇激素为主,可在短时间内有效,但容易对药物产生依赖性,停药后易反复发作,并有可能诱发皮肤感染等局部不良反应,甚至产生全身性的副作用。而中药外治具有疗效好,副作用小,专利CN112933237A公开了一种用于慢性湿疹的中药组合物,其能有效的改善慢性湿疹,但经临床应用研究发现其对于手部湿疹改善效果较差,停止使用后手部湿疹易复发。因此寻找出有效的中药复方,以期能够更好的治疗手部湿疹。
发明内容
为解决上述问题,本发明提供了一种用于手部湿疹的中药组合物,它是含有如下重量配比的原料制备而成:
桂花5~15份,乌梅20~40份、丹参10~30份、马齿苋5~15份、姜黄5~15份、冰片2~7份、白矾5~15份,猪油5-35份。
进一步地,它是含有如下重量配比的原料制备而成:
桂花10份,乌梅30份、丹参20份、马齿苋10份、姜黄10份、冰片5份、白矾10份,猪油30份。
进一步地,所述桂花为桂花蕾。
进一步地,它是由原料药的药粉、或原料药的水或有机溶剂提取物为活性成分,加上药品或化妆品上可接受的辅料制备而成的制剂。
更进一步地,所述制剂为外用制剂。
更进一步地,所述外用制剂为溶液剂、膏剂、喷雾剂、贴剂,优选膏剂。
本发明还提供了一种前述中药组合物的制备方法,它包括以下步骤:
(1)按配比称取原料;
(2)取乌梅、丹参、马齿苋、姜黄、冰片和白矾研为粉末,加水煎煮,煎煮液加猪油煎煮成膏状,再加入桂花蕾,拌匀冷却,即得。
进一步地,步骤(2)所述粉末加20~30倍量的水煎煮至滴水成珠。
本发明最后提供了一种前述的中药组合物在制备用于手部湿疹的药物和/或化妆品中的用途。
进一步地,所述药物是治疗手部湿疹的药物。
进一步地,所述化妆品是修复手部湿疹皮肤的化妆品。
本发明中药组合物中桂花、乌梅味酸软化角质层,二味合用顾护肝脾二经,并且增加手膏香味,丹参活血化瘀,养护表皮,共为君,马齿苋祛风止痒,改善表皮皲裂,与姜黄共为臣,冰片、白矾促进药物渗透,为佐,最后猪油润泽肌肤,并予以赋形为使,全方共奏祛风止痒,润泽肌肤。
经临床研究统计,本发明中药组合物具有滋润手部肌肤的作用,且味道芳香自然,能改善手部湿疹反复发作,消除手部皲裂带来的痛苦。本发明中药组合物中各原料价格低廉,制成的膏剂可作为日常护手霜使用,具备实际推广应用价值。
显然,根据本发明的上述内容,按照本领域的普通技术知识和惯用手段,在不脱离本发明上述基本技术思想前提下,还可以做出其它多种形式的修改、替换或变更。
以下通过实施例形式的具体实施方式,对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
具体实施方式
实施例1、本发明组合物的制备
配方:桂花10g,乌梅30g、丹参20g、马齿苋10g、姜黄10g、冰片5g、白矾10g,猪油30g。
制备方法:按配比称取上述原料,取乌梅、丹参、马齿苋、姜黄、冰片和白矾研为粉末,加2000ml水熬成滴水成珠,再加入猪油继续熬一小时,成缓慢流动的膏糊状,加入桂花蕾,冷却成膏状,即得。
实施例2、本发明药物的制备
配方:桂花5g,乌梅20g、丹参10g、马齿苋5g、姜黄5g、冰片2g、白矾5g,猪油30g。
制备方法:同实施例1
实施例3、本发明药物的制备
配方:桂花15g,乌梅40g、丹参30g、马齿苋15g、姜黄15g、冰片7g、白矾15g,猪油30g。
制备方法:同实施例1。
以下通过试验例进一步说明本发明的有益效果。
试验例1临床研究
1临床资料
1.1一般资料:选取2022年4月至2023年4月我院门诊患者42例,随机分为两组。治疗组21例。对照组21例,两组一般资料比较,差异无统计学意义(P>0.05)。
1.2诊断标准:参照《中国临床皮肤病学》中手部湿疹的诊断依据、证候分类标准制定。
1.3纳入标准:符合上述诊断标准;排除近3个月内接受过系统糖皮质激素或免疫抑制剂治疗者。
2治疗方法
2.1对照组:保持手部湿疹处皮肤清洁、干燥,每天三次大宝牌SOD蜜涂抹。
2.1治疗组:在对照组基础上同时使用桂香润手膏(按实施例1制备),直接涂于患者手掌心湿疹处,厚度以1~2mm为宜。每天涂擦3次。共治疗4周。
3疗效观察
3.1评定方法:参考《中医病证诊断疗效标准》进行评定。临床痊愈:皮疹全部消退,瘙痒症状消失,疗效指数≥95%;显效:皮疹大部分消退,瘙痒症状有所改善,95%>疗效指数≥70%;有效:皮损部分消退,瘙痒症状有所改善,70%>疗效指数≥30%;无效:皮损消退不明显,瘙痒症状未见减轻或反见恶化,疗效指数<30%。总有效率=痊愈率+显效率。
3.2治疗结果:治疗组总有效率为85.71%,对照组为38.10%,治疗组明显高于对照组。两组之间差异有显著性(P<0.01)。本发明桂香润手膏具有自然芳香,患者依从性高,经1月的使用手部湿疹治疗效果显著。回访统计,治疗组手部湿疹复发率为14.19%,对照组63.2%。治疗组远低于对照组的复发率。
表1两组患者疗效比较
组别 | 例数 | 痊愈 | 有效 | 无效 | 总有效率 |
治疗组 | 21 | 10 | 8 | 3 | 85.71%* |
对照组 | 21 | 3 | 4 | 14 | 33.33% |
注:与对照组比较,*P<0.0
综上,本发明中药组合物能有效治疗手部湿疹,防止手部湿疹复发,消除手部皲裂带来的痛苦。本发明中药组合物中各原料价格低廉,制成的膏剂自然芳香,可作为日常护手霜使用,具备实际推广应用价值。
Claims (10)
1.一种用于手部湿疹的中药组合物,其特征在于:它是含有如下重量配比的原料制备而成:
桂花5~15份,乌梅20~40份、丹参10~30份、马齿苋5~15份、姜黄5~15份、冰片2~7份、白矾5~15份,猪油5~35份。
2.根据权利要求1所述的中药组合物,其特征在于:它是含有如下重量配比的原料制备而成:
桂花10份,乌梅30份、丹参20份、马齿苋10份、姜黄10份、冰片5份、白矾10份,猪油30份。
3.根据权利要求1或2所述的中药组合物,其特征在于:所述桂花为桂花蕾。
4.根据权利要求1或2所述的中药组合物,其特征在于:它是由原料药的药粉、或原料药的水或有机溶剂提取物为活性成分,加上药品或化妆品上可接受的辅料制备而成的制剂。
5.根据权利要求4所述的中药组合物,其特征在于:所述制剂为外用制剂;所述外用制剂为溶液剂、膏剂、喷雾剂、贴剂,优选膏剂。
6.权利要求1~5任一项所述中药组合物的制备方法,其特征在于:它包括以下步骤:
(1)按配比称取原料;
(2)取乌梅、丹参、马齿苋、姜黄、冰片和白矾研为粉末,加水煎煮,煎煮液加猪油煎煮成膏状,再加入桂花蕾,拌匀冷却,即得。
7.根据权利要求6所述的制备方法,其特征在于:步骤(2)所述粉末加20~30倍量的水煎煮至滴水成珠。
8.权利要求1~5任一项所述的中药组合物在制备用于手部湿疹的药物和/或化妆品中的用途。
9.根据权利要求8所述的用途,其特征在于:所述药物是治疗手部湿疹的药物。
10.根据权利要求8所述的用途,其特征在于:所述化妆品是修复手部湿疹皮肤的化妆品。
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