CN117731733A - Ointment for treating neuropathic pain and preparation method thereof - Google Patents
Ointment for treating neuropathic pain and preparation method thereof Download PDFInfo
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Abstract
The invention provides an ointment for treating neuropathic pain and a preparation method thereof, and belongs to the technical field of treating neuropathic pain, wherein the ointment for treating neuropathic pain comprises, by mass, 10-20 parts of gastrodia elata, 10-20 parts of ligusticum wallichii, 12-20 parts of selaginella tamariscina, 12-20 parts of fructus Piperis Longi, 20-50 parts of radix paeoniae alba, 1-3 parts of scorpion, 10-20 parts of borneol, 20-40 parts of sea cucumber intestines, 700-750 parts of sesame oil and 50-70 parts of beeswax; the invention provides an ointment for treating neuropathic pain and a preparation method thereof, which can solve the problems that western medicines for treating neuropathic pain produce certain drug dependence and adverse drug reaction, the illness state is easy to relapse after stopping the medicine, and the toxic effect on livers and other organs is large.
Description
Technical Field
The invention belongs to the technical field of treatment of neuropathic pain, and particularly relates to an ointment for treating neuropathic pain and a preparation method thereof.
Background
Neuropathic pain (NPP) is one of common neurological diseases, belongs to chronic pain syndrome which is difficult to cure, can cause electric shock and tearing pain, and has different degrees of anxiety and depression, so that the daily life of patients is seriously influenced. It belongs to the category of arthralgia syndrome in traditional Chinese medicine. At present, epidemiological characteristics of NPP are not unified, so that the research of NPP at the present stage mostly takes specific diseases such as cancer pain, postoperative neuralgia, postherpetic neuralgia and the like as research objects, and the related research shows that the incidence rate of NPP is 7% -10%.
At present, the treatment of NPP is mainly western medicine treatment, mainly anti-depression, anti-epileptic and other medicine treatment, has the advantages of definite curative effect and quick response, and the calcium ion channel regulator is a first-line medicine for treating neuropathic pain at present clinically, mainly comprises gabapentin and pregabalin, and tramadol and capsaicin are listed as second-line treatment medicines; powerful opiates and botulinum toxins a are listed as trilinear therapeutic drugs for peripheral neuropathic pain.
However, NPP belongs to chronic pain, and has long course of disease, relatively long course of treatment, possibly produces certain drug dependence and adverse drug reaction in the long-time drug treatment process, and the disease is easy to recur after drug withdrawal, and has great toxic effect on liver and other organs.
Disclosure of Invention
In view of the above, the invention provides an ointment for treating neuropathic pain and a preparation method thereof, which can solve the problems that western medicines for treating neuropathic pain produce certain drug dependence and adverse drug reaction, the illness state is easy to relapse after stopping the drug, and toxic effects on livers and other organs are large.
The invention is realized in the following way:
the first aspect of the invention provides an ointment for treating neuropathic pain, which comprises gastrodia elata, ligusticum wallichii, selaginella tamariscina, long pepper, white paeony root, scorpion, borneol, sea cucumber intestines, sesame oil and beeswax.
Gastrodia elata is sweet and calm, enters liver meridian. Has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals, and can be used for treating giddiness, eye black, headache, limbs anesthesia, hemiplegia, slurred speech, infantile convulsion, epilepsy, and wind movement.
Chuan Xiong, pungent and warm in nature, enters liver and gallbladder meridians. Has the effects of dispersing and activating the flow of qi, promoting blood circulation by removing blood stasis, promoting qi circulation and relieving pain, is a qi-flowing medicine in blood, can ascend the head and eyes, dispel wind and relieve pain, and is an essential medicine for treating headache.
Bai Shao, bitter and sour, with slight cold nature, enters liver and spleen meridians. Has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang, and can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous sweat, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache, and giddiness.
Herba Selaginellae, pungent and flat, can enter liver and heart channels, has effects of promoting blood circulation, dredging channels, removing blood stasis and stopping bleeding, and can be used for treating amenorrhea dysmenorrhea, abdominal mass, lump, and traumatic injury.
Fructus Piperis Longi, pungent and hot, and can enter stomach and large intestine channel, with effects of warming spleen and stomach, dispelling cold, and relieving pain, and can be used for treating stomach and abdomen crymodynia, emesis, diarrhea, cold stagnation of qi, chest pain, headache, and toothache.
Scorpio, pungent and flat, has effects of calming endogenous wind and relieving spasm, dredging collaterals and relieving pain, and removing toxic substances and resolving hard mass, and can be used for treating liver wind internal movement, spasm and convulsion, infantile convulsion, apoplexy, and oral cavity infectionHemiplegia, tetanus, chronic and persistent rheumatism, migraine, sore and ulcer, scrofula.
Borneol, which is pungent, bitter and slightly cold, enters heart, spleen and lung meridians. Has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. Can be used for treating apoplexy, vomiting, fever, unconsciousness, convulsion, epilepsy, phlegm, deafness due to qi-obstruction, pharyngitis, aphtha, otitis media, carbuncle, hemorrhoid, nebula, and enterobiasis.
Sesame oil, traditional Chinese medicine holds that: it is sweet and cool in nature and has the actions of relaxing bowel, removing toxicity and promoting tissue regeneration. According to the description of Ben Cao gang mu: has the effects of moistening dryness, removing toxic substances, relieving pain and detumescence. "miscellaneous records" say: the large intestine is protected, and the envelope is not fallen. The raw materials are used for treating swelling and alopecia. The ointment is decocted with sesame oil clinically, and has the effects of promoting muscle generation, relieving pain, eliminating carbuncle and swelling and nourishing skin. It can moisten intestine and moisten lung when taken orally; the external use is used as ointment and plaster matrix; is applied topically, such as scald, burn, and sore, with oleum Sesami and (mixed) medicine (powder), and applied to affected part without drying or cracking. Is extracted from Chinese pharmacopoeia
Cera flava, sweet, slightly warm, enters the spleen meridian. Has effects in removing toxic materials, healing sore, promoting granulation, and relieving pain. It is used for treating ulcer, ecthyma, erosion, traumatic ulcer, burn and scald.
Sea cucumber intestines, which are echinoderm and sea cucumber class organisms, have higher economic and medicinal values, contain various antioxidant active ingredients, and are currently researched and reported to be polypeptide, polysaccharide, phenols and flavonoid substances, wherein the phenols and the flavonoid substances are commonly used for treating neuropathic pain.
Based on the technical scheme, the ointment for treating neuropathic pain can be further improved as follows:
wherein the components comprise, by mass, 10-20 parts of gastrodia elata, 10-20 parts of Ligusticum wallichii, 12-20 parts of selaginella, 12-20 parts of long pepper, 20-50 parts of white peony root, 1-3 parts of scorpion, 10-20 parts of borneol, 20-40 parts of sea cucumber intestines, 700-750 parts of sesame oil and 50-70 parts of beeswax.
Neuropathic pain belongs to the category of arthralgia syndrome in traditional Chinese medicine, pain is a common disease, and the traditional Chinese medicine has a lot of discussion on the etiology and pathogenesis and treatment of the pain from the era of 'Nei Jing'. For example, "the circulation of the channels is not stopped, the circulation of cold is delayed, the circulation of cold is stopped when … … is stopped, and the circulation of cold is stopped when … … is stopped, so that the patient is suffering from pain, and" the patient suffering from pain … … m from typhoid fever "can not sweat when the patient is delayed, so that the patient is deficient in the circulation of cold, and the patient suffers from blood deficiency". Pathogenic factors invade the channels and collaterals, the channels and collaterals are urgent, the qi movement is not smooth, the normal rail is not overcome, and qi and blood are blocked in the bones and the extremities to cause pain; pain can also be caused by deficiency of qi and blood, deficiency of yang-qi, deficiency of yin-qi, viscera, orifices of veins, and general limbs and bones failing to nourish and warm. Common pathogenesis of pain is qi and blood retention, contracted venation, impaired nutrient and defensive qi, blood vessel deficiency and stagnation, blood qi stagnation, blood astringency and urgent pulse, yang Rekang exuberance, cold coagulation of muscle striae, cold-sinking of meridians and the like. Therefore, the "pain due to incoordination and incoordination" refers to the pathogenesis of the pain syndrome, i.e., the obstruction and incoordination of qi in the viscera and meridians.
The applicant found that neuropathic pain is mostly caused by pathogenic wind in the early stage of onset, and belongs to external wind. For long-term illness, mainly caused by internal wind, the "wind-like nature is good and the number changes" are similar to those of neuralgia, and they occur when touching. Liver is the viscera of wind-wood, initiative, and the main functions of dredging and discharging, and "excessive qi is the fire", the sexual condition is dysphoria, depression and anger hurt the liver, liver failing to dredge and discharge, depression and transformation of fire, and the liver wind is motivated, and wind-fire is accompanied with the inflammation, which is pain. In addition, stagnation of liver-qi, qi failing to circulate blood, or long-term disease entering collaterals, blood stasis and obstruction of collaterals, pain and pain are common. Therefore, fire heat and blood stasis are important factors for the pathogenesis of the disease and aggravating the disease to make the disease lingering and difficult to heal. Aiming at the basic pathogenesis of wind-fire stasis, the applicant takes the basic rules of suppressing hyperactive liver, calming endogenous wind, clearing heat, purging pathogenic fire, promoting blood circulation, removing obstruction in collaterals and relieving pain.
Further, the components comprise, by mass, 11-19 parts of gastrodia elata, 11-19 parts of ligusticum wallichii, 13-19 parts of selaginella tamariscina, 13-19 parts of fructus Piperis Longi, 15-40 parts of radix paeoniae alba, 1.5-2.5 parts of scorpion, 15-20 parts of borneol, 25-35 parts of sea cucumber intestines, 700-730 parts of sesame oil and 50-60 parts of beeswax.
Further, the components comprise 12 parts of gastrodia tuber, 12 parts of szechuan lovage rhizome, 15 parts of selaginella, 15 parts of long pepper, 30 parts of white paeony root, 2 parts of scorpion, 20 parts of borneol, 30 parts of sea cucumber intestines, 720 parts of sesame oil and 60 parts of beeswax according to the parts by weight.
The beneficial effects of adopting above-mentioned improvement scheme are: in the recipe, gastrodia tuber is a monarch drug, enters liver meridian, has the effects of calming endogenous wind and relieving spasm, suppressing liver yang, dispelling wind and dredging collaterals, is sweet and moist in taste and mild in property, and can be applied to liver wind movement of various causes, no matter what is cold, heat, deficiency and excess. Ligusticum wallichii, rhizoma Ligustici Chuanxiong, with pungent and dispersed effects, can promote blood circulation to remove blood stasis, promote qi circulation to relieve pain, is a qi-flowing medicine in blood, can ascend the head and eyes, dispel wind to relieve pain, is a key medicine for treating headache, and rhizoma Ligustici Chuanxiong can play a role in multiple effects, and the medicine is a ministerial medicine, and helps monarch medicine to calm wind, remove meridian obstruction and calm liver yang. Scorpio enters liver meridian, is good at moving, and can calm liver wind, and dispel wind and unblock collaterals, so it is often used for treating various intractable pains. Fructus Piperis Longi is an essential herb for headache, nasosinusitis and toothache, and is used for treating yang meridian and dispelling floating heat. Herba Selaginellae, has the effects of promoting blood circulation and dredging channels. In addition, selaginella tamariscina can remove yang from yin and harmonize yin and yang, and in this recipe, pathogenic factors in interior cause the effect of removing body surface. Bai Shao is sour and sweet in taste, and can nourish blood, regulate menstruation, calm liver, alleviate pain and astringe yin. The sea cucumber intestine has antioxidant, antibacterial, antitumor, immunity enhancing, and nerve repairing and growth promoting effects. The transdermal absorption capacity of borneol in the components is combined, so that the transdermal absorption effect can be improved.
In a second aspect, the present invention provides a method for preparing an ointment for treating neuropathic pain, comprising the steps of:
s10: weighing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the weight parts for standby;
s20: washing, freeze-drying and crushing the sea cucumber intestines, filtering by a 90-mesh screen, and weighing according to the weight parts for later use;
s30: slicing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the component ratio, and then soaking in sesame oil;
s40: adding the soaking solution of the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion slices into an iron pan for treatment, and filtering out residues in a sterile operation table to form treated sesame oil;
s50: when the temperature is reduced to 90 ℃, adding the beeswax, the sea cucumber intestines and the borneol into the treated sesame oil, slowly collecting the ointment with slow fire, bottling, and preserving at normal temperature for standby.
The preparation method of the ointment for treating neuropathic pain has the following technical effects: the ointment for treating neuropathic pain adopts a modern preparation process, has accurate medicine components and more thorough medicinal material treatment, ensures better drug property of the traditional Chinese medicine, has accurate and efficient processing process control, comprises more accurate and efficient weighing components, stirring speed in the processing process, processing temperature, time and the like, can be rapidly produced in batches, ensures better drug property and more greatly improves the quality.
Based on the technical scheme, the preparation method of the ointment for treating neuropathic pain can be further improved as follows:
further, slicing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba, and Scorpio, soaking in oleum Sesami for 72 hr.
Further, when the soaking liquid of the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion slices is treated, the liquid medicine is fried by slow fire until the surface is dark brown, and the middle part is burnt to the degree.
Further, 60g of the beeswax was added per 720g of the treated sesame oil.
Further, the specific steps of adding the beeswax, the sea cucumber intestines and the borneol are that the beeswax is added first, and then the sea cucumber intestines and the borneol are added.
Further, the method comprises the following steps:
s10: weighing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the weight part ratio, processing into fine powder, and uniformly mixing for later use;
s20: 200 parts of cotton seed oil and 40 parts of yellow lead are taken according to the parts by weight, the cotton seed oil is poured into a pot, decocted for 2-3 hours with slow fire, and when the oil temperature is raised to about 280 ℃, the fire is turned off;
s30: when the oil temperature is reduced to about 70 ℃, the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are sliced and poured into a pot under the stirring condition, and the mixture is boiled for 2-3 hours by firing and slow fire;
s40: when the temperature reaches about 300 ℃, turning off the fire, adding the yellow lead under the stirring condition, and stirring for about 20min until the yellow lead is dripped into beads;
s50: when the temperature is reduced to about 75 ℃, adding the borneol and the sea cucumber intestines under the stirring condition, and stirring for about 20min to obtain the ointment.
Compared with the prior art, the ointment for treating neuropathic pain and the preparation method thereof have the beneficial effects that: in the recipe, gastrodia tuber is a monarch drug, enters liver meridian, has the effects of calming endogenous wind and relieving spasm, suppressing liver yang, dispelling wind and dredging collaterals, is sweet and moist in taste and mild in property, and can be applied to liver wind movement of various causes, no matter what is cold, heat, deficiency and excess. Ligusticum wallichii, rhizoma Ligustici Chuanxiong, with pungent and dispersed effects, can promote blood circulation to remove blood stasis, promote qi circulation to relieve pain, is a qi-flowing medicine in blood, can ascend the head and eyes, dispel wind to relieve pain, is a key medicine for treating headache, and rhizoma Ligustici Chuanxiong can play a role in multiple effects, and the medicine is a ministerial medicine, and helps monarch medicine to calm wind, remove meridian obstruction and calm liver yang. Scorpio enters liver meridian, is good at moving, and can calm liver wind, and dispel wind and unblock collaterals, so it is often used for treating various intractable pains. Fructus Piperis Longi is an essential herb for headache, nasosinusitis and toothache, and is used for treating yang meridian and dispelling floating heat. Herba Selaginellae, has the effects of promoting blood circulation and dredging channels. In addition, selaginella tamariscina can remove yang from yin and harmonize yin and yang, and in this recipe, pathogenic factors in interior cause the effect of removing body surface. Bai Shao is sour and sweet in taste, and can nourish blood, regulate menstruation, calm liver, alleviate pain and astringe yin. The sea cucumber intestine has antioxidant, antibacterial, antitumor, immunity enhancing, and nerve repairing and growth promoting effects. The transdermal absorption capacity of borneol in the components is combined, so that the transdermal absorption effect can be improved. The ointment for treating neuropathic pain can enable the medicine to be directly absorbed by skin, has high cure rate and no sequelae after healing. The total effective rate of the external plaster for treating neuropathic pain for treating postherpetic neuralgia reaches 93-97%, and the cure rate reaches 80-87%. Can obviously relieve local nerve pain and itch caused by postherpetic neuralgia, and improve the life quality of patients; the application range is wide, the medicine can directly reach the affected part, the effect is rapid, the effect is cheap and convenient, the popularization is easy, the application is wide, the toxicity and adverse reaction of the medicine can be slowed down, the defect of internal treatment can be overcome, and the medicine is safe and reliable; has stable performance, good penetrability, good absorption, no toxicity, no harm, no side effect, obvious curative effect, dredging channels and collaterals, regulating five viscera and nourishing six viscera. The sea cucumber intestines are added, so that natural resources are fully utilized, the added value of sea cucumber processing is improved, and the method has environmental protection significance. The ointment for treating neuropathic pain adopts a modern preparation process, has accurate medicine components and more thorough medicinal material treatment, ensures better drug property of the traditional Chinese medicine, has accurate and efficient processing process control, comprises more accurate and efficient weighing components, stirring speed in the processing process, processing temperature, time and the like, can be rapidly produced in batches, ensures better drug property and more greatly improves the quality.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments of the present invention will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a flow chart of the operation of a method of preparing an ointment for treating neuropathic pain;
FIG. 2 is a flow chart illustrating the operation of a second embodiment of a method for preparing an ointment for treating neuropathic pain;
in the drawings, the list of components represented by the various numbers is as follows:
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
The first embodiment of the ointment for treating neuropathic pain provided by the invention comprises gastrodia elata, ligusticum wallichii, selaginella tamariscina, long pepper, white paeony root, scorpion, borneol, sea cucumber intestines, sesame oil and beeswax.
Wherein, in the technical proposal, the components comprise, by mass, 10-20 parts of gastrodia elata, 10-20 parts of ligusticum wallichii, 12-20 parts of selaginella tamariscina, 12-20 parts of fructus Piperis Longi, 20-50 parts of radix paeoniae alba, 1-3 parts of scorpion, 10-20 parts of borneol, 20-40 parts of sea cucumber intestines, 700-750 parts of sesame oil and 50-70 parts of beeswax.
In the second embodiment of the ointment for treating neuropathic pain, the ointment comprises, by mass, 11-19 parts of gastrodia elata, 11-19 parts of ligusticum wallichii, 13-19 parts of selaginella tamariscina, 13-19 parts of long pepper, 15-40 parts of white paeony root, 1.5-2.5 parts of scorpion, 15-20 parts of borneol, 25-35 parts of sea cucumber intestines, 700-730 parts of sesame oil and 50-60 parts of beeswax.
In the third embodiment of the ointment for treating neuropathic pain, the ointment comprises, by mass, 12 parts of gastrodia elata, 12 parts of ligusticum wallichii, 15 parts of selaginella tamariscina, 15 parts of fructus Piperis Longi, 30 parts of radix paeoniae alba, 2 parts of scorpion, 20 parts of borneol, 30 parts of sea cucumber intestines, 720 parts of sesame oil and 60 parts of beeswax.
When in use, the recommended dose of 50kg of ointment for treating neuropathic pain of a human body is 0.05g/cm < 2 >, a proper amount of the ointment is taken and smeared on an affected part twice a day, each time a day and a night, two weeks are a treatment course, 1-2 treatment courses are cured, and the ointment can be continuously used between the treatment courses.
As shown in fig. 1, a first embodiment of a method for preparing an ointment for treating neuropathic pain according to the present invention includes the following steps:
s10: weighing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio according to the weight ratio;
s20: cleaning sea cucumber intestines, freeze-drying, crushing, filtering by a 90-mesh screen, and weighing according to the weight parts for later use;
s30: slicing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio, soaking in oleum Sesami;
s40: adding the soaking solution of rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba, and Scorpio slices into iron pan, processing, filtering to remove residues in sterile operation table to obtain processed oleum Sesami;
s50: when the temperature is reduced to 90 ℃, beeswax, sea cucumber intestines and borneol are added into the treated sesame oil, the mixture is slowly collected by slow fire, bottled and preserved at normal temperature for standby.
When in use, the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are weighed according to the weight parts for standby; cleaning sea cucumber intestines, freeze-drying, crushing, filtering by a 90-mesh screen, and weighing according to the weight parts for later use; slicing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio, soaking in oleum Sesami; adding the soaking solution of rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba, and Scorpio slices into iron pan, processing, filtering to remove residues in sterile operation table to obtain processed oleum Sesami; when the temperature is reduced to 90 ℃, beeswax, sea cucumber intestines and borneol are added into the treated sesame oil, the mixture is slowly collected by slow fire, bottled and preserved at normal temperature for standby.
Further, in the technical scheme, the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are sliced and then soaked in sesame oil for 72 hours.
Further, in the technical scheme, when the soaking solution of the gastrodia elata, ligusticum wallichii, selaginella tamariscina, fructus piperis longi, white paeony root and scorpion slices is treated, the liquid medicine is fried by slow fire until the surface is dark brown, and the middle part is burnt to the degree.
Further, in the above technical scheme, 60g of beeswax is added to every 720g of treated sesame oil.
Further, in the technical scheme, the specific steps of adding the beeswax, the sea cucumber intestines and the borneol are that the beeswax is added first, and then the sea cucumber intestines and the borneol are added.
When in use, the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are weighed according to the weight parts for standby; cleaning sea cucumber intestines, freeze-drying, crushing, filtering by a 90-mesh screen, and weighing according to the weight parts for later use; slicing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio, soaking in oleum Sesami for 72 hr; adding sliced soaking solution of rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio into iron pan, processing, frying with slow fire until the surface turns dark brown, filtering out residues in sterile operation table to obtain treated oleum Sesami; when the temperature is reduced to 90 ℃, beeswax is added into the treated sesame oil, then sea cucumber intestines and borneol are added, the ointment is slowly collected by slow fire, and the mixture is bottled and stored at normal temperature for standby.
As shown in fig. 2, a second embodiment of a method for preparing an ointment for treating neuropathic pain according to the present invention includes the following steps:
s10: weighing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio according to weight ratio, processing into fine powder, and mixing;
s20: 200 parts of cotton seed oil and 40 parts of yellow lead are taken according to the parts by weight, the cotton seed oil is poured into a pot, decocted for 2-3 hours with slow fire, and when the oil temperature is raised to about 280 ℃, the fire is turned off;
s30: when the oil temperature is reduced to about 70 ℃, slicing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba and Scorpio, pouring into a pot, and decocting with slow fire for 2-3 hours;
s40: when the temperature reaches about 300 ℃, turning off the fire, adding yellow lead under the stirring condition, and stirring for about 20min until dripping water is formed into beads;
s50: when the temperature is reduced to about 75 ℃, adding the borneol and the sea cucumber intestines under the stirring condition, and stirring for about 20min to obtain the ointment.
Embodiment four:
the formula of the embodiment comprises the following raw materials of 12g of gastrodia elata, 12g of ligusticum wallichii, 15g of selaginella tamariscina, 15g of long pepper, 30g of white peony root, 2g of scorpion, 20g of borneol, 30g of sea cucumber intestines, 720g of sesame oil and 60g of beeswax in parts by weight.
The preparation method of the plaster for treating neuropathic pain comprises the following steps:
(1) Cleaning sea cucumber intestines, freeze-drying, crushing, filtering by a 90-mesh screen, and weighing according to the weight part ratio for standby
(2) Weighing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, herba Selaginellae, fructus Piperis Longi, radix Paeoniae alba, scorpio, and slicing;
(3) Soaking the above Chinese medicinal materials in oleum Sesami for 72 hr, heating to fry oil, and filtering to obtain medicinal oil;
(4) When the temperature is reduced to 90 ℃, adding borneol and sieved sea cucumber intestine fine powder, slowly collecting the ointment with slow fire, and bottling.
(5) The recommended dosage of the common analgesic plaster for human body (50 kg) is 0.05g/cm < 2 >, a proper amount of plaster is taken and smeared for Yu Huanchu twice a day, each time in the morning and evening, two weeks are a treatment course, 1-2 treatment courses are cured, and the plaster can be continuously used between the treatment courses.
Fifth embodiment:
the formula of the embodiment comprises the following raw materials of, by weight, 11g of gastrodia elata, 11g of ligusticum wallichii, 15g of selaginella tamariscina, 15g of long pepper, 30g of white peony root, 3g of scorpion, 20g of borneol, 30g of sea cucumber intestines, 700g of sesame oil and 60g of beeswax.
The preparation method of the plaster for treating neuropathic pain refers to the fourth embodiment.
Example six:
the formula of the embodiment comprises the following raw materials of 12g of gastrodia elata, 12g of ligusticum wallichii, 15g of selaginella tamariscina, 20g of long pepper, 30g of white peony root, 3g of scorpion, 20g of borneol, 40g of sea cucumber intestines, 710g of sesame oil and 50g of beeswax in parts by weight.
The preparation method of the plaster for treating neuropathic pain refers to the fourth embodiment.
Embodiment seven:
the formula of the embodiment comprises the following raw materials of, by weight, 20g of gastrodia elata, 20g of ligusticum wallichii, 15g of selaginella tamariscina, 15g of long pepper, 30g of white peony root, 2.5g of scorpion, 20g of borneol, 30g of sea cucumber intestines, 700g of sesame oil and 50g of beeswax.
The preparation method of the plaster for treating neuropathic pain refers to the fourth embodiment.
Example eight:
the formula of the embodiment comprises the following raw materials of, by weight, 20g of gastrodia elata, 20g of ligusticum wallichii, 15g of selaginella tamariscina, 15g of long pepper, 30g of white peony root, 2.5g of scorpion, 20g of borneol, 30g of sea cucumber intestines, 730g of sesame oil and 55g of bees.
The preparation method of the plaster for treating neuropathic pain refers to the fourth embodiment.
The clinical practice of the invention is summarized as follows:
standard: clinical recovery: pain disappears or basically disappears, and the curative effect index is more than or equal to 95%; the effect is shown: the pain is obviously improved, and the curative effect index is more than or equal to 70% and less than 95%; the method is effective: pain improvement, curative effect index less than 70% and more than 30%; invalidation: pain is not obviously improved, and the curative effect index is less than 30%. Total effective rate= (number of recovery cases + number of significant cases + number of effective cases/total number of cases) ×100%.
Table 1 shows the statistics of the treatment effect of 2 treatment courses for patients with postherpetic neuralgia as an example. Each example randomly selects 40 cases, 50% of men and women, the case ages between 45 and 80 years, the shortest course of disease is several months, and the longest course of disease is 1 year. The plaster for treating neuropathic pain of one of the fourth to eighth embodiments is used in each case until the end of the course of treatment without changing the drug halfway. The statistical results are shown in table 1:
TABLE 1 statistics of efficacy of postherpetic neuralgia
As can be seen from Table 1, the total effective rate of the postherpetic neuralgia reaches 93-97%, and the cure rate reaches 80-87%. The external plaster for treating postherpetic neuralgia is used for tracking and revisiting the patients who are healed after 1 year from the time of stopping the case in the upper surface, wherein the patients who are healed after the revisitation have no sequela symptoms.
Specifically, the principle of the invention is as follows: weighing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the weight parts for standby; washing, freeze-drying and crushing the sea cucumber intestines, filtering by a 90-mesh screen, and weighing according to the weight parts for later use; slicing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the component ratio, and then soaking in sesame oil for 72 hours; adding the soaking solution of the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion slices into an iron pan for treatment, frying the liquid medicine with slow fire until the surface is dark brown, filtering the residues in a sterile operation table until the middle part is brown, and forming treated sesame oil; when the temperature is reduced to 90 ℃, the beeswax is firstly added into the treated sesame oil, then the sea cucumber intestines and the borneol are added, the ointment is slowly collected by slow fire, and the mixture is bottled and stored at normal temperature for standby.
Claims (10)
1. An ointment for treating neuropathic pain is characterized by comprising rhizoma gastrodiae, ligusticum wallichii, selaginella tamariscina, fructus piperis longi, radix paeoniae alba, scorpion, borneol, sea cucumber intestines, sesame oil and beeswax.
2. The ointment for treating neuropathic pain according to claim 1, wherein the components comprise, by mass, 10-20 parts of gastrodia elata, 10-20 parts of ligusticum wallichii, 12-20 parts of selaginella tamariscina, 12-20 parts of fructus Piperis Longi, 20-50 parts of radix paeoniae alba, 1-3 parts of scorpion, 10-20 parts of borneol, 20-40 parts of sea cucumber intestines, 700-750 parts of sesame oil and 50-70 parts of beeswax.
3. The ointment for treating neuropathic pain according to claim 2, wherein the components comprise, by mass, 11-19 parts of gastrodia elata, 11-19 parts of ligusticum wallichii, 13-19 parts of selaginella tamariscina, 13-19 parts of fructus Piperis Longi, 15-40 parts of radix paeoniae alba, 1.5-2.5 parts of scorpion, 15-20 parts of borneol, 25-35 parts of sea cucumber intestines, 700-730 parts of sesame oil and 50-60 parts of beeswax.
4. The ointment for treating neuropathic pain according to claim 3, wherein the components include, by mass, 12 parts of gastrodia elata, 12 parts of ligusticum wallichii, 15 parts of selaginella tamariscina, 15 parts of fructus Piperis Longi, 30 parts of white peony root, 2 parts of scorpion, 20 parts of borneol, 30 parts of sea cucumber intestines, 720 parts of sesame oil and 60 parts of beeswax.
5. A method for preparing an ointment for treating neuropathic pain, which is characterized by comprising the following steps:
s10: weighing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the weight parts for standby;
s20: washing, freeze-drying and crushing the sea cucumber intestines, filtering by a 90-mesh screen, and weighing according to the weight parts for later use;
s30: slicing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the component ratio, and then soaking in sesame oil;
s40: adding the soaking solution of the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion slices into an iron pan for treatment, and filtering out residues in a sterile operation table to form treated sesame oil;
s50: when the temperature is reduced to 90 ℃, adding the beeswax, the sea cucumber intestines and the borneol into the treated sesame oil, slowly collecting the ointment with slow fire, bottling, and preserving at normal temperature for standby.
6. The method according to claim 5, wherein the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are sliced and then soaked in sesame oil for 72 hours.
7. The method according to claim 6, wherein the soaking solution of gastrodia elata, ligusticum wallichii, selaginella tamariscina, fructus piperis longi, radix paeoniae alba and scorpion slices is treated, and the medicinal solution is fried by slow fire until the surface is dark brown and the middle part is brown.
8. The method of claim 7, wherein 60g of beeswax is added per 720g of treated sesame oil.
9. The method for preparing ointment for treating neuropathic pain according to claim 8, wherein the specific steps of adding the beeswax, the sea cucumber intestines and the borneol are adding the beeswax first, and then adding the sea cucumber intestines and the borneol.
10. The method for preparing the ointment for treating neuropathic pain according to claim 9, comprising the following steps:
s10: weighing the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion according to the weight part ratio, processing into fine powder, and uniformly mixing for later use;
s20: 200 parts of cotton seed oil and 40 parts of yellow lead are taken according to the parts by weight, the cotton seed oil is poured into a pot, decocted for 2-3 hours with slow fire, and when the oil temperature is raised to about 280 ℃, the fire is turned off;
s30: when the oil temperature is reduced to about 70 ℃, the gastrodia elata, the ligusticum wallichii, the selaginella tamariscina, the long pepper, the white paeony root and the scorpion are sliced and poured into a pot under the stirring condition, and the mixture is boiled for 2-3 hours by firing and slow fire;
s40: when the temperature reaches about 300 ℃, turning off the fire, adding the yellow lead under the stirring condition, and stirring for about 20min until the yellow lead is dripped into beads;
s50: when the temperature is reduced to about 75 ℃, adding the borneol and the sea cucumber intestines under the stirring condition, and stirring for about 20min to obtain the ointment.
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