CN117700395A - 作为d1正变构调节剂的取代的四氢异喹啉衍生物 - Google Patents

作为d1正变构调节剂的取代的四氢异喹啉衍生物 Download PDF

Info

Publication number
CN117700395A
CN117700395A CN202311788931.8A CN202311788931A CN117700395A CN 117700395 A CN117700395 A CN 117700395A CN 202311788931 A CN202311788931 A CN 202311788931A CN 117700395 A CN117700395 A CN 117700395A
Authority
CN
China
Prior art keywords
formula
compound
methyl
compounds
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311788931.8A
Other languages
English (en)
Chinese (zh)
Inventor
A·阿苔丝
D·斯科尔克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CN117700395A publication Critical patent/CN117700395A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN202311788931.8A 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物 Pending CN117700395A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP19183643.6 2019-07-01
EP19183643 2019-07-01
PCT/EP2020/068183 WO2021001288A1 (en) 2019-07-01 2020-06-29 A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator
CN202080043657.XA CN113993857B (zh) 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080043657.XA Division CN113993857B (zh) 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物

Publications (1)

Publication Number Publication Date
CN117700395A true CN117700395A (zh) 2024-03-15

Family

ID=67137843

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311788931.8A Pending CN117700395A (zh) 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物
CN202080043657.XA Active CN113993857B (zh) 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080043657.XA Active CN113993857B (zh) 2019-07-01 2020-06-29 作为d1正变构调节剂的取代的四氢异喹啉衍生物

Country Status (23)

Country Link
US (1) US20220259179A1 (https=)
EP (1) EP3993794A1 (https=)
JP (1) JP7510444B2 (https=)
KR (1) KR20220029686A (https=)
CN (2) CN117700395A (https=)
AR (1) AR119318A1 (https=)
AU (1) AU2020299953B2 (https=)
BR (1) BR112021022378A2 (https=)
CA (1) CA3139571A1 (https=)
CL (1) CL2021002946A1 (https=)
CO (1) CO2021018155A2 (https=)
EC (1) ECSP21093559A (https=)
IL (2) IL289314B2 (https=)
MA (1) MA56440A (https=)
MX (2) MX2021015873A (https=)
MY (1) MY210361A (https=)
PE (1) PE20221020A1 (https=)
PH (1) PH12021552825A1 (https=)
SA (1) SA521431279B1 (https=)
SG (1) SG11202112537YA (https=)
TW (2) TWI875776B (https=)
WO (1) WO2021001288A1 (https=)
ZA (1) ZA202109193B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2976784T3 (es) 2020-10-07 2024-08-08 Lilly Co Eli Derivados de fenil-3,4-dihidroisoquinolin-2(1H)-il-etan-1-ona como moduladores alostéricos positivos del receptor de dopamina D1
US20240083925A1 (en) 2020-12-18 2024-03-14 UCB Biopharma SRL Prodrugs of 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
JP7798891B2 (ja) 2020-12-18 2026-01-14 ユーシービー バイオファルマ エスアールエル Ｄ１陽性アロステリック調節因子としての置換テトラヒドロイソキノリン誘導体
WO2022129267A1 (en) * 2020-12-18 2022-06-23 UCB Biopharma SRL Amorphous solid dispersions
EP4304577A1 (en) * 2021-03-09 2024-01-17 Eli Lilly And Co. Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression
WO2026022198A1 (en) 2024-07-25 2026-01-29 UCB Biopharma SRL Process for the preparation of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1 s,3 r)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1 h-isoquinolin-2-yl]ethanone monohydrate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105228985A (zh) * 2013-05-30 2016-01-06 伊莱利利公司 3,4-二氢异喹啉-2(1h)-基化合物
CN107001278A (zh) * 2014-10-08 2017-08-01 Ucb生物制药私人有限公司 四氢异喹啉衍生物
CN108884050A (zh) * 2016-04-13 2018-11-23 Ucb生物制药私人有限公司 四氢异喹啉衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2679735A1 (en) 2007-03-01 2008-09-12 Janssen Pharmaceutica N.V. Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor
KR101284796B1 (ko) 2011-10-05 2013-07-10 (주)포인트엔지니어링 캔 패지키 타입의 광 디바이스 제조 방법 및 이에 의해 제조된 광 디바이스
TWI725408B (zh) 2018-04-20 2021-04-21 美商美國禮來大藥廠 多巴胺d1受體正向異位調節劑

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105228985A (zh) * 2013-05-30 2016-01-06 伊莱利利公司 3,4-二氢异喹啉-2(1h)-基化合物
CN107001278A (zh) * 2014-10-08 2017-08-01 Ucb生物制药私人有限公司 四氢异喹啉衍生物
CN108884050A (zh) * 2016-04-13 2018-11-23 Ucb生物制药私人有限公司 四氢异喹啉衍生物

Also Published As

Publication number Publication date
CN113993857B (zh) 2024-01-02
SG11202112537YA (en) 2021-12-30
CL2021002946A1 (es) 2022-07-15
US20220259179A1 (en) 2022-08-18
WO2021001288A1 (en) 2021-01-07
IL289314A (en) 2022-02-01
MX2021015873A (es) 2022-02-03
IL289314B1 (en) 2025-05-01
AU2020299953A1 (en) 2022-01-06
AR119318A1 (es) 2021-12-09
PE20221020A1 (es) 2022-06-16
EP3993794A1 (en) 2022-05-11
JP2022539152A (ja) 2022-09-07
KR20220029686A (ko) 2022-03-08
MY210361A (en) 2025-09-13
ECSP21093559A (es) 2022-02-25
TWI875776B (zh) 2025-03-11
IL289314B2 (en) 2025-09-01
PH12021552825A1 (en) 2022-10-03
TW202115010A (zh) 2021-04-16
WO2021001288A9 (en) 2021-09-02
MX2024015493A (es) 2025-02-10
JP7510444B2 (ja) 2024-07-03
CA3139571A1 (en) 2021-01-07
MA56440A (fr) 2022-05-11
SA521431279B1 (ar) 2024-01-09
IL319939A (en) 2025-05-01
TW202537959A (zh) 2025-10-01
CN113993857A (zh) 2022-01-28
CO2021018155A2 (es) 2022-01-17
AU2020299953B2 (en) 2025-06-05
BR112021022378A2 (pt) 2022-03-08
ZA202109193B (en) 2023-11-29

Similar Documents

Publication Publication Date Title
CN113993857B (zh) 作为d1正变构调节剂的取代的四氢异喹啉衍生物
EP4263522B1 (en) Dihydroisoquinolinyl derivatives
CN114008032B (zh) 作为d1正变构调节剂的取代的四氢异喹啉衍生物
JP7798891B2 (ja) Ｄ１陽性アロステリック調節因子としての置換テトラヒドロイソキノリン誘導体
RU2824581C2 (ru) Замещенное производное тетрагидроизохинолина как позитивный аллостерический модулятор d1
JP2023551173A (ja) オクタヒドロイソキノリニル誘導体
HK40058931A (en) A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator
HK40058931B (zh) 作为d1正变构调节剂的取代的四氢异喹啉衍生物
HK40096273A (zh) 用作d1正向别构调节剂的经取代的四氢异喹啉衍生物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination