SA521431279B1 - D1 مشتق تتراهيدرو إيزوكينولين بديل كمعدِّل تفارغي إيجابي - Google Patents
D1 مشتق تتراهيدرو إيزوكينولين بديل كمعدِّل تفارغي إيجابيInfo
- Publication number
- SA521431279B1 SA521431279B1 SA521431279A SA521431279A SA521431279B1 SA 521431279 B1 SA521431279 B1 SA 521431279B1 SA 521431279 A SA521431279 A SA 521431279A SA 521431279 A SA521431279 A SA 521431279A SA 521431279 B1 SA521431279 B1 SA 521431279B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- positive allosteric
- allosteric modulator
- tetrahydroisoquinoline derivative
- substituted tetrahydroisoquinoline
- substituted
- Prior art date
Links
- 229940126027 positive allosteric modulator Drugs 0.000 title abstract 2
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
يتعلق الاختراع الحالي بمركب وفقًا للصيغة (I)، (I) وهو معدِّل تفارغي إيجابي positive allosteric modulator من D1 ويكون بالتالي مفيدًا كعامل صيدلاني لمعالجة الأمراض التي تلعب فيها مستقبلات D1 دورًا.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19183643 | 2019-07-01 | ||
| PCT/EP2020/068183 WO2021001288A1 (en) | 2019-07-01 | 2020-06-29 | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA521431279B1 true SA521431279B1 (ar) | 2024-01-09 |
Family
ID=67137843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA521431279A SA521431279B1 (ar) | 2019-07-01 | 2021-12-30 | D1 مشتق تتراهيدرو إيزوكينولين بديل كمعدِّل تفارغي إيجابي |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20220259179A1 (ar) |
| EP (1) | EP3993794A1 (ar) |
| JP (1) | JP7510444B2 (ar) |
| KR (1) | KR20220029686A (ar) |
| CN (2) | CN113993857B (ar) |
| AR (1) | AR119318A1 (ar) |
| AU (1) | AU2020299953A1 (ar) |
| BR (1) | BR112021022378A2 (ar) |
| CA (1) | CA3139571A1 (ar) |
| CL (1) | CL2021002946A1 (ar) |
| CO (1) | CO2021018155A2 (ar) |
| EC (1) | ECSP21093559A (ar) |
| IL (1) | IL289314A (ar) |
| MA (1) | MA56440A (ar) |
| MX (1) | MX2021015873A (ar) |
| PE (1) | PE20221020A1 (ar) |
| SA (1) | SA521431279B1 (ar) |
| SG (1) | SG11202112537YA (ar) |
| TW (1) | TW202115010A (ar) |
| WO (1) | WO2021001288A1 (ar) |
| ZA (1) | ZA202109193B (ar) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240000769A1 (en) | 2020-12-18 | 2024-01-04 | UCB Biopharma SRL | Amorphous solid dispersions |
| JP2024500391A (ja) | 2020-12-18 | 2024-01-09 | ユーシービー バイオファルマ エスアールエル | ２－（３，５－ジクロロ－１－メチル－インダゾール－４－イル）－１－［（１ｓ，３ｒ）－３－（ヒドロキシメチル）－５－（１－ヒドロキシ－１－メチル－エチル）－１－メチル－３，４－ジヒドロ－１ｈ－イソキノリン－２－イル］エタノンのプロドラッグ |
| JP2023553671A (ja) | 2020-12-18 | 2023-12-25 | ユーシービー バイオファルマ エスアールエル | Ｄ１陽性アロステリック調節因子としての置換テトラヒドロイソキノリン誘導体 |
| WO2022192255A1 (en) * | 2021-03-09 | 2022-09-15 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0808525A2 (pt) | 2007-03-01 | 2014-08-19 | Janssen Pharmaceutica Nv | Compostos de tetraidroisoquinolina como moduladors do receptor de histamina h3 |
| KR101284796B1 (ko) | 2011-10-05 | 2013-07-10 | (주)포인트엔지니어링 | 캔 패지키 타입의 광 디바이스 제조 방법 및 이에 의해 제조된 광 디바이스 |
| JO3316B1 (ar) | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| WO2016055479A1 (en) | 2014-10-08 | 2016-04-14 | Ucb Biopharma Sprl | Tetrahydroisoquinoline derivatives |
| CN108884050B (zh) * | 2016-04-13 | 2022-07-05 | Ucb生物制药私人有限公司 | 四氢异喹啉衍生物 |
| TWI725408B (zh) | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
-
2020
- 2020-06-29 WO PCT/EP2020/068183 patent/WO2021001288A1/en active Application Filing
- 2020-06-29 EP EP20734406.0A patent/EP3993794A1/en active Pending
- 2020-06-29 AU AU2020299953A patent/AU2020299953A1/en active Pending
- 2020-06-29 CN CN202080043657.XA patent/CN113993857B/zh active Active
- 2020-06-29 SG SG11202112537YA patent/SG11202112537YA/en unknown
- 2020-06-29 KR KR1020227002600A patent/KR20220029686A/ko active Search and Examination
- 2020-06-29 JP JP2021577411A patent/JP7510444B2/ja active Active
- 2020-06-29 US US17/621,851 patent/US20220259179A1/en active Pending
- 2020-06-29 MA MA056440A patent/MA56440A/fr unknown
- 2020-06-29 CN CN202311788931.8A patent/CN117700395A/zh active Pending
- 2020-06-29 BR BR112021022378A patent/BR112021022378A2/pt unknown
- 2020-06-29 MX MX2021015873A patent/MX2021015873A/es unknown
- 2020-06-29 PE PE2021002218A patent/PE20221020A1/es unknown
- 2020-06-29 CA CA3139571A patent/CA3139571A1/en active Pending
- 2020-06-30 AR ARP200101853A patent/AR119318A1/es unknown
- 2020-06-30 TW TW109122035A patent/TW202115010A/zh unknown
-
2021
- 2021-11-08 CL CL2021002946A patent/CL2021002946A1/es unknown
- 2021-11-17 ZA ZA2021/09193A patent/ZA202109193B/en unknown
- 2021-12-23 IL IL289314A patent/IL289314A/en unknown
- 2021-12-29 EC ECSENADI202193559A patent/ECSP21093559A/es unknown
- 2021-12-29 CO CONC2021/0018155A patent/CO2021018155A2/es unknown
- 2021-12-30 SA SA521431279A patent/SA521431279B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021002946A1 (es) | 2022-07-15 |
| CN117700395A (zh) | 2024-03-15 |
| WO2021001288A9 (en) | 2021-09-02 |
| TW202115010A (zh) | 2021-04-16 |
| PE20221020A1 (es) | 2022-06-16 |
| CO2021018155A2 (es) | 2022-01-17 |
| ECSP21093559A (es) | 2022-02-25 |
| CN113993857A (zh) | 2022-01-28 |
| IL289314A (en) | 2022-02-01 |
| CN113993857B (zh) | 2024-01-02 |
| AU2020299953A1 (en) | 2022-01-06 |
| AR119318A1 (es) | 2021-12-09 |
| ZA202109193B (en) | 2023-11-29 |
| WO2021001288A1 (en) | 2021-01-07 |
| EP3993794A1 (en) | 2022-05-11 |
| BR112021022378A2 (pt) | 2022-03-08 |
| US20220259179A1 (en) | 2022-08-18 |
| MA56440A (fr) | 2022-05-11 |
| CA3139571A1 (en) | 2021-01-07 |
| SG11202112537YA (en) | 2021-12-30 |
| KR20220029686A (ko) | 2022-03-08 |
| JP7510444B2 (ja) | 2024-07-03 |
| JP2022539152A (ja) | 2022-09-07 |
| MX2021015873A (es) | 2022-02-03 |
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