CN117547025B - Composition for controlling weight as well as preparation method and application thereof - Google Patents

Composition for controlling weight as well as preparation method and application thereof Download PDF

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Publication number
CN117547025B
CN117547025B CN202410046372.1A CN202410046372A CN117547025B CN 117547025 B CN117547025 B CN 117547025B CN 202410046372 A CN202410046372 A CN 202410046372A CN 117547025 B CN117547025 B CN 117547025B
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powder
weight
parts
lactobacillus
composition
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CN117547025A (en
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张硕
李亚惠
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Guangdong Xirui Biotechnology Co ltd
Beijing Xinxirui Biotechnology Co ltd
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Guangdong Xirui Biotechnology Co ltd
Beijing Xinxirui Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60—Edible seaweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
    • A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a composition for controlling weight, a preparation method and application thereof, and belongs to the technical field of weight management, wherein the composition comprises the following raw materials in parts by weight: 5-25 parts of seaweed powder, 10-60 parts of chestnut powder, 10-30 parts of mulberry leaf extract and 0.04-0.1 part of lactobacillus powder; the lactobacillus in the lactobacillus powder is Lactobacillus paracasei YJS05199. The preparation method comprises mixing seaweed powder, chestnut powder, mulberry leaf extract and lactobacillus powder according to the formula amount, and sieving. The composition of the present invention blocks caloric absorption against the food digestive path, and reduces excessive caloric conversion to fat, thereby reducing the formation of obesity.

Description

Composition for controlling weight as well as preparation method and application thereof
Technical Field
The invention relates to the technical field of weight management, in particular to a composition for controlling weight, a preparation method and application thereof.
Background
Maintaining a desired weight is challenging for many people. Furthermore, as people age, maintaining a desired weight generally becomes more difficult. Excessive or undesired body weight may be caused by an imbalance in caloric (energy) intake and energy expenditure. Such imbalance may be related to a variety of factors, including: binge eating, non-active or sedentary lifestyle, familial genetics and various medical conditions, etc. In order to prevent or prevent obesity or overweight, lifestyle changes may be one of the main solutions, however, in general lifestyle changes may be difficult to implement, resulting in poor results.
Dietary planning, reducing total caloric intake from the diet can help maintain a desired weight, including reducing dietary intake, or ingesting medications or supplements such as caloric blockers, meal replacers, appetite reducers, and the like. However, the effectiveness of currently available drugs or supplements in promoting weight control or weight loss is unpredictable. The efficacy of these drugs or supplements is questionable if they are not used in conjunction with caloric restricted diets and exercise regimens.
Thus, the lack of effective drugs or supplements to promote weight control or weight loss is currently a challenge for weight management.
Disclosure of Invention
The invention aims to provide a composition for controlling weight, a preparation method and application thereof, wherein the composition blocks heat absorption through a whole link aiming at a food digestion path, reduces excessive heat to be converted into fat, and thus reduces the formation of obesity.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
in a first aspect, the present invention provides a weight control composition comprising seaweed meal, chestnut meal, mulberry leaf extract and lactic acid bacteria meal.
The weight control composition of the present invention can achieve full-link heat absorption blocking by blocking carbohydrate decomposition into disaccharides, disaccharide decomposition into monosaccharides, lipase decomposition, etc., and reduce the conversion of excess heat into fat, thereby reducing the formation of obesity. Specifically, the seaweed meal can inhibit the digestion and decomposition of fat by inhibiting the activity of alpha-amylase in the oral cavity to block the decomposition of carbohydrate into disaccharides (maltose, sucrose and lactose) and inhibiting the activity of intestinal lipase; chestnut powder can block the decomposition of carbohydrate into disaccharide by inhibiting the activity of alpha-amylase in the oral cavity and stomach, inhibit the activity of maltase and sucrase in the small intestine and block the decomposition of disaccharide into monosaccharide; the mulberry leaf extract can act on a plurality of parts to block heat absorption, for example, can act on the oral cavity and the stomach to inhibit the activity of alpha-amylase and block the decomposition of carbohydrate into disaccharide, can act on the small intestine to inhibit the activities of alpha-glucosidase, maltase, sucrase and lactase and block the decomposition of disaccharide into monosaccharide, can act on blood vessels to block the entry of glucose into blood vessels, and can relieve insulin resistance and reduce blood sugar; the Lactobacillus paracasei YJS05199 can act on small intestine, and is combined with a-glucosidase preferentially, so that starch food is inhibited from being combined with the enzymes to produce decomposition and digestion, and can act on blood vessels to increase glucose metabolism level obviously.
In some specific embodiments, the weight control composition comprises the following raw materials in parts by weight: 5-25 parts of seaweed powder, 10-60 parts of chestnut powder, 10-30 parts of mulberry leaf extract and 0.04-0.1 part of lactobacillus powder.
Preferably, the mass ratio of the chestnut powder to the mulberry leaf extract to the lactobacillus powder is 20-50:12-25:0.04-0.01.
In some specific embodiments, the weight control composition comprises the following raw materials in parts by weight: 10-25 parts of seaweed powder, 20-50 parts of chestnut powder, 12-25 parts of mulberry leaf extract and 0.04-0.1 part of lactobacillus powder.
Preferably, the mass ratio of the chestnut powder to the mulberry leaf extract to the lactobacillus powder is 30:20:0.05.
In some specific embodiments, the weight control composition comprises the following raw materials in parts by weight: 20 parts of seaweed powder, 30 parts of chestnut powder, 20 parts of mulberry leaf extract and 0.05 part of lactobacillus powder.
In a second aspect, the present invention provides a method for preparing the above composition for controlling body weight, comprising the steps of mixing seaweed meal, chestnut meal, mulberry leaf extract and lactic acid bacteria meal, and sieving.
In a third aspect, the present invention provides the use of a weight control composition as described above for the preparation of a caloric blocker.
In a fourth aspect, the present invention provides a caloric blocker comprising the above-described weight control composition.
In a fifth aspect, the present invention provides the use of a weight control composition as described above for the preparation of a weight control product.
In a sixth aspect, the invention provides a weight management product comprising a weight management composition as described above.
The product is granular, powdery or blocky.
The beneficial effects of the invention are as follows:
(1) The weight control composition disclosed by the invention is prepared by carefully selecting seaweed powder, chestnut powder, mulberry leaf extract and lactobacillus powder (Lactobacillus paracasei YJS 05199) for compounding, and aims at a food digestion path, so that full-link heat absorption is blocked, excessive heat is reduced to be converted into fat, and the formation of obesity is effectively reduced.
(2) Experiments show that when the weight control composition comprises 20-50% of chestnut powder, 20% of mulberry leaf extract and 20% of lactobacillus powder by mass: 12-25: when the weight is 0.04-0.1, the effects of reducing fat and weight are better.
Detailed Description
The following examples are presented only to aid in understanding the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that various modifications and adaptations of the invention can be made without departing from the principles of the invention and these modifications and adaptations are intended to be within the scope of the invention as defined in the following claims. The following description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The invention does not limit the sources of the adopted raw materials, and if no special description exists, the adopted raw materials are all common commercial products in the technical field.
The seaweed powder is obtained by cleaning seaweed such as spirulina, undaria pinnatifida, kelp, sargassum horneri and sargassum fusiforme to remove sediment impurities, drying and crushing. For example, available from Tianjin coastal strapdown proprietary chemical industry Co., ltd., product number: 202041. the seaweed meal is used in an amount of 5 to 25 parts by weight, preferably 5 parts by weight, 10 parts by weight, 20 parts by weight, 25 parts by weight, and more preferably 20 parts by weight.
The chestnut powder is chestnut raw powder; such as available from Shaanxi Humicon development Co., ltd., product number: HK20230517. The amount of the chestnut powder is 10-60 parts by weight, preferably 10 parts by weight, 20 parts by weight, 30 parts by weight, 50 parts by weight and 60 parts by weight; further preferably 30 parts by weight.
The mulberry leaf extract of the present invention contains 1-deoxynojirimycin in an amount of not less than 1wt%, for example, commercially available from the company of biotechnology Co., ltd. The mulberry leaf extract is used in an amount of 10-30 parts by weight, preferably 10 parts by weight, 12 parts by weight, 20 parts by weight, 25 parts by weight, 30 parts by weight; further preferably 20 parts by weight.
The lactic acid bacteria powder of the present invention contains 55wt% maltodextrin and 45wt% of Lactobacillus paracasei YJS05199, wherein the Lactobacillus paracasei YJS05199 is inactivated, and is available from, for example, the biological technology Co., ltd. In the middle-aged Cryptographic (Shanghai), commercial product number: yl.kh.12.00181. The amount of the lactic acid bacteria powder is 0.04 to 0.1 part by weight, preferably 0.04 part by weight, 0.05 part by weight, 0.06 part by weight, 0.08 part by weight, 0.1 part by weight, and more preferably 0.05 part by weight.
It was unexpectedly found in the test that when the mass ratio of chestnut powder, mulberry leaf extract and lactic acid bacteria powder is 20-50:12-25: at 0.04-0.1, the weight-controlling composition of the present invention exhibits a better lipid-lowering effect.
The "weight control composition", "caloric blocker" and "weight control product" described herein are generally compositions comprising a number of weight control compositions (abbreviated as active ingredients) and pharmaceutically acceptable excipients, and in particular embodiments, the active ingredients described herein are provided in the compositions in an effective amount (e.g., a therapeutically effective amount).
The "pharmaceutically acceptable auxiliary materials" in the present invention include inert diluents, dispersants and/or granulating agents, surfactants and/or emulsifying agents, disintegrants, binders, preservatives, buffers, lubricants and/or oils. Excipients, colorants, coatings, sweeteners, and flavoring agents may also be present in the composition.
The compositions of the present invention may be prepared by any method known in the art of pharmacy. Generally, these methods of preparation involve associating the active ingredient with a carrier or excipient and/or one or more other auxiliary ingredients, and then shaping and/or packaging the product into the desired single or multi-dose unit if needed and/or desired.
The composition of the present invention can be prepared according to a known method, for example, the method set forth in the general rules for the preparation of japanese pharmacopoeia (Japanese Pharmacopoeia) 16 th edition, united states pharmacopoeia (United States Pharmacopoeia) and european pharmacopoeia (European Pharmacopoeia) 9 th edition. Depending on the dosage form, the compositions of the present invention may be suitably administered to patients. For example, the compositions of the present invention may be in the form of granules, powders or cubes.
The active ingredients, adjuvants in the compositions herein will vary depending on the nature, size and/or condition of the subject being treated and further depending on the route of administration of the composition. The composition may comprise between 0.1% and 100% (w/w) active ingredient.
By "controlling body weight" as used herein is meant treating or alleviating obesity by providing a higher amount of calories consumed than ingested. "treating" in the present invention, unless indicated otherwise, means reversing, alleviating, inhibiting the progression of, or preventing a disorder or condition for which the term applies or one or more symptoms of such disorder or condition.
The heat blocker can also be called as a carbohydrate blocker or a carbohydrate blocker, and can inhibit decomposition and absorption of carbohydrates by a human body, so that digestion and absorption of the carbohydrates by the human body are reduced, the carbohydrates are prevented from being converted into fat, and the purpose of controlling the weight is achieved.
The weight control composition, the heat blocker and the weight control product can be used as raw materials in medicines. In the case where the "weight control composition", "caloric blocker" and "weight control product" of the present invention are used as raw materials, the "weight control composition", "caloric blocker" and "weight control product" are preferably contained in a proportion of 10% to 90% by weight.
The following examples and comparative examples of the present invention will be described in more detail with respect to the weight control composition of the present invention, but the present invention is not limited thereto.
Purchase information of the raw materials is shown in table 1 below.
TABLE 1
Examples 1 to 5 and comparative examples 1 to 5
Weight control compositions of the different examples and comparative examples were prepared according to Table 2 and the following preparation methods
The preparation method comprises the following steps: mixing seaweed powder, semen Castaneae powder, folium Mori extract and lactobacillus powder, and sieving with 80 mesh sieve.
TABLE 2 formulation of weight controlling compositions prepared in examples 1-5 and comparative examples 1-5 (unit: parts by weight)
The raw materials in the table are white kidney bean extract, which is purchased from Sieboldite Biotechnology Co., ltd. Alpha. -AIP is 20000u/g, and the "-" in the table indicates no addition.
Weight loss function test
Healthy male C57BL/6 mice of 5 weeks of age were selected, and after 3 days of adaptive feeding, they were randomly divided into 12 groups of a normal group, a model group and a composition group (examples 1 to 5 and comparative examples 1 to 5) according to body weight, 8 groups each. The normal group is continuously fed with basic feed (purchased from the medical animal experiment center in Guangdong province), the model group and the composition group are fed with high-fat nutritional feed (prepared from 80% of basic feed, 10% of lard and 10% of yolk powder, purchased from the medical animal experiment center in Guangdong province), and the feeding amount is 2.5g/25g of mouse weight per day.
The composition group was filled with the same amount of physiological saline as that of the normal group and the model group, and was continuously filled with the same amount of physiological saline for 4 weeks, per day, per weight of the mice prepared in the corresponding examples and comparative examples. All groups of mice were normally drinking and exercising during the trial, and the mice were weighed at week 1 and week 4 after the gavage composition, respectively. At the end of the experiment, body fat (testis and perirenal fat pad) was dissected and weighed.
SPSS16.0 software is adopted to carry out single factor analysis of variance, and the processed data are expressed as mean value plus or minus standard deviationS) represents.
The results are shown in tables 3 to 4.
TABLE 3 weight of rats of different groups±s）
Note that: p < 0.05, P < 0.01 compared to normal group; compared with the model group, the # P is less than 0.05, and the # P is less than 0.01; compared with the group of example 5, ΔP is less than 0.05, ΔΔP is less than 0.01.
As can be seen from table 3, there was no significant difference between the initial weights of the mice in each group.
After one week of feeding, the body weight of mice in the model group had a very significant difference (P < 0.01) compared to the normal group, indicating that high diet can induce mice to develop obesity.
The weight loss of the mice in the groups of examples 1-5 all had very significant differences (P < 0.01) compared to the model group, while the weight loss of the mice in the groups of comparative examples 1-5 all had no significant differences (P > 0.05), indicating that the compositions of the present invention significantly alleviated weight gain in obese mice induced by a high fat diet, whereas the compositions provided by the comparative examples did not alleviate weight gain in obese mice induced by a high fat diet.
The weight gain of the mice in the comparative examples 1-5 was significantly different (P < 0.05) compared to the group of example 5, indicating that the compositions of the present invention had better effect on alleviating weight gain in obese mice induced by a high fat diet than the compositions provided in comparative examples 1-5.
After 4 weeks of continuous feeding, the weight loss of mice in the groups of examples 1-5 all had very significant differences (P < 0.01) compared to the model group, while the weight loss of mice in the groups of comparative examples 1-5 all had no significant differences (P > 0.05), indicating that the compositions of the present invention can significantly alleviate weight gain in obese mice induced by a high-fat diet, whereas the compositions provided by the comparative examples did not have the effect of alleviating weight gain in obese mice induced by a high-fat diet.
The weight gain of the mice in the comparative examples 1-5 was very significantly different (P < 0.01) compared to the group of example 5, indicating that the compositions of the present invention had a better effect of alleviating weight gain in obese mice induced by a high fat diet than the compositions provided in comparative examples 1-5.
Table 4 shows the total weight of fat in rats of different groups around±s）
Note that: p < 0.05, P < 0.01 compared to normal group; compared with the model group, the # P is less than 0.05, and the # P is less than 0.01; compared with the group of example 5, ΔP is less than 0.05, ΔΔP is less than 0.01.
As can be seen from Table 4, after 4 weeks of gastric lavage, the total fat in the mice of the model group had a very significant difference (P < 0.01) compared to the normal group, indicating that there was significant fat accumulation in the mice of the model group.
Compared with the model group, the total amount of fat in mice in the groups of examples 1-5 has extremely significant difference (P < 0.01), and the total amount of fat in mice in the groups of comparative examples 1-5 has no significant difference (P > 0.05), which shows that the composition of the invention can significantly reduce fat accumulation in mice, and the composition provided by the comparative example has no effect of reducing fat accumulation in mice.
The total fat levels of the mice in the comparative examples 1-5 were significantly different (P < 0.01) compared to the group of example 5, indicating that the compositions of the present invention had better fat accumulation reducing effects than the compositions provided in comparative examples 1-5.
The invention has been further described above in connection with specific embodiments, which are exemplary only and do not limit the scope of the invention in any way. It will be understood by those skilled in the art that various changes and substitutions of details and forms of the technical solution of the present invention may be made without departing from the spirit and scope of the present invention, but these changes and substitutions fall within the scope of the present invention.

Claims (6)

1. The weight control composition is characterized by comprising the following raw materials in parts by weight: 5-25 parts of seaweed powder, 10-60 parts of chestnut powder, 10-30 parts of mulberry leaf extract and 0.04-0.1 part of lactobacillus powder;
The lactobacillus in the lactobacillus powder is Lactobacillus paracasei YJS05199.
2. The weight control composition according to claim 1, wherein the mass ratio of chestnut powder, mulberry leaf extract and lactic acid bacteria powder is 20-50:12-25:0.04-0.1.
3. The weight control composition according to claim 2, characterized by comprising the following raw materials in parts by weight: 10-25 parts of seaweed powder, 20-50 parts of chestnut powder, 12-25 parts of mulberry leaf extract and 0.04-0.1 part of lactobacillus powder.
4. A weight control composition according to claim 3, wherein the mass ratio of chestnut powder, mulberry leaf extract and lactic acid bacteria powder is 30:20:0.05.
5. The weight control composition according to claim 4, which is characterized by comprising the following raw materials in parts by weight: 20 parts of seaweed powder, 30 parts of chestnut powder, 20 parts of mulberry leaf extract and 0.05 part of lactobacillus powder.
6. A method for preparing a weight control composition according to any one of claims 1 to 5, comprising the steps of: mixing seaweed powder, semen Castaneae powder, folium Mori extract and lactobacillus powder, and sieving.
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CN116235955A (en) * 2023-05-12 2023-06-09 北京新浠芮生物技术有限公司 Composition with functions of balancing immunity and protecting liver
CN117137136A (en) * 2023-08-14 2023-12-01 杭州千岛湖康诺邦健康产品有限公司 Composition with fat reducing function and preparation method and application thereof
CN116836893A (en) * 2023-08-31 2023-10-03 北京新浠芮生物技术有限公司 Lactobacillus paracasei, and metaplastic product and application thereof
CN117044945A (en) * 2023-10-09 2023-11-14 北京衡美金叶营养健康科技有限公司 Food composition with function of controlling blood sugar rise, and preparation method and application thereof

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