CN117137136A - Composition with fat reducing function and preparation method and application thereof - Google Patents

Composition with fat reducing function and preparation method and application thereof Download PDF

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Publication number
CN117137136A
CN117137136A CN202311014140.XA CN202311014140A CN117137136A CN 117137136 A CN117137136 A CN 117137136A CN 202311014140 A CN202311014140 A CN 202311014140A CN 117137136 A CN117137136 A CN 117137136A
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composition
powder
lipid
parts
green tea
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Inventor
胡钢亮
吴芝岳
罗欣
陈海平
吕庆中
吴红宇
姚瑞卿
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Hangzhou Qiandaohu Canobank Health Product Co ltd
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Hangzhou Qiandaohu Canobank Health Product Co ltd
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Priority to CN202311014140.XA priority Critical patent/CN117137136A/en
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    • A—HUMAN NECESSITIES
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Abstract

The application discloses a composition with a lipid-lowering function, a preparation method and application thereof, wherein the composition with the lipid-lowering function comprises the following raw materials, by weight, 1-15 parts of raw tea powder, 1-10 parts of lactobacillus casei, 1-10 parts of lactobacillus plantarum, 75-85 parts of prebiotics and 5-15 parts of fruit powder. The beneficial effects of the application are as follows: the composition with the lipid-lowering function has the advantages of low water activity and high bacterial activity. Meanwhile, the mulberry green tea and the probiotics have the function of reducing fat, and the fat reducing function effect of the mulberry green tea probiotic composition is better than the effect of simply supplementing the same amount of mulberry green tea or probiotics. The preparation method of the mulberry green tea probiotic composition can effectively reduce the water activity of the composition, thereby improving the storage stability of probiotics therein.

Description

Composition with fat reducing function and preparation method and application thereof
Technical Field
The application belongs to the field of functional foods, and particularly relates to a composition with a fat reducing function, and a preparation method and application thereof.
Background
Obesity has been formally defined by the world health organization (world health organization, WHO) as a chronic metabolic disease as early as 1997, and is typically characterized by increased adipose tissue and weight. With the development and progress of global economy, people's living standard and daily diet have been greatly improved and raised, which has also led to the development of explosive fashion trends of obesity worldwide.
Obesity is an increase in fat deposition due to a long-term imbalance in energy metabolism, i.e., excessive energy intake and/or insufficient energy expenditure. There is no effective solution to the problems of obesity caused by long-term imbalance of energy metabolism, and a series of metabolic disorders. The weight-losing method mainly solves the problems through weight-losing, but the common weight-losing method mainly comprises the steps of exercise weight-losing and medicine weight-losing, the time required by the exercise weight-losing is long, the effect is not clear, and the exercise weight-losing method is not easy for most people to adhere to, and the medicine weight-losing effect is obvious, but the long-term taking of the medicine weight-losing method affects the health of a human body, and the medicine is easy to rebound after stopping taking the medicine.
The probiotic fermented green tea beverage is a common green tea combined probiotic form with the weight-losing function at present, and the probiotic fermentation forms micromolecular tea polyphenol by breaking tea polyphenol and glycosidic bond, so that the absorption of the tea polyphenol is facilitated, but the fermented green tea beverage has the advantages that the bitter taste of the beverage is increased due to the fact that most of the tea polyphenol exists in a free form, the taste is poor, the quality control difficulty of the beverage is high in the production process, and the production cost is increased.
Disclosure of Invention
The application aims to provide a composition with scientific and balanced proportion, a fat-reducing function and high stability, and a preparation method and application thereof.
In order to achieve the above object, the present application adopts the following technical scheme:
a composition with fat reducing function comprises the following raw materials, by weight, 1-15 parts of powdered mulberry green tea, 1-10 parts of lactobacillus casei, 1-10 parts of lactobacillus plantarum, 75-85 parts of prebiotics and 5-15 parts of fruit powder.
In the above composition with the lipid-reducing function, as a preferred embodiment, the mass ratio of the mulberry leaf to the green tea in the mulberry green tea powder is 1:5-5:1, a step of; preferably, the content of theanine in the green tea is 0.5-3.0%, and the content of tea polyphenol is 10-18%; more preferably, the content of DNJ in the mulberry leaves is 0.15% -0.33%.
Matcha is a micropowder product which is prepared by taking fresh tea leaves cultivated in a covering way as a raw material, picking the fresh tea leaves, deactivating enzymes by steam (or hot air), drying, and grinding. Matcha is rich in vitamins, tea polyphenols, alkaloids, polysaccharides, amino acids, aroma and volatile components. Wherein, the tea polyphenol has the functions of preventing obesity and reducing fat, mainly improves intestinal microbiota, inhibits pancreatic lipase activity, promotes oxidation of dietary fat, reduces absorption of exogenous lipid by an organism, increases excretion and energy output, inhibits expression of genes related to lipogenesis, promotes lipolysis and expression of genes related to energy metabolism, reduces lipid deposition by improving high-density lipoprotein level and self antioxidation, and further achieves the effects of losing weight and reducing fat.
The finished product of the micro powder formula green tea prepared by the green tea process after the green tea and the mulberry leaves are scientifically proportioned is emerald and durable, fine and smooth in powder quality and elegant in taste, and has great difference from the conventional green tea in taste and mouthfeel. The mulberry leaf contains a unique natural alkaloid 1-Deoxynojirimycin (DNJ), and the DNJ is found to be a powerful sugar metabolism enzyme inhibitor (such as alpha-glucosidase, hexokinase, glucuronidase, glycogen phosphatase and the like), and the DNJ can obviously delay the degradation process of polysaccharide, reduce the peak value of postprandial blood sugar and stabilize fasting blood sugar. The research shows that the mulberry green tea can also effectively prevent the rise of serum total cholesterol, triglyceride and low-density lipoprotein, effectively increase the content of high-density lipoprotein, and has obvious blood lipid reducing effect.
The probiotics can promote the absorption of polyphenol substances, so that the bioavailability of polyphenol is improved. The probiotics not only can improve glucose and fat metabolism level, but also can regulate liver dysfunction caused by high fat feeding, thereby improving insulin sensitivity and steatosis symptoms and helping weight loss. The probiotics can also effectively increase gastrointestinal hormone, reduce the secretion level of ghrelin, effectively inhibit gastrointestinal motility, increase satiety, and reduce accumulation of body weight and fat.
The above composition with lipid reducing effect, as a preferred embodiment, the Lactobacillus casei is Lactobacillus casei Zhang, preferably the viable cell size of Lactobacillus casei Zhang is 1×10 9 CFU/g-10×10 9 CFU/g。
Lactobacillus casei Zhang can reduce obesity and fat accumulation caused by high fat diet, can significantly reduce triglyceride and low density lipoprotein content, and regulate lipid metabolism of hypercholesterolemia rats by affecting gene expression in liver.
The composition with lipid-lowering function is preferably one wherein the Lactobacillus plantarum is Lactobacillus plantarum P-8, and the viable cell count of Lactobacillus plantarum P-8 is 1×10 9 CFU/g-10×10 9 CFU/g。
The lactobacillus plantarum P-8 can obviously reduce the total cholesterol, triglyceride and low-density lipoprotein cholesterol content in serum and liver, obviously increase the high-density lipoprotein cholesterol content, and has good blood lipid reducing effect. In addition, the low concentration of tea polyphenol can promote the growth of probiotics and improve the stability of the probiotics.
The composition with the fat reducing function is taken as a preferable embodiment, wherein the prebiotic is at least one of fructo-oligosaccharide, resistant dextrin, polydextrose, erythritol, galacto-oligosaccharide, inulin, lactulose, resistant starch, xylo-oligosaccharide and wheat dextrin; preferably, the fruit powder is at least one of acerola cherry powder, blueberry powder, orange powder, cranberry powder, strawberry powder, raspberry powder, grape powder and grapefruit powder.
In a second aspect of the present application, there is provided a method for preparing a composition having a lipid-lowering function, comprising the steps of:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics;
(3) uniformly mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder to obtain the composition with the fat reducing function.
In the preparation method of the composition with the lipid-lowering function, as a preferred embodiment, in the step (1), the mulberry green tea powder, the prebiotics and the fruit powder are respectively dried to the water activity (Aw) of less than or equal to 0.1; preferably, in the step (2), the speed of premixing is 10-15r/min, and the time of premixing is 10-15min.
In the preparation method of the composition with the fat reducing function, as a preferred implementation manner, in the step (3), the mixing speed is 10-15r/min, and the mixing time is 30-60min; preferably, the water activity (Aw) of the resulting composition with lipid-lowering function is less than or equal to 0.1.
In a third aspect, the application provides an application of the composition with the fat reducing function according to any one of claims 1-5 or the composition with the fat reducing function obtained by the preparation method according to any one of claims 6-8 in the aspects of fat reducing health products and fat reducing medicines.
The use as described above, as a preferred embodiment, the lipid-lowering medicament comprises a pharmaceutically acceptable carrier or excipient; preferably, the lipid-lowering drug may be a powder, granule, tablet or capsule.
The beneficial effects of the application are as follows: the composition with the lipid-lowering function has the advantages of low water activity and high bacterial activity. Meanwhile, the mulberry green tea and the probiotics have the function of reducing fat, and the fat reducing function effect of the mulberry green tea probiotic composition is better than the effect of simply supplementing the same amount of mulberry green tea or probiotics. The preparation method of the mulberry green tea probiotic composition can effectively reduce the water activity of the composition, thereby improving the storage stability of probiotics therein.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the technical solutions of the present application will be described in detail below. It will be apparent that the described embodiments are only some, but not all, embodiments of the application. All other embodiments, based on the examples herein, which are within the scope of the application as defined by the claims, will be within the scope of the application as defined by the claims.
Example 1
A composition with the function of reducing fat comprises the following raw materials, by weight, 10 parts of raw tea powder, 5 parts of lactobacillus casei, 5 parts of lactobacillus plantarum, 80 parts of prebiotics and 10 parts of acerola cherry powder;
the mass ratio of the mulberry leaves to the green tea in the mulberry green tea powder is 7:3, the content of theanine in the green tea is 2.0%, and the content of tea polyphenol is 13%; the DNJ content in the mulberry leaves is 0.26%;
the Lactobacillus casei is Lactobacillus casei Zhang, and the viable bacterial count of the Lactobacillus casei Zhang is 5×10 9 CFU/g, wherein the lactobacillus plantarum is lactobacillus plantarum P-8, and the viable count of the lactobacillus plantarum P-8 is 5 multiplied by 10 9 CFU/g；
The prebiotics comprise 40 parts of fructo-oligosaccharide, 20 parts of galacto-oligosaccharide and 20 parts of xylo-oligosaccharide.
A method for preparing a composition with lipid-lowering function according to embodiment 1 comprises the following steps:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder until the water activity (Aw) is less than or equal to 0.1;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics for 10min under the condition of premixing rotating speed of 15 r/min;
(3) Mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder for 30min under the condition of the rotating speed of 10r/min to obtain the composition with the lipid-reducing function and the water activity (Aw) of less than or equal to 0.1.
Example 2
A composition with the function of reducing fat comprises the following raw materials by weight part, 8 parts of raw tea powder, 5 parts of lactobacillus casei, 10 parts of lactobacillus plantarum, 75 parts of prebiotics and 15 parts of grape powder;
the mass ratio of the mulberry leaves to the green tea in the mulberry green tea powder is 7:3, the content of theanine in the green tea is 1.0%, and the content of tea polyphenol is 16%; the DNJ content in the mulberry leaves is 0.26%;
the Lactobacillus casei is Lactobacillus casei Zhang, and the viable bacterial count of the Lactobacillus casei Zhang is 5×10 9 CFU/g, wherein the lactobacillus plantarum is lactobacillus plantarum P-8, and the viable count of the lactobacillus plantarum P-8 is 1 multiplied by 10 9 CFU/g；
The prebiotics comprise 40 parts of fructo-oligosaccharide, 20 parts of galacto-oligosaccharide and 15 parts of xylo-oligosaccharide.
The preparation method of the composition with the lipid-lowering function in the embodiment 2 comprises the following steps:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder until the water activity (Aw) is less than or equal to 0.1;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics for 15min under the condition of 10r/min of premixing rotating speed;
(3) Mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder for 40 minutes under the condition of the rotating speed of 10r/min to obtain the composition with the lipid-reducing function, wherein the water activity (Aw) is less than or equal to 0.1.
Adding distilled water into the composition with the fat reducing function in the embodiment 2 to prepare a soft material which is kneaded into a mass, pressed and dispersed by hands, then passing through a 14-22 mesh screen (plate) in an extrusion mode to prepare uniform particles, controlling a certain temperature, drying at 37 ℃ to ensure that the water activity (Aw) is less than or equal to 0.1, and sieving the dried particles after cooling to ensure that the particles are uniform, thus obtaining the finished product of the granule.
Example 3
A composition with fat reducing function comprises the following raw materials, by weight, 5 parts of raw tea powder, 7 parts of lactobacillus casei, 8 parts of lactobacillus plantarum, 75 parts of prebiotics and 15 parts of grapefruit powder;
the mass ratio of the mulberry leaves to the green tea in the mulberry green tea powder is 7:3, the content of theanine in the green tea is 1.0%, and the content of tea polyphenol is 16%; the DNJ content in the mulberry leaves is 0.26%;
the Lactobacillus casei is Lactobacillus casei Zhang, and the viable bacterial count of the Lactobacillus casei Zhang is 7×10 9 CFU/g, wherein the lactobacillus plantarum is lactobacillus plantarum P-8, and the viable count of the lactobacillus plantarum P-8 is 8 multiplied by 10 9 CFU/g；
The prebiotics comprise 35 parts of fructo-oligosaccharide, 25 parts of galacto-oligosaccharide and 15 parts of xylo-oligosaccharide.
The preparation method of the composition with the lipid-lowering function in the embodiment 3 comprises the following steps:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder until the water activity (Aw) is less than or equal to 0.1;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics for 10min under the condition of premixing rotating speed of 15 r/min;
(3) Mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder for 30min under the condition of the rotating speed of 10r/min to obtain the composition with the lipid-reducing function and the water activity (Aw) of less than or equal to 0.1.
Adding distilled water into the composition of the green tea probiotics of the embodiment 3 to prepare a soft material which is kneaded into a ball, pressed and dispersed by hand, then passing through a 14-22 mesh screen (plate) in an extrusion mode to prepare uniform particles, controlling a certain temperature, drying at 37 ℃ to ensure that the water activity (Aw) is less than or equal to 0.1, and sieving the dried particles after cooling to prepare the particles. The preparation of the empty capsule is carried out according to the conventional method, the particles are filled with hard capsules by a mechanical filling method, and finally the capsules are sealed, so that the finished hard capsule is obtained.
Example 4
A composition with a fat reducing function comprises the following raw materials in parts by weight, 7 parts of raw tea powder, 10 parts of lactobacillus casei, 5 parts of lactobacillus plantarum, 76 parts of prebiotics and 14 parts of blueberry powder;
the mass ratio of the mulberry leaves to the green tea in the mulberry green tea powder is 7:3, the content of theanine in the green tea is 1.0%, and the content of tea polyphenol is 16%; the DNJ content in the mulberry leaves is 0.26%;
the Lactobacillus casei is Lactobacillus casei Zhang, and the viable bacterial count of the Lactobacillus casei Zhang is 1×10 10 CFU/g, wherein the lactobacillus plantarum is lactobacillus plantarum P-8, and the viable count of the lactobacillus plantarum P-8 is 5 multiplied by 10 9 CFU/g；
The prebiotics comprise 40 parts of fructo-oligosaccharide, 20 parts of galacto-oligosaccharide and 16 parts of xylo-oligosaccharide.
The preparation method of the composition with the lipid-lowering function in the embodiment 4 comprises the following steps:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder until the water activity (Aw) is less than or equal to 0.1;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics for 10min under the condition of premixing rotating speed of 15 r/min;
(3) Mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder for 30min under the condition of the rotating speed of 10r/min to obtain the composition with the lipid-reducing function and the water activity (Aw) of less than or equal to 0.1.
Fully and uniformly mixing the mulberry green tea probiotic composition of the example 4 with magnesium stearate, adding distilled water for wet granulation, then drying the granules to ensure that the water activity (Aw) is less than or equal to 0.1, and tabletting and forming to obtain a tablet finished product.
Comparative example 1
The composition having a lipid-lowering function described in comparative example 1 is different from the composition described in example 1 in that:
the preparation method of the composition with the fat reducing function described in the comparative example 1 comprises the following steps:
(1) Premixing lactobacillus casei, lactobacillus plantarum and prebiotics for 10min under the condition of premixing rotating speed of 15 r/min;
(2) Mixing the premixed powder with the folium Mori powder and fruit powder at a rotation speed of 10r/min for 30min to obtain the composition with fat reducing effect.
1. Determination of the Water Activity of the composition with lipid-lowering function according to the application
The water activities of the finished products of examples 1-4 and comparative example 1 were determined and the test results are shown in Table 1:
TABLE 1
Group of Water Activity (Aw)
Example 1 0.06±0.01
Example 2 0.06±0.01
Example 3 0.06±0.01
Example 4 0.07±0.01
Comparative example 1 0.36±0.07
As can be seen from table 1: in the preparation process of the mulberry green tea probiotic composition in comparative example 1, the mulberry green tea powder, the prebiotics and the fruit powder are not dried to the water activity (Aw) of less than or equal to 0.1, and the water activity (Aw) of the total mixed powder is not controlled to be less than or equal to 0.1, so that the water activity (Aw) of the prepared mulberry green tea probiotic composition reaches 0.36, which is not beneficial to long-term storage stability of probiotics. The water activities of the tea-based probiotic compositions of examples 1-4 were all 0.1 less, which is beneficial for the probiotics to remain active, thereby improving the stability of the probiotics in the tea-based probiotic composition.
2. Stability determination of probiotics in the composition with lipid-lowering function
The samples of examples 1-4 and comparative 1 were placed in a constant temperature and humidity cabinet (temperature 25 ℃ C., humidity 75%) for storage acceleration test. The total viable count of Lactobacillus casei Zhan and Lactobacillus plantarum P-8 was measured every 15 days according to national standard GB 4789.35-2016, and the measurement results are shown in Table 2:
TABLE 2
Group of Day 0 For 15 days For 30 days 45 days For 60 days 75 days 90 days
Example 1 10×10 9 10×10 9 9.8×10 9 9.8×10 9 9.7×10 9 9.6×10 9 9.6×10 9
Example 2 16×10 9 15.9×10 9 15.8×10 9 15.8×10 9 15.7×10 9 15.7×10 9 15.6×10 9
Example 3 15×10 9 14.9×10 9 14.9×10 9 14.8×10 9 14.8×10 9 14.7×10 9 14.6×109
Example 4 15×10 9 15×10 9 14.9×10 9 14.8×10 9 14.8×10 9 14.7×10 9 14.7×10 9
Comparative example 1 10×10 9 9.5×10 9 9.1×10 9 8.7×10 9 8.3×10 9 8.0×10 9 7.7×10 9
As can be seen from table 2: in 9 days of the accelerated test, the number of the probiotics in the sample of the comparative example 1 is obviously reduced, while the total number of the probiotics in the samples of the examples 1 to 4 is not obviously changed, namely the composition with the lipid-reducing function has high probiotic stability.
3. The application relates to a research on the lipid-reducing effect of a composition with lipid-reducing function
3.1. Experimental materials
Mulberry Matcha, probiotic and composition with lipid-lowering function obtained in example 1
3.2. Animal experiment model establishment
8-week-old male C57BL/6 mice are selected and fed for more than one week under the photoperiod condition of 12L to 12D, so that the animal center environment is adapted.
After one week of adaptation, the mice were randomly divided into five groups of 10 mice each, wherein three experimental groups were labeled A, B, C groups, one experimental control group was labeled D group, one blank control group was labeled E group, and the five groups of mice were fed respectively.
Group A: feeding the mice with the high-fat feed while feeding the sample prepared in example 1 with drinking water;
group B: the same amount of the same mulberry green tea as that contained in the sample prepared in example 1 was converted into a certain amount of a probiotic-free composition and drinking water, and the mice were fed with the same amount of high-fat feed;
group C: the same amount of probiotics contained in the sample prepared in example 1 was converted into a certain amount of composition without folium mori green tea and drinking water by stomach irrigation, and the mice were fed with an equal amount of high-fat feed;
group D: filling the stomach with the same volume of drinking water as the experimental group, and feeding the mice with an equal amount of high-fat feed to serve as experimental control;
group E: the mice are fed with the same amount of common feed as blank control while the mice are irrigated with the same volume of drinking water as the experimental group.
After 8 weeks of feeding, the body weight of each group of mice was weighed and recorded, the mice were sacrificed after eyeball blood collection, and total Cholesterol (CHOL) in the blood of the mice was measured, and the test results are shown in table 3.
TABLE 3 influence of the samples of the groups on the body weight of the mice (unit: g)
Group of Initial initiation Week 8
Group A 20.7±0.9 34.9±2.5
Group B 19.8±0.4 37.6±2.3
Group C 20.1±0.5 39.4±2.1
Group D 19.7±0.4 42.2±3.2
Group E 19.9±0.6 30.1±2.2
As can be seen from table 3: after 8 weeks of different gastric lavage samples, the average body weight of the mice in the group A is increased by about 14.2g, the average body weight of the mice in the group B is increased by about 17.8g, the average body weight of the mice in the group C is increased by about 19.3g, the average body weight of the mice in the group D is increased by about 22.5g, and the average body weight of the mice in the group E is increased by about 10.2g, so that the results show that the weight increase of the mice can be controlled by the composition of the matcha and the probiotics, and the effect of the composition of the matcha and the probiotics is better than that of the composition of the matcha and the probiotics which are simply supplemented with the same amount of matcha.
TABLE 4 influence of the samples of the groups on the total cholesterol in the blood of mice (unit: mmol/L)
Group of CHOL
Group A 2.67±0.21
Group B 3.38±0.23
Group C 3.52±0.31
Group D 3.96±0.29
Group E 2.12±0.26
As can be seen from table 4: A. the total cholesterol concentration in the blood of the B, C group mice is obviously lower than that of the D group, which indicates that the total cholesterol in the blood of the mice can be reduced by the folium mori and the probiotics, and the effects of the folium mori probiotic composition are better than those of the composition which is simply supplemented with the same amount of folium mori or probiotics.
The above description is only of the preferred embodiments of the present application and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims (10)

1. The composition with the fat reducing function is characterized by comprising the following raw materials, by weight, 1-15 parts of raw tea powder, 1-10 parts of lactobacillus casei, 1-10 parts of lactobacillus plantarum, 75-85 parts of prebiotics and 5-15 parts of fruit powder.
2. The composition with the fat reducing function according to claim 1, wherein the mass ratio of the mulberry leaves to the green tea in the mulberry green tea powder is 1:5-5:1, a step of; preferably, the content of theanine in the green tea is 0.5-3.0%, and the content of tea polyphenol is 10-18%; more preferably, the content of DNJ in the mulberry leaves is 0.15% -0.33%.
3. A composition with fat reducing function according to claim 1, wherein the lactobacillus casei is lactobacillus casei Zhang, preferably the viable bacterial count of lactobacillus casei Zhang is 1 x 10 9 CFU/g-10×10 9 CFU/g。
4. The composition with lipid-lowering function according to claim 1, wherein the Lactobacillus plantarum is Lactobacillus plantarum P-8, and the viable bacterial count of Lactobacillus plantarum P-8 is 1×10 9 CFU/g-10×10 9 CFU/g。
5. The composition with fat reducing function according to claim 1, wherein the prebiotic is at least one of fructo-oligosaccharide, resistant dextrin, polydextrose, erythritol, galacto-oligosaccharide, inulin, lactulose, resistant starch, xylo-oligosaccharide, and wheat dextrin; preferably, the fruit powder is at least one of acerola cherry powder, blueberry powder, orange powder, cranberry powder, strawberry powder, raspberry powder, grape powder and grapefruit powder.
6. A method for preparing a composition having a lipid-lowering function as claimed in any one of claims 1 to 5, comprising the steps of:
(1) Respectively drying the mulberry green tea powder, the prebiotics and the fruit powder;
(2) Premixing lactobacillus casei, lactobacillus plantarum and dried prebiotics;
(3) And (3) uniformly mixing the mixed powder obtained in the step (2) with the mulberry green tea powder and the fruit powder to obtain the composition with the fat reducing function.
7. The method for producing a composition having a lipid-lowering function according to claim 6, wherein in the step (1), the powdered mulberry leaf, the prebiotic and the fruit powder are dried to a water activity (Aw) of 0.1 or less, respectively; preferably, in the step (2), the speed of premixing is 10-15r/min, and the time of premixing is 10-15min.
8. The method for preparing a composition with a lipid-lowering function according to claim 6, wherein in the step (3), the mixing speed is 10-15r/min and the mixing time is 30-60min; preferably, the water activity (Aw) of the resulting composition with lipid-lowering function is less than or equal to 0.1.
9. Use of a composition with lipid-lowering function according to any one of claims 1 to 5 or a composition with lipid-lowering function obtained by a preparation method according to any one of claims 6 to 8 in lipid-lowering health products and lipid-lowering medicaments.
10. The use according to claim 9, wherein the lipid-lowering drug comprises a pharmaceutically acceptable carrier or excipient; preferably, the lipid-lowering drug may be a powder, granule, tablet or capsule.
CN202311014140.XA 2023-08-14 2023-08-14 Composition with fat reducing function and preparation method and application thereof Pending CN117137136A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117547025A (en) * 2024-01-12 2024-02-13 北京新浠芮生物技术有限公司 Composition for controlling weight as well as preparation method and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117547025A (en) * 2024-01-12 2024-02-13 北京新浠芮生物技术有限公司 Composition for controlling weight as well as preparation method and application thereof
CN117547025B (en) * 2024-01-12 2024-04-26 北京新浠芮生物技术有限公司 Composition for controlling weight as well as preparation method and application thereof

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