CN103082003A - Dietary supplement having immunoloregulation effect - Google Patents
Dietary supplement having immunoloregulation effect Download PDFInfo
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- CN103082003A CN103082003A CN2011103477875A CN201110347787A CN103082003A CN 103082003 A CN103082003 A CN 103082003A CN 2011103477875 A CN2011103477875 A CN 2011103477875A CN 201110347787 A CN201110347787 A CN 201110347787A CN 103082003 A CN103082003 A CN 103082003A
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- China
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- dietary supplement
- colostrum
- taurine
- nutrient
- mouse
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Abstract
The invention provides a dietary supplement having an immunoloregulation effect. The dietary supplement comprises, by weight, 80 to 84% of bovine colostrum powder, 13 to 15% of taurine, 2 to 3% of vitamin C and 1 to 1.2% of magnesium stearate. The dietary supplement inhibits impairment of immune functions from a plurality of links through enhancing active immunity and passive immunity. According to results of functional experiments, the compound bovine coloctrum immunomodulator provided by the invention can improve delayed hypersensitivity (P < 0.05) of mice, ConA-induced lymphocyte transformation capability (P < 0.05) of mice and the like and has an obvious synergistic effect compared to individual usage of bovine coloctrum. The dietary supplement provided by the invention overcomes the disadvantages of single mechanism of action and poor effects of conventional products, is beneficial for improvement of sub-health conditions and has a great application value.
Description
Technical field
The present invention relates to health products, be specifically related to a kind of nutrient and healthcare products with immunoregulation effect.
Background technology
Inferior health is a kind of state between disease and health, and because social competition is day by day fierce, people's life and work rhythm quickening, tensity strengthen, and inferior health has become general situation.The investigation result demonstration, the prevalence rate of sub-health population is at 60%-70%, and inferior health has had a strong impact on people's ability to work and life quality.Therefore inquire into the mechanism of inferior health, effectively prevent and treat inferior health, become the medical circle problem demanding prompt solution.
Hypoimmunity is a kind of common important symptom and the sign of sub-health state, how to improve immunity for breaking away from inferior health, reducing the ill probability of health and seem very important.Immunity promotes it is to improve that immunity is the most direct, rapid, effective method, and the basic means that immunity promotes comprises passive immunity and active immunity.Immune system is a complexity, sensitivity, the orderly network system, any one link damaged or extremely all can cause immune defense function impaired.Therefore, safeguard that the normal physiological function of immune system is to improve the indispensable important step of immunologic function.A lot of about the nutrient and healthcare products of regulating immunologic function at present, but most mechanism of action is single, not yet plays effective immunization.Colostrum is the milk in 3 days after the cow calving.Not only contain abundant nutriment in colostrum, and contain a large amount of immune factors and growth factor, as immunoglobulin (Ig), lactoferrin, lysozyme, insulin-like growth factor, EGF etc.
Thereby exploitation colostrum nutrient and healthcare products have become the focus of paying close attention to.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and research and design has the colostrum nutrient and healthcare products of immunoregulation effect.
The invention provides a kind of nutrient and healthcare products (commodity are doctor's board colostrum recovering capsule difficult to understand) with immunoregulation effect.
The nutrient and healthcare products that the present invention has an immunoregulation effect are grouped into by the one-tenth of following weight percent proportioning:
| Composition | Weight (%) |
| Bovine colostrum | 80～84 |
| Taurine | 13～15 |
| The stability vitamin C | 2～3 |
| Dolomol | 1 |
。
The present invention has the nutrient and healthcare products of immunoregulation effect, and is preferred,
One-tenth by following weight percent proportioning is grouped into:
| Composition | Weight (%) |
| Bovine colostrum | 81～83 |
| Taurine | 14～15 |
| The stability vitamin C | 2～3 |
| Dolomol | 1 |
。
The present invention has the nutrient and healthcare products of immunoregulation effect, and is most preferred,
One-tenth by following weight proportion is grouped into:
| Composition | Weight kg |
| Bovine colostrum | 82 |
| Taurine | 14 |
| The stability vitamin C | 3 |
| Dolomol | 1 |
。
Raw material of the present invention is commercially available acquisition all.
The effect of each component of the present invention is as follows:
Colostrum is the milk in 3 days after the cow calving.Not only contain abundant nutriment in colostrum, and contain a large amount of immune factors and growth factor, as immunoglobulin (Ig), lactoferrin, lysozyme, insulin-like growth factor, EGF etc., through scientific experiment proof have immunological regulation, improve intestines and stomach, a series of physiological functions such as enhancing development, the multiple germ of inhibition.
Taurine not only participates in the growth metabolism of body as a kind of nutriment, and indirectly participates in keeping and improving the immunologic function of body, as antioxidant and membrane stabilizer protection body cell, regulates neuroendocrine system.
V
CBe effective antioxidant, can effectively remove oxygen radical, stabilizing cell membrane prevents the oxidative damage of immunocyte, recovers the physiological function of impaired immunocyte, and immunocyte is had significant protective effect, and can activating immune system.
The nutrient and healthcare products that the present invention has immunoregulation effect prepare by following method:
Get bovine colostrum, taurine, vitamin C, cross respectively 80 mesh sieves; Get dolomol, mix with above-mentioned three kinds of raw materials, homogeneous with colloid mill, as capsule 's content, insert on full-automatic hard shell capsules filling machine in capsulae vacuus.
Colostrum contains the nutriment of a large amount of needed by human and biologically active peptide and the immunologic active material of balance the body function, and the panimmunity regulatory factor that it is rich in can provide good passive immunity for body.Especially with the colostrum in 24 hours, Immunity active factor content is the abundantest.24 hours colostrum freeze-dried powders that this product adopts low-temperature centrifugation degrease and freeze drying process to process are raw material, the complete active ingredient that keeps colostrum.
The present invention is compound cow foremilk immune conditioning agent, adds taurine and the V of suitable dosage with colostrum
C, by strengthening active immunity, passive immunity, from a plurality of link Immunosuppression function damages.prove through functional experiment, compound cow foremilk immune conditioning agent of the present invention is compared with alone colostrum, can improve the delayed allergy ability (P＜0.05) of mouse, strengthen the mouse lymphocyte conversion capability (P＜0.05) that ConA induces, the carbon of mouse is cleaned up ability (P＜0.05), improve mouse antibodies cellulation number (P＜0.05), improve mouse HD50 value (P＜0.05), mouse macrophage engulfs chicken erythrocyte phagocytic rate (P＜0.05) and mouse macrophage is engulfed chicken erythrocyte phagocytic index (P＜0.05), has obvious synergistic action effect.Doctor's board colostrum recovering capsule difficult to understand is a kind of, effect significant product immune by the adjusting of number of mechanisms too many levels, has overcome the existing product mechanism of action single, and the deficiency that effect is not good enough is conducive to improve sub-health status, and larger using value is arranged.
The specific embodiment
Following raw material is commercially available acquisition all, and wherein (1) colostrum freeze-dried powder is available from Urumchi Nuo Likang bioengineering Co., Ltd (immunoglobulin G (IgG) content 20%); (2) taurine is available from Yongan, Qianjiang pharmaceutcal corporation, Ltd (99% content); (3) V
CAvailable from the stone medicine medicine company (99% content) of supporting one's family
Embodiment 1 has the nutrient and healthcare products (doctor's board colostrum recovering capsule difficult to understand) of immunoregulation effect
Formula:
(1) bovine colostrum 84kg
(2) taurine 13kg
(3) vitamin C 2kg
(4) dolomol 1kg
Preparation:
Get bovine colostrum 84kg; taurine 13kg; stability Catergen kg; cross respectively 80 mesh sieves; mix, add dolomol 1kg, homogeneous with colloid mill; (model NJP 1200) filling capsulae vacuus according to a conventional method on full-automatic hard shell capsules filling machine, then make 31.25 ten thousand capsules through madreporic vesicle, polishing, sealing process.
Embodiment 2 has the nutrient and healthcare products (doctor's board colostrum recovering capsule difficult to understand) of immunoregulation effect
Formula:
(1) bovine colostrum 81kg
(2) taurine 15kg
(3) vitamin C 3kg
(4) dolomol 1kg
The preparation method makes 31.25 ten thousand capsules with embodiment 1.
Embodiment 3 has the nutrient and healthcare products (doctor's board colostrum recovering capsule difficult to understand) of immunoregulation effect
Formula:
(1) bovine colostrum 82kg
(2) taurine 14kg
(3) vitamin C 3kg
(4) dolomol 1kg
The preparation method makes 31.25 ten thousand capsules with embodiment 1.
Embodiment 4 has the nutrient and healthcare products functional experiment (zoopery) of immunoregulation effect
Sample:
(1) the colostrum freeze-dried powder is available from Urumchi Nuo Likang bioengineering Co., Ltd (IgG20% content); (2) taurine is available from Yongan, Qianjiang pharmaceutcal corporation, Ltd (99% content); (3) V
CAvailable from the stone medicine medicine company (99% content) of supporting one's family; (4) nutrient and healthcare products with immunoregulation effect that embodiment 1 makes (doctor's board colostrum recovering capsule difficult to understand)
Method:
(1) animal experiment using dosage design
Crowd's recommended intake every day of doctor's board colostrum recovering capsule difficult to understand: IgG 4.27mg/kg, taurine 1.2mg/kg, vitamin C 0.23mg/kg.The animal experiment using dosage is designed to 20 times of crowd's recommended amounts, and namely the about 85mg/kg of IgG, be equivalent to bovine colostrum (IgG20% content) 425mg; Taurine (99% content) 25mg, vitamin C (97% content) 4.7mg.
(2) test method
Choose the male SPF level of healthy adult Kunming mouse, body weight 19-22 gram is divided into colostrum control group, colostrum+taurine, colostrum+V at random
C, colostrum+taurine+V
CGroup, by 20 times of sample solutions of giving above-mentioned corresponding dosage of crowd's RD, every day is gavage at twice, and after feeding continuously 30 days, sampling detects.Test method is undertaken by " health food check and assessment technique standard ".Wherein delayed allergy (DTH) test adopts the SRBC inducing mouse foot sole of the foot to thicken method (DTH); The mouse spleen lymphocyte conversion test that ConA induces is with Methlthiazoletrazolium trace enzyme reaction colorimetric method (MTT).The mensuration Hemagglutination Method of serum hemolysin; Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell test, uses half intracorporal method.
Experimental result
Table 1 is on the impact of mouse cell immunologic function indices (X ± SD)
* compared significant difference (P＜0.05) with the colostrum control group
Table 2 is on the impact of mouse humoral immune function indices (X ± SD)
* compared significant difference (P＜0.05) with the colostrum control group
Table 3 is on the impact of mouse monokaryon-macrophage function indices (X ± SD)
* compared significant difference (P＜0.05) with the colostrum control group
Per os gave the different tested material of mouse after 30 days, compared with the colostrum control group, and the experimental result that this tested material strengthens immunity function is as follows:
the dosage taurines such as colostrum interpolation, the VC group can improve the delayed allergy ability (P＜0.05) of mouse, the carbon of mouse lymphocyte conversion capability (P＜0.05) mouse that enhancing ConA induces is cleaned up ability (P＜0.05), improve mouse antibodies cellulation number (P＜0.05), improve mouse HD50 value (P＜0.05) mouse macrophage and engulf chicken erythrocyte phagocytic rate (P＜0.05), engulf chicken erythrocyte phagocytic index (P＜0.05) (seeing Table the dosage group in 1-table 3) with mouse macrophage.
Claims (3)
1. the nutrient and healthcare products with immunoregulation effect, is characterized in that, described nutrient and healthcare products are grouped into by the one-tenth of following weight percent proportioning:
2. the nutrient and healthcare products with immunoregulation effect, is characterized in that, described nutrient and healthcare products are grouped into by the one-tenth of following weight percent proportioning:
3. the nutrient and healthcare products with immunoregulation effect, is characterized in that, described nutrient and healthcare products are grouped into by the one-tenth of following weight:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103477875A CN103082003A (en) | 2011-11-07 | 2011-11-07 | Dietary supplement having immunoloregulation effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103477875A CN103082003A (en) | 2011-11-07 | 2011-11-07 | Dietary supplement having immunoloregulation effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103082003A true CN103082003A (en) | 2013-05-08 |
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| CN2011103477875A Pending CN103082003A (en) | 2011-11-07 | 2011-11-07 | Dietary supplement having immunoloregulation effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109221864A (en) * | 2018-08-28 | 2019-01-18 | 杭州千岛湖标普健康食品有限公司 | A kind of functional solid beverage and preparation method thereof that the multicomponent enhanced human immunity is compound |
| CN109275794A (en) * | 2018-09-04 | 2019-01-29 | 深圳市旺金生物科技有限公司 | A kind of butafosfan immunologic facilitation nutritive cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872338A (en) * | 2005-06-03 | 2006-12-06 | 闫玉森 | Chewing tablet for discharging lead, and preparation method |
| CN102178699A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for enhancing human immunity and promoting growth and development |
-
2011
- 2011-11-07 CN CN2011103477875A patent/CN103082003A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872338A (en) * | 2005-06-03 | 2006-12-06 | 闫玉森 | Chewing tablet for discharging lead, and preparation method |
| CN102178699A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for enhancing human immunity and promoting growth and development |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109221864A (en) * | 2018-08-28 | 2019-01-18 | 杭州千岛湖标普健康食品有限公司 | A kind of functional solid beverage and preparation method thereof that the multicomponent enhanced human immunity is compound |
| CN109275794A (en) * | 2018-09-04 | 2019-01-29 | 深圳市旺金生物科技有限公司 | A kind of butafosfan immunologic facilitation nutritive cream and preparation method thereof |
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Application publication date: 20130508 |