CN117534639A - 酰胺类化合物及其制备方法和农学应用 - Google Patents
酰胺类化合物及其制备方法和农学应用 Download PDFInfo
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- CN117534639A CN117534639A CN202311268630.2A CN202311268630A CN117534639A CN 117534639 A CN117534639 A CN 117534639A CN 202311268630 A CN202311268630 A CN 202311268630A CN 117534639 A CN117534639 A CN 117534639A
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- -1 Amide compound Chemical class 0.000 title claims abstract description 39
- 230000009418 agronomic effect Effects 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title abstract description 52
- 150000001875 compounds Chemical class 0.000 claims abstract description 900
- 230000008635 plant growth Effects 0.000 claims abstract description 10
- 230000036579 abiotic stress Effects 0.000 claims abstract description 4
- 208000035240 Disease Resistance Diseases 0.000 claims abstract description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 703
- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 229910052760 oxygen Inorganic materials 0.000 claims description 44
- 125000005842 heteroatom Chemical group 0.000 claims description 35
- 229910052736 halogen Inorganic materials 0.000 claims description 30
- 150000002367 halogens Chemical class 0.000 claims description 30
- 150000001408 amides Chemical class 0.000 claims description 20
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 229940125904 compound 1 Drugs 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- 230000007226 seed germination Effects 0.000 claims description 13
- 238000006467 substitution reaction Methods 0.000 claims description 13
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 229920006395 saturated elastomer Polymers 0.000 claims description 11
- 230000001737 promoting effect Effects 0.000 claims description 9
- 125000004414 alkyl thio group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- VEFGCFNCYQTPHP-UHFFFAOYSA-N 2-(3-phenylpropyl)thiophene Chemical compound C=1C=CC=CC=1CCCC1=CC=CS1 VEFGCFNCYQTPHP-UHFFFAOYSA-N 0.000 claims description 5
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 5
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 5
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 230000001965 increasing effect Effects 0.000 claims description 4
- WWTBZEKOSBFBEM-SPWPXUSOSA-N (2s)-2-[[2-benzyl-3-[hydroxy-[(1r)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)O)C(=O)C(CP(O)(=O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1 WWTBZEKOSBFBEM-SPWPXUSOSA-N 0.000 claims description 3
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims description 3
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 229940126208 compound 22 Drugs 0.000 claims description 3
- 229940125898 compound 5 Drugs 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 111
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims 1
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 claims 1
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 claims 1
- ABJSOROVZZKJGI-OCYUSGCXSA-N (1r,2r,4r)-2-(4-bromophenyl)-n-[(4-chlorophenyl)-(2-fluoropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide Chemical compound C1=NC(F)=CC(C(NC(=O)[C@H]2[C@@H](C[C@@H](CC2)N2CCOCC2)C=2C=CC(Br)=CC=2)C=2C=CC(Cl)=CC=2)=C1 ABJSOROVZZKJGI-OCYUSGCXSA-N 0.000 claims 1
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 1
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- GCTFTMWXZFLTRR-GFCCVEGCSA-N (2r)-2-amino-n-[3-(difluoromethoxy)-4-(1,3-oxazol-5-yl)phenyl]-4-methylpentanamide Chemical compound FC(F)OC1=CC(NC(=O)[C@H](N)CC(C)C)=CC=C1C1=CN=CO1 GCTFTMWXZFLTRR-GFCCVEGCSA-N 0.000 claims 1
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical compound C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 claims 1
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 claims 1
- VIJSPAIQWVPKQZ-BLECARSGSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4,4-dimethylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O VIJSPAIQWVPKQZ-BLECARSGSA-N 0.000 claims 1
- STBLNCCBQMHSRC-BATDWUPUSA-N (2s)-n-[(3s,4s)-5-acetyl-7-cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)N(C(C)=O)C2=CC(C#N)=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 STBLNCCBQMHSRC-BATDWUPUSA-N 0.000 claims 1
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
- FNHHVPPSBFQMEL-KQHDFZBMSA-N (3S)-5-N-[(1S,5R)-3-hydroxy-6-bicyclo[3.1.0]hexanyl]-7-N,3-dimethyl-3-phenyl-2H-1-benzofuran-5,7-dicarboxamide Chemical compound CNC(=O)c1cc(cc2c1OC[C@@]2(C)c1ccccc1)C(=O)NC1[C@H]2CC(O)C[C@@H]12 FNHHVPPSBFQMEL-KQHDFZBMSA-N 0.000 claims 1
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 claims 1
- OOKAZRDERJMRCJ-KOUAFAAESA-N (3r)-7-[(1s,2s,4ar,6s,8s)-2,6-dimethyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-hydroxy-5-oxoheptanoic acid Chemical compound C1=C[C@H](C)[C@H](CCC(=O)C[C@@H](O)CC(O)=O)C2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C[C@@H]21 OOKAZRDERJMRCJ-KOUAFAAESA-N 0.000 claims 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 claims 1
- MPDDTAJMJCESGV-CTUHWIOQSA-M (3r,5r)-7-[2-(4-fluorophenyl)-5-[methyl-[(1r)-1-phenylethyl]carbamoyl]-4-propan-2-ylpyrazol-3-yl]-3,5-dihydroxyheptanoate Chemical compound C1([C@@H](C)N(C)C(=O)C2=NN(C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C2C(C)C)C=2C=CC(F)=CC=2)=CC=CC=C1 MPDDTAJMJCESGV-CTUHWIOQSA-M 0.000 claims 1
- OMBVEVHRIQULKW-DNQXCXABSA-M (3r,5r)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-propan-2-yl-5,6-dihydro-4h-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoate Chemical compound O=C1C=2N(C(C)C)C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C=3C=CC(F)=CC=3)C=2CCCN1C1=CC=CC=C1 OMBVEVHRIQULKW-DNQXCXABSA-M 0.000 claims 1
- YQOLEILXOBUDMU-KRWDZBQOSA-N (4R)-5-[(6-bromo-3-methyl-2-pyrrolidin-1-ylquinoline-4-carbonyl)amino]-4-(2-chlorophenyl)pentanoic acid Chemical compound CC1=C(C2=C(C=CC(=C2)Br)N=C1N3CCCC3)C(=O)NC[C@H](CCC(=O)O)C4=CC=CC=C4Cl YQOLEILXOBUDMU-KRWDZBQOSA-N 0.000 claims 1
- STPKWKPURVSAJF-LJEWAXOPSA-N (4r,5r)-5-[4-[[4-(1-aza-4-azoniabicyclo[2.2.2]octan-4-ylmethyl)phenyl]methoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2h-1$l^{6}-benzothiepin-4-ol Chemical compound O[C@H]1C(CCCC)(CCCC)CS(=O)(=O)C2=CC=C(N(C)C)C=C2[C@H]1C(C=C1)=CC=C1OCC(C=C1)=CC=C1C[N+]1(CC2)CCN2CC1 STPKWKPURVSAJF-LJEWAXOPSA-N 0.000 claims 1
- OIIOPWHTJZYKIL-PMACEKPBSA-N (5S)-5-[[[5-[2-chloro-3-[2-chloro-3-[6-methoxy-5-[[[(2S)-5-oxopyrrolidin-2-yl]methylamino]methyl]pyrazin-2-yl]phenyl]phenyl]-3-methoxypyrazin-2-yl]methylamino]methyl]pyrrolidin-2-one Chemical compound C1(=C(N=C(C2=C(C(C3=CC=CC(=C3Cl)C3=NC(OC)=C(N=C3)CNC[C@H]3NC(=O)CC3)=CC=C2)Cl)C=N1)OC)CNC[C@H]1NC(=O)CC1 OIIOPWHTJZYKIL-PMACEKPBSA-N 0.000 claims 1
- DEVSOMFAQLZNKR-RJRFIUFISA-N (z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-n'-pyrazin-2-ylprop-2-enehydrazide Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=NN(\C=C/C(=O)NNC=3N=CC=NC=3)C=N2)=C1 DEVSOMFAQLZNKR-RJRFIUFISA-N 0.000 claims 1
- KKHFRAFPESRGGD-UHFFFAOYSA-N 1,3-dimethyl-7-[3-(n-methylanilino)propyl]purine-2,6-dione Chemical compound C1=NC=2N(C)C(=O)N(C)C(=O)C=2N1CCCN(C)C1=CC=CC=C1 KKHFRAFPESRGGD-UHFFFAOYSA-N 0.000 claims 1
- MHSLDASSAFCCDO-UHFFFAOYSA-N 1-(5-tert-butyl-2-methylpyrazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 MHSLDASSAFCCDO-UHFFFAOYSA-N 0.000 claims 1
- KQZLRWGGWXJPOS-NLFPWZOASA-N 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile Chemical compound ClC1=C(C=CC(=C1)Cl)[C@@H](C)N1N=C(C=2C1=NC(=CN=2)C1=CC[C@@H]([C@@H](C1)C)N1[C@@H](CCC1)CO)C#N KQZLRWGGWXJPOS-NLFPWZOASA-N 0.000 claims 1
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 1
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 1
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 claims 1
- SVPKNMBRVBMTLB-UHFFFAOYSA-N 2,3-dichloronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(Cl)=C(Cl)C(=O)C2=C1 SVPKNMBRVBMTLB-UHFFFAOYSA-N 0.000 claims 1
- WGFNXGPBPIJYLI-UHFFFAOYSA-N 2,6-difluoro-3-[(3-fluorophenyl)sulfonylamino]-n-(3-methoxy-1h-pyrazolo[3,4-b]pyridin-5-yl)benzamide Chemical compound C1=C2C(OC)=NNC2=NC=C1NC(=O)C(C=1F)=C(F)C=CC=1NS(=O)(=O)C1=CC=CC(F)=C1 WGFNXGPBPIJYLI-UHFFFAOYSA-N 0.000 claims 1
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- VCUXVXLUOHDHKK-UHFFFAOYSA-N 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound ClC1=CC(OC)=CC=C1C1=C(C(N)=O)SC(C=2N=C(N)N=CC=2)=N1 VCUXVXLUOHDHKK-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P21/00—Plant growth regulators
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Abstract
本发明涉及农药化学领域,公开了一种酰胺类化合物及其制备方法和农学应用、生物刺激剂,该化合物具有式(I)所示的结构。本发明的化合物能够有效的促进种子的萌发、提高作物的产量、调节植物的生长、增强植物抗病能力、对植物进行非生物胁迫管理。
Description
技术领域
本发明涉及农药化学领域,具体涉及一种酰胺类化合物及其制备方法和农学应用。
背景技术
全球每年因杂草危害给粮食生产所造成的经济损失高达950亿美元,而土壤中庞大的种子库是杂草危害的直接原因。萌发是种子植物进行生命活动的必要条件。促进种子萌发一方面可以改进种子发芽率减少农业生产中种子使用量,提高肉苁蓉、锁阳接种率,保护野生中药资源;另外一方面通过对出苗后的杂草施用苗后除草剂可控制杂草。
独脚金内酯是一类从植物中分离出来的含有烯基醚丁烯羟酸内酯结构单元的天然产物。研究表明,独脚金内酯类化合物不仅能够促进根寄生杂草,如列当和独脚金等种子的萌发,还能促进丛枝菌根真菌孢子萌发和菌丝的分枝。另外,作为一种新发现的植物激素,独脚金内酯类化合物还能调控植物生长发育的多个过程,如抑制植物的分枝,控制腋芽的萌发,抑制植物侧根的生长和促进主根的伸长等(“Strigolactones:plant hormoneswith promising features”(Bouwmeester,H.J.etc.,《Angew.Chem.Int.Ed.》,2019,58卷,p12778–12786)。现有的独脚金内酯类化合物获取困难,且稳定性较差,限制了它们在农业生长中的应用。
“Tentative molecular mechanism for germination stimulation ofstrigaand orobanche seeds by strigol and its synthetic analogs”(Mangnus,E.M.;Zwanenburg,B.;《J.Agric.Food Chem.》,1992,卷40,p1066-1070)指出独脚金内酯类化合物中烯基醚丁烯羟酸内酯结构单元对维持化合物的活性至关重要,如果将烯醇醚键换成亚甲基将会导致化合物活性的丧失。目前,所报道的独脚金内酯类似物或模拟物结构中也都含有稳定性较差的烯基醚丁烯羟酸内酯结构单元(如WO2018060865A1和WO2012146374A3),这一结构片段也是导致该类化合物稳定性较差,制约它们田间应用的重要因素。
目前,绝大多数高活性的独脚金内酯激动剂,如nijmegen-1,MP1等由于稳定性差,其并不能用于实际的生产中。因此,需要一种稳定性好且能够有效地应用于农学生长中的新化合物。
发明内容
本发明的目的是为了提供一种具有种子萌发、提高作物产量和调节植物生长中的至少一种功效的新型酰胺类化合物。
为了实现上述目的,本发明的第一方面提供一种酰胺类化合物,该化合物具有式(I)所示的结构,
其中,在式(I)中,
R1和R2各自独立地选自H、取代或未取代的C1-12的烷基、取代或未取代的C3-12的环烷基、取代或未取代的含有选自N、O和S中的至少一种的杂原子的C1-8的杂环,其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-9个卤素取代的C1-6烷基、C1-6的烷氧基、由1-9个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-9个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9、R10、R11中的任意相邻两者一起环合形成3-8元的环状结构;
且R1和R2上任选存在的取代基各自独立地选自C1-12的烷基、苯基;
R3、R4、R5和R6各自独立地选自H、C1-12的烷基和C3-12的环烷基;
n为0、1、2、3或4;
X为O、S、-S(O)-或-S(O)2-;Y为O、S、CH2或-N(CH3)-。
本发明的第二方面提供一种制备第一方面中所述的酰胺类化合物的方法,该方法包括:将式(V-1)所示的化合物与式(V-2)所示的化合物进行接触反应;
其中,式(V-1)和式(V-2)中的取代基的取代情况与第一方面中所述的酰胺类化合物中的取代情况对应相同,且Z1和Z2中的一者为-Br,另一者为-XH,X的定义与第一方面中所述的酰胺类化合物中的定义对应相同。
本发明的第三方面提供一种制备第一方面中所述的酰胺类化合物的方法,该方法包括:将式(II)所示的化合物与式(III)所示的化合物进行偶联反应;
其中,式(III)和式(II)中的取代基的取代情况与第一方面中所述的酰胺类化合物中的取代情况对应相同。
本发明的第四方面提供第一方面所述的酰胺类化合物在农学中的应用。
本发明的第五方面提供一种生物刺激剂,该生物刺激剂中含有植物生长调节有效量的第一方面所述的酰胺类化合物中的至少一种,并且任选含有辅料。
本发明提供的酰胺类化合物能够有效地促进种子的萌发,调节植物的生长发育,提高作物的品质和产量。
特别地,本发明提供的具有式(I)所示的结构的化合物中,当X和Y均为O时,本发明提供的化合物能够有效地提高作物的产量。
本发明提供的具有式(I)所示的结构的化合物中,当X和Y不同时为O时,本发明提供的化合物能够有效地促进种子的萌发,调节植物的生长发育,提高作物的品质和产量。
特别地,本发明提供的酰胺类化合物与现有技术中含有烯基醚取代的丁烯羟酸内酯环结构的化合物相比,在具有良好的种子萌发促进活性的同时,还能具有很好地稳定性、植物生长调节活性和作物增产促进活性,因而能够很好地应用于田间。
附图说明
图1为本发明提供的瓜列当种子经过1×10-7mol/L的化合物1处理后的种子萌发图;图2为本发明提供的瓜列当种子经过空白对照(CK)处理后的种子萌发图;图3为本发明提供的小麦种子经过空白对照(CK)处理后的种子萌发图;图4为本发明提供的小麦种子经过经过1ppm的化合物1处理后的种子萌发图;图5为本发明提供的小麦种子经过1ppm的化合物768处理后的种子萌发图;图6为本发明提供的小麦经过1×10-6mol/L的化合物1处理后的小麦抗旱效果图;图7为本发明提供的小麦经过空白对照(CK)处理后的小麦抗旱效果图;图8为本发明提供的玉米实验田经过空白对照(图8中的A所示)和4×10-5mol/L的化合物1(图8中的B所示)处理后的作物增产图。
具体实施方式
在本文中所披露的范围的端点和任何值都不限于该精确的范围或值,这些范围或值应当理解为包含接近这些范围或值的值。对于数值范围来说,各个范围的端点值之间、各个范围的端点值和单独的点值之间,以及单独的点值之间可以彼此组合而得到一个或多个新的数值范围,这些数值范围应被视为在本文中具体公开。
本发明所述C1-12的烷基表示碳原子总数为1-12的烷基,包括直链烷基、支链烷基,例如可以为碳原子总数为1、2、3、4、5、6、7、8、9、10、11或12的直链烷基、支链烷基,例如可以为甲基、乙基、正丙基、异丙基、正丁基、异丁基、叔丁基、正戊基、异戊基、正己基等。针对“C1-6的烷基”、“C1-4的烷基”和“C1-3的烷基”具有与此相似的解释,所不同的是,碳原子总数不同而已。
本发明所述C3-12的环烷基表示碳原子总数为3-12的环烷基,例如碳原子总数为3、4、5、6、7、8、9、10、11或12的环烷基,对成环的碳数没有特别的要求,例如可以为环丙基、甲基环丙基、乙基环丙基、环戊基、甲基环戊基、环己基等。针对“C3-8的环烷基”、“C3-6的环烷基”等具有与此相似的解释,所不同的是,碳原子数不同。
本发明所述“含有选自N、O和S中的至少一种的杂原子的C1-8的杂环”表示碳原子总数为1-8的环状结构,且成环的原子中含有选自N、O和S中的至少一种杂原子,可以为饱和结构,也可以为不饱和结构。例如可以为三元环、四元环、五元环、六元环、七元环、八元环等。
本发明所述卤素包括氟、氯、溴、碘。
本发明所述由1-9个卤素取代的C1-6的烷基表示C1-6的烷基上的1-9个H由卤素取代,可以为同一个碳上的1、2或3个H原子被取代,也可以为不同C上的H被取代,例如可以为三氟甲基、二氟甲基、一氟甲基、一氟乙基、二氟乙基、三氟乙基等。
本发明所述的C1-6的烷氧基表示-O-Ra所示的基团,其中的Ra为C1-6的烷基。
本发明所述的C1-6的烷硫基表示-S-Rb所示的基团,其中的Rb为C1-6的烷基。
本发明所述的由1-9个卤素取代的C1-6烷氧基表示C1-6的烷氧基上的1-9个H由卤素取代,可以为同一个碳上的1、2或3个H原子被取代,也可以为不同C上的H被取代。“由1-9个卤素取代的C1-6烷硫基”均有与此相似的定义。
本发明所述的“-COO-C1-6的烷基”表示酯基直接与母核结构连接,而酯基上的单键O原子的另一端与C1-6的烷基连接。
本发明所述的“-S(O)2-C1-6的烷基”表示砜基直接与母核结构连接。
本发明所述的“R7、R8、R9、R10、R11中的任意相邻两者一起环合形成3-8元的环状结构”表示R7、R8、R9、R10和R11中的任意相邻两者一起环合与其所在的苯环结构上的2个碳原子一起形成含3、4、5、6、7或8个原子的环。
本发明在没有限定具体的取代位置时,本发明所述“取代或未取代的”表示该基团能够被后续定义的取代基取代,也可以为没有后续定义的取代基的基团;若是有取代基取代,则取代基可以位于任意能够被取代的位置。例如,本发明所述取代或未取代的C1-12的烷基表示,C1-12的烷基上任意能够被取代的位置均可以被取代。
本发明中,波浪线表示连接位置,例如示出的波浪线表示连接位置,也即该基团通过该波浪线所在的位点与母核结构通过化学键连接。
“-(CH2)z-苯基”表示亚甲基直接与母核结构连接,且末端基团为苯基。
“含有选自B类杂原子的不饱和五元环基团”表示该基团为五元环基团,且该五元环基团为不饱和基团,其中含有至少一个双键结构,且该五元环基团的成环原子中含有至少一个选自B类杂原子的杂原子。“含有B类杂原子的不饱和六元环基团”具有与此相似的解释。
“含有B类杂原子的饱和四元环基团”表示该基团为四元环基团,且该四元环基团为饱和基团,且该四元环基团的成环原子中含有至少一个选自B类杂原子的杂原子。
“C4-8的饱和环烷基”表示含有4-8个碳原子的环烷基,且该环烷基为饱和环烷基,成环原子均为C原子。
本发明对“苯并噻唑基、苯并恶唑基、苯并吡唑基、苯丙噻吩基、N-甲基-苯并吡咯基”等与母核结构相连接的位点没有特别的要求,其可以在任意能够与母核结构连接的位置与母核结构连接,只要能够形成稳定的化学键即可。也即,可以是任意一个位置的H被离去而形成前述基团,并与母核结构连接。
如前所述,本发明的第一方面提供了一种酰胺类化合物。
优选地,在式(1)中,X和Y不同时为O。
优选地,在式(I)中,R1和R2各自独立地选自H、C1-6的烷基、-(CH2)z-苯基、含有选自B类杂原子的不饱和五元环基团、含有B类杂原子的饱和四元环基团、含有B类杂原子的不饱和六元环基团、C4-8的饱和环烷基、苯并噻唑基、苯并恶唑基、苯并吡唑基、苯丙噻吩基、N-甲基-苯并吡咯基、/>z为1-6的整数;各个所述B类杂原子各自独立地选自O、S、N中的至少一种;且任选地,所述B类杂原子上含有C1-3的烷基作为取代基;其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-6个卤素取代的C1-6烷基、C1-6烷氧基、由1-6个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-3个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有O原子的C3-6的饱和环烷结构;或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有A类杂原子的C3-6的不饱和环烷结构,所述A类杂原子选自O、S、N中的至少一种,且任选地,所述A类杂原子上含有C1-3的烷基作为取代基;R3、R4、R5和R6各自独立地选自H、C1-6的烷基和C3-6的环烷基;n为0、1、2或3;X为S、-S(O)-或-S(O)2-;Y为O、-CH2-或-N(CH3)-。
根据一种特别优选的具体实施方式,在式(I)中,R1为其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-6个卤素取代的C1-6烷基、C1-6烷氧基、由1-6个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-3个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有O原子的C3-6的饱和环烷结构;或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有A类杂原子的C3-6的不饱和环烷结构,所述A类杂原子选自O、S、N中的至少一种,且任选地,所述A类杂原子上含有C1-3的烷基作为取代基;R2、R5和R6各自独立地选自H、甲基、乙基、正丙基、异丙基、叔丁基;或者R2为苯基;R3和R4均为H;n为0、1或2;X为S、-S(O)-或-S(O)2-;Y为O、-CH2-或-N(CH3)-。
根据一种更优选的具体实施方式,式(I)所示的化合物具有式(I-A)所示的化合物的结构:
其中,在式(I-A)中,n、X、Y、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11的取代情况如化合物1至化合物693、以及化合物697中所示。
根据另一种优选的具体实施方式,在式(I)中,R1选自C1-6的烷基、-(CH2)z-苯基、含有选自B类杂原子的不饱和五元环基团、含有B类杂原子的饱和四元环基团、含有B类杂原子的不饱和六元环基团、C4-8的饱和环烷基、苯并噻唑基、苯并恶唑基、苯并吡唑基、苯丙噻吩基、N-甲基-苯并吡咯基、z为1、2、3、4、5或6的整数;各个所述B类杂原子各自独立地选自O、S、N中的至少一种;且任选地,所述B类杂原子上含有C1-3的烷基作为取代基;R2选自H、正丁基、-CH2-苯基;R3、R4和R5均为H;R6为甲基;n为0;X为S;Y为O。
更优选情况下,在式(I)中,n、X、Y、R1、R2、R3、R4、R5、R6的取代情况如化合物694至化合物696、以及化合物698至化合物767中所示。
优选地,在式(1)中,X和Y均为O。
更优选地,式(I)所示的化合物具有式(I-A)所示的化合物的结构:
其中,在式(I-A)中,n、X、Y、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11的取代情况如化合物768至化合物795中所示。
本发明中对所述式(I)所示的化合物的立体结构没有特别限制,所述式(I)所示的化合物可以以不同的立体异构体或光学异构体或互变异构的形式存在,本发明包含所有立体异构体或光学异构体或互变异构及其各种比例的混合物。
本发明对制备第一方面所述的酰胺类化合物的具体方法没有特别的限定,本领域技术人员可以根据本发明提供的具体结构式,结合有机合成领域内的已知工艺路线获得本发明前述的化合物,并且,本发明的后文中示例性地列举了几个实例以说明本发明的化合物的制备方法,本领域技术人员也可以根据本发明的后文中的化合物的制备方法,通过替换原料的种类获得其余所有化合物的具体制备方法。本发明不再对全部化合物的制备方法进行详述,本领域技术人员不应理解为对本发明的限制。
优选地,为了更高收率地获得本发明所述的具有式(I)所示结构的化合物,本发明提供了第二方面中所述的方法制备第一方面中所述的酰胺类化合物,该方法包括:将式(V-1)所示的化合物与式(V-2)所示的化合物进行接触反应;
其中,式(V-1)和式(V-2)中的取代基的取代情况与第一方面中所述的酰胺类化合物中的取代情况对应相同,且Z1和Z2中的一者为-Br,另一者为-XH,X的定义与第一方面中所述的酰胺类化合物中的定义对应相同。
本发明对所述接触反应的具体操作条件没有特别的要求,本领域技术人员可以根据有机合成领域内的已知知识结合本发明后文中示例性地提供的制备方法确定合理的范围或者数值。本发明在此不再赘述,本领域技术人员不应理解为对本发明的限制。
优选地,为了更高收率地获得本发明所述的具有式(I)所示结构的化合物,本发明还提供了第三方面中所述的方法制备第一方面中所述的酰胺类化合物,该方法包括:将式(II)所示的化合物与式(III)所示的化合物进行偶联反应;
其中,式(III)和式(II)中的取代基的取代情况与第一方面中所述的酰胺类化合物中的取代情况对应相同。
本发明对所述式(III)所示的化合物与所述式(II)所示的化合物用量摩尔比和反应条件没有特别的要求,本领域技术人员可以根据结构式特点结合本领域内已知的有机合成知识确定合适的用量比例和反应条件。
本发明对所述偶联反应的具体操作条件没有特别的要求,本领域技术人员可以根据有机合成领域内的已知知识结合本发明后文中示例性地提供的制备方法确定合理的范围或者数值。本发明在此不再赘述,本领域技术人员不应理解为对本发明的限制。
更优选地,所述具有式(II)结构的化合物的制备方法包括:在酸性物质和溶剂存在的条件下,脱除式(IV)所示化合物中的叔丁氧基;
其中,在式(IV)中,
n、X、Y、R3、R4、R5、R6的定义与本发明前文中所述的定义对应相同。
本发明对所述式(IV)所示的化合物脱除叔丁氧基的反应条件没有特别的要求,本领域技术人员可以根据结构式特点结合本领域内已知的有机合成知识确定合适反应条件。
本领域技术人员应该理解的是,本发明所述的方法还可以包括对所得产物进行提纯的步骤,对于提纯的方法没有特别的要求,可以采用本领域技术人员常规使用的各种提纯方法,例如,可以采用过滤、除溶剂、用萃取剂萃取,用干燥剂干燥,并通过柱层析等方法除杂。
本发明的第四方面提供第一方面所述的酰胺类化合物在农学中的应用。
优选地,所述农学中的应用选自提高作物产量、对植物进行非生物胁迫管理、调节植物生长、增强植物抗病能力、促进种子萌发中的至少一种应用。
优选地,所述种子选自小麦、大豆、大麦、玉米、水稻、高粱、茄科类、稗草、花生等豆科类、马唐、狗尾草中的至少一种。
本发明中的所述的酰胺类化合物在第二方面所述的应用中可以单独存在,也可以作为有效成分存在于粉剂、溶液等中,本领域技术人员不应理解为对本发明的限制。
本发明的第五方面提供一种生物刺激剂,该生物刺激剂中含有植物生长调节有效量的第一方面所述的酰胺类化合物中的至少一种,并且任选含有辅料。
优选地,所述生物刺激剂应用到植物上,通过调节植物的生长发育过程,从而提高植物的生物量或产量;所述植物选自小麦、花生、玉米、大豆、苜蓿中的至少一种。
本发明对所述生物刺激剂中的辅料的具体种类没有特别的要求,本领域技术人员可以根据剂型选择本领域已知的相应辅料制备本发明的所述生物刺激剂,本发明在此不再详述,本领域技术人员不应理解为对本发明的限制。
优选情况下,在所述生物刺激剂中,所述酰胺类化合物的含量为1-99.99wt%,或者,所述酰胺类化合物的含量为0.001ppm-100ppm。
本发明还提供一种施药方法,该方法包括向含有植物繁殖材料和/或植物生长区域施用有效量的第一方面所述的酰胺类化合物和/或第三方面所述的调节剂。
需要说明的是,本发明所述的酰胺类化合物可以单独使用也可以和植物激素,如,生长素类、赤霉素类、细胞分裂素类、乙烯和脱落酸等化合物复配使用。示例性地,本发明提供的酰胺类化合物可以与油菜素内酯、多胺和茉莉酸,唑菌胺酯、metyltetraprole、氯啶菌酯、唑胺菌酯、烯肟菌胺、嘧菌酯、氟嘧菌酯、肟菌酯、丁香菌酯、氟唑菌酰羟胺、吡唑醚菌酯、啶酰菌胺、苯并烯氟菌唑、吡唑萘菌胺、氟唑环菌胺、氟唑菌苯胺、氟唑菌酰胺、氟吡菌酰胺等联合使用,联合使用可以达到协同增效的效果。
本发明的还提供一种杂草防控方法,该方法包括:向含有杂草的区域施用萌发促进量的第一方面所述的酰胺类化合物和/或第三方面所述的调节剂,使杂草“时空错配萌发”,然后向出苗后的杂草喷施除草剂。
本发明中,所述含有杂草的区域包括具有根寄生杂草的农业用地,所述农业用地可以包括但不限于水稻田、小麦田、向日葵田、胡萝卜田、烟草田、茄科植物田、玉米田、花生等豆科植物田或高粱田;优选地,所述根寄生杂草为独脚金和/或列当;所述独脚金选自独脚金(Striga asiatica(L.)O.Kuntze)、大独脚金(Striga masuria(Ham.ex Benth.)Benth)和密花独脚金(Striga densiflora Benth)中的至少一种;所述列当选自小列当(Orobanche minor Sm)、分支列当(Orobanche ramosa L)中的至少一种。
本发明对所述除草剂中的具体种类没有特别的要求,本领域技术人员可以选择本领域已知的除草剂,本发明在此不再详述,本领域技术人员不应理解为对本发明的限制。
以下将通过实例对本发明进行详细描述。
在没有特别说明的情况下,以下实例中涉及的室温或者常温均表示25±3℃。
在没有特别说明的情况下,以下实例使用的各种原料均来自商购,制备所得产物用核磁数据进行表征。
在没有特别说明的情况下,本发明中的收率均以获得该化合物的最后一步化学反应中主要原料为基准计算获得。
在没有特别说明的情况下,CK代表空白对照。
制备例1:化合物I-1的制备
该制备例用来说明化合物I-1的合成。
将20mmol的碳酸钾和20mmol的2-巯基乙酸叔丁酯加入到反应瓶中,搅拌下加入50mL丙酮,室温反应15min后,加入20mmol的5-溴-3-甲基呋喃-2(5H)-酮,继续搅拌反应3h后,用硅藻土辅助抽滤除去不溶物,减压脱除溶液中的丙酮,所得中间物经柱层析纯化后得到化合物IV-1,其收率为65%;核磁数据为1H NMR(400MHz,CDCl3)δ7.00(s,1H),6.15(s,1H),3.43(d,J=15.6Hz,1H),3.19(d,J=15.6Hz,1H),1.96(s,3H),1.47(s,9H);
将10mmol的所述化合物IV-1溶于20mL的二氯甲烷溶液中,加入5mL的三氟乙酸,室温条件下反应2小时后,经柱层析纯化后得到化合物I-1,收率为90%;核磁数据为1H NMR(400MHz,DMSO-d6)δ12.76(s,1H),7.36(s,1H),6.37(s,1H),3.40(q,J=15.6Hz,2H),1.84(s,3H)。
制备例2:化合物I-2的制备
该制备例用来说明化合物I-2的合成,本发明中示例性的提供了以下一种合成方法得到所述的化合物I-2。
将30mol的制备例1合成得到的化合物I-1溶于60mL的二氯甲烷中,冰浴条件下向加入30mmol的甲氯过氧苯甲酸,反应4小时后,加入饱和碳酸氢钠溶液淬灭反应,然后用水进行萃取、有机相用饱和食盐水洗涤、无水硫酸钠干燥,真空浓缩后柱层析纯化得到化合物I-2,收率为60%;核磁数据为1H NMR(400MHz,DMSO-d6)δ13.48(s,1H),7.53(s,1H),6.24(s,1H),3.81(dd,J=17.6,15.2Hz,2H),1.90(s,3H).
制备例3:化合物I-3的制备
将21mmol苯胺和21mmol巯基乙酸溶于20mL无水甲苯溶液,加热至110℃,反应12小时。反应液冷却至室温后真空浓缩,得油状物经柱层析得白色固体I-3,收率80%;核磁数据为:1H NMR(400MHz,DMSO-d6)δ10.07(d,J=10.3Hz,1H),7.57(t,J=6.6Hz,2H),7.29(dt,J=13.3,7.8Hz,2H),7.05(q,J=6.7,6.0Hz,1H),3.39–3.20(m,2H),2.95(s,1H).
制备例4:化合物I-4的制备
将20mmol苯胺溶于20mL二氯甲烷中,让后加入21mmol溴乙酰溴和25mmol碳酸钾,室温条件下反应2小时,反应完全后抽滤出去固体,浓缩有机相经柱层析的化合物I-4,收率为85%;核磁数据为1H NMR(400MHz,CDCl3)δ9.90(s,1H),7.75–7.49(m,2H),7.40–7.24(m,2H),7.07(tt,J=7.2,2.0Hz,1H),4.24(s,2H).
制备例5:化合物I-5的制备
将10mmol 5-羟基-3-甲基呋喃-2(5H)-酮溶于10mL甲苯溶液,然后加入5mmol劳森试剂,加热至回流反应12小时.反应完全后用冰水淬灭,乙酸乙酯进行萃取、有机相用饱和食盐水洗涤、无水硫酸钠干燥,真空浓缩后柱层析纯化得到化合物I-5,收率为36%,核磁数据为1H NMR(400MHz,DMSO-d6)δ7.41(dd,J=6.4,1.2Hz,1H),6.07(dd,J=6.4,1.2Hz,1H),2.02(s,3H)1.40(s,1H).
制备例6:化合物1的制备
将化合物I-4(3mmol)和I-5(2.8mmol)溶于5mL N,N-二甲基甲酰胺中,然后加入碳酸钾(4.5mmol),室温条件下反应3小时。反应完全后抽滤去除固体,用乙酸乙酯和水萃取,收集有机相,并用饱和食盐水洗涤,无水硫酸钠干燥,真空浓缩得油状物,柱层析的化合物1,收率为25%;核磁数据为1H NMR(400MHz,DMSO-d6)δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40–7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56–3.43(m,2H),1.82(s,3H)。
制备例7:化合物1的制备
冰浴条件下将化合物13.3mmol I-3和13.3mmol 5-溴-3-甲基呋喃-2(5H)-酮)溶于200mL二氯甲烷中,然后加入15mmol三乙胺,转移至室温搅拌1小时,TLC显示反应完全,真空浓缩得油状物,经柱层析的得化合物1,收率67%;1H NMR(400MHz,DMSO-d6)δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40–7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56–3.43(m,2H),1.82(s,3H)。
制备例8:化合物1的制备
将1mmol的制备例1合成得到的化合物I-1溶于5mL的二氯甲烷溶液中,然后加入1.5mmol的(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯(HATU)和2mmol的三乙胺,室温下搅拌15分钟后,向反应液中加入1.1mmol的苯胺,室温条件下反应6小时后,向反应液中加入水进行萃取,有机相分别用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥、真空浓缩,然后经柱层析纯化得到述化合物1,收率为50%;核磁数据为1H NMR(400MHz,DMSO-d6)δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40–7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56–3.43(m,2H),1.82(s,3H)。
制备例9:化合物4的制备
在冰浴条件下,将1mmol制备例1合成得到的化合物I-1溶于5mL二氯甲烷溶液中,然后加入1.1mmol的草酰氯和0.1mmol的N,N-二甲基甲酰胺,室温反应2小时后,得到油状物,将所得油状物溶于5mL的二氯甲烷溶液中,然后加入1mmol的对氟苯胺和1mmol的三乙胺,室温条件下反应2小时后,经柱层析纯化得到化合物4,收率为63%;核磁数据为1H NMR(400MHz,CDCl3)δ8.29(s,1H),7.57–7.50(m,2H),7.11–6.98(m,3H),6.15–6.03(m,1H),3.62–3.41(m,2H),1.99(t,J=2.0Hz,3H)。
制备例10:化合物5的制备
将1mmol的制备例1合成得到的化合物I-1溶于5mL二氯甲烷溶液中,然后加入1.5mmol的1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDCI)和0.1mmol的4-二甲氨基吡啶(DMAP),然后向反应液中加入1.1mmol的邻氯苯胺,在氩气保护下,室温条件下反应6小时后,向反应液中加入水进行萃取,有机相用饱和食盐水洗涤,并用无水硫酸钠干燥,真空浓缩后经柱层析纯化得到化合物5,收率为75%;核磁数据为1H NMR(400MHz,CDCl3)δ8.80(s,1H),8.32(d,J=8.0Hz,1H),7.39(d,J=9.2Hz,1H),7.29(t,J=8.0Hz,1H),7.08(t,J=8.4Hz,1H),7.02(s,1H),6.09(s,1H),3.62(d,J=16.8Hz,1H),3.46(d,J=16.8Hz,1H),1.96(s,3H)。
制备例11:化合物9的制备
将1mmol的制备例1合成得到的化合物I-1溶于5mL的二氯甲烷溶液中,然后加入1.5mmol的(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯(HATU)和2mmol的N-乙基二异丙胺(DIPEA),室温下搅拌15分钟后,向反应液中加入1.1mmol的间溴苯胺,室温条件下反应3小时后,向反应液中加入水进行萃取,有机相依次用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥,真空浓缩后经柱层析纯化得到化合物9,收率为71%;核磁数据为1H NMR(400MHz,CDCl3)δ8.34(s,1H),7.85(s,1H),7.45(d,J=8.4Hz,1H),7.31–7.26(m,1H),7.21(t,J=8.0Hz,1H),7.02(s,1H),6.09(s,1H),3.51(q,J=16.8Hz,2H),1.99(s,3H)。
制备例12:化合物19的制备
将1mmol的制备例1合成得到的化合物I-1溶于5mL的二氯甲烷溶液中,然后加入1.5mmol的苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸盐(HBTU)和2mmol的N-乙基二异丙胺(DIPEA),室温下搅拌15分钟,向反应液中加入1.1mmol的4-三氟甲基苯胺,继续反应3小时后,向反应液中加入水进行萃取,有机相依次用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥,真空浓缩后经柱层析纯化得到化合物19,收率为68%;核磁数据为1H NMR(400MHz,DMSO-d6)δ10.52(s,1H),7.77(d,J=8.4Hz,2H),7.68(d,J=8.4Hz,2H),7.36(s,1H),6.42(s,1H),3.62–3.46(m,2H),1.82(s,3H)。
制备例13:化合物22的制备
将1mmol制备例1合成得到的化合物I-1溶于5mL的二氯甲烷溶液中,然后加入2mmol的1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDCI)和2mmol的1-羟基苯并三唑(HOBT),再向反应液中加入1.1mmol的4-三氟甲氧基苯胺,室温条件下反应5小时后,向反应液中加入水进行萃取,有机相用饱和食盐水洗涤并用无水硫酸钠干燥,真空浓缩后经柱层析纯化得到化合物22,收率为62%;核磁数据为1H NMR(400MHz,CDCl3)δ8.43(s,1H),7.60(d,J=8.8Hz,2H),7.20(d,J=8.4Hz,2H),7.03(s,1H),6.10(s,1H),3.61–3.43(m,2H),1.99(s,3H)。
制备例14:化合物768的制备
将5mmol 5-羟基-3-甲基-2(5H)-呋喃酮溶于10mL的N,N-二甲基甲酰胺中,然后加入6mmol碳酸钾和6mmol溴乙酸叔丁酯。加热至60℃反应3小时后用水和乙酸乙酯萃取,有机相用饱和食盐水洗涤并用无水硫酸钠干燥,真空浓缩后经柱层析纯化所得淡黄色固体(收率为62%;核磁数据为1H NMR(400MHz,CDCl3)δ6.97–6.86(m,1H),5.98–5.90(m,1H),4.22(s,2H),1.95(s,3H),1.49(s,9H)。所得固体溶于10mL二氯甲烷溶液,然后加入2mL三氟乙酸,室温反应2小时,真空浓缩的油状物经柱层析得化合物I-6,收率为92%,核磁数据为1HNMR(400MHz,DMSO-d6)δ12.94(s,1H),7.32–6.97(m,1H),6.07(m,1H),4.27(d,J=3.8Hz,2H),1.85(s,3H);
将2mmol化合物I-6溶于5mL二氯甲烷中,然后加入3mmol(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯(HATU)和5mmol的三乙胺,室温下搅拌15分钟后,向反应液中加入2.5mmol的苯胺,室温条件下反应6小时后,向反应液中加入水进行萃取,有机相分别用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥、真空浓缩,然后经柱层析纯化得到化合物768,收率为58%;核磁数据为1H NMR(400MHz,CDCl3)δ8.07(s,1H),7.54(d,J=7.6Hz,2H),7.34(t,J=8.0Hz,2H),7.15(t,J=7.6Hz,1H),6.94–6.87(m,1H),5.94(s,1H),4.34(dd,J=35.6,14.8Hz,2H),2.17(s,3H)。
制备例15:化合物782的制备
将2mmol化合物I-6溶于5mL二氯甲烷中,然后加入3mmol(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯(HATU)和5mmol的三乙胺,室温下搅拌15分钟后,向反应液中加入2.5mmol的3-三氟甲基苯胺,室温条件下反应5小时后,向反应液中加入水进行萃取,有机相分别用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥、真空浓缩,然后经柱层析纯化得到化合物782,收率为65%,核磁数据为:1HNMR(400MHz,CDCl3)δ8.20(s,1H),7.83(s,1H),7.78(d,J=8.0Hz,1H),7.46(t,J=8.0Hz,1H),7.40(d,J=7.6Hz,1H),6.97–6.91(m,1H),5.96(s,1H),4.37(dd,J=36.4,15.2Hz,2H),2.02(s,3H)。
制备例16:化合物789的制备
将2mmol化合物I-6溶于5mL二氯甲烷中,然后加入3mmol(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯(HATU)和5mmol的三乙胺,室温下搅拌15分钟后,向反应液中加入2.5mmol的4-甲基苯胺,室温条件下反应5小时后,向反应液中加入水进行萃取,有机相分别用1mol/L的盐酸和饱和食盐水洗涤,并用无水硫酸钠干燥、真空浓缩,然后经柱层析纯化得到化合物789,收率为60%,核磁数据为:1H NMR(400MHz,CDCl3)δ8.01(s,1H),7.42(d,J=7.6Hz,2H),7.14(d,J=7.6Hz,2H),6.91(s,1H),5.93(s,1H),4.33(dd,J=36.8,14.9Hz,2H),2.32(s,3H),2.00(s,3H)。
表1中列举了本发明部分化合物的表征数据。
表1
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实施例1
瓜列当种子的萌发促进活性测试
步骤1:称取化合物于二甲基亚砜溶液中,溶解并配置成浓度为10mM的母液,使用时用水稀释至所需的浓度;以及,
将瓜列当种子先用1重量%的次氯酸钠溶液浸泡1min,接着用75体积%的乙醇浸泡1min,并用无菌水洗涤3次,于超净台中晾干备用;
步骤2:取一直径为9cm的培养皿,在其底部放入2层滤纸,向其中加入5mL无菌水将其润湿,将直径为9mm的玻璃纤维滤纸(Whatman GF/A)均匀的铺于滤纸上,将消毒后的瓜列当种子均匀洒在玻璃纤维滤纸上,每片滤纸约40粒;将培养皿用Parafilm封口膜封口并放于30℃培养箱中预培养7天;
步骤3:取出带有瓜列当种子的玻璃纤维滤纸,并用滤纸吸干其表面水分,将其放于24孔板中,向其中加入100μL含有1体积%二甲基亚砜的浓度为10-7mol/L的化合物溶液,用Parafilm封口膜封口后放于30℃培养箱中培养3天后统计其萌发率;空白对照为1体积%的二甲基亚砜水溶液。每组实验重复3次,最终数据为3次实验的平均值,萌发促进率按照下述公式计算:
萌发率=萌发的种子数/全部种子数*100%
采用以下分级方法对化合物的萌发促进率进行分级:
A级:90-100%;B级:80-89%;C级:70-79%;D级:60-69;E级:50-59%;F级:30-49%;G级:29%以下。
结果数据见表2。
表2
通过表2的数据可以看出,本发明的化合物对瓜列当种子的萌发具有很好的促进作用,表明本发明的化合物能够有效地促进根寄生杂草种子的萌发,能够很好地应用于田间防治根寄生杂草。
本发明示例性的提供了空白对照和化合物1处理后的瓜列当种子的种子萌发图,如图1和图2所示,从图中可以很明显的看出,经过本发明提供的化合物处理的瓜列当种子的萌发率明显优于空白对照组。
实施例2
小麦种子萌发实验
步骤1:称取化合物于二甲基亚砜溶液中,溶解并配置成浓度为1000ppm的母液,使用时用水稀释至所需的浓度;以及,
将小麦种子分别先用1重量%的次氯酸钠溶液浸泡2min,接着用75体积%的乙醇浸泡2min,并用无菌水洗涤3次,于超净台中晾干备用;
步骤2:取一直径为9cm的培养皿,在其底部放入2层滤纸,将消毒后的小麦种子分别均匀洒在滤纸上,每片滤纸约30粒,向其中加入20体积%PEG6000的5ml水溶液,其中含有0.1体积%二甲基亚砜的浓度为1000ppm的化合物溶液,将培养皿用Parafilm封口膜封口并放于25℃培养箱中恒温培养,第5天时统计其萌发率,以芽长达到种子长度或根长达到种子长度作为发芽标准;空白对照为0.1体积%的二甲基亚砜水溶液。每组实验重复3次,最终数据为3次实验的平均值,萌发促进率按照下述公式计算:
萌发率=萌发的种子数/全部种子数*100%
结果数据见表3。
表3
化合物编号 | 小麦种子萌发率% |
CK | 35.6 |
1 | 48.9 |
2 | 41.1 |
27 | 63.3 |
74 | 43.3 |
230 | 41.1 |
538 | 46.7 |
615 | 44.4 |
696 | 58.9 |
768 | 63.3 |
通过表3的数据可以看出,本发明的化合物对小麦种子的萌发具有很好的促进作用,表明本发明的化合物能够有效地促进小麦种子的萌发。
本发明示例性的提供了空白对照(图3)、化合物1(图4)和化合物768(图5)处理后的小麦种子的种子萌发图,从图中可以很明显的看出,经过本发明提供的化合物处理的小麦种子的萌发率明显优于空白对照组。
实施例3
作物的增产测试
步骤1:称取本发明的化合物、油菜素内酯、氟唑菌酰羟胺、吡唑醚菌酯于二甲基亚砜溶液中,溶解并配置成浓度为10mM的母液,使用时用水稀释至所需的浓度;
步骤2:待田间花生生长至花下针期,玉米长至小喇叭,水稻长至孕穗期,小麦长至抽穗期时开始向作物叶面喷施含有1体积%二甲基亚砜的浓度为1×10-5mol/L的化合物溶液、1体积%二甲基亚砜的浓度为10×10-5mol/L的化合物溶液、1体积%二甲基亚砜的浓度为100×10-5mol/L的化合物溶液、二甲基亚砜的浓度为1×10-5mol/L的化合物和二甲基亚砜的浓度为7×10-7mol/L油菜素内酯溶液以及二甲基亚砜的浓度为20×10-5mol/L的吡唑醚菌酯溶液(体积比为1:0.1:5)、二甲基亚砜的浓度为7×10-7mol/L油菜素内酯溶液以及二甲基亚砜的浓度为20×10-5mol/L的吡唑醚菌酯溶液(体积比为0.1:5)(具体参见表3中所列举的)。对照组喷施含有1体积%二甲基亚砜的溶液。每个田间小区面积为25m2。收获时为减少误差,采用人工收割各小区作物。待收获粮食晒干后,称取各个处理小区的粮食重量。各小区粮食增产率按照下述公式计算:
增产率(%)=[(处理组收获粮食重量-对照组收获粮食重量)/对照组收获粮食重量]×100%;
结果数据见表4。
表4
通过表4的数据可以看出,本发明的化合物对小麦、花生、玉米和水稻均具有优异的的增产效果;本发明的化合物与其他化合物复配使用时增产率优于单独施药;表明本发明的化合物能够有效地促进作物增产。
本发明示例性地提供了图6和图7作为小麦空白对照组和施加1×10-6mol/L的化合物1处理后的小麦抗旱效果图。具体地,图6为本发明提供的小麦经过1×10-6mol/L的化合物1处理后的小麦抗旱效果图;图7为本发明提供的小麦经过空白对照(CK)处理后的小麦抗旱效果图。从图6和图7的对比可知,本发明提供的化合物能够显著提高小麦的耐旱效果,进而证实了本发明提供的化合物有利于对植物进行非生物胁迫管理。
另外,本发明示例性的提供了玉米田空白对照组和施加4×10-5mol/L的化合物1的作物增产图,如图8所示,可以很明显的看出,经过本发明提供的化合物1处理后的玉米田中的玉米作物生长得更加茂密,而对照组则表现出下垂萎蔫的状态。表明本发明的化合物能够有效地促进作物增产。
另外,本发明提供的化合物在温室实验条件下还能够对模式植物拟南芥、水稻实现高达40%以上的增产率,因此能够预测本发明提供的化合物都具有很好的增产效果。
进一步地,本发明的表4提供的数据为在田间试验获得的结果,受病虫害、气候等因素的影响,表4提供的增产率低于40%,但是,本发明提供的化合物对作物的增产效果比较明显,具有显著的商业化开发前景。
以上详细描述了本发明的优选实施方式,但是,本发明并不限于此。在本发明的技术构思范围内,可以对本发明的技术方案进行多种简单变型,包括各个技术特征以任何其它的合适方式进行组合,这些简单变型和组合同样应当视为本发明所公开的内容,均属于本发明的保护范围。
Claims (12)
1.一种酰胺类化合物,其特征在于,该化合物具有式(I)所示的结构,
其中,在式(I)中,
R1和R2各自独立地选自H、取代或未取代的C1-12的烷基、取代或未取代的C3-12的环烷基、取代或未取代的含有选自N、O和S中的至少一种的杂原子的C1-8的杂环,其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-9个卤素取代的C1-6烷基、C1-6的烷氧基、由1-9个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-9个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9、R10、R11中的任意相邻两者一起环合形成3-8元的环状结构;
且R1和R2上任选存在的取代基各自独立地选自C1-12的烷基、苯基;
R3、R4、R5和R6各自独立地选自H、C1-12的烷基和C3-12的环烷基;
n为0、1、2、3或4;
X为O、S、-S(O)-或-S(O)2-;Y为O、S、CH2或-N(CH3)-。
2.根据权利要求1所述的化合物,其中,在式(I)中,X和Y不同时为O。
3.根据权利要求2所述的化合物,其中,在式(I)中,
R1和R2各自独立地选自H、C1-6的烷基、-(CH2)z-苯基、含有选自B类杂原子的不饱和五元环基团、含有B类杂原子的饱和四元环基团、含有B类杂原子的不饱和六元环基团、C4-8的饱和环烷基、苯并噻唑基、苯并恶唑基、苯并吡唑基、苯丙噻吩基、N-甲基-苯并吡咯基、/>z为1-6的整数;各个所述B类杂原子各自独立地选自O、S、N中的至少一种;且任选地,所述B类杂原子上含有C1-3的烷基作为取代基;
其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-6个卤素取代的C1-6烷基、C1-6烷氧基、由1-6个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-3个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有O原子的C3-6的饱和环烷结构;或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有A类杂原子的C3-6的不饱和环烷结构,所述A类杂原子选自O、S、N中的至少一种,且任选地,所述A类杂原子上含有C1-3的烷基作为取代基;
R3、R4、R5和R6各自独立地选自H、C1-6的烷基和C3-6的环烷基;
n为0、1、2或3;
X为S、-S(O)-或-S(O)2-;
Y为O、-CH2-或-N(CH3)-。
4.根据权利要求2或3所述的化合物,其中,在式(I)中,
R1为其中,R7、R8、R9、R10和R11各自独立地选自H、卤素、硝基、氰基、C1-6的烷基、C3-6的环烷基、由1-6个卤素取代的C1-6烷基、C1-6烷氧基、由1-6个卤素取代的C1-6烷氧基、C1-6的烷硫基、由1-3个卤素取代的C1-6烷硫基、-COO-C1-6的烷基和-S(O)2-C1-6的烷基,或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有O原子的C3-6的饱和环烷结构;或者R7、R8、R9中的任意相邻两者一起环合形成含有或者不含有A类杂原子的C3-6的不饱和环烷结构,所述A类杂原子选自O、S、N中的至少一种,且任选地,所述A类杂原子上含有C1-3的烷基作为取代基;
R2、R5和R6各自独立地选自H、甲基、乙基、正丙基、异丙基、叔丁基;或者R2为苯基;
R3和R4均为H;
n为0、1或2;
X为S、-S(O)-或-S(O)2-;
Y为O、-CH2-或-N(CH3)-。
5.根据权利要求4所述的化合物,其中,式(I)所示的化合物具有式(I-A)所示的化合物的结构:
其中,在式(I-A)中,n、X、Y、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11的取代情况如下:
化合物1:n为0,X为S,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物2:n为0,X为S,Y为O,R6为Me,R7为F,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物3:n为0,X为S,Y为O,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物4:n为0,X为S,Y为O,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物5:n为0,X为S,Y为O,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物6:n为0,X为S,Y为O,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物7:n为0,X为S,Y为O,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物8:n为0,X为S,Y为O,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物9:n为0,X为S,Y为O,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物10:n为0,X为S,Y为O,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物11:n为0,X为S,Y为O,R6为Me,R7为I,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物12:n为0,X为S,Y为O,R6为Me,R8为I,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物13:n为0,X为S,Y为O,R6为Me,R9为I,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物14:n为0,X为S,Y为O,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物15:n为0,X为S,Y为O,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物16:n为0,X为S,Y为O,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物17:n为0,X为S,Y为O,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物18:n为0,X为S,Y为O,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物19:n为0,X为S,Y为O,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物20:n为0,X为S,Y为O,R6为Me,R7为OCF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物21:n为0,X为S,Y为O,R6为Me,R8为OCF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物22:n为0,X为S,Y为O,R6为Me,R9为OCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物23:n为0,X为S,Y为O,R6为Me,R7为OCHF2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物24:n为0,X为S,Y为O,R6为Me,R8为OCHF2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物25:n为0,X为S,Y为O,R6为Me,R9为OCHF2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物26:n为0,X为S,Y为O,R6为Me,R9为SCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物27:n为0,X为S,Y为O,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物28:n为0,X为S,Y为O,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物29:n为0,X为S,Y为O,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物30:n为0,X为S,Y为O,R6为Me,R9为COOC2H5,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物31:n为0,X为S,Y为O,R6为Me,R7为CN,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物32:n为0,X为S,Y为O,R6为Me,R8为CN,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物33:n为0,X为S,Y为O,R6为Me,R9为CN,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物34:n为0,X为S,Y为O,R6和R7为Me,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物35:n为0,X为S,Y为O,R6和R8为Me,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物36:n为0,X为S,Y为O,R6和R9为Me,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物37:n为0,X为S,Y为O,R6为Me,R7为CH3SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物38:n为0,X为S,Y为O,R6为Me,R8为CH3SO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物39:n为0,X为S,Y为O,R6为Me,R9为CH3SO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物40:n为0,X为S,Y为O,R6为Me,R7为C2H5SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物41:n为0,X为S,Y为O,R6为Me,R7和R8均为Cl,R2、R3、R4、R5、R9、R10、R11均为H;
化合物42:n为0,X为S,Y为O,R6为Me,R7和R9均为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物43:n为0,X为S,Y为O,R6为Me,R7和R10均为Cl,R2、R3、R4、R5、R8、R9、R11均为H;
化合物44:n为0,X为S,Y为O,R6为Me,R7和R11均为Cl,R2、R3、R4、R5、R8、R9、R10均为H;
化合物45:n为0,X为S,Y为O,R6为Me,R8和R9均为Cl,R2、R3、R4、R5、R7、R10、R11均为H;
化合物46:n为0,X为S,Y为O,R6和R7为Me,R9为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物47:n为0,X为S,Y为O,R6、R7、R8均为Me,R2、R3、R4、R5、R9、R10、R11均为H;
化合物48:n为0,X为S,Y为O,R6、R7、R9为均Me,R2、R3、R4、R5、R8、R10、R11均为H;
化合物49:n为0,X为S,Y为O,R6、R7、R10均为Me,R2、R3、R4、R5、R8、R9、R11均为H;
化合物50:n为0,X为S,Y为O,R6、R7、R11均为Me,R2、R3、R4、R5、R8、R9、R10均为H;
化合物51:n为0,X为S,Y为O,R6、R7、R8、R11均为Me,R2、R3、R4、R5、R9、R10均为H;
化合物52:n为0,X为S,Y为O,R6、R7、R9、R11均为Me,R2、R3、R4、R5、R8、R10均为H;
化合物53:n为0,X为S,Y为O,R6为Me,R7、R9为均CF3,R2、R3、R4、R5、R8、R10、R11均为H;
化合物54:n为0,X为S,Y为O,R6为Me,R8、R10为均CF3,R2、R3、R4、R5、R7、R9、R11均为H;
化合物55:n为0,X为S,Y为O,R6为Me,R2、R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物56:n为0,X为S,Y为O,R6为Me,R7为CH3CH2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物57:n为0,X为S,Y为O,R6为Me,R8为CH3CH2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物58:n为0,X为S,Y为O,R6为Me,R9为CH3CH2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物59:n为0,X为S,Y为O,R6为Me,R7为CH(CH3)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物60:n为0,X为S,Y为O,R6为Me,R8为CH(CH3)2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物61:n为0,X为S,Y为O,R6为Me,R9为CH(CH3)2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物62:n为0,X为S,Y为O,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物63:n为0,X为S,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物64:n为0,X为S,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物65:n为0,X为S,Y为O,R6为Me,R7为CO2CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物66:n为0,X为S,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物67:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物68:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物69:n为0,X为S,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物70:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物71:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11为H;
化合物72:n为0,X为S,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物73:n为0,X为S,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物74:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物75:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物76:n为0,X为S,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物77:n为0,X为S,Y为O,R5为Me,R2、R3、R4、R6、R7、R8、R9、R10、R11均为H;
化合物78:n为0,X为S,Y为O,R5为Me,R7为F,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物79:n为0,X为S,Y为O,R5为Me,R8为F,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物80:n为0,X为S,Y为O,R5为Me,R9为F,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物81:n为0,X为S,Y为O,R5为Me,R7为Cl,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物82:n为0,X为S,Y为O,R5为Me,R8为Cl,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物83:n为0,X为S,Y为O,R5为Me,R9为Cl,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物84:n为0,X为S,Y为O,R5为Me,R7为Br,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物85:n为0,X为S,Y为O,R5为Me,R8为Br,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物86:n为0,X为S,Y为O,R5为Me,R9为Br,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物87:n为0,X为S,Y为O,R5为Me,R7为I,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物88:n为0,X为S,Y为O,R5为Me,R8为I,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物89:n为0,X为S,Y为O,R5为Me,R9为I,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物90:n为0,X为S,Y为O,R5为Me,R7为NO2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物91:n为0,X为S,Y为O,R5为Me,R8为NO2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物92:n为0,X为S,Y为O,R5为Me,R9为NO2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物93:n为0,X为S,Y为O,R5为Me,R7为CF3,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物94:n为0,X为S,Y为O,R5为Me,R8为CF3,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物95:n为0,X为S,Y为O,R5为Me,R9为CF3,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物96:n为0,X为S,Y为O,R5为Me,R7为OCF3,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物97:n为0,X为S,Y为O,R5为Me,R8为OCF3,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物98:n为0,X为S,Y为O,R5为Me,R9为OCF3,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物99:n为0,X为S,Y为O,R5为Me,R7为OCHF2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物100:n为0,X为S,Y为O,R5为Me,R8为OCHF2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物101:n为0,X为S,Y为O,R5为Me,R9为OCHF2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物102:n为0,X为S,Y为O,R5为Me,R9为SCF3,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物103:n为0,X为S,Y为O,R5为Me,R7为OCH3,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物104:n为0,X为S,Y为O,R5为Me,R8为OCH3,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物105:n为0,X为S,Y为O,R5为Me,R9为OCH3,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物106:n为0,X为S,Y为O,R5为Me,R9为OC2H5,R2、R3、R4、R6、R8、R7、R10、R11均为H;
化合物107:n为0,X为S,Y为O,R5为Me,R7为CN,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物108:n为0,X为S,Y为O,R5为Me,R8为CN,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物109:n为0,X为S,Y为O,R5为Me,R9为CN,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物110:n为0,X为S,Y为O,R5和R7为Me,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物111:n为0,X为S,Y为O,R5和R8为Me,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物112:n为0,X为S,Y为O,R5和R9为Me,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物113:n为0,X为S,Y为O,R5为Me,R7为CH3SO2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物114:n为0,X为S,Y为O,R5为Me,R8为CH3SO2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物115:n为0,X为S,Y为O,R5为Me,R9为CH3SO2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物116:n为0,X为S,Y为O,R5为Me,R7为C2H5SO2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物117:n为0,X为S,Y为O,R5为Me,R7和R8均为Cl,R2、R3、R4、R6、R9、R10、R11均为H;
化合物118:n为0,X为S,Y为O,R5为Me,R7和R9均为Cl,R2、R3、R4、R6、R8、R10、R11均为H;
化合物119:n为0,X为S,Y为O,R5为Me,R7和R10均为Cl,R2、R3、R4、R6、R8、R9、R11均为H;
化合物120:n为0,X为S,Y为O,R5为Me,R7和R11均为Cl,R2、R3、R4、R6、R8、R9、R10均为H;
化合物121:n为0,X为S,Y为O,R5为Me,R8和R9均为Cl,R2、R3、R4、R6、R7、R10、R11均为H;
化合物122:n为0,X为S,Y为O,R5和R7为Me,R9为Cl,R2、R3、R4、R6、R8、R10、R11均为H;
化合物123:n为0,X为S,Y为O,R5、R7、R8均为Me,R2、R3、R4、R6、R9、R10、R11均为H;
化合物124:n为0,X为S,Y为O,R5、R7、R9为均Me,R2、R3、R4、R6、R8、R10、R11均为H;
化合物125:n为0,X为S,Y为O,R5、R7、R10均为Me,R2、R3、R4、R6、R8、R9、R11均为H;
化合物126:n为0,X为S,Y为O,R5、R7、R11均为Me,R2、R3、R4、R6、R8、R9、R10均为H;
化合物127:n为0,X为S,Y为O,R5、R7、R8、R11均为Me,R2、R3、R4、R6、R9、R10均为H;
化合物128:n为0,X为S,Y为O,R5、R7、R9、R11均为Me,R2、R3、R4、R6、R8、R10均为H;
化合物129:n为0,X为S,Y为O,R5为Me,R7、R9为均CF3,R2、R3、R4、R6、R8、R10、R11均为H;
化合物130:n为0,X为S,Y为O,R5为Me,R8、R10为均CF3,R2、R3、R4、R6、R7、R9、R11均为H;
化合物131:n为0,X为S,Y为O,R5为Me,R2、R3、R4、R6均为H,R7、R8、R9、R10、R11均为F;
化合物132:n为0,X为S,Y为O,R5为Me,R7为CH3CH2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物133:n为0,X为S,Y为O,R5为Me,R8为CH3CH2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物134:n为0,X为S,Y为O,R5为Me,R9为CH3CH2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物135:n为0,X为S,Y为O,R5为Me,R7为CH(CH3)2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物136:n为0,X为S,Y为O,R5为Me,R8为CH(CH3)2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物137:n为0,X为S,Y为O,R5为Me,R9为CH(CH3)2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物138:n为0,X为S,Y为O,R5为Me,R7为CH3(CH2)2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物139:n为0,X为S,Y为O,R5为Me,R7为R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物140:n为0,X为S,Y为O,R5为Me,R7为R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物141:n为0,X为S,Y为O,R5为Me,R7为CO2CH3,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物142:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物143:n为0,X为S,Y为O,R5为Me,R8和R9环合形成R2、R3、R4、R6、R7、R10、R11均为H;
化合物144:n为0,X为S,Y为O,R5为Me,R8和R9环合形成R2、R3、R4、R6、R7、R10、R11均为H;
化合物145:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物146:n为0,X为S,Y为O,R5为Me,R8和R9环合形成R2、R3、R4、R6、R7、R10、R11均为H;
化合物147:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物148:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物149:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物150:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物151:n为0,X为S,Y为O,R5为Me,R7和R8环合形成R2、R3、R4、R6、R9、R10、R11均为H;
化合物152:n为0,X为S,Y为O,R5为Me,R8和R9环合形成R2、R3、R4、R6、R7、R10、R11均为H;
化合物153:n为0,X为S,Y为O,R5、R6均为Me,R2、R3、R4、R7、R8、R9、R10、R11均为H;
化合物154:n为0,X为S,Y为O,R5、R6均为Me,R7为F,R2、R3、R4、R8、R9、R10、R11均为H;
化合物155:n为0,X为S,Y为O,R5、R6均为Me,R8为F,R2、R3、R4、R7、R9、R10、R11均为H;
化合物156:n为0,X为S,Y为O,R5、R6均为Me,R9为F,R2、R3、R4、R7、R8、R10、R11均为H;
化合物157:n为0,X为S,Y为O,R5、R6均为Me,R7为Cl,R2、R3、R4、R8、R9、R10、R11均为H;
化合物158:n为0,X为S,Y为O,R5、R6均为Me,R8为Cl,R2、R3、R4、R7、R9、R10、R11均为H;
化合物159:n为0,X为S,Y为O,R5、R6均为Me,R9为Cl,R2、R3、R4、R7、R8、R10、R11均为H;
化合物160:n为0,X为S,Y为O,R5、R6均为Me,R7为Br,R2、R3、R4、R8、R9、R10、R11均为H;
化合物161:n为0,X为S,Y为O,R5、R6均为Me,R8为Br,R2、R3、R4、R7、R9、R10、R11均为H;
化合物162:n为0,X为S,Y为O,R5、R6均为Me,R9为Br,R2、R3、R4、R7、R8、R10、R11均为H;
化合物163:n为0,X为S,Y为O,R5、R6均为Me,R7为I,R2、R3、R4、R8、R9、R10、R11均为H;
化合物164:n为0,X为S,Y为O,R5、R6均为Me,R8为I,R2、R3、R4、R7、R9、R10、R11均为H;
化合物165:n为0,X为S,Y为O,R5、R6均为Me,R9为I,R2、R3、R4、R7、R8、R10、R11均为H;
化合物166:n为0,X为S,Y为O,R5、R6均为Me,R7为NO2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物167:n为0,X为S,Y为O,R5、R6均为Me,R8为NO2,R2、R3、R4、R7、R9、R10、R11均为H;
化合物168:n为0,X为S,Y为O,R5、R6均为Me,R9为NO2,R2、R3、R4、R7、R8、R10、R11均为H;
化合物169:n为0,X为S,Y为O,R5、R6均为Me,R7为CF3,R2、R3、R4、R8、R9、R10、R11均为H;
化合物170:n为0,X为S,Y为O,R5、R6均为Me,R8为CF3,R2、R3、R4、R7、R9、R10、R11均为H;
化合物171:n为0,X为S,Y为O,R5、R6均为Me,R9为CF3,R2、R3、R4、R7、R8、R10、R11均为H;
化合物172:n为0,X为S,Y为O,R5、R6均为Me,R7为OCF3,R2、R3、R4、R8、R9、R10、R11均为H;
化合物173:n为0,X为S,Y为O,R5、R6均为Me,R8为OCF3,R2、R3、R4、R7、R9、R10、R11均为H;
化合物174:n为0,X为S,Y为O,R5、R6均为Me,R9为OCF3,R2、R3、R4、R7、R8、R10、R11均为H;
化合物175:n为0,X为S,Y为O,R5、R6均为Me,R7为OCHF2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物176:n为0,X为S,Y为O,R5、R6均为Me,R8为OCHF2,R2、R3、R4、R7、R9、R10、R11均为H;
化合物177:n为0,X为S,Y为O,R5、R6均为Me,R9为OCHF2,R2、R3、R4、R7、R8、R10、R11均为H;
化合物178:n为0,X为S,Y为O,R5、R6均为Me,R9为SCF3,R2、R3、R4、R7、R8、R10、R11均为H;
化合物179:n为0,X为S,Y为O,R5、R6均为Me,R7为OCH3,R2、R3、R4、R8、R9、R10、R11均为H;
化合物180:n为0,X为S,Y为O,R5、R6均为Me,R8为OCH3,R2、R3、R4、R7、R9、R10、R11均为H;
化合物181:n为0,X为S,Y为O,R5、R6均为Me,R9为OCH3,R2、R3、R4、R7、R8、R10、R11均为H;
化合物182:n为0,X为S,Y为O,R5、R6均为Me,R9为OC2H5,R2、R3、R4、R8、R7、R10、R11均为H;
化合物183:n为0,X为S,Y为O,R5、R6均为Me,R7为CN,R2、R3、R4、R8、R9、R10、R11均为H;
化合物184:n为0,X为S,Y为O,R5、R6均为Me,R8为CN,R2、R3、R4、R7、R9、R10、R11均为H;
化合物185:n为0,X为S,Y为O,R5、R6均为Me,R9为CN,R2、R3、R4、R7、R8、R10、R11均为H;
化合物186:n为0,X为S,Y为O,R5、R6和R7为Me,R2、R3、R4、R8、R9、R10、R11均为H;
化合物187:n为0,X为S,Y为O,R5、R6和R8为Me,R2、R3、R4、R7、R9、R10、R11均为H;
化合物188:n为0,X为S,Y为O,R5、R6和R9为Me,R2、R3、R4、R7、R8、R10、R11均为H;
化合物189:n为0,X为S,Y为O,R5、R6均为Me,R7为CH3SO2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物190:n为0,X为S,Y为O,R5、R6均为Me,R8为CH3SO2,R2、R3、R4、R7、R9、R10、R11均为H;
化合物191:n为0,X为S,Y为O,R5、R6均为Me,R9为CH3SO2,R2、R3、R4、R7、R8、R10、R11均为H;
化合物192:n为0,X为S,Y为O,R5、R6均为Me,R7为C2H5SO2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物193:n为0,X为S,Y为O,R5、R6均为Me,R7和R8均为Cl,R2、R3、R4、R9、R10、R11均为H;
化合物194:n为0,X为S,Y为O,R5、R6均为Me,R7和R9均为Cl,R2、R3、R4、R8、R10、R11均为H;
化合物195:n为0,X为S,Y为O,R5、R6均为Me,R7和R10均为Cl,R2、R3、R4、R8、R9、R11均为H;
化合物196:n为0,X为S,Y为O,R5、R6均为Me,R7和R11均为Cl,R2、R3、R4、R8、R9、R10均为H;
化合物197:n为0,X为S,Y为O,R5、R6均为Me,R8和R9均为Cl,R2、R3、R4、R7、R10、R11均为H;
化合物198:n为0,X为S,Y为O,R5、R6和R7为Me,R9为Cl,R2、R3、R4、R8、R10、R11均为H;
化合物199:n为0,X为S,Y为O,R5、R6、R7、R8均为Me,R2、R3、R4、R9、R10、R11均为H;
化合物200:n为0,X为S,Y为O,R5、R6、R7、R9为均Me,R2、R3、R4、R8、R10、R11均为H;
化合物201:n为0,X为S,Y为O,R5、R6、R7、R10均为Me,R2、R3、R4、R8、R9、R11均为H;
化合物202:n为0,X为S,Y为O,R5、R6、R7、R11均为Me,R2、R3、R4、R8、R9、R10均为H;
化合物203:n为0,X为S,Y为O,R5、R6、R7、R8、R11均为Me,R2、R3、R4、R9、R10均为H;
化合物204:n为0,X为S,Y为O,R5、R6、R7、R9、R11均为Me,R2、R3、R4、R8、R10均为H;
化合物205:0,X为S,Y为O,R5、R6均为Me,R7、R9为均CF3,R2、R3、R4、R8、R10、R11均为H;
化合物206:0,X为S,Y为O,R5、R6均为Me,R8、R10为均CF3,R2、R3、R4、R7、R9、R11均为H;
化合物207:0,X为S,Y为O,R5、R6均为Me,R2、R3、R4均为H,R7、R8、R9、R10、R11均为F;
化合物208:0,X为S,Y为O,R5、R6均为Me,R7为CH3CH2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物209:0,X为S,Y为O,R5、R6均为Me,R8为CH3CH2,R2、R3、R4、R7、R9、R10、R11均为H;
化合物210:0,X为S,Y为O,R5、R6均为Me,R9为CH3CH2,R2、R3、R4、R7、R8、R10、R11均为H;
化合物211:0,X为S,Y为O,R5、R6均为Me,R7为CH(CH3)2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物212:0,X为S,Y为O,R5、R6均为Me,R8为CH(CH3)2,R2、R3、R4、R7、R9、R10、R11均为H;
化合物213:0,X为S,Y为O,R5、R6均为Me,R9为CH(CH3)2,R2、R3、R4、R7、R8、R10、R11均为H;
化合物214:0,X为S,Y为O,R5、R6均为Me,R7为CH3(CH2)2,R2、R3、R4、R8、R9、R10、R11均为H;
化合物215:0,X为S,Y为O,R5、R6均为Me,R7为C(CH3)3,R2、R3、R4、R8、R9、R10、R11均为H;
化合物216:0,X为S,Y为O,R5、R6均为Me,R7为R2、R3、R4、R8、R9、R10、R11均为H;
化合物217:0,X为S,Y为O,R5、R6均为Me,R7为R2、R3、R4、R8、R9、R10、R11均为H;
化合物218:0,X为S,Y为O,R5、R6均为Me,R7为CO2CH3,R2、R3、R4、R8、R9、R10、R11均为H;
化合物219:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物220:n为0,X为S,Y为O,R5、R6均为Me,R8和R9环合形成R2、R3、R4、R7、R10、R11均为H;
化合物221:n为0,X为S,Y为O,R5、R6均为Me,R8和R9环合形成R2、R3、R4、R7、R10、R11均为H;
化合物222:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物223:n为0,X为S,Y为O,R5、R6均为Me,R8和R9环合形成R2、R3、R4、R7、R10、R11均为H;
化合物224:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物225:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物226:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物227:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物228:n为0,X为S,Y为O,R5、R6均为Me,R7和R8环合形成R2、R3、R4、R9、R10、R11均为H;
化合物229:n为0,X为S,Y为O,R5、R6均为Me,R8和R9环合形成R2、R3、R4、R7、R10、R11均为H;
化合物230:n为0,X为S,Y为CH2,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物231:n为0,X为S,Y为CH2,R6为Me,R7为F,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物232:n为0,X为S,Y为CH2,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物233:n为0,X为S,Y为CH2,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物234:n为0,X为S,Y为CH2,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物235:n为0,X为S,Y为CH2,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物236:n为0,X为S,Y为CH2,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物237:n为0,X为S,Y为CH2,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物238:n为0,X为S,Y为CH2,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物239:n为0,X为S,Y为CH2,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物240:n为0,X为S,Y为CH2,R6为Me,R7为I,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物241:n为0,X为S,Y为CH2,R6为Me,R8为I,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物242:n为0,X为S,Y为CH2,R6为Me,R9为I,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物243:n为0,X为S,Y为CH2,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物244:n为0,X为S,Y为CH2,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物245:n为0,X为S,Y为CH2,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物246:n为0,X为S,Y为CH2,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物247:n为0,X为S,Y为CH2,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物248:n为0,X为S,Y为CH2,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物249:n为0,X为S,Y为CH2,R6为Me,R7为OCF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物250:n为0,X为S,Y为CH2,R6为Me,R8为OCF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物251:n为0,X为S,Y为CH2,R6为Me,R9为OCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物252:n为0,X为S,Y为CH2,R6为Me,R7为OCHF2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物253:n为0,X为S,Y为CH2,R6为Me,R8为OCHF2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物254:n为0,X为S,Y为CH2,R6为Me,R9为OCHF2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物255:n为0,X为S,Y为CH2,R6为Me,R9为SCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物256:n为0,X为S,Y为CH2,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物257:n为0,X为S,Y为CH2,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物258:n为0,X为S,Y为CH2,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物259:n为0,X为S,Y为CH2,R6为Me,R9为OC2H5,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物260:n为0,X为S,Y为CH2,R6为Me,R7为CN,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物261:n为0,X为S,Y为CH2,R6为Me,R8为CN,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物262:n为0,X为S,Y为CH2,R6为Me,R9为CN,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物263:n为0,X为S,Y为CH2,R6和R7为Me,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物264:n为0,X为S,Y为CH2,R6和R8为Me,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物265:n为0,X为S,Y为CH2,R6和R9为Me,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物266:n为0,X为S,Y为CH2,R6为Me,R7为CH3SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物267:n为0,X为S,Y为CH2,R6为Me,R8为CH3SO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物268:n为0,X为S,Y为CH2,R6为Me,R9为CH3SO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物269:n为0,X为S,Y为CH2,R6为Me,R7为C2H5SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物270:n为0,X为S,Y为CH2,R6为Me,R7和R8均为Cl,R2、R3、R4、R5、R9、R10、R11均为H;
化合物271:n为0,X为S,Y为CH2,R6为Me,R7和R9均为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物272:n为0,X为S,Y为CH2,R6为Me,R7和R10均为Cl,R2、R3、R4、R5、R8、R9、R11均为H;
化合物273:n为0,X为S,Y为CH2,R6为Me,R7和R11均为Cl,R2、R3、R4、R5、R8、R9、R10均为H;
化合物274:n为0,X为S,Y为CH2,R6为Me,R8和R9均为Cl,R2、R3、R4、R5、R7、R10、R11均为H;
化合物275:n为0,X为S,Y为CH2,R6和R7为Me,R9为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物276:n为0,X为S,Y为CH2,R6、R7、R8均为Me,R2、R3、R4、R5、R9、R10、R11均为H;
化合物277:n为0,X为S,Y为CH2,R6、R7、R9为均Me,R2、R3、R4、R5、R8、R10、R11均为H;
化合物278:n为0,X为S,Y为CH2,R6、R7、R10均为Me,R2、R3、R4、R5、R8、R9、R11均为H;
化合物279:n为0,X为S,Y为CH2,R6、R7、R11均为Me,R2、R3、R4、R5、R8、R9、R10均为H;
化合物280:n为0,X为S,Y为CH2,R6、R7、R8、R11均为Me,R2、R3、R4、R5、R9、R10均为H;
化合物281:n为0,X为S,Y为CH2,R6、R7、R9、R11均为Me,R2、R3、R4、R5、R8、R10均为H;
化合物282:n为0,X为S,Y为CH2,R6为Me,R7、R9为均CF3,R2、R3、R4、R5、R8、R10、R11均为H;
化合物283:n为0,X为S,Y为CH2,R6为Me,R8、R10为均CF3,R2、R3、R4、R5、R7、R9、R11均为H;
化合物284:n为0,X为S,Y为CH2,R6为Me,R2、R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物285:n为0,X为S,Y为CH2,R6为Me,R7为CH3CH2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物286:n为0,X为S,Y为CH2,R6为Me,R8为CH3CH2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物287:n为0,X为S,Y为CH2,R6为Me,R9为CH3CH2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物288:n为0,X为S,Y为CH2,R6为Me,R7为CH(CH3)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物289:n为0,X为S,Y为CH2,R6为Me,R8为CH(CH3)2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物290:n为0,X为S,Y为CH2,R6为Me,R9为CH(CH3)2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物291:n为0,X为S,Y为CH2,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物292:n为0,X为S,Y为CH2,R6为Me,R7为C(CH3)3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物293:n为0,X为S,Y为CH2,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;/>
化合物294:n为0,X为S,Y为CH2,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物295:n为0,X为S,Y为CH2,R6为Me,R7为CO2CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物296:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物297:n为0,X为S,Y为CH2,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物298:n为0,X为S,Y为CH2,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物299:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物300:n为0,X为S,Y为CH2,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物300:n为0,X为S,Y为CH2,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物301:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物302:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物303:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物304:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物305:n为0,X为S,Y为CH2,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;/>
化合物306:n为0,X为S,Y为CH2,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物307:n为0,X为S,Y为NMe,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物308:n为0,X为S,Y为NMe,R6为Me,R7为F,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物309:n为0,X为S,Y为NMe,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物310:n为0,X为S,Y为NMe,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物311:n为0,X为S,Y为NMe,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物312:n为0,X为S,Y为NMe,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物313:n为0,X为S,Y为NMe,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物314:n为0,X为S,Y为NMe,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物315:n为0,X为S,Y为NMe,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物316:n为0,X为S,Y为NMe,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物317:n为0,X为S,Y为NMe,R6为Me,R7为I,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物318:n为0,X为S,Y为NMe,R6为Me,R8为I,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物319:n为0,X为S,Y为NMe,R6为Me,R9为I,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物320:n为0,X为S,Y为NMe,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物321:n为0,X为S,Y为NMe,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物322:n为0,X为S,Y为NMe,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物323:n为0,X为S,Y为NMe,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物324:n为0,X为S,Y为NMe,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物325:n为0,X为S,Y为NMe,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物326:n为0,X为S,Y为NMe,R6为Me,R7为OCF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物327:n为0,X为S,Y为NMe,R6为Me,R8为OCF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物328:n为0,X为S,Y为NMe,R6为Me,R9为OCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物329:n为0,X为S,Y为NMe,R6为Me,R7为OCHF2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物330:n为0,X为S,Y为NMe,R6为Me,R8为OCHF2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物331:n为0,X为S,Y为NMe,R6为Me,R9为OCHF2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物332:n为0,X为S,Y为NMe,R6为Me,R9为SCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物333:n为0,X为S,Y为NMe,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物334:n为0,X为S,Y为NMe,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物335:n为0,X为S,Y为NMe,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物336:n为0,X为S,Y为NMe,R6为Me,R9为OC2H5,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物337:n为0,X为S,Y为NMe,R6为Me,R7为CN,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物338:n为0,X为S,Y为NMe,R6为Me,R8为CN,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物339:n为0,X为S,Y为NMe,R6为Me,R9为CN,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物340:n为0,X为S,Y为NMe,R6为Me,R7为CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物341:n为0,X为S,Y为NMe,R6为Me,R8为CH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物342:n为0,X为S,Y为NMe,R6为Me,R9为CH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物343:n为0,X为S,Y为NMe,R6为Me,R7为CH3SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物344:n为0,X为S,Y为NMe,R6为Me,R8为CH3SO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物345:n为0,X为S,Y为NMe,R6为Me,R9为CH3SO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物346:n为0,X为S,Y为NMe,R6为Me,R7为C2H5SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物347:n为0,X为S,Y为NMe,R6为Me,R7和R8均为Cl,R2、R3、R4、R5、R9、R10、R11均为H;
化合物348:n为0,X为S,Y为NMe,R6为Me,R7和R9均为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物349:n为0,X为S,Y为NMe,R6为Me,R7和R10均为Cl,R2、R3、R4、R5、R8、R9、R11均为H;
化合物350:n为0,X为S,Y为NMe,R6为Me,R7和R11均为Cl,R2、R3、R4、R5、R8、R9、R10均为H;
化合物351:n为0,X为S,Y为NMe,R6为Me,R8和R9均为Cl,R2、R3、R4、R5、R7、R10、R11均为H;
化合物352:n为0,X为S,Y为NMe,R6和R7为Me,R9为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物353:n为0,X为S,Y为NMe,R6、R7和R8为Me,R2、R3、R4、R5、R9、R10、R11均为H;
化合物354:n为0,X为S,Y为NMe,R6、R7和R9为Me,R2、R3、R4、R5、R8、R10、R11均为H;
化合物355:n为0,X为S,Y为NMe,R6、R7和R10为Me,R2、R3、R4、R5、R8、R9、R11均为H;
化合物356:n为0,X为S,Y为NMe,R6、R7和R11为Me,R2、R3、R4、R5、R8、R9、R10均为H;
化合物357:n为0,X为S,Y为NMe,R6、R7、R8和R11为Me,R2、R3、R4、R5、R9、R10均为H;
化合物358:n为0,X为S,Y为NMe,R6、R7、R9和R11为Me,R2、R3、R4、R5、R8、R10均为H;
化合物359:n为0,X为S,Y为NMe,R6为Me,R7和R9均为CF3,R2、R3、R4、R5、R8、R10、R11均为H;
化合物360:n为0,X为S,Y为NMe,R6为Me,R8和R10均为CF3,R2、R3、R4、R5、R7、R9、R11均为H;
化合物361:n为0,X为S,Y为NMe,R6为Me,R2、R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物362:n为0,X为S,Y为NMe,R6为Me,R7为CH3CH2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物363:n为0,X为S,Y为NMe,R6为Me,R8为CH3CH2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物364:n为0,X为S,Y为NMe,R6为Me,R9为CH3CH2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物365:n为0,X为S,Y为NMe,R6为Me,R7为CH(CH3)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物366:n为0,X为S,Y为NMe,R6为Me,R8为CH(CH3)2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物367:n为0,X为S,Y为NMe,R6为Me,R9为CH(CH3)2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物368:n为0,X为S,Y为NMe,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物369:n为0,X为S,Y为NMe,R6为Me,R7为C(CH3)3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物370:n为0,X为S,Y为NMe,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物371:n为0,X为S,Y为NMe,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物372:n为0,X为S,Y为NMe,R6为Me,R7为CO2CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物373:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物374:n为0,X为S,Y为NMe,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;/>
化合物375:n为0,X为S,Y为NMe,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物376:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物377:n为0,X为S,Y为NMe,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物378:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物379:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物380:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物381:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物382:n为0,X为S,Y为NMe,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物383:n为0,X为S,Y为NMe,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物384:n为0,X为S,Y为O,R2、R6为Me,R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物385:n为0,X为S,Y为O,R2、R6为Me,R7为F,R3、R4、R5、R8、R9、R10、R11均为H;
化合物386:n为0,X为S,Y为O,R2、R6为Me,R8为F,R3、R4、R5、R7、R9、R10、R11均为H;
化合物387:n为0,X为S,Y为O,R2、R6为Me,R9为F,R3、R4、R5、R7、R8、R10、R11均为H;
化合物388:n为0,X为S,Y为O,R2、R6为Me,R7为Cl,R3、R4、R5、R8、R9、R10、R11均为H;
化合物389:n为0,X为S,Y为O,R2、R6为Me,R8为Cl,R3、R4、R5、R7、R9、R10、R11均为H;
化合物390:n为0,X为S,Y为O,R2、R6为Me,R9为Cl,R3、R4、R5、R7、R8、R10、R11均为H;
化合物391:n为0,X为S,Y为O,R2、R6为Me,R7为Br,R3、R4、R5、R8、R9、R10、R11均为H;
化合物392:n为0,X为S,Y为O,R2、R6为Me,R8为Br,R3、R4、R5、R7、R9、R10、R11均为H;
化合物393:n为0,X为S,Y为O,R2、R6为Me,R9为Br,R3、R4、R5、R7、R8、R10、R11均为H;
化合物394:n为0,X为S,Y为O,R2、R6为Me,R7为I,R3、R4、R5、R8、R9、R10、R11均为H;
化合物395:n为0,X为S,Y为O,R2、R6为Me,R8为I,R3、R4、R5、R7、R9、R10、R11均为H;
化合物396:n为0,X为S,Y为O,R2、R6为Me,R9为I,R3、R4、R5、R7、R8、R10、R11均为H;
化合物397:n为0,X为S,Y为O,R2、R6为Me,R7为NO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物398:n为0,X为S,Y为O,R2、R6为Me,R8为NO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物399:n为0,X为S,Y为O,R2、R6为Me,R9为NO2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物400:n为0,X为S,Y为O,R2、R6为Me,R7为CF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物401:n为0,X为S,Y为O,R2、R6为Me,R8为CF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物402:n为0,X为S,Y为O,R2、R6为Me,R9为CF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物403:n为0,X为S,Y为O,R2、R6为Me,R7为OCF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物404:n为0,X为S,Y为O,R2、R6为Me,R8为OCF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物405:n为0,X为S,Y为O,R2、R6为Me,R9为OCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物406:n为0,X为S,Y为O,R2、R6为Me,R7为OCHF2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物407:n为0,X为S,Y为O,R2、R6为Me,R8为OCHF2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物408:n为0,X为S,Y为O,R2、R6为Me,R9为OCHF2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物409:n为0,X为S,Y为O,R2、R6为Me,R9为SCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物410:n为0,X为S,Y为O,R2、R6为Me,R7为OCH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物411:n为0,X为S,Y为O,R2、R6为Me,R8为OCH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物412:n为0,X为S,Y为O,R2、R6为Me,R9为OCH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物413:n为0,X为S,Y为O,R2、R6为Me,R9为OC2H5,R3、R4、R5、R7、R8、R10、R11均为H;
化合物414:n为0,X为S,Y为O,R2、R6为Me,R7为CN,R3、R4、R5、R8、R9、R10、R11均为H;
化合物415:n为0,X为S,Y为O,R2、R6为Me,R8为CN,R3、R4、R5、R7、R9、R10、R11均为H;
化合物416:n为0,X为S,Y为O,R2、R6为Me,R9为CN,R3、R4、R5、R7、R8、R10、R11均为H;
化合物417:n为0,X为S,Y为O,R2、R6为Me,R7为CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物418:n为0,X为S,Y为O,R2、R6为Me,R8为CH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物419:n为0,X为S,Y为O,R2、R6为Me,R9为CH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物420:n为0,X为S,Y为O,R2、R6为Me,R7为CH3SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物421:n为0,X为S,Y为O,R2、R6为Me,R8为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物422:n为0,X为S,Y为O,R2、R6为Me,R9为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物423:n为0,X为S,Y为O,R2、R6为Me,R7为C2H5SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物424:n为0,X为S,Y为O,R2、R6为Me,R7和R8均为Cl,R3、R4、R5、R9、R10、R11均为H;
化合物425:n为0,X为S,Y为O,R2、R6为Me,R7和R9均为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物426:n为0,X为S,Y为O,R2、R6为Me,R7和R10均为Cl,R3、R4、R5、R8、R9、R11均为H;
化合物427:n为0,X为S,Y为O,R2、R6为Me,R7和R11均为Cl,R3、R4、R5、R8、R9、R10均为H;
化合物428:n为0,X为S,Y为O,R2、R6为Me,R8和R9均为Cl,R3、R4、R5、R7、R10、R11均为H;
化合物429:n为0,X为S,Y为O,R2、R6和R7为Me,R9为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物430:n为0,X为S,Y为O,R2、R6、R7和R8为Me,R3、R4、R5、R9、R10、R11均为H;
化合物431:n为0,X为S,Y为O,R2、R6、R7和R9为Me,R3、R4、R5、R8、R10、R11均为H;
化合物432:n为0,X为S,Y为O,R2、R6、R7和R10为Me,R3、R4、R5、R8、R9、R11均为H;
化合物433:n为0,X为S,Y为O,R2、R6、R7和R11为Me,R3、R4、R5、R8、R9、R10均为H;
化合物434:n为0,X为S,Y为O,R2、R6、R7、R8和R11为Me,R3、R4、R5、R9、R10均为H;
化合物435:n为0,X为S,Y为O,R2、R6、R7、R9和R11为Me,R3、R4、R5、R8、R10均为H;
化合物436:n为0,X为S,Y为O,R2、R6为Me,R7和R9均为CF3,R3、R4、R5、R8、R10、R11均为H;
化合物437:n为0,X为S,Y为O,R2、R6为Me,R8和R10均为CF3,R3、R4、R5、R7、R9、R11均为H;
化合物438:n为0,X为S,Y为O,R2、R6为Me,R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物439:n为0,X为S,Y为O,R2、R6为Me,R7为CH3CH2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物440:n为0,X为S,Y为O,R2、R6为Me,R8为CH3CH2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物441:n为0,X为S,Y为O,R2、R6为Me,R9为CH3CH2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物442:n为0,X为S,Y为O,R2、R6为Me,R7为CH(CH3)2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物443:n为0,X为S,Y为O,R2、R6为Me,R8为CH(CH3)2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物444:n为0,X为S,Y为O,R2、R6为Me,R9为CH(CH3)2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物445:n为0,X为S,Y为O,R2、R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物446:n为0,X为S,Y为O,R2、R6为Me,R7为C(CH3)3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物447:n为0,X为S,Y为O,R2、R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物448:n为0,X为S,Y为O,R2、R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物449:n为0,X为S,Y为O,R2、R6为Me,R7为CO2CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物450:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物451:n为0,X为S,Y为O,R2、R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物452:n为0,X为S,Y为O,R2、R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物453:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物454:n为0,X为S,Y为O,R2、R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物455:n为0,X为S,Y为O,R2、R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;/>
化合物456:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物457:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物458:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物459:n为0,X为S,Y为O,R2、R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物460:n为0,X为S,Y为O,R2、R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物461:n为0,X为S,Y为O,R2为C2H5,R6为Me,R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物462:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为F,R3、R4、R5、R8、R9、R10、R11均为H;
化合物463:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为F,R3、R4、R5、R7、R9、R10、R11均为H;
化合物464:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为F,R3、R4、R5、R7、R8、R10、R11均为H;
化合物465:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为Cl,R3、R4、R5、R8、R9、R10、R11均为H;
化合物466:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为Cl,R3、R4、R5、R7、R9、R10、R11均为H;
化合物467:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为Cl,R3、R4、R5、R7、R8、R10、R11均为H;
化合物468:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为Br,R3、R4、R5、R8、R9、R10、R11均为H;
化合物469:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为Br,R3、R4、R5、R7、R9、R10、R11均为H;
化合物470:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为Br,R3、R4、R5、R7、R8、R10、R11均为H;
化合物471:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为I,R3、R4、R5、R8、R9、R10、R11均为H;
化合物472:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为I,R3、R4、R5、R7、R9、R10、R11均为H;
化合物473:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为I,R3、R4、R5、R7、R8、R10、R11均为H;
化合物474:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为NO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物475:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为NO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物476:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为NO2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物477:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物478:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物479:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物480:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为OCF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物481:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为OCF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物482:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为OCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物483:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为OCHF2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物484:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为OCHF2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物485:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为OCHF2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物486:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为SCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物487:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为OCH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物488:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为OCH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物489:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为OCH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物490:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为OC2H5,R3、R4、R5、R7、R8、R10、R11均为H;
化合物491:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CN,R3、R4、R5、R8、R9、R10、R11均为H;
化合物492:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CN,R3、R4、R5、R7、R9、R10、R11均为H;
化合物493:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CN,R3、R4、R5、R7、R8、R10、R11均为H;
化合物494:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物495:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物496:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物497:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CH3SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物498:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物499:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物500:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为C2H5SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物501:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8均为Cl,R3、R4、R5、R9、R10、R11均为H;
化合物502:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R9均为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物503:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R10均为Cl,R3、R4、R5、R8、R9、R11均为H;
化合物504:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R11均为Cl,R3、R4、R5、R8、R9、R10均为H;
化合物505:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9均为Cl,R3、R4、R5、R7、R10、R11均为H;
化合物506:n为0,X为S,Y为O,R2为C2H5,R6和R7为Me,R9为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物507:n为0,X为S,Y为O,R2为C2H5,R6、R7和R8为Me,R3、R4、R5、R9、R10、R11均为H;
化合物508:n为0,X为S,Y为O,R2为C2H5,R6、R7和R9为Me,R3、R4、R5、R8、R10、R11均为H;
化合物509:n为0,X为S,Y为O,R2为C2H5,R6、R7和R10为Me,R3、R4、R5、R8、R9、R11均为H;
化合物510:n为0,X为S,Y为O,R2为C2H5,R7和R11为Me,R3、R4、R5、R8、R9、R10均为H;
化合物511:n为0,X为S,Y为O,R2为C2H5,R6、R7、R8和R11为Me,R3、R4、R5、R9、R10均为H;
化合物512:n为0,X为S,Y为O,R2为C2H5,R6、R7、R9和R11为Me,R3、R4、R5、R8、R10均为H;
化合物513:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R9均为CF3,R3、R4、R5、R8、R10、R11均为H;
化合物514:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R10均为CF3,R3、R4、R5、R7、R9、R11均为H;
化合物515:n为0,X为S,Y为O,R2为C2H5,R6为Me,R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物516:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CH3CH2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物517:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CH3CH2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物518:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CH3CH2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物519:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CH(CH3)2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物520:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8为CH(CH3)2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物521:n为0,X为S,Y为O,R2为C2H5,R6为Me,R9为CH(CH3)2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物522:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物523:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为C(CH3)3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物524:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物525:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物526:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7为CO2CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物527:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物528:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物529:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;/>
化合物530:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物531:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物532:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物533:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物534:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物535:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物536:n为0,X为S,Y为O,R2为C2H5,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物537:n为0,X为S,Y为O,R2为C2H5,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物796:n为0,X为S,Y为O,R2为OMe,R6为Me,R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物797:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为F,R3、R4、R5、R8、R9、R10、R11均为H;
化合物798:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为F,R3、R4、R5、R7、R9、R10、R11均为H;
化合物799:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为F,R3、R4、R5、R7、R8、R10、R11均为H;
化合物800:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为Cl,R3、R4、R5、R8、R9、R10、R11均为H;
化合物801:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为Cl,R3、R4、R5、R7、R9、R10、R11均为H;
化合物802:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为Cl,R3、R4、R5、R7、R8、R10、R11均为H;
化合物803:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为Br,R3、R4、R5、R8、R9、R10、R11均为H;
化合物804:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为Br,R3、R4、R5、R7、R9、R10、R11均为H;
化合物805:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为Br,R3、R4、R5、R7、R8、R10、R11均为H;
化合物806:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为I,R3、R4、R5、R8、R9、R10、R11均为H;
化合物807:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为I,R3、R4、R5、R7、R9、R10、R11均为H;
化合物808:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为I,R3、R4、R5、R7、R8、R10、R11均为H;
化合物809:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为NO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物810:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为NO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物811:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为NO2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物812:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物813:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物814:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物815:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为OCF3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物816:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为OCF3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物817:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为OCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物818:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为OCHF2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物819:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为OCHF2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物820:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为OCHF2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物821:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为SCF3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物822:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为OCH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物823:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为OCH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物824:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为OCH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物825:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为OC2H5,R3、R4、R5、R7、R8、R10、R11均为H;
化合物826:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CN,R3、R4、R5、R8、R9、R10、R11均为H;
化合物827:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CN,R3、R4、R5、R7、R9、R10、R11均为H;
化合物828:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CN,R3、R4、R5、R7、R8、R10、R11均为H;
化合物829:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物830:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CH3,R3、R4、R5、R7、R9、R10、R11均为H;
化合物831:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CH3,R3、R4、R5、R7、R8、R10、R11均为H;
化合物832:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CH3SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物833:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物834:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CH3SO2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物835:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为C2H5SO2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物836:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8均为Cl,R3、R4、R5、R9、R10、R11均为H;
化合物837:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R9均为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物838:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R10均为Cl,R3、R4、R5、R8、R9、R11均为H;
化合物839:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R11均为Cl,R3、R4、R5、R8、R9、R10均为H;
化合物840:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9均为Cl,R3、R4、R5、R7、R10、R11均为H;
化合物841:n为0,X为S,Y为O,R2为OMe,R6和R7为Me,R9为Cl,R3、R4、R5、R8、R10、R11均为H;
化合物842:n为0,X为S,Y为O,R2为OMe,R6、R7和R8为Me,R3、R4、R5、R9、R10、R11均为H;
化合物843:n为0,X为S,Y为O,R2为OMe,R6、R7和R9为Me,R3、R4、R5、R8、R10、R11均为H;
化合物844:n为0,X为S,Y为O,R2为OMe,R6、R7和R10为Me,R3、R4、R5、R8、R9、R11均为H;
化合物845:n为0,X为S,Y为O,R2为OMe,R7和R11为Me,R3、R4、R5、R8、R9、R10均为H;
化合物846:n为0,X为S,Y为O,R2为OMe,R6、R7、R8和R11为Me,R3、R4、R5、R9、R10均为H;
化合物847:n为0,X为S,Y为O,R2为OMe,R6、R7、R9和R11为Me,R3、R4、R5、R8、R10均为H;
化合物848:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R9均为CF3,R3、R4、R5、R8、R10、R11均为H;
化合物849:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R10均为CF3,R3、R4、R5、R7、R9、R11均为H;
化合物850:n为0,X为S,Y为O,R2为OMe,R6为Me,R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物851:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CH3CH2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物852:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CH3CH2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物853:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CH3CH2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物854:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CH(CH3)2,R3、R4、R5、R8、R9、R10、R11均为H;
化合物855:n为0,X为S,Y为O,R2为OMe,R6为Me,R8为CH(CH3)2,R3、R4、R5、R7、R9、R10、R11均为H;
化合物856:n为0,X为S,Y为O,R2为OMe,R6为Me,R9为CH(CH3)2,R3、R4、R5、R7、R8、R10、R11均为H;
化合物857:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物858:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为C(CH3)3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物859:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物860:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为R3、R4、R5、R8、R9、R10、R11均为H;
化合物861:n为0,X为S,Y为O,R2为OMe,R6为Me,R7为CO2CH3,R3、R4、R5、R8、R9、R10、R11均为H;
化合物862:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;/>
化合物863:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物864:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物865:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物866:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物867:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物868:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物869:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物870:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物871:n为0,X为S,Y为O,R2为OMe,R6为Me,R7和R8环合形成R3、R4、R5、R9、R10、R11均为H;
化合物872:n为0,X为S,Y为O,R2为OMe,R6为Me,R8和R9环合形成R3、R4、R5、R7、R10、R11均为H;
化合物538:n为0,X为SO,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物539:n为0,X为SO,Y为O,R6为Me,R7为F,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物540:n为0,X为SO,Y为O,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物541:n为0,X为SO,Y为O,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物542:n为0,X为SO,Y为O,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物543:n为0,X为SO,Y为O,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物544:n为0,X为SO,Y为O,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物545:n为0,X为SO,Y为O,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物546:n为0,X为SO,Y为O,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物547:n为0,X为SO,Y为O,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物548:n为0,X为SO,Y为O,R6为Me,R7为I,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物549:n为0,X为SO,Y为O,R6为Me,R8为I,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物550:n为0,X为SO,Y为O,R6为Me,R9为I,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物551:n为0,X为SO,Y为O,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物552:n为0,X为SO,Y为O,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物553:n为0,X为SO,Y为O,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物554:n为0,X为SO,Y为O,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物555:n为0,X为SO,Y为O,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物556:n为0,X为SO,Y为O,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物557:n为0,X为SO,Y为O,R6为Me,R7为OCF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物558:n为0,X为SO,Y为O,R6为Me,R8为OCF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物559:n为0,X为SO,Y为O,R6为Me,R9为OCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物560:n为0,X为SO,Y为O,R6为Me,R7为OCHF2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物561:n为0,X为SO,Y为O,R6为Me,R8为OCHF2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物562:n为0,X为SO,Y为O,R6为Me,R9为OCHF2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物563:n为0,X为SO,Y为O,R6为Me,R9为SCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物564:n为0,X为SO,Y为O,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物565:n为0,X为SO,Y为O,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物566:n为0,X为SO,Y为O,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物567:n为0,X为SO,Y为O,R6为Me,R9为OC2H5,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物568:n为0,X为SO,Y为O,R6为Me,R7为CN,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物569:n为0,X为SO,Y为O,R6为Me,R8为CN,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物570:n为0,X为SO,Y为O,R6为Me,R9为CN,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物571:n为0,X为SO,Y为O,R6为Me,R7为CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物572:n为0,X为SO,Y为O,R6为Me,R8为CH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物573:n为0,X为SO,Y为O,R6为Me,R9为CH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物574:n为0,X为SO,Y为O,R6为Me,R7为CH3SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物575:n为0,X为SO,Y为O,R6为Me,R8为CH3SO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物576:n为0,X为SO,Y为O,R6为Me,R9为CH3SO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物577:n为0,X为SO,Y为O,R6为Me,R7为C2H5SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物578:n为0,X为SO,Y为O,R6为Me,R7和R8均为Cl,R2、R3、R4、R5、R9、R10、R11均为H;
化合物579:n为0,X为SO,Y为O,R6为Me,R7和R9均为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物580:n为0,X为SO,Y为O,R6为Me,R7和R10均为Cl,R2、R3、R4、R5、R8、R9、R11均为H;
化合物581:n为0,X为SO,Y为O,R6为Me,R7和R11均为Cl,R2、R3、R4、R5、R8、R9、R10均为H;
化合物582:n为0,X为SO,Y为O,R6为Me,R8和R9均为Cl,R2、R3、R4、R5、R7、R10、R11均为H;
化合物583:n为0,X为SO,Y为O,R6和R7为Me,R9为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物584:n为0,X为SO,Y为O,R6、R7和R8为Me,R2、R3、R4、R5、R9、R10、R11均为H;
化合物585:n为0,X为SO,Y为O,R6、R7和R9为Me,R2、R3、R4、R5、R8、R10、R11均为H;
化合物586:n为0,X为SO,Y为O,R6、R7和R10为Me,R2、R3、R4、R5、R8、R9、R11均为H;
化合物587:n为0,X为SO,Y为O,R6、R7和R11为Me,R2、R3、R4、R5、R8、R9、R10均为H;
化合物588:n为0,X为SO,Y为O,R6、R7、R8和R11为Me,R2、R3、R4、R5、R9、R10均为H;
化合物589:n为0,X为SO,Y为O,R6、R7、R9和R11为Me,R2、R3、R4、R5、R8、R10均为H;
化合物590:n为0,X为SO,Y为O,R6为Me,R7和R9均为CF3,R2、R3、R4、R5、R8、R10、R11均为H;
化合物591:n为0,X为SO,Y为O,R6为Me,R8和R10均为CF3,R2、R3、R4、R5、R7、R9、R11均为H;
化合物592:n为0,X为SO,Y为O,R6为Me,R2、R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物593:n为0,X为SO,Y为O,R6为Me,R7为CH3CH2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物594:n为0,X为SO,Y为O,R6为Me,R8为CH3CH2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物595:n为0,X为SO,Y为O,R6为Me,R9为CH3CH2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物596:n为0,X为SO,Y为O,R6为Me,R7为CH(CH3)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物597:n为0,X为SO,Y为O,R6为Me,R8为CH(CH3)2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物598:n为0,X为SO,Y为O,R6为Me,R9为CH(CH3)2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物599:n为0,X为SO,Y为O,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物600:n为0,X为SO,Y为O,R6为Me,R7为C(CH3)3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物601:n为0,X为SO,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物602:n为0,X为SO,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物603:n为0,X为SO,Y为O,R6为Me,R7为CO2CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物604:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物605:n为0,X为SO,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物606:n为0,X为SO,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物607:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物608:n为0,X为SO,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物609:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物610:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物611:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物612:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物613:n为0,X为SO,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物614:n为0,X为SO,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物615:n为0,X为SO2,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物616:n为0,X为SO2,Y为O,R6为Me,R7为F,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物617:n为0,X为SO2,Y为O,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物618:n为0,X为SO2,Y为O,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物619:n为0,X为SO2,Y为O,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物620:n为0,X为SO2,Y为O,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物621:n为0,X为SO2,Y为O,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物622:n为0,X为SO2,Y为O,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物623:n为0,X为SO2,Y为O,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物624:n为0,X为SO2,Y为O,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物625:n为0,X为SO2,Y为O,R6为Me,R7为I,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物626:n为0,X为SO2,Y为O,R6为Me,R8为I,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物627:n为0,X为SO2,Y为O,R6为Me,R9为I,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物628:n为0,X为SO2,Y为O,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物629:n为0,X为SO2,Y为O,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物630:n为0,X为SO2,Y为O,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物631:n为0,X为SO2,Y为O,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物632:n为0,X为SO2,Y为O,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物633:n为0,X为SO2,Y为O,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物634:n为0,X为SO2,Y为O,R6为Me,R7为OCF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物635:n为0,X为SO2,Y为O,R6为Me,R8为OCF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物636:n为0,X为SO2,Y为O,R6为Me,R9为OCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物637:n为0,X为SO2,Y为O,R6为Me,R7为OCHF2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物638:n为0,X为SO2,Y为O,R6为Me,R8为OCHF2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物639:n为0,X为SO2,Y为O,R6为Me,R9为OCHF2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物640:n为0,X为SO2,Y为O,R6为Me,R9为SCF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物641:n为0,X为SO2,Y为O,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物642:n为0,X为SO2,Y为O,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物643:n为0,X为SO2,Y为O,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物644:n为0,X为SO2,Y为O,R6为Me,R9为OC2H5,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物645:n为0,X为SO2,Y为O,R6为Me,R7为CN,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物646:n为0,X为SO2,Y为O,R6为Me,R8为CN,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物647:n为0,X为SO2,Y为O,R6为Me,R9为CN,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物648:n为0,X为SO2,Y为O,R6为Me,R7为CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物649:n为0,X为SO2,Y为O,R6为Me,R8为CH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物650:n为0,X为SO2,Y为O,R6为Me,R9为CH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物651:n为0,X为SO2,Y为O,R6为Me,R7为CH3SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物652:n为0,X为SO2,Y为O,R6为Me,R8为CH3SO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物653:n为0,X为SO2,Y为O,R6为Me,R9为CH3SO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物654:n为0,X为SO2,Y为O,R6为Me,R7为C2H5SO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物655:n为0,X为SO2,Y为O,R6为Me,R7和R8均为Cl,R2、R3、R4、R5、R9、R10、R11均为H;
化合物656:n为0,X为SO2,Y为O,R6为Me,R7和R9均为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物657:n为0,X为SO2,Y为O,R6为Me,R7和R10均为Cl,R2、R3、R4、R5、R8、R9、R11均为H;
化合物658:n为0,X为SO2,Y为O,R6为Me,R7和R11均为Cl,R2、R3、R4、R5、R8、R9、R10均为H;
化合物659:n为0,X为SO2,Y为O,R6为Me,R8和R9均为Cl,R2、R3、R4、R5、R7、R10、R11均为H;
化合物660:n为0,X为SO2,Y为O,R6和R7为Me,R9为Cl,R2、R3、R4、R5、R8、R10、R11均为H;
化合物661:n为0,X为SO2,Y为O,R6、R7和R8为Me,R2、R3、R4、R5、R9、R10、R11均为H;
化合物662:n为0,X为SO2,Y为O,R6、R7和R9为Me,R2、R3、R4、R5、R8、R10、R11均为H;
化合物663:n为0,X为SO2,Y为O,R6、R7和R10为Me,R2、R3、R4、R5、R8、R9、R11均为H;
化合物664:n为0,X为SO2,Y为O,R6、R7和R11为Me,R2、R3、R4、R5、R8、R9、R10均为H;
化合物665:n为0,X为SO2,Y为O,R6、R7、R8和R11为Me,R2、R3、R4、R5、R9、R10均为H;
化合物666:n为0,X为SO2,Y为O,R6、R7、R9和R11为Me,R2、R3、R4、R5、R8、R10均为H;
化合物667:n为0,X为SO2,Y为O,R6为Me,R7和R9均为CF3,R2、R3、R4、R5、R8、R10、R11均为H;
化合物668:n为0,X为SO2,Y为O,R6为Me,R8和R10均为CF3,R2、R3、R4、R5、R7、R9、R11均为H;
化合物669:n为0,X为SO2,Y为O,R6为Me,R2、R3、R4、R5均为H,R7、R8、R9、R10、R11均为F;
化合物670:n为0,X为SO2,Y为O,R6为Me,R7为CH3CH2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物671:n为0,X为SO2,Y为O,R6为Me,R8为CH3CH2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物672:n为0,X为SO2,Y为O,R6为Me,R9为CH3CH2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物673:n为0,X为SO2,Y为O,R6为Me,R7为CH(CH3)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物674:n为0,X为SO2,Y为O,R6为Me,R8为CH(CH3)2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物675:n为0,X为SO2,Y为O,R6为Me,R9为CH(CH3)2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物676:n为0,X为SO2,Y为O,R6为Me,R7为CH3(CH2)2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物677:n为0,X为SO2,Y为O,R6为Me,R7为C(CH3)3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物678:n为0,X为SO2,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物679:n为0,X为SO2,Y为O,R6为Me,R7为R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物680:n为0,X为SO2,Y为O,R6为Me,R7为CO2CH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物681:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物682:n为0,X为SO2,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物683:n为0,X为SO2,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物684:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物685:n为0,X为SO2,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物686:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物687:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物688:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物689:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;
化合物690:n为0,X为SO2,Y为O,R6为Me,R7和R8环合形成R2、R3、R4、R5、R9、R10、R11均为H;/>
化合物691:n为0,X为SO2,Y为O,R6为Me,R8和R9环合形成R2、R3、R4、R5、R7、R10、R11均为H;
化合物692:n为1,X为S,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物693:n为2,X为S,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物697:n为0,X为S,Y为O,R2为R3、R4、R5、R7、R8、R9、R10、R11均为H,R6为CH3。
6.根据权利要求2或3所述的化合物,其中,在式(I)中,
R1选自C1-6的烷基、-(CH2)z-苯基、含有选自B类杂原子的不饱和五元环基团、含有B类杂原子的饱和四元环基团、含有B类杂原子的不饱和六元环基团、C4-8的饱和环烷基、苯并噻唑基、苯并恶唑基、苯并吡唑基、苯丙噻吩基、N-甲基-苯并吡咯基、z为1-6的整数;各个所述B类杂原子各自独立地选自O、S、N中的至少一种;且任选地,所述B类杂原子上含有C1-3的烷基作为取代基;
R2选自H、正丁基、-CH2-苯基;
R3、R4和R5均为H;R6为甲基;n为0;X为S;Y为O。
7.根据权利要求6所述的化合物,其中,在式(I)中,
n、X、Y、R1、R2、R3、R4、R5、R6的取代情况如下:
化合物694:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物695:n为0,X为S,Y为O,R1为R2为H,R3、R4、R5均为H,R6为CH3;
化合物696:n为0,X为S,Y为O,R1为R2为/>R3、R4、R5均为H,R6为CH3;
化合物698:n为0,X为S,Y为O,R1为CH3,R2为CH3,R3、R4、R5均为H,R6为CH3;
化合物699:n为0,X为S,Y为O,R1为CH3CH2,R2为CH3,R3、R4、R5均为H,R6为CH3;
化合物700:n为0,X为S,Y为O,R1为CH3CH2,R2为CH3CH2,R3、R4、R5均为H,R6为CH3;
化合物701:n为0,X为S,Y为O,R1为(CH3)2CH2,R2为(CH3)2CH2,R3、R4、R5均为H,R6为CH3;
化合物702:n为0,X为S,Y为O,R1为(CH3)2CH2,R2为CH3CH2,R3、R4、R5均为H,R6为CH3;
化合物703:n为0,X为S,Y为O,R1为CH3CH3CH2,R2为CH3CH3CH2,R3、R4、R5均为H,R6为CH3;
化合物704:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物705:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;/>
化合物706:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物707:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物708:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物709:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物710:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物711:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物712:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物713:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物714:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物715:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物716:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物717:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物718:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物719:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物720:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;/>
化合物721:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物722:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物723:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物724:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物725:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物726:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物727:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物728:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物729:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物730:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物731:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物732:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物733:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物734:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;/>
化合物735:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物736:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物737:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物738:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物739:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物740:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物741:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物742:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物743:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物744:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物745:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物746:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物747:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;/>
化合物748:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物749:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物750:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物751:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物752:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物753:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物754:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物755:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物756:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物757:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物758:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物759:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物760:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物761:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;/>
化合物762:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物763:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物764:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物765:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物766:n为0,X为S,Y为O,R1为R2、R3、R4、R5均为H,R6为CH3;
化合物767:n为0,X为S,Y为O,R1为CH3(CH2)3,R2为CH3(CH2)3,R3、R4、R5均为H,R6为CH3。
8.根据权利要求1所述的化合物,其中,在式(I)中,X和Y均为O;
优选地,式(I)所示的化合物具有式(I-A)所示的化合物的结构:
其中,在式(I-A)中,n、X、Y、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11的取代情况如下:
化合物768:n为0,X为O,Y为O,R6为Me,R2、R3、R4、R5、R7、R8、R9、R10、R11均为H;
化合物769:n为0,X为O,Y为O,R6为Me,R7为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物770:n为0,X为O,Y为O,R6为Me,R8为F,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物771:n为0,X为O,Y为O,R6为Me,R9为F,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物772:n为0,X为O,Y为O,R6为Me,R7为Cl,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物773:n为0,X为O,Y为O,R6为Me,R8为Cl,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物774:n为0,X为O,Y为O,R6为Me,R9为Cl,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物775:n为0,X为O,Y为O,R6为Me,R7为Br,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物776:n为0,X为O,Y为O,R6为Me,R8为Br,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物777:n为0,X为O,Y为O,R6为Me,R9为Br,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物778:n为0,X为O,Y为O,R6为Me,R7为NO2,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物779:n为0,X为O,Y为O,R6为Me,R8为NO2,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物780:n为0,X为O,Y为O,R6为Me,R9为NO2,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物781:n为0,X为O,Y为O,R6为Me,R7为CF3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物782:n为0,X为O,Y为O,R6为Me,R8为CF3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物783:n为0,X为O,Y为O,R6为Me,R9为CF3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物784:n为0,X为O,Y为O,R6为Me,R7为OCH3,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物785:n为0,X为O,Y为O,R6为Me,R8为OCH3,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物786:n为0,X为O,Y为O,R6为Me,R9为OCH3,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物787:n为0,X为O,Y为O,R6和R7为Me,R2、R3、R4、R5、R8、R9、R10、R11均为H;
化合物788:n为0,X为O,Y为O,R6和R8为Me,R2、R3、R4、R5、R7、R9、R10、R11均为H;
化合物789:n为0,X为O,Y为O,R6和R9为Me,R2、R3、R4、R5、R7、R8、R10、R11均为H;
化合物790:n为0,X为O,Y为O,R5为Me,R7为CH3CH2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物791:n为0,X为O,Y为O,R5为Me,R8为CH3CH2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物792:n为0,X为O,Y为O,R5为Me,R9为CH3CH2,R2、R3、R4、R6、R7、R8、R10、R11均为H;
化合物793:n为0,X为O,Y为O,R5为Me,R7为CH(CH3)2,R2、R3、R4、R6、R8、R9、R10、R11均为H;
化合物794:n为0,X为O,Y为O,R5为Me,R8为CH(CH3)2,R2、R3、R4、R6、R7、R9、R10、R11均为H;
化合物795:n为0,X为O,Y为O,R5为Me,R9为CH(CH3)2,R2、R3、R4、R6、R7、R8、R10、R11均为H。
9.一种制备权利要求1-8中任意一项所述的酰胺类化合物的方法,其特征在于,该方法包括:将式(V-1)所示的化合物与式(V-2)所示的化合物进行接触反应;
其中,式(V-1)和式(V-2)中的取代基的取代情况与权利要求1-8中任意一项所述的酰胺类化合物中的取代情况对应相同,且Z1和Z2中的一者为-Br,另一者为-XH,X的定义与权利要求1-8中任意一项所述的酰胺类化合物中的定义对应相同。
10.一种制备权利要求1-8中任意一项所述的酰胺类化合物的方法,其特征在于,该方法包括:将式(II)所示的化合物与式(III)所示的化合物进行偶联反应;
其中,式(III)和式(II)中的取代基的取代情况与权利要求1-8中任意一项所述的酰胺类化合物中的取代情况对应相同。
11.权利要求1-8中任意一项所述的酰胺类化合物在农学中的应用;
优选地,所述农学中的应用选自提高作物产量、对植物进行非生物胁迫管理、调节植物生长、增强植物抗病能力、促进种子萌发中的至少一种应用。
12.一种生物刺激剂,其特征在于,该生物刺激剂中含有植物生长调节有效量的权利要求1-8中任意一项所述的酰胺类化合物中的至少一种,并且任选含有辅料;
优选地,所述酰胺类化合物的含量为1-99.99wt%,或者,所述酰胺类化合物的含量为0.001ppm-100ppm。
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